Download or read book The Comparative Physiology of Regulatory Peptides written by Susanne Holmgren and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strictly speaking, the term regulatory peptides may include any peptide which has a regulatory function in any organism. In recent years, how ever, the term has come to mean those originally classified as brain-gut peptides. The peptides initially defined as those belonging to the brain gut axis had a dual location in neurones of the brain and endocrine cells of the gut. We now include a number of neuropeptides found in the autonomic nervous system of the gut, the cardiovascular system and other systems. To many scientists comparative physiology means comparison of the mechanisms of certain functions in the rat, the guinea-pig, the cat and maybe some other mammal. If the philosophy is that man is the centre of the universe and other mammals can be used as 'models' of man, this may well be the most useful way to study the functions of the human being, without actually chopping somebody up. However, with a some what wider perspective on life, it is easy to see the importance of a full understanding of the function of all living organisms, in its own right as well as a link in the evolution towards individuals able to survive and reproduce in very different environments. The importance of com parative studies in all living organisms cannot be emphasized too much. It has been the ambition with this book to treat all animals as equally important.
Download or read book Regulatory Peptides in Neuroscience and Endocrinology A New Era Begins written by Lee E. Eiden and published by Frontiers Media SA. This book was released on 2019 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic features recent developments in the field of regulatory peptide physiology and peptide-based therapeutics.
Download or read book Regulatory Peptides and Cognate Receptors written by Dietmar Richter and published by Springer Science & Business Media. This book was released on 2013-06-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last two decades, our knowledge on regulatory peptides and their cognate receptors, most of which are members of the seven transmembrane receptor families, has increased enormously. Regulatory peptides are small proteins which, besides their hormonal functions in regulating cellular metabolism in various tissues, may also act as neurotransmitters, and thus they often carry the prefix "neuro." Many of the cognate receptors involved in transducing the peptidergic signal across the cell membrane via a family of G proteins exist in multiple forms, the number of which frequently exceeds that of the corresponding peptide ligands. In this book, various peptide-receptor systems are discussed, e.g. CRF, somatostatin, TRH, opioid peptides, vasopressin, and oxytocin. It also discusses new strategies such as "reverse physiology" to uncover new peptides and orphan receptors.
Download or read book The Comparative Physiology of Regulstory Peptides written by and published by . This book was released on 1989 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Pathophysiology of Regulatory Peptides written by Adam Rijnberk and published by . This book was released on 1987 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory Peptides written by Lee E. Eiden and published by . This book was released on 2019 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The fifteen papers in this special Annals issue provide a snapshot of the physiological, pharmacological, and therapeutic frontiers of the field of regulatory peptide research."--New York Academy of Sciences website, viewed November 8, 2019.
Download or read book Comparative Physiology and Evolution of the Autonomic Nervous System written by Charlotte B. Nilsson and published by CRC Press. This book was released on 1994-12-01 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the most ancient of cultures, Mother India, Pearl S Buck's understanding of the Eastern mind is timeless.
Download or read book Peptide Therapeutics written by Ved Srivastava and published by Royal Society of Chemistry. This book was released on 2019-08-28 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
Download or read book Peptidomics written by Mikhail Soloviev and published by John Wiley & Sons. This book was released on 2007-12-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.
Download or read book Fishes of Antarctica written by Guido di Prisco and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Antarctic fish fauna has evolved over a long period of geographic and climatic isolation. In the course of this evolution, Antarctic fish have developed specialized adaptations, some of which characterize these organisms as unique. In strong contrast to the continental shelf faunas elsewhere, the Antarctic shelf ichthyofauna is dominated by a single highly endemic group, the Notothenioidei. This group of perciform fish probably first appeared and diversified in the early Tertiary. The development of the Polar Front (referred to as the Antarctic Convergence in the older literature) resulted in a natural oceanographic barrier to migration in either direction, and thus became a key factor in the evolution of Antarctic fish. The dominance of the Antarctic continental shelf fauna by a single taxonomic group of fish provides a simplified natural laboratory for exploring the wealth of physiological, biochemical and ecological adaptations that characterize the fauna. Understanding of the patterns of adaptation in this highly specialized group of fish can tell us much about of evolution.
Download or read book Peptide Transport and Delivery into the Central Nervous System written by Laszlo Prokai and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.
Download or read book The Cardiovascular System written by and published by Academic Press. This book was released on 1992-10-16 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cardiovascular System, Part B
Download or read book International Review of Cytology written by and published by Academic Press. This book was released on 1996-12-02 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Download or read book Neuropeptides written by Fleur L. Strand and published by MIT Press. This book was released on 1999 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.
Download or read book The Biology of Hagfishes written by Jørgen Mørup Jørgensen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hagfishes comprise a uniform group of some 60 species inhabiting the cool or deep parts of the oceans of both hemispheres. They are considered the most primitive representatives of the group of craniate chordates, which - apart from the hagfishes that show no traces of verte brae -includes all vertebrate animals. Consequently the hagfishes have played and still playa central role in discussions concerning the evolution of the vertebrates. Although most of the focus on hagfishes may be the result of their being primitive, it should not be forgotten that, at the same time, they are specialized animals with a unique way of life that is interesting in its own right. It is now more than 30 years since a comprehensive treatise on hagfishes was published. The Biology of Myxine, edited by Alf Brodal and Ragnar Fange (Universitetsforlaget, Oslo, 1963), provided a wealth of information on the biology of hagfishes, and over the years remained a major source of information and inspiration to students of hagfishes.
Download or read book Fish Diseases and Disorders written by John F. Leatherland and published by CABI. This book was released on 2006 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: `The book is important for those involved in aquaculture and those wishing to learn more about the effects of non-infectious disorders and the mechanisms of response within fish and is thoroughly recommended.' Journal of Fish Diseases --
Download or read book Molecular Endocrinology of Fish written by and published by Academic Press. This book was released on 1994-12-23 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones have a manifold impact upon growth and metabolism. This book focuses upon the molecular biology of fish hormones and their regulation. Chapters dealing with gonadotropin, corticotropin, vasotocin, isotocin, somatolactin, and other hormones are written by an international team of fish physiologists and endocrinologists. In addition, there are chapters that survey a growing literature on the ways hormones are regulated both in terms of their actions and in terms of the gene transcription that leads to their formation. The first two sections of the book covers brain and pituitary hormones and the latter two sections are devoted to other hormones and their regulation. As more and more endocrinologists and physiologists seek to use hormones that are inexpensive, provide for more facile experimental replication, and are less subject to cumbersome regulation, they will turn to the sorts of fish models reviewed in this book.
