Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Download or read book The Mesolithic in Britain written by Chantal Conneller and published by Routledge. This book was released on 2021-11-29 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mesolithic in Britain proposes a new division of the Mesolithic period into four parts, each with its distinct character. The Mesolithic has previously been seen as timeless, where little changed over thousands of years. This new synthesis draws on advances in scientific dating to understand the Mesolithic inhabitation of Britain as a historical process. The period was, in fact, a time of profound change: houses, monuments, middens, long-term use of sites and regions, manipulation of the environment and the symbolic deposition of human and animal remains all emerged as significant practices in Britain for the first time. The book describes the lives of the first pioneers in the Early Mesolithic; the emergence of new modes of inhabitation in the Middle Mesolithic; the regionally diverse settlement of the Late Mesolithic; and the radical changes of the final millennium of the period. The first synthesis of Mesolithic Britain since 1932, it takes both a chronological and a regional approach. This book will serve as an essential text for anyone studying the period: undergraduate and graduate students, specialists in the field and community archaeology groups.

Download or read book Transgenesis and Targeted Mutagenesis in Immunology written by and published by Elsevier. This book was released on 2014-06-28 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for fresh observations and interpretations when designing future experiments.Special Features Include:Contributions of two Nobel Prize winnersAddresses the use of mouse models in studying the immune systemTargets gene distribution in embryonic stem cells and their introduction into blastocyte mice modelsAnalyzes the in vivo functional loss of embryonic cellsA practical, useful guidebook for individual researchers, laboratories, and libraries

Download or read book Thymic Development and Selection of T Lymphocytes written by Thomas Boehm and published by Springer Science & Business Media. This book was released on 2013-11-06 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Download or read book T Cell Development written by Rémy Bosselut and published by Humana. This book was released on 2015-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation VI written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

Download or read book Lymphocyte Signal Transduction written by Constantine Tsoukas and published by Springer Science & Business Media. This book was released on 2007-01-16 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third workshop on this topic that took place in Crete from May 27 to June 1, 2005. Similar to the two previous workshops, held in Santorini October 2000 and 2002 respectively, the purpose of this workshop is to bring together scientists from all over the world to discuss their latest findings on the various aspects of lymphocyte signal transduction. The participants represented academia, industry, foundation and governmental laboratories.

Download or read book Monoclonal Antibodies and T cell Hybridomas written by Günter J. Hämmerling and published by North Holland. This book was released on 1981-01-01 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lipid Signaling in T Cell Development and Function written by Karsten Sauer and published by Frontiers Media SA. This book was released on 2015-11-12 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.

Download or read book Gene Therapy of Cancer written by Stanton L. Gerson and published by Elsevier. This book was released on 2002-04-04 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. - Provides in-depth description of targeted systems and treatment strategies - Explains the underlying cancer biology necessary for understanding a given therapeutic approach - Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses - Presents translational focus with emphasis on requirements for clinical implementation - Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Download or read book The Hereditary Basis of Rheumatic Diseases written by Rikard Holmdahl and published by Springer Science & Business Media. This book was released on 2006-07-02 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.

Download or read book Medical Immunology written by Gabriel Virella and published by CRC Press. This book was released on 2007-03-28 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an abundance of illustrations, diagrams, and algorithms, this sixth edition of Medical Immunology provides a reader-friendly review of critical material on the current diagnostic and clinical applications of immunology. Organized into four sections that describe clinical applications, methodological advances, immunological diseases, and innova

Download or read book Ubiquitination in Immune System and Immune Response written by Hongbo Hu and published by Springer Nature. This book was released on with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book T Cell Subsets in Infectious and Autoimmune Diseases written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.

Download or read book Immune Profile after Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases Where Do We Stand written by Kelen Cristina Ribeiro Malmegrim and published by Frontiers Media SA. This book was released on 2020-02-12 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autologous hematopoietic stem cell transplantation (AHSCT) was proposed 20 years ago as an alternative therapeutic approach for patients with severe and refractory autoimmune diseases. Since then, this innovative therapy has been successfully used to treat several autoimmune diseases, such as neurological disorders (Multiple Sclerosis), connective tissue diseases (Systemic Sclerosis and Systemic Lupus Erythematous), gastrointestinal inflammatory diseases (Crohn’s Disease) and others (Juvenile Arthritis, Type 1 Diabetes, Vasculitis). Experience in phase I-II and III clinical trials over the years has led to increased safety and efficacy of this procedure. Recent studies have demonstrated superior therapeutic efficacy of AHSCT versus conventional therapies, showing that transplantation can induce long-term disease remission in the absence of any further immunosuppressive treatment. Immune monitoring studies have showed that AHSCT is able to reduce the inflammatory milieu, to reset the immune balance and to promote the generation of a new auto-tolerant immune repertoire. However, some patients fail to remain in remission, and disease is re-activated after some time post-transplantation. This scenario indicates that further immunological interventions may be still required to improve AHSCT efficacy. Clear understanding of the operating immune mechanisms that contribute to specific clinical outcomes is vital to enable improvement of AHSCT protocols for autoimmune diseases.

Download or read book T Cell Activation I written by Gary A. Koretzky and published by . This book was released on 2003 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nuclear Receptors and Coregulators in Metabolism and Immunity written by Rongrong Fan and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: