Download or read book Testing for Abuse Liability of Drugs in Humans written by Marian W. Fischman and published by . This book was released on 1989 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and development are needed.
Download or read book Testing for Abuse Liability of Drugs in Humans written by Mariam W. Fischman and published by . This book was released on 1989 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Testing Drugs for Physical Dependence Potential and Abuse Liability written by and published by . This book was released on 1984 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nonclinical Assessment of Abuse Potential for New Pharmaceuticals written by Carrie Markgraf and published by Academic Press. This book was released on 2015-07-14 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
Download or read book Testing for Abuse Liability of Drugs in Humans written by Mariam W. Fischman and published by . This book was released on 1989 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological components of substance abuse and addiction written by and published by DIANE Publishing. This book was released on with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Safety Pharmacology written by Michael K. Pugsley and published by Springer. This book was released on 2015-06-19 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Download or read book NIDA Research Monograph written by and published by . This book was released on 1976 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Abuse Handbook written by Steven B. Karch, MD, FFFLM and published by CRC Press. This book was released on 2019-07-17 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the handbook that professionals who deal with problems related to drugs and drug abuse have been waiting for. The impressive list of more than 80 contributors, each experts and leaders in their field, testifies to the importance of this outstanding new handbook. The volume contains detailed discussions of drug-related issues in criminalistics, pathology, and toxicology. Impairment testing and the pharmacokinetics of abused drugs are examined in detail, as is the field of workplace drug testing, the use of alternate testing matrices, drugs in sports, addiction medicine, and drug-related medical emergencies. The handbook focuses on the most urgent drug abuse-related problems of today An entire section is devoted to alcohol abuse, including a scientific appraisal of the most common drunk driving defenses, complete with sample calculations. Problems of postmortem toxicology are thoroughly detailed and an appendix lists key references for the most widely used analytic methods. An in-depth analysis of legal questions, including fetal rights and workplace testing Examination of the principles of addiction medicine and how doctors handle substance abuse problems A section addressing drug use by athletes, including a summary of current Olympic Committee Regulations regarding substance use and the latest information on detecting abuse of Human Growth Hormone and Erythropoietin Whether you are approaching the issue of drug abuse from a medical, psychological, toxicological, or legal perspective, the Drug Abuse Handbook is the most authoritative and complete resource available.
Download or read book Federal Register written by and published by . This book was released on 1996-08-28 with total page 1208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Cigarettes and Smokeless Tobacco Under the Federal Food Drug and Cosmetic Act Final rule with jurisdictional determination written by United States. Food and Drug Administration and published by . This book was released on 1996 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Addiction Medicine written by Bankole A. Johnson and published by Springer Science & Business Media. This book was released on 2010-10-10 with total page 1611 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spectrum of addiction disorders presents practitioners with numerous challenges—among them the widening gap between a growing evidence base and the translation of this knowledge into treatment outcomes. Addiction Medicine addresses this disconnect, clearly explaining the role of brain function in drug taking and other habit-forming behaviors, and applying this biobehavioral framework to the delivery of evidence-based treatment. Its state-of-the-art coverage provides clinically relevant details on not only traditional sources of addiction such as cocaine, opiates, and alcohol, but also more recently recognized substances of abuse (e.g., steroids, inhalants) as well as behavioral addictions (e.g., binge eating, compulsive gambling, hoarding). Current behavioral and medical therapies are discussed in depth, and the book’s close attention to social context gives readers an added lens for personalizing treatment. An international panel of expert contributors offers the most up-to-date information on: Diagnosis and classification Neurobiological and molecular theories of addiction Behavioral concepts of addiction Clinical aspects of addiction to a wide range of substances, including opiates, stimulants, sedatives, hallucinogens, alcohol, nicotine, and caffeine Science-based treatment options: pharmacotherapy, pharmacogenetics, potential vaccines, brief and compliance-enhancing interventions, cognitive behavioral treatment, behavioral management, and other psychosocial interventions Behavioral addictions—including compulsive eating, Internet messaging, and hypersexuality—and their treatment Addiction in specific populations, including adolescents, the elderly, pregnant women, and health care professionals Legal, disability, and rehabilitation issues At once comprehensive and integrative, Addiction Medicine is an essential text and a practice-expanding tool for psychiatrists, health psychologists, pharmacologists, social workers, drug counselors, trainees, and general physicians/family practitioners.
Download or read book Drug Abuse Handbook written by Jozef Bicerano and published by CRC Press. This book was released on 2006-12-21 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the well-received first edition, the Drug Abuse Handbook, Second Edition is a thorough compendium of the knowledge of the pharmacological, medical, and legal aspects of drugs. The book examines criminalistics, pathology, pharmacokinetics, neurochemistry, treatment, as well as drugs and drug testing in the workplace and in sports, and the
Download or read book Ethics and Regulation of Clinical Research written by Robert J. Levine and published by Yale University Press. This book was released on 1988-01-01 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of human subjects in medical and scientific research has given rise to troubling ethical questions. How should human subjects be selected for experiments? What should they be told about the research in which they are involved? How can their privacy be protected? When is it permissible to deceive them? How do we deal with subjects such as children, fetuses, and the mentally infirm, for whom informed consent is impossible? In this book, Dr. Robert J. Levine reviews federal regulations, ethical analysis, and case studies in an attempt to answer these questions. His book is an essential reference for everyone--members of institutional review boards, scientists, philosophers, lawyers--addressing the ethical issues involved. "[Levine's] experience as a clinician, IRB chairman, writer and editor of a journal devoted exclusively to issues faced by IRBS makes him uniquely qualified to bring together the legal, ethical, and practical dimensions. . . [The book] is sophisticated but readable. . . [and] should be on every IRB administrator's desk and in every medical ethics library."--Norman Fost, M.D., The New England Journal of Medicine "Levine. . . is one of the foremost historians of contemporary clinical science. . . . His book is at once a guide to primary sources for the history of clinical research in the late twentieth century and a pioneering secondary source about that history."--Daniel M. Fox, Bulletin of the History of Medicine "You will be charmed by the [book's] elegance and lucidity and. . . persuaded of its relevance to doctors in any country."--Alex Paton, British Medical Journal "Should be of wide interest to those keen to see advances in medical research brought into general medical practice."--Gilbert Omenn, Issues in Science and Technology
Download or read book Nicotine Addiction in Britain written by Royal College of Physicians of London. Tobacco Advisory Group and published by Royal College of Physicians. This book was released on 2000 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2009-02-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
