Download or read book Synthesis Characterization and Theranostic Applications of Pyridine Containing Macrocyclic Ligands and Their Divalent Transition Metal Complexes written by Kristof Pota and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Transitional Metal Pyridine Containing Complexes with Both Catalytic and Therapeutic Applications written by Magy Amir Maurice Mekhail and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pyridinophanes derived from pyclen are the focus of many studies as biological mimics, chelators, and catalytic precursors. Therefore, the desire to tune the reactivity of metal pyridinophane complexes has inspired modifications that include expansion of ring size and substitutions to the N-atoms. However, substitution on the pyridine moiety is largely unexplored to date. Herein, new synthetic strategies for pyclen-congeners bearing electron donating and electron withdrawing groups are introduced, resulting in doubling the number of pyridine functionalized molecules in literature. Further, the influence of such modifications on properties and reactivity of two metals (Fe(III) and Cu(II)) is described. For the Fe(III) system, 4-substitution of the pyridine ring successfully provides a regulatory handle on the electronic properties and the catalytic C-C coupling activity of the respective Fe complexes. These are the first examples of a structure-activity relationship study with the impact of electronic properties decoupled from structural properties and investigated. The Fe(III) system was also explored in a catalase mimetic study to determine the role of ligand design on the activity of the metal center through changing electronic properties and rigidity of the ligand. Varying the electronic properties of the ligand has a minor effect on catalase activity, but changes to the geometry of the complex have significant impacts on the system. This activity was also successfully observed to cellular models. The Cu(II) system was investigated as a superoxide dismutase mimic. Cu(II) Pyclen complexes, specifically, has been shown to match its coordination environment and to have high binding affinity. My studies highlight that modifications to the pyridine ring of the ligand can tune the redox potential, while exhibiting high binding stabilities and retaining the coordination environment. In fact, one of the complexes studied exhibits one of the highest SOD activities reported to date, which is hypothesized to be the result of not only the electronic properties of the Cu center but also the high binding stability exhibited by this complex. Altogether, this work focused on functionalizing the pyridine ring in pyridinophanes and studying the effect of the modifications on the electronics of metal complexes and their reactivity with both catalytic and potential therapeutic application.
Download or read book Synthesis Characterization and Applications of Pyridine and Pyridol based Azamacrocyclic Transition Metal Complexes written by Hannah May Johnston and published by . This book was released on 2018 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent Developments in the Synthesis and Applications of Pyridines written by Parvesh Singh and published by Elsevier. This book was released on 2022-09-17 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry. The role of computational chemistry in the development of pyridine-based bioactive molecules is also included. This reference is essential for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. Includes a detailed review of recent research on the reactivity, synthesis and applications of pyridines Features concise accounts of the reactivity, synthetic and optimized protocols Discusses the medicinal, inorganic and polymer chemistry applications of pyridines
Download or read book Chiral Iron Pyridine Complexes and Ruthenium Complexes with N Heterocyclic Carbene and Macrocyclic N O Donor Atom Ligands written by Kar-Yee Lam and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Chiral Iron Pyridine Complexes and Ruthenium Complexes With N-heterocyclic Carbene and Macrocyclic (N, O) Donor Atom Ligands: Synthesis, Catalytic Activity and Biological Studies" by Kar-yee, Lam, 林嘉儀, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled CHIRAL IRON PYRIDINE COMPLEXES AND RUTHENIUM COMPLEXES WITH N-HETEROCYCLIC CARBENE AND MACROCYCLIC(N, O) DONOR ATOM LIGANDS: SYNTHESIS, CATALYTIC ACTIVITY AND BIOLOGICAL STUDIES Submitted by Lam Kar Yee For the degree of Doctor of Philosophy at The University of Hong Kong in April 2016 Transition metal complexes are widely applied as catalysts for organic transformation reactions such as the oxygen atom and nitrene transfer reactions and there is a growing interest to develop the medicinal applications of transition metal complexes. The studies of reactive metal-oxo and metal-nitrene intermediates are important in probing the underlying reaction mechanisms. This thesis is comprised of three main parts. In the first part, iron complexes with chiral pyridine ligands, such as 4′,6-disubstituted 2,2′ 6′,2″-terpyridine (NNN ) and 4′,6,6″-trisubstituted 2,2′ 6′,2″''-terpyridine (NNN ), were studied for their catalytic activities in asymmetric epoxidation, aziridination, amidation and sulfimidation reactions. The Fe-NNN complex catalyzed intermolecular nitrene transfer/CN bond formation reactions of styrenes with PhINTs in moderate product yields. For the asymmetric intramolecular amidation, the Fe-NNN complex can catalyze intramolecular C-N bond formation using PhI(OAc) as oxidant to form five- or six-membered ring products. The highest product yield obtained was 91 %. The complete conversion of para-substituted phenyl methyl sulfides to corresponding sulfimides was observed by using the Fe-NNN 1 2 complex as catalyst. Both the Fe-NNN and Fe-NNN complexes catalyzed asymmetric epoxidation of styrene using PhIO as oxidant at 0 C. The reaction intermediates of the nitrene/oxygen transfer reactions were studied by ESI-MS and high-valent iron-ligand multiple bonded species are proposed to be the reaction intermediates. In the second part, ruthenium pincer N-heterocyclic carbene (CNC) complexes were prepared and characterized by spectroscopic means and X-ray crystallography. II 2+ Complex [Ru (CNC)(bpy)(MeCN)], in which the CNC ligand adopts a fac-coordination mode and contains reactive CH bond of bridging methylene group, was found to react with PhINTs to result in the formation of a new CN bond and cleavage of one existing NC(methylene) bond of the CNC ligand, as revealed by X-ray crystal structure determination of the ruthenium complex product. The reaction 2+ of [Ru(CNC)(bpy)(MeCN)] with PhINTs was monitored by ESI-MS, UV-vis, and NMR spectroscopy; a paramagnetic Ru(III)-amido complex was isolated, which apparently resulted from intramolecular imido/nitrene CH insertion of a Ru(IV)-imido/nitrene intermediate and was found to undergo the observed CN bond cleavage. Such type of CN bond cleavage induced by metal-mediated imido/nitrene insertion is unprecedented in literature. The final part of this thesis is the study of the anti-angiogenic and anti-metastatic properties of the ruthenium complexes. Ruthenium complexes with different oxidation states (+2 and +3) and ligands (pincer NHC and macrocyclic (N, O) donor atom ligands) were examined for their cytotoxicity and anti-angiogenesis activity. III Among the complexes studied, [Ru (N O )Cl ]Cl (Ru-1) displays promising 2 2 2 inhibi
Download or read book Exploring Chemistry with Pyridine Derivatives written by Satyanarayan Pal and published by BoD – Books on Demand. This book was released on 2023-01-04 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the chemistry and applications of pyridine derivatives. The library of pyridine derivatives is growing steadily with numerous synthetic analogues already described and the identification of new, naturally occurring pyridine-based compounds. The book includes ten chapters organized into two parts. The first part focuses on the numerous types of reactions that arise from pyridine derivatives. The second part examines the pharmaceutical applications of pyridine derivatives as well as their usefulness as sensors for metal cations and extracting agents for platinum group metals.
Download or read book Rational Design Synthesis and Characterization of Amide Functionalized Pyridine and Benzimidazole Transition Metal Complexes written by Samuel S. K. Asem and published by . This book was released on 2011 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and benzimidazole ligands. These heterocycles, amide functionalized at position 2 with aryl and alkyl pendants, rapidly change their mode of coordination depending on the pH of the medium. These ligands, synthesized using condensation chemistry, also coordinate to Co(II), Ni(H), Cu(lI), and Zn(1I) generally as anionic bis-chelates through the benzimidazole nitrogen and the carbonyl oxygen, creating a four-coordinate complex with the exception of an unusual trigonal bipyramidal Zn(H) complex. I H NMR temperature studies reveal that these ligands interconvert between imide and amide isomers and that electron withdrawing pendants favor amide isomers. Crystal structures of Co(II) and Ni(1I) complexes of N-( I-methylbenzimidazol-2-yl)cyclohexanecarboxamide, for example, show two ligands bind per metal ion when reacted with acetate and nitrate salts. The bischelates of these Ni(1I) complexes also show expansions of their coordination spheres from four to five-coordinate. Furthermore, these Ni(II) bis-chelated complexes possess square planar or distorted 4-coordinate geometries. The synthesis and properties of several new Pt (II) complexes containing these ligands will be presented. A second generation and novel complex class containing metal-binding, linker and recognition domains is reported. Both classes of Pt complexes were obtained using a synthetic methodology which favors the cis isomers. The second generation complex crystallizes in the monoclinic space group P2dn with lattice dimensions a = 17.7393(5) A, b = 11.4632(3) A, c = 19.3959(5) A and ~ = 99.794(3)°. These complexes have been characterized using physical methods that include X-ray crystallography, IH &13C NMR, Mass spectrometry, UV and IR spectroscopies. Complexes similar in structure to cisplatin and carboplatin show varying cytotoxic properties toward different cancer cell lines. Additionally, some of these new Pt complexes show comparable and promising cytotoxicity against prostate cancer cell lines.
Download or read book Transition Metal Catalyzed Pyridine Synthesis written by Xiao-Feng Wu and published by Elsevier. This book was released on 2016-02-07 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition Metal-Catalyzed Pyridine Synthesis provides an overview of pyridines, describing properties of these heterocycle compounds and describing traditional synthetic procedures for them. The book then explores catalyzed procedures for pyridine synthesis in greater detail and depth than is currently available in published Review articles. The short series Transition Metal-Catalyzed Heterocycles Synthesis, authored by Xiao-Feng Wu, summarizes recent achievements on heterocycles synthesis with transition metal as the catalysts, with each volume dedicated to one heterocycle compound. Brief, focused review of this active research area, Pyridine synthesis via transition metal catalysis Useful coverage of Pyridine properties and both intermolecular and intramolecular cyclization Volume Two in Elsevier’s short work series, "Transition Metal-Catalyzed Heterocycles Synthesis"
Download or read book Pyridine and Its Derivatives Volume 14 Part 1 written by Erwin Klingsberg and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
Download or read book Synthesis Characterization and Spectroscopic Investigation of Pyridine Complexes of Ruthenium Rhodium and Iridium written by Dennis Wayne Raichart and published by . This book was released on 1972 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pyridine Metal Complexes Part 6A written by Desmond J. Brown and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 2247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
Download or read book Pyridine and Its Derivatives Volume 14 Part 5 written by George R. Newkome and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: A continuation of the treatise describing the organic chemistry of pyridine derivates. Includes chapters on the synthetic and natural sources of the pyridine ring, the carbocyclic annelated pyridines, macrocyclic pyridines, and reviews of pyridine chemistry appearing from 1968 through 1982.
Download or read book Pyridines From Lab to Production written by Eric F.V. Scriven and published by Academic Press. This book was released on 2013-01-08 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. Reviews tried and tested practical methods to help the reader select the best method for their research Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on
Download or read book Perhalopyridines Synthesis and Synthetic Utility written by Reza Ranjbar-Karimi and published by Bentham Science Publishers. This book was released on 2020-09-08 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Halogenated pyridines can be used as interesting starting materials in a wide range of organic synthesis methods. Substituted pyridine compounds are used generally as starting materials in the nucleophilic substitution reactions and have unique scaffolds for the construction of other heterocyclic and macrocyclic compounds. They also have important medicinal properties. Due to synthetic difficulties in the synthesis of the highly substituted pyridine derivatives from pyridine itself, perhalopyridines have a special importance in this regard. This book covers the synthetic reactions and applications of perhalopyridines. An introductory chapter introduces the reader to the physical and chemical properties of halopyridines, followed by 3 chapters which focus on pentafluoropyridine, pentachloropyridine and pentabromopyridine, respectively. The focused chapters provide information about synthetic methods and relevant nucleophilic reactions for each of the listed perhalopyridines and their derivatives. The book is a quick reference on perhalopyridines for students of applied chemistry, organic chemistry and chemical engineering.
Download or read book Synthesis and Characterization of Redox noninnocent Pyrazine diimine Iron Complexes and an Inverted Pyridine diimine Ligand written by Jaylan Billups and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cooperativity between the metal center and the ligand has been shown in nature to be an important feature of systems that catalyze two-electron processes that first-row transition metals usually cannot catalyze on their own. In these cases, the ligand acts as a site of reactivity that in many instances can store electrons or react directly with substrates in solution. The design and study of systems where there is synergy between the metal and the ligand have been leveraged to catalyze polymerization and hydrogenation-type reactions as well as the activation of small molecules such as dihydrogen. Specifically, the pyridine(diimine) ligand scaffold has been reported to store up to three electrons on the ligand backbone that can later be used in catalysis. Wanting to expand on this work, we have designed and synthesized a new pincer that has redox-noninnocent properties similar to pyridine(diimine) ligands but incorporates a pyrazine ring instead of a pyridine ring to give rise to new electronic properties. Pyrazine(diimines) also have an uncoordinated 4-position nitrogen that can be further functionalized to fine-tune the electronic properties of the ligand. In Chapter II we will discuss bisligated iron(II) pyrazine(diimine) (PZDI) complexes in three different oxidation states where we used spectroscopic and computational techniques as well as comparison to known pyridine(diimine) iron(II) complexes to support our assignments of ligand-based reduction. Chapter III will focus on monoligated pyrazine(diimine) iron(II) complexes as compared to analogous pyrazine(diimine) systems where the central metal is manganese, cobalt, or nickel, as well as compare our pyrazine(diimine) iron(II) complexes to reported pyridine(diimine) iron(II) analogs. We have also synthesized a new inverted pyridine(diimine) ligand scaffold that has an NCN binding pocket, which will be discussed in Chapter IV. In the design of the inverted pyridine(diimine) ligand we have left in place the 4-position nitrogen from our previously described pyrazine(diimine) ligand, maintaining a Lewis basic site for functionalization. Overall, we hope to describe the results we observed with both monoligated and bisligated iron(II) pyrazine(diimine) complexes as well as discuss our approach to the design of and progress towards a new inverted pyridine(diimine) ligand scaffold.
Download or read book Mechanistic Investigations Into the Thermal C C Bond Forming Cyclization of Metal Pyridine Enamide Complexes and the Synthesis and Reactivity of Cationic and Neutral Iron IV Alkylidene Complexes written by Brian Lindley and published by . This book was released on 2016 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of first row transition metal pyridine-enamide complexes has been synthesized. In the course of reactivity studies, it was discovered that heating a solution of the cobalt bis(pyridine-enamide) pyridine adduct resulted in intraligand CC coupling to form an indolamide ligand. Control experiments with the corresponding lithium pyridine-enamide afforded the same indolamide. In order to probe the mechanism of cyclization, deuterium labeling experiments for the lithium pyridineenamide compound were conducted. Careful kinetics measurements supported a mechanism consisting of reversible hydrogen transfer followed by rate-determining CC bond formation, in accord with computational results. Iron(II) complexes bearing cyclometalated benzyldialkylphosphine ligands were synthesized via a salt metathesis approach by treating FeCl2(PMe3)2 with two equivalents of (2-lithiobenzyl)diphenyl- and (2-lithiobenzyl)dicyclohexylphosphine reagents. For the phenyl derivative, a 6-coordinate diamagnetic complex containing two chelating phosphine ligands and two trimethylphosphine ligands was obtained. Contrarily, for the cyclohexyl derivative, a 5-coordinate complex containing two chelating phosphines and one molecule of trimethylphosphine was obtained. This compound is paramagnetic with an S = 1 ground state. Efforts to synthesize Fe(IV) alkylidenes by treating these Fe(II) complexes with diphenyldiazomethane were ultimately unsuccessful. An iron(II) vinyl complex was synthesized by reaction of cis-Me2Fe(PMe3)4 with a 2-propynylaniline benzylidene ligand. Protonation of this complex with [H(OEt2)2]BArF4 (BArF4 = B(3,5-(CF3)2C6H3)4) gave access to a cationic Fe(IV) alkylidene complex. By treating this complex with different anionic nucleophiles, a rare series of neutral Fe(IV) alkylidene complexes was obtained. In addition, treatment of the cationic alkylidene complex with MeMgCl afforded a novel Fe(IV) methyl complex. Attempts at catalyzing olefin metathesis with both the cationic and neutral alkylidene complexes proved unsuccessful, likely due to recalcitrant phosphine dissociation and the sterics at the alkylidene carbon.
Download or read book The Development of Pyridine Containing Macrocyclic Chelates for Measurement of Free Magnesium II in Biological Systems Synthesis and Properties of New Macrocyclic Polyaza Ligands and Preliminary Screening of the Ligands as MRI Contrast Agents Synthesis and Structure of Tris trimethylsiloxy silyl Compounds of Hydroxybenzoic Acids written by Won Dae Kim and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
