Download or read book The Design and Construction of the Cyclotron Mass Spectrometer written by Amy Fan-Yee Tsang and published by . This book was released on 1994 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Construction of a Cyclotron Mass Spectrometer written by Jill Testa and published by . This book was released on 1999 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design and Construction of a Simple Mass Spectrometer written by Arthur Bernard Marchant and published by . This book was released on 1958 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Abatement of Spectral Interferences in Elemental Mass Spectrometry written by Kenneth Eric Milgram and published by . This book was released on 1997 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design and Construction of a Mass Spectrometer for the Study of Basic Processes in Plasma Physics written by Moustafa Aly Mosharrafa and published by . This book was released on 1961 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advanced Electronics for Fourier transform Ion Cyclotron Resonance Mass Spectrometry written by Tzu-Yung Lin and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With the development of mass spectrometry (MS) instruments starting in the late 19th century, more and more research emphasis has been put on MS related subjects, especially the instrumentation and its applications. Instrumentation research has led modern mass spectrometers into a new era where the MS performance, such as resolving power and mass accuracy, is close to its theoretical limit. Such advanced performance releases more opportunities for scientists to conduct analytical research that could not be performed before. This thesis reviews general MS history and some of the important milestones, followed by introductions to ion cyclotron resonance (ICR) technique and quadrupole operation. Existing electronic designs, such as Fourier-transform ion cyclotron resonance (FT-ICR) preamplifiers (for ion signal detection) and radio-frequency (RF) oscillators (for ion transportation/filtering) are reviewed. Then the potential scope for improvement is discussed. Two new FT-ICR preamplifiers are reported; both preamplifiers operate at room temperature. The first preamplifier uses an operational amplifier (op amp) in a transimpedance configuration. When a 18-k feedback resistor is used, this preamplifier delivers a transimpedance of about 85 dB , and an input current noise spectral density of around 1 pA/ p Hz. The total power consumption of this circuit is around 310 mW when tested on the bench. This preamplifier has a bandwidth of fi3 kHz to 10 MHz, which corresponds to the mass-to-charge ratio, m/z, of approximately 18 to 61k at 12 T for FT-ICR MS. The transimpedance and the bandwidth can be adjusted by replacing passive components such as the feedback resistor and capacitor. The feedback and bandwidth limitation of the circuit is also discussed. When using an 0402 type surface mount resistor, the maximum possible transimpedance, without sacrificing its bandwidth, is approximated to 5.3 M . Under this condition, the preamplifier is estimated to be able to detect ~110 charges. The second preamplifier employs a single-transistor design using a different feedback arrangement, a T-shaped feedback network. Such a feedback system allows ~100-fold less feedback resistance at a given transimpedance, hence preserving bandwidth, which is beneficial to applications demanding high gain. The single-transistor preamplifier yields a low power consumption of ~5.7 mW, and a transimpedance of 80 dB in the frequency range between 1 kHz and 1 MHz (m/z of around 180 to 180k for a 12-T FT-ICR system). In trading noise performance for higher transimpedance, an alternative preamplifier design has also been presented with a transimpedance of 120 dB in the same frequency range. The previously reported room-temperature FT-ICR preamplifier had a voltage gain of about 25, a bandwidth of around 1 MHz when bench tested, and a voltage noise spectral density of ~7.4 nV/ p Hz. The bandwidth performance when connecting this preamplifier to an ICR cell has not been reported. However, from the transimpedance theory, the transimpedance preamplifiers reported in this work will have a bandwidth wider by a factor of the open-loop gain of the amplifier. In a separate development, an oscillator is proposed as a power supply for a quadrupole mass filter in a mass spectrometer system. It targets a stabilized output frequency, and a feedback control for output amplitude stabilization. The newly designed circuit has a very stable output frequency at 1 MHz, with a frequency tolerance of 15 ppm specified by the crystal oscillator datasheet. Within this circuit, an automatic gain control (AGC) unit is built for output amplitude stabilisation. A new transformer design is also proposed. The dimension of the quadrupole being used as a mass filter will be determined in the future. This circuit (in particular the transformer and the quadrupole connection/mounting device) will be finalised after the design of the quadrupole. Finally, this thesis concludes with a discussion between the gain and the noise performance of an FT-ICR preamplifier. A brief analysis about the correlation between the gain, cyclotron frequency, and input capacitance is performed. Future work is also suggested for extending this research.
Download or read book The Encyclopedia of Mass Spectrometry written by Keith A. Nier and published by Elsevier. This book was released on 2015-07-02 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry of The Encyclopedia of Mass Spectrometry briefly reviews the lives and works of many of the major people who carried out this development, providing insights into the history of mass spectrometry applications through the personal stories of pioneers and innovators in the field. The book presents biographies of notable contributors, including Nobel Prize winners J. J. Thomson, Francis W. Aston, Wolfgang Paul, John B. Fenn, and Koichi Tanaka, along with other luminaries in the field, including Franz Hillenkamp, Catherine Clarke Fenselau, Alfred O. C. Nier, and many more, discussing not only the instruments and their uses, but also providing interesting information on the careers, characters, and life stories of the people who did the work. Highlights over 120 innovators in mass spectrometry, including several Nobel Prize winners Discusses instrumentation and their uses, also providing interesting information on the careers, characters, and life stories of the people who did the work Offers unique insight into the careers and personalities of luminaries in the field Coordinates with Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry, an overview of mass spectrometry development and progress Ideal reference for those interested in a wide variety of topics, including analytical chemistry and chemical analysis, amongst others
Download or read book A Mass Spectrometer written by Henry G. McComb and published by . This book was released on 1965 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design and Construction of a Mass Spectrometer written by Truman L. Franklin and published by . This book was released on 1953 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Construction and Testing of a Single Particle Mass Spectrometer written by Raghunarayanan Mahadevan and published by . This book was released on 2001 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design and Construction of an All Metal 90 Sector Mass Spectrometer written by Leland Russell Stein and published by . This book was released on 1951 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design and Construction of a Radiofrequency Mass Spectrometer Bennett Type written by Donald Piquet Miller and published by . This book was released on 1952 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book On the Design and Construction of a Mass Spectrometer written by John Alexander Ziegler and published by . This book was released on 1942 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Computational and Instrumentation Methodologies for Biological Fourier transform Ion Cyclotron Resonance Mass Spectrometric FT ICR MS Imaging written by Konstantin Aizikov and published by . This book was released on 2010 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mass spectrometry imaging (MSI) is an emerging experimental methodology whose primary objective is the investigation of spatial variation of molecular composition within and across selected biological tissues to enable biomarker discovery, molecular diagnosis, and studies of drug metabolism, among other applications. The two major challenges, therefore, are the unambiguous identification and precise localization of biologically relevant compounds. These challenges can be recast as a problem of improving the accuracy and resolution of mass analyzers as well as the accuracy of the sample positioning robotics. The first part of this work reports on the progress and outlines the strategies of application of a recently developed high resolution spectral analysis technique, called the Filter Diagonalization Method (FDM), for the investigation of space-charge related phenomena inside the detection cell of a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR MS), understanding of which lies at the heart of the quest for further improvements in mass accuracy and resolution. The FDM spectrographic analysis revealed previously unobserved rapid isotope- beat space-charge induced ICR frequency modulations, shown to reach up to +/- 400 ppm even on high quality spectra. The application of this methodology to the investigation of a frequently observed but previously unexplained phenomenon in FT-ICR MS, the Spontaneous Loss of Coherence Catastrophe, conclusively demonstrated that it is tied directly to the space charge effect and magnetron expansion. The second part of this work reports on the development of the ionization source and vacuum compatible high precision sample positioning robotics for biological MSI applications, purpose built for FT-ICR MS. The complete design and implementation is reported herein, along with the demonstration of its performance and biological application. The XY-positioning stage capable of operating under 10 -8 mbar vacuum with submicron positioning accuracy along the entire ranges of motion of 100x100 mm was designed, built, and installed into the ionization sources of three MALDI FT-ICR MS instruments. Two dimensional chemo-spatial maps of rat brain tissue selections were constructed with 150 micron spatial resolution, identifying multiple ionic species with their distinct and discreet spatial localizations. These demonstrated performance characteristics greatly surpass current state-of-the-art robotics available for MALDI MSI and shift the effort of further improvements in spatial resolution to the ionization methodologies, and other ion source design issues, such as laser optics.
Download or read book Design and Construction of a Mass Spectrometer a Thesis written by Ronald E. Ferri and published by . This book was released on 1968 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Construction and Evaluation of an Omegatron Mass Spectrometer written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design and Construction of a Four Sector Mass Spectrometer written by Nicholas Hill and published by . This book was released on 1988 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
