Download or read book The Automated Flow Synthesis of Fluorine Containing Organic Compounds written by Chantal Scholtz and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine has a rich history, spanning as far back as the 16th century in which mineral fluorides were first recognized, up to current times where it is frequently used in the pharmaceutical industry. The incorporation of fluorine within a molecule has the ability to modify the pharmacokinetic as well as physiochemical properties of that compound. This means that the presence of fluorine can have a profound impact on the nature and functioning of a drug. As a result of these properties of fluorine it has been incorporated in many successful drugs such as Prozac, Lipitor, Celebrex (celecoxib) and numerous anti-cancer agents. However, the incorporation of fluorine is not always simple, which has resulted in the development of a number of different fluorinating agents and fluorinating processes. Flow chemistry is the newest addition to this ever-evolving field, allowing for more efficient syntheses with substantially improved safety profiles and yields.
Download or read book The Synthesis of Fluorine containing Organic Compounds written by John Savory and published by . This book was released on 1961 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fluorine containing Synthons written by V. A. Soloshonok and published by . This book was released on 2005 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains 35 top-notch chapter-reviews on recent methodological developments in the area of synthetic fluoro-organic chemistry based on fluorinated synthons approach. Special emphases are given to the synthesis of biologically relevant compounds (alcohols, amines, alpha- and beta-amino acids, peptides), industrial-scale production of highly versatile, synthetically useful fluorinated synthons, as well as asymmetric synthesis of fluorinated synthons. The book has been designed to be a comprehensive snap-shot of current research activity in the field reviewed by internationally renowned leading experts from academic and industrial laboratories around the world. The topics covered in the book range from synthesis of small fluorinated molecules to peptides and macromolecules for crystal engineering. Substantial amount of data reviewed in the book have never been published. In particular cutting-age technology from industrial laboratories, summarized in the book, will give the reader unprecedented prospective on commercial availability of variety of structurally diverse fluorinated synthons which will be on market in the nearest future. Taking into account the significant impact that fluorinated compounds have made on nearly all aspects of modern life this book is expected to be a current prime reference in the field and might be of interest to diverse readership.
Download or read book Efficient Preparations of Fluorine Compounds written by Herbert W. Roesky and published by John Wiley & Sons. This book was released on 2012-10-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to creating fluorine-based compounds—and the materials of tomorrow Discovered as an element by the French chemist Henri Moissan in 1886, through electrolysis of potassium fluoride in anhydrous hydrogen fluoride—"le fluor," or fluorine, began its chemical history as a substance both elusive and dangerous. With a slight pale yellow hue, fluorine is at room temperature a poisonous diatomic gas. Resembling a spirit from a chemical netherworld, fluorine is highly reactive, difficult to handle, yet very versatile as a reagent—with the power to form compounds with almost any other element. Comprising 20% of pharmaceutical products and 30% of agrochemical compounds, as well as playing a key role in electric cars, electronic devices, and space technology, compounds containing fluorine have grown in importance across the globe. Learning how to safely handle fluorine in the preparation of innovative new materials—with valuable new properties—is of critical importance to chemists today. Bringing together the research and methods of leading scientists in the fluorine field, Efficient Preparations of Fluorine Compounds is the definitive manual to creating, and understanding the reaction mechanisms integral to a wide variety of fluorine compounds. With sixty-eight contributed chapters, the book's extensive coverage includes: Preparation of Elemental Fluorine Synthesis Methods for Exotic Inorganic Fluorides with Varied Applications Introduction of Fluorine into Compounds via Electrophilic and Nucleophilic Reactions Direct Fluorination of Organic Compounds with Elemental Fluorine Efficient Preparations of Bioorganic Fluorine Compounds Asymmetric Fluorocyclization Reactions Preparations of Rare Earth Fluorosulfides and Oxyfluorosulfides The book offers methods and results that can be reproduced by students involved in advanced studies, as well as practicing chemists, pharmaceutical scientists, biologists, and environmental researchers. The only chemical resource of its kind, Efficient Preparations of Fluorine Compounds—from its first experiment to its last—is a unique window into the centuries old science of fluorine and the limitless universe of fluorine-based compounds.
Download or read book New Fluorinating Agents in Organic Synthesis written by L.A. Alekseeva and published by Springer. This book was released on 1989-11-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes and gives a critical analysis of the literature on the use of reactive covalent fluorides (organic and inorganic) for the synthesis of fluoroorganic compounds. New methods of using SF4 for the fluorination of complex polyfunctional organic compounds are described. The prospects are shown for the selective fluorinations of complex compounds with non-traditional fluorinating agents (halogen fluorides, XeF2, fluorosulphuranes, N-F- and O-F-containing compounds). The book gives recommendations for the practical use of these fluorides, and typical synthetic procedures. It introduces the beginner to modern methods of fluorination and helps qualified scientists and technologists to choose the optimal methods of synthesis. Using the fluorinating agents described in this book, it is possible to synthesize various fluorine-containing substances.
Download or read book Modern Synthesis Processes and Reactivity of Fluorinated Compounds written by Henri Groult and published by Elsevier. This book was released on 2016-11-04 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. - Contains quality content edited, and contributed, by leading scholars in the field - Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications - Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics
Download or read book New Approaches in the Synthesis of Fluorine Containing Organic Compounds Using Radical Reagents written by and published by . This book was released on 1998 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enantiocontrolled Synthesis of Fluoro Organic Compounds written by V. A. Soloshonok and published by John Wiley & Sons. This book was released on 1999-07-09 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a leading expert in the field, this is a comprehensivereview of the methods for preparing stereochemically definedfluorine-containing compounds of biomedical importance. Fluorinated organic compounds are well known for their unusualreactivity but the growing importance of these compounds in thebiomedical field has been accompanied by an increasing awareness ofthe necessity to synthesise and explore the biological propertiesof stereochemically defined fluoro-compounds. This is the firstbook written on this exciting area of research. It contains: * detailed reviews on stereocontrolled synthesis of biologicallyimportant compounds * 21 chapters covering the main areas of asymmetric synthesis andbiocatalysts where fluorine plays a key role * mechanisms and methods for synthesizing fluoro-organiccompounds Written for professionals involved in organic, physical andorganofluorine chemistry, natural product synthesis, biological,pharmaceutical and other life science related industries.
Download or read book Advanced Inorganic Fluorides Synthesis Characterization and Applications written by T. Nakajima and published by Elsevier. This book was released on 2000-05-12 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent progresses in inorganic fluorine chemistry. Highlights include new aspects of inorganic fluorine chemistry, such as new synthetic methods, structures of new fluorides and oxide fluorides, their physical and chemical properties, fluoride catalysts, surface modifications of inorganic materials by fluorination process, new energy conversion materials and industrial applications. Fluorine has quite unique properties (highest electronegativity; very small polarizability). In fact, fluorine is so reactive that it forms fluorides with all elements except with the lightest noble gases helium, neon and argon. Originally, due to its high reactivity, fluoride chemistry faced many technical difficulties and remained undeveloped for many years. Now, however, a large number of fluorine-containing materials are currently produced for practical uses on an industrial scale and their applications are rapidly extending to many fields. Syntheses and structure analyses of thermodynamically unstable high-oxidation-state fluorides have greatly contributed to inorganic chemistry in this decade. Fluoride catalysts and surface modifications using fluorine are developing a new field of fluorine chemistry and will enable new syntheses of various compounds. The research on inorganic fluorides is now contributing to many chemical energy conversion processes such as lithium batteries. Furthermore, new theoretical approaches to determining the electronic structures of fluorine compounds are also progressing. On the industrial front, the use of inorganic fluorine compounds is constantly increasing, for example, in semi-conductor industry. "Advanced Inorganic Fluorides: Synthesis, Characterization and Applications" focuses on these new features in inorganic fluorine chemistry and its industrial applications. The authors are outstanding experts in their fields, and the contents of the book should prove to be of valuable assistance to all chemists, graduates, students and researchers in the field of fluorine chemistry.
Download or read book Fluorine in Organic Chemistry written by Richard D. Chambers and published by Blackwell Pub. This book was released on 2004 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of carbon - fluorine bonds into organic compounds can profoundly influence their chemical and physical properties when compared to their non-fluorine containing analogues, leading to a range of man-made materials with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, from pharmaceuticals, through fine and specialty chemicals to polymers. From Prozac to Teflon, many of the most important products of the chemical and life-science industries rely on organic fluorine chemistry for their useful properties. In this new book the author, internationally known for his contribution to organic fluorine chemistry, covers both the preparative methodologies and chemical properties of partially and highly fluorinated organic systems. Written as an authoritative guide to the subject for organic chemists in universities and the pharmaceutical, agrochemical, specialty organic and polymer industries, the book will also be an important resource for university advanced courses. Dick Chambers is a Fellow of the Royal Society and Emeritus Professor of Chemistry at the University of Durham, Durham, UK.
Download or read book Chemistry of Organic Fluorine Compounds written by Milos Hudlicky and published by Prentice Hall. This book was released on 1992 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: This republication of an established classic coincides with a surge in the indistrial development of fluorine chemistry. Comprehensive and authoritative, it provides finger tip access to methods for introducing small or large numbers of fluorine atoms into organic chemistry. Serving as a practical bench manual and source book for theoretical and industrial knowledge, the reference provides 3,857 references to the original literature; 1,520 illustrated equations indicating reactions and yields of fluorinated products; more than 200 detailed experimental procedures indicating types of reagent that can be used, types of compounds with which they react, and types of products that can be prepared; over 200 tables of highly relevant data; and much more.
Download or read book Fluorination written by Jinbo Hu and published by Springer. This book was released on 2020-08-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the recent advances in formation of C-F bonds and X-F bonds (X = heteroatom) to produce useful fluorinated molecules for pharmaceuticals, materials and more. Reactions and methods associated with fluorination, including monofluorination, difluorination, trifluorination and other polyfluorination that have emerged within the past few years are systematically discussed. With contributions from front-line researchers in this field from both academia and industry, this book provides a valuable resource for scholars, graduate students as well as professionals.
Download or read book Flash Chemistry written by Jun-ichi Yoshida and published by John Wiley & Sons. This book was released on 2008-10-13 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Have you ever wished you could speed up your organic syntheses without losing control of the reaction? Flash Chemistry is a new concept which offers an integrated scheme for fast, controlled organic synthesis. It brings together the generation of highly reactive species and their reactions in Microsystems to enable highly controlled organic syntheses on a preparative scale in timescales of a few seconds or less. Flash Chemistry: Fast Organic Synthesis in microsystems is the first book to describe this exciting new technique, with chapters covering: an introduction to flash chemistry reaction dynamics: how fast is the act of chemical transformation, what is the rate of reaction, and what determines the selectivity of a reaction? examples of why flash chemistry is needed: the rapid construction of chemical libraries, rapid synthesis of radioactive PET probes, and on-demand rapid synthesis in industry the generation of highly reactive species through thermal, microwave, chemical, photochemical, and electrochemical activation microsystems: What are microsystems and how are they made? Why is size so important? What are the characteristic features of microsystems? conduction and control of extremely fast reactions using microsystems applications of flash chemistry in organic synthesis polymer synthesis based on flash chemistry industrial applications of flash chemistry Flash Chemistry: Fast Organic Synthesis in Microsystems is an essential introduction to anyone working in organic synthesis, process chemistry, chemical engineering and physical organic chemistry concerned with fundamental aspects of chemical reactions an d synthesis and the production of organic compounds.
Download or read book Modern Carbonylation Methods written by László Kollár and published by John Wiley & Sons. This book was released on 2008-06-25 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensively covering modern carbonylation chemistry, this book is an indispensable companion for all synthetic chemists working in industry and academia. This monograph contains everything there is to know from recent advances in the investigation of carbonylation catalysts, via coordination chemistry to the synthetic application of transition metal catalyzed carbonylations.
Download or read book Organofluorine Chemistry written by Kalman J. Szabo and published by John Wiley & Sons. This book was released on 2021-03-22 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1995 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microreactors in Organic Chemistry and Catalysis written by Thomas Wirth and published by John Wiley & Sons. This book was released on 2013-02-22 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the second edition of 'Microreactors in Organic Chemistry and Catalysis' all chapters have been revised and updated to reflect the latest developments in this rapidly developing field. This new edition has 60% more content, and it remains a comprehensive publication covering most aspects of the topic. The use of microreactors in homogeneous, heterogeneous as well as biphasic reactions is covered in the main part of the book, together with catalytic, bioorganic and automation approaches. The initial chapters also provide a solid physical chemistry background on fluidics in microdevices. Finally, a chapter on industrial applications and developments covers recent progress in process chemistry. An excellent reference for beginners and experts alike.
