Download or read book Synthesis Characterisation and Evaluation of Novel Methacrylate based Water soluble Block Copolymers written by Vural Bütün and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterisation of Novel Ionic Block Copolymers written by Andrew Brian Lowe and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterisation of Novel Copolymers and Latexes Via ATRP written by Shaun Antony Furlong and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents written by Manju Rawat Singh and published by Academic Press. This book was released on 2020-04-21 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Download or read book Synthesis of Novel Zwitterionic Polymers written by Matthew Skinner and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation describes the synthesis, characterization, and investigation of novel zwitterionic polymers containing phosphorylcholine (PC), sulfobetaine (SB), and functional choline phosphate (CP) zwitterions for use as surfactants, self-assembled nanomaterials, and therapeutics. Facile, reproducible, and modular chemistries were utilized for incorporating zwitterions into a range of polymer backbones, and strategies were developed for overcoming difficult challenges encountered in zwitterionic polymer synthesis, especially related to the varying solubility of zwitterions, hydrophobic polymers, and functional comonomers. Synthetic strategies utilized in this work give access to well-defined materials with narrow molecular weight distributions, tunable compositions and architectures, and versatile chemical functionality. Chapter 2 describes the synthesis of water-soluble PC- and SB-functionalized siloxane polymers. PC- and SB-siloxane homopolymers and block copolymers were synthesized using thiol-ene 'click' chemistry, and their assembly in water and at oil-water interfaces was investigated. Chapter 3 describes the preparation of zwitterionic block copolymer analogues of commercial Pluronic® surfactants. PC-containing triblock copolymers were prepared with tunable zwitterion content (5-47 mole percent) and relatively narrow molecular weight distributions. These block copolymer amphiphiles readily formed nanoparticles in water and served as novel surfactants. Through the copolymerization of PC- and CP-methacrylate monomers, functional mimics of conventional Pluronic structures became amenable to crosslinking and the successful synthesis of nanomaterials and robust gels. Chapter 4 presents the in vivo evaluation of poly(2-methacryloyloxyethyl phosphorylcholine)-doxorubicin (polyMPC-Dox) prodrugs for treating human ovarian tumors (SKOV-3). In human ovarian tumor-bearing mice, polyMPC-Dox prodrugs with an approximate Dox loading of 19 weight percent accumulated in tumor tissue at twice the level of free Dox, and animals treated with polyMPC-Dox exhibited enhanced survival and retarded tumor growth compared to conventional Dox treatment. Finally, Chapter 5 augments the polyMPC prodrug concept with the development of polymer-temozolomide (TMZ) conjugates intended for glioblastoma treatment. PolyMPC-TMZ prodrugs were prepared by the controlled free radical copolymerization of MPC and novel TMZ-methacrylate monomers, affording copolymers with random and block architectures. Polymer conjugation significantly improved the solution stability of TMZ, and the antitumor activity of polyMPC-TMZ prodrugs was demonstrated in TMZ-sensitive (U87MG) and TMZ-resistant (T98G) glioblastoma cell lines. The impact of drug loading, polymer architecture, and adjuvant co-delivery on the cytotoxicity of polyMPC-TMZ conjugates was investigated.

Download or read book The Synthesis and Characterisation of Oil Soluble Block Copolymers written by Christine Mary Fernyhough and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Development of Novel Polymeric Materials for Gene Therapy and PH Sensitive Drug Delivery written by and published by . This book was released on 2002 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and drug delivery projects.

Download or read book Synthesis and Characterization of Polymandelide and Lactide methacrylate Block Copolymers written by Tianqi Liu and published by . This book was released on 2002 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Methacrylate based Amphiphilic Block Copolymers in Solution and at Surfaces written by Ekaterina Rakhmatullina and published by . This book was released on 2008 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis of Novel Hydrophilic Methacrylate based Block Copolymers written by Kay Louise Robinson and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Smart Block Copolymers for Biomineralization and Biomedical Applications written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembly is a powerful tool in forming structures with nanoscale dimensions. Self-assembly of macromolecules provides an efficient and rapid pathway for the formation of structures from the nanometer to micrometer range that are difficult, if not impossible to obtain by conventional lithographic techniques [1]. Depending on the morphologies obtained (size, shape, periodicity, etc.) these self-assembled systems have already been applied or shown to be useful for a number of applications in nanotechnology [2], biomineralization [3, 4], drug delivery [5, 6] and gene therapy [7]. In this respect, amphiphilic block copolymers that self-organize in solution have been found to be very versatile [1]. In recent years, polymer-micellar systems have been designed that are adaptable to their environment and able to respond in a controlled manner to external stimuli. In short, synthesis of 'nanoscale objects' that exhibit 'stimulus-responsive' properties is a topic gathering momentum, because their behavior is reminiscent of that exhibited by proteins [8]. By integrating environmentally sensitive homopolymers into amphiphilic block copolymers, smart block copolymers with self assembled supramolecular structures that exhibit stimuli or environmentally responsive properties can be obtained [1]. Several synthetic polymers are known to have environmentally responsive properties. Changes in the physical, chemical or biochemical environment of these polymers results in modulation of the solubility or chain conformation of the polymer [9]. There are many common schemes of engineering stimuli responsive properties into materials [8, 9]. Polymers exhibiting lower critical solution temperature (LCST) are soluble in solvent below a specific temperature and phase separate from solvent above that temperature while polymers exhibiting upper critical solution temperatures (UCST) phase separate below a certain temperature. The solubility of polymers with ionizable moieties depends on the pH of the solution. Polymers with polyzwitterions, anions and cations have been shown to exhibit pH responsive self assembly. Other stimuli responsive polymers include glucose sensitive polymers, calcium ion-sensitive polymers and so on. Progress in living radical polymerization (LRP) methods [10] has made it possible for the facile synthesis of these block copolymer systems with controlled molecular weights and well defined architectures. The overall theme of this work is to develop novel smart block copolymers for biomineralization and biomedical applications. Synthesis and characterization of self-assembling thermoreversible ionic block copolymers as templates in biomimetic nanocomposite synthesis using a bottom-up approach is a novel contribution in this respect. Further, we have extended these families of copolymers to include block copolymer-peptide conjugates to enhance biological specificity. Future directions on this work will focus on enhancing the polymer templating properties for biomineralization by expanding the family of block copolymers with organic polypeptides and biological polypeptide scaffolds as well as a detailed understanding of the polymer-inorganic nanocomposites at the molecular level using small angle scattering analysis. Glucose responsive polymer hydrogels for drug delivery, polymer-ligand conjugates for non-viral therapy and thermoresponsive injectable photocrosslinkable hydrogels for posttraumatic arthritis cartilage healing are other applications of these novel copolymers synthesized in our work.

Download or read book Synthesis Characterization and Kinetic Studies of Novel Polyisobutylene based Block Copolymers written by L. Bryan Brister and published by . This book was released on 1999 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis of Novel Block Copolymer Dispersants for Water borne Pigments written by Xavier Bories-Azeau and published by . This book was released on 2003 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterisation of Novel Block Copolymers of Poly methylphenylsilylene written by Roger Clive Hiorns and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biodegradable Amphiphilic Block Copolymers written by Yasser Assem and published by . This book was released on 2011 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Some Novel Block Copolymers written by Brian Carl Auman and published by . This book was released on 1987 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Novel Polyisobutylene based Materials written by Lisa Kay Kemp and published by . This book was released on 2007 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: