Download or read book Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method TER written by OECD and published by OECD Publishing. This book was released on 2013-07-26 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical. Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin ...
Download or read book Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test TER written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Globally Harmonised System for the Classification and Labelling of Chemicals defines skin corrosion as the production of irreversible tissue damage in the skin following the application of a test material. The test material (150 μL for liquids ...
Download or read book Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method TER written by and published by . This book was released on 2015 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function. This Test Guideline was originally adopted in 2004 and updated in 2015 to refer to the IATA guidance document.
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method TER written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.
Download or read book Test No 431 In vitro skin corrosion reconstructed human epidermis RHE test method written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Download or read book Regulatory Toxicology in the European Union written by Tim Marrs and published by Royal Society of Chemistry. This book was released on 2018-02-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumer and environmental protection depend on the careful regulation of all classes of chemicals. Toxicology is the key science used to evaluate safety and so underpins regulatory decisions on chemicals. With the growing body of EU legislation involved in chemical regulation, there is a concomitant need to understand the toxicological principles underlying safety assessments Regulatory Toxicology in the European Union is the first book to cover regulatory toxicology specifically in Europe. It addresses the need for a wider understanding of the principles of regulatory toxicology and their application and presents the relationship between toxicology and legislative processes in regulating chemical commodities across Europe. This title has a broad scope, covering historical and current chemical regulation in Europe, the role of European agencies and institutions, and also the use of toxicology data for important classes of chemicals, including human and veterinary medicines, animal feed and food additives, biocides, pesticides and nanomaterials. This book is therefore extremely pertinent and timely in the toxicology field at present. This book is an essential reference for regulatory authorities, industrialists, academics, undergraduates and postgraduates working within safety and hazards, toxicology, the biological sciences, and the medicinal and pharmaceutical sciences across the European Union.
Download or read book Handbook of Cosmetic Science and Technology written by Frank Dreher and published by CRC Press. This book was released on 2022-08-11 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
Download or read book OECD Series on Testing and Assessment Guidance Document on an Integrated Approach on Testing and Assessment IATA for Skin Corrosion and Irritation written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Guidance Document proposes an integrated approach on testing and assessment (IATA) for skin corrosion and irritation. It also provides consistent information on key characteristics of each of the individual information sources of the IATA, and relevant guidance on how to integrate ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 403 Acute Inhalation Toxicity written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Download or read book A Practical Guide to Toxicology and Human Health Risk Assessment written by Laura Robinson and published by John Wiley & Sons. This book was released on 2018-11-20 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
Download or read book Cosmetic Formulation written by Heather A.E. Benson and published by CRC Press. This book was released on 2019-04-05 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects. Key Features: Covers cosmetic products/formulation from theory to practice Includes case studies to illustrate real-life formulation development and problem solving Offers a practical, user-friendly approach, relying on the work of recognized experts in the field Provides insights into the future directions in cosmetic product development Presents basic formulation, skin science, advanced formulation and cosmetic product development
Download or read book Code of Federal Regulations written by and published by . This book was released on 2011 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Code of Federal Regulations Title 49 Transportation PT 100 177 Revised as of October 1 2012 written by U S Office of the Federal Register and published by Government Printing Office. This book was released on 2013-01-08 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agencies of the United States Federal Government.
Download or read book Biological Concepts and Techniques in Toxicology written by Jim E. Riviere and published by CRC Press. This book was released on 2006-03-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol
Download or read book Test No 405 Acute Eye Irritation Corrosion written by OECD and published by OECD Publishing. This book was released on 2002-04-24 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Health Effects Test No 436 Acute Inhalation Toxicity Acute Toxic Class Method written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...
