Download or read book Cytokine Storm Syndrome written by Randy Q. Cron and published by Springer Nature. This book was released on 2019-09-09 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
Download or read book Six Generations Here written by Marjorie McLellan and published by . This book was released on 1997-12-15 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Six Generations Here is a unique collection of words and photographs taken across the first half of the 20th century by Wisconsin dairy farmer Alexander Krueger and his descendants. The Kruegers turned the camera lens on their Dodge County farm, its environs, their family, and the networks of kin that framed their lives. Their photographs and family stories comprise a unique record not only of who the Kruegers were but also of how they sought to be remembered.
Download or read book The Business of News written by Heiko Droste and published by BRILL. This book was released on 2021-05-25 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exchange of news belongs to the fabric of functional elites and affects institutionalisation processes in seventeenth century. The news market was part of the elite’s social economy. Investment in news resulted in participation and privilege.
Download or read book Cousin Sadie written by Daisy Anderton and published by . This book was released on 1920 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Download or read book Shame written by Paul Gilbert and published by Oxford University Press. This book was released on 1998-08-27 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most commonly reported emotions in people seeking psychotherapy is shame, and this emotion has become the subject of intense research and theory over the last 20 years. In Shame: Interpersonal Behavior, Psychopathology, and Culture, Paul Gilbert and Bernice Andrews, together with some of the most eminent figures in the field, examine the effect of shame on social behavior, social values, and mental states. The text utilizes a multidisciplinary approach, including perspectives from evolutionary and clinical psychology, neurobiology, sociology, and anthropology. In Part I, the authors cover some of the core issues and current controversies concerning shame. Part II explores the role of shame on the development of the infant brain, its evolution, and the relationship between shame as a personal and interpersonal construct and stigma. Part III examines the connection between shame and psychopathology. Here, authors are concerned with outlining how shame can significantly influence the formation, manifestation, and treatment of psychopathology. Finally, Part IV discusses the notion that shame is not only related to internal experiences but also conveys socially shared information about one's status and standing in the community. Shame will be essential reading for clinicians, clinical researchers, and social psychologists. With a focus on shame in the context of social behavior, the book will also appeal to a wide range of researchers in the fields of sociology, anthropology, and evolutionary psychology.
Download or read book Current Advances in Molecular Mycology written by Youssuf Gherbawy and published by Nova Science Pub Incorporated. This book was released on 2009 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular mycology has been playing a pivotal role in 21st century. It is emerging with full impact. It is multi-disciplinary and includes molecular markers, recombinant DNA techniques, cloning, phylogeny and bioinformatics. Varying in application of concepts, practice, scale, style and substance, molecular mycology is amongst the latest globalising frontiers of the corporate world. This branch is being regarded as a core subject in many colleges and universities. In the book, various topics on molecular mycology are uniquely combined to provide a complete overview of the subject. The book addresses the role of molecular and bioinformatics tools in solving the problems of identification of fungi and discusses current trends in Molecular Mycology.
Download or read book Hidden Champions of the Twenty First Century written by Hermann Simon and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 5: Customers, Products, Services . . . . . . . . . . . . . 129 Close Customer Relations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Customer Requirements. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 Dependence on the Customer and Risk Aspects . . . . . . . . . . . . . . . . . 135 Achieving Closeness to Customer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139 Product and Service Spectrum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156 Chapter 6: Innovation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 What Does Innovation Mean?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 High Level of Innovativeness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 Driving Forces of Innovation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172 The Origin of Innovations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 176 Leadership and Organizational Aspects of Innovation . . . . . . . . . . . . 179 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 Chapter 7: Competition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Competitive Structure and Conduct . . . . . . . . . . . . . . . . . . . . . . . . . . 191 The Hidden Champions in the Light of Porter’s “Five Forces” . . . . . 195 Competitive Advantages. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 Sustainability of Competitive Advantages . . . . . . . . . . . . . . . . . . . . . . 203 Demonstration of Competitive Superiority . . . . . . . . . . . . . . . . . . . . 205 Competitive Edge and Costs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 Sparring Partners for Competitive Fitness . . . . . . . . . . . . . . . . . . . . . . 214 Excessive Competitive Orientation . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218 Chapter 8: Financing, Organization, and Business Environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 Financing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 224 Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 228 Contents ix Organization of the Value Chain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 Business Environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 Entrepreneurial Clusters. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253 Chapter 9: Employees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 Job Creation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 Corporate Culture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 260 Quali?cations and Learning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 274 Creativity of Employees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 278 Recruiting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282 Chapter 10: The Leaders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285 Structures of Ownership and Leadership . . . . . . . . . . . . . . . . . . . . . . 286 How Crucial Is Leadership? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Leadership Continuity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Young to the Top . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293 Powerful Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294 Internationalization of Management . . . . . . . . . . . . . . . . . . . . . . . . . . 298 Personalities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300 Leadership Styles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305 Management Succession . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 306 Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 310 Chapter 11: Hidden Champions: Audit and Strategy Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315 What Is Strategy? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 316 Hidden Champion Strategy: For Whom? . . . . . . . . . . . . . . . . . . . . . . 316 Hidden Champions – Audits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317 Strategy Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325 Strategies for Value Propositions and Pricing . . . . . . . . . . . . . . . . . . . 335 Organization and Implementation . . . . . . . . . . . . . . . . . . . . . . . . . . .
Download or read book Advances in Comparative Immunology written by Edwin L. Cooper and published by Springer. This book was released on 2018-08-07 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunologists, perhaps understandably, most often concentrate on the human immune system, an anthropocentric focus that has resulted in a dearth of information about the immune function of all other species within the animal kingdom. However, knowledge of animal immune function could help not only to better understand human immunology, but perhaps more importantly, it could help to treat and avoid the blights that affect animals, which consequently affect humans. Take for example the mass death of honeybees in recent years – their demise, resulting in much less pollination, poses a serious threat to numerous crops, and thus the food supply. There is a similar disappearance of frogs internationally, signaling ecological problems, among them fungal infections. This book aims to fill this void by describing and discussing what is known about non-human immunology. It covers various major animal phyla, its chapters organized in a progression from the simplest unicellular organisms to the most complex vertebrates, mammals. Chapters are written by experts, covering the latest findings and new research being conducted about each phylum. Edwin L. Cooper is a Distinguished Professor in the Laboratory of Comparative Immunology, Department of Neurobiology at UCLA’s David Geffen School of Medicine.
Download or read book Forms of Knowledge written by Johan Östling and published by Nordic Academic Press. This book was released on 2020-02-21 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of knowledge is a dynamic field of research with bright prospects. In recent years it has been established as an exciting, forward-looking field internationally, with a strong presence in the Nordic countries. Forms of Knowledge is the first publication by the Lund Centre for the History of Knowledge (LUCK). The volume brings together some twenty historians from different scholarly traditions to develop the history of knowledge. The knowledge under scrutiny here is the sort which people have regarded and valued as knowledge in various historical settings. The authors apply different perspectives to this knowledge, maintaining the historicity and situatedness of the production and circulation of knowledge.The book presents the history of knowledge in all its rich diversity. The role of knowledge in public life is the focus of some chapters, while others concentrate on the importance of knowledge for individuals or local communities; some chart the realities of academic or systematic knowledge, others consider its existential or mundane dimensions. Taken together, they make a significant contribution to the theoretical, conceptual, and methodological advances in the field.
Download or read book The Official History of the Eighty Sixth Division written by John G. Little and published by . This book was released on 1921 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Medieval Gospel of Nicodemus written by Zbigniew S Izydorczyk and published by Franklin Classics. This book was released on 2018-10-15 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book German Book Plates written by Karl Emich Leiningen-Westerburg and published by Franklin Classics. This book was released on 2018-10-08 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book God s Middlemen written by Reuven Alpert and published by . This book was released on 1998 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gods Middlemen is a brief and highly readable history of the Hasidic movement through the Habad lineage, with a major section of stories about great rebbes and their followers.
Download or read book Diabetes written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2013-04-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is a complex disease and is also one of the most common. It is very difficult to reach an accurate estimate for the global prevalence of diabetes since the standards and methods of data collection vary widely in different parts of the world. In addition, many potential sufferers are not included in the count because according to an estimate about 50% of cases remain undiagnosed for up to 10 years. However, according to an estimate for 2010, globally, there are about 285 million people (amounting to 6.4% of the adult population) suffering from this disease. This number is estimated to increase to 439 million by 2030 if no cure is found. The general increase in life expectancy, leading to an ageing population, and the global rise in obesity are two main reasons for the increase. With the basic platform set, Editor presents his views and advice to the readers, especially to diabetic patients suffering from T2DM, on the basis of his observations and information collected from other diabetics.
Download or read book Genetic Transformation Systems in Fungi Volume 2 written by Marco A. van den Berg and published by Springer. This book was released on 2014-10-31 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are an economic very important class of microbes. Not only do they host a range of versatile enzymes used in industrial applications (biofuels, laundry, food processing), as well do they produce several very important pharmaceutical drugs (statins and penicillins). Moreover, fungal pathogens can cause great damage in agricultural production (Phytophthora and Botrytis) and during mammalian infections (Penicillium marneffei and Candida). Transformation of DNA is used to understand the genetic basis behind these traits. Several different techniques have been developed over the years and readily shown to be decisive methods to improve fungal biotechnology. This book will cover the basics behind the most commonly used transformation methods, as well as associated tools and techniques. Each chapter will provide protocols along with examples to be used in laboratories worldwide.
Download or read book Who s Who in America written by Marquis Who's Who, Inc and published by Marquis Who's Who. This book was released on 2002 with total page 3000 pages. Available in PDF, EPUB and Kindle. Book excerpt: