Download or read book Targeting Cardiac Proteotoxicity written by Xuejun Wang and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Drug Targets for Proteotoxicity in Cardiometabolic Diseases written by Jun Ren and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolic Cardiomyopathy written by H. Böhles and published by CRC Press. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
Download or read book Histone Deacetylase Inhibitors as Cancer Therapeutics written by Steven Grant and published by Academic Press. This book was released on 2012-11 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides information on the exciting and fast-moving field of cancer research.
Download or read book Post Translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease written by Huabo Su and published by Frontiers Media SA. This book was released on 2021-10-18 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Pathology written by L. Maximilian Buja and published by Academic Press. This book was released on 2022-01-22 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field. Includes expanded coverage of diagnostic guidelines, standards and normal values Provides a summary of cardiac catheterization laboratory and diagnostic imaging tests to guide pathologists in clinicopathological correlation Presents a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows in pathology, cardiology, cardiac surgery, and internal medicine Provides comprehensive coverage, including, when appropriate, Central Concept Figure, Definition, Epidemiology, Clinical Presentation, Pathogenesis, Molecular Genetics, Light and Electron Microscopy, Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications, and a Bulleted Summary
Download or read book Cardio Protection and Heart Repair New Drugs Targets and Approaches written by Benzhi Cai and published by Frontiers Media SA. This book was released on 2022-01-19 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardioskeletal Myopathies in Children and Young Adults written by John Lynn Jefferies and published by Academic Press. This book was released on 2016-10-22 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40’s-50’s and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health. Reveals the link between cardiac muscle disease and skeletal muscle disease Explains how genetics and environmental factors effect muscle function of diverse origins Designates current and novel therapeutic strategies that target both cardiac and skeletal muscle systems
Download or read book Understanding Molecular Mechanisms in Diabetic Cardiomyopathy DCM written by VijayaKumar Sukumaran and published by Frontiers Media SA. This book was released on 2022-08-03 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microtubules in vivo written by and published by Academic Press. This book was released on 2010-09-24 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules: in vivo includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton. The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation. Includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation
Download or read book Cardiac Remodeling New Insights in Physiological and Pathological Adaptations written by Leonardo Roever and published by Frontiers Media SA. This book was released on 2017-11-15 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.
Download or read book Targeted drug discovery in ectopic calcification Mechanism prospect and clinical application written by Kang Xu and published by Frontiers Media SA. This book was released on 2023-05-26 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Failure E Book written by G. Michael Felker and published by Elsevier Health Sciences. This book was released on 2014-12-18 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead editor of Braunwald's Heart Disease, Dr. Douglas L. Mann, and nationally and internationally recognized heart failure expert Dr. G. Michael Felker, bring you the latest, definitive state-of-the art information on heart failure in this outstanding Braunwald's companion volume. Heart Failure, 3rd Edition keeps you current with recent developments in the field, improved patient management strategies, and new drug therapies and implantable devices that will make a difference in your patients' lives and your practice.
Download or read book Biochemistry of Apoptosis and Autophagy written by Lorrie A. Kirshenbaum and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.
Download or read book The End of Alzheimer s written by Thomas J. Lewis and published by Academic Press. This book was released on 2017-05-12 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: The End of Alzheimer’s: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer’s outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer’s disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer’s outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer’s, and will hopefully redirect many into new avenues of cellular research and discovery. Comprehensive literature-based summary of the current state of molecular Alzheimer’s disease research Details the shortcomings of the prevailing model and therapeutics in development Reviews blood-based biomarkers for Alzheimer’s and their link to amyloid- and Tau-independent causes outside the brain Describes the tissues outside the brain impacted by Alzheimer’s and the underlying molecular causes Explains the whole-body risks associated with Alzheimer’s, along with concomitant measures to slow or prevent the disease Provides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer’s patients
Download or read book Proteostasis and Disease written by Rosa Barrio and published by Springer Nature. This book was released on 2020-04-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Download or read book Cell Signaling Pathways in Development written by and published by Academic Press. This book was released on 2022-05-20 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Ephrin signaling, Cell signaling to the extracellular matrix, Signaling by TGF-b superfamily members, Hedgehog signaling, Parallels in signaling during development and regeneration, Hippo signaling, Wnt/PCP signaling, Signaling oscillations in presomitic mesoderm, FGFs/RTKs subcellular signaling compartments, and Signaling dynamics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on Cell Signaling Pathways in Development
