Download or read book SYNTHESIS AND CHARACTERIZATION OF CARBONYL TUNGSTEN 0 COMPLEXES OF N N BIS FERROCENYLMETHYLENE ETHYLENEDIAMINE written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this study a bidentate ligand containing two ferrocenyl moieties, N, N'-bis(ferrocenylmethylene)ethylenediamine, was prepared by condensation reaction of ferrocenecarboxyaldehyde and ethylenediamine on refluxing in benzene. The molecule was identified by IR, Raman, UV-VIS, 1H-, 13C-NMR spectroscopies. Then, this bidentate ligand was reacted with pentacarbonylbis-(trimethyl)silylethyne)tungsten(0). The ligand substitution reaction in dichloromethane yielded the new complex, tetracarbonyl [N, N'-bis(ferrocenylmethylene)ethylenediamine]tungsten(0) (W(CO)4(BFEDA)). This new complex was isolated from the reaction solution in the form of orange crystals and fully characterized by elemental analysis, IR, UV-VIS, MS, 1H- and 13C-NMR spectroscopies. As a bidentate ligand, [N, N'-bis(ferrocenylmethylene)ethylenediamine] binds the metal atom in the two cis positions in the pseudooctahedral geometry of the tungsten-complex. Electrochemistry of the tetracarbonyl [N, N'-bis(ferrocenylmethylene)ethylenediamine]tungsten(0) was studied by cyclic voltammetry, and controlled potential electrolysis combined with the UV-VIS spectroscopy. One irreversible oxidation and three reversible oxidations were observed in the cyclic voltammogram. One of these reversible and the irreversible oxidations are attributed to tungsten and the other two reversible oxidations to iron centers. It is found that the two ferrocene groups started communication with each other after formation of tungsten-complex. N, N'-bis(ferrocenylmethylene)ethylenediamine was also reacted with photogenerated pentacarbonyl(tetrahydrofuran)tungsten(0) complex and the pentacarbonyl [N, N'-bis(ferrocenylmethylene)ethylenediamine]tungsten(0) (W(CO)5(BFEDA)) as an intermediate on the route to the tetracarbonyl[N, N'-bis(ferrocenylmethylene)ethylenediamine]tungsten(0) was isolated from the reaction medium in the form of red crystals and fully characterized by, IR, 1H- and 13C-NMR spectroscopies. The conversion of W(CO)5(BFEDA) to the W.
Download or read book SYNTHESIS AND CHARACTERIZATION OF TETRACARBONYL N N BIS FERROCENYLMETHYLENE ETHYLENEDIAMINE MOLYBDENUM 0 COMPLEX written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this study a bidentate ligand containing two ferrocenyl moieties, N, N'-bis(ferrocenylmethylene)ethylenediamine, was prepared by condensation reaction of ferrocenecarboxyaldehyde and ethylenediamine on refluxing in benzene. The molecule was identified by IR, Raman, UV-Vis, 1H-, 13C-NMR spectroscopies. Then, this bidentate molecule was reacted with tetracarbonyl(bicyclo[2.1.1] hepta-2,5-diene)molybdenum(0). The ligand substitution reaction in toluene yielded the new complex, tetracarbonyl[N, Nþ-bis(ferrocenylmethylene)ethylenediamine] molybdenum(0). This new complex could be isolated from the reaction solution in the form of orange crystals and fully characterized by elemental analysis, IR, UV-Vis, MS, 1H- and 13C-NMR spectroscopies. As a bidentate ligand, N, Nþ-bis(ferrocenylmethylene)ethylenediamine binds the metal atom in the two cis positions in the pseudooctahedral geometry of the molybdenum-complex. Electrochemistry of the tetracarbonyl[N, Nþ-bis(ferrocenylmethylene) ethylenediamine]molybdenum(0) was studied by cyclic voltammetry, chronoamperometry and controlled potential electrolysis combined with the UV-Vis or infrared spectroscopy. One irreversible oxidation and three reversible oxidations were observed in the cyclic voltammogram. Irreversible and a reversible oxidations are attributed to molybdenum and the other two reversible oxidation to iron centers. It is found that the two ferrocene groups started communication with each other after formation of molybdenum-complex.
Download or read book TETRACARBONYL N N2 BIS FERROCENYLMETHYLENE ETHYLENEDIAMINE CHROMIUM 0 Cr CO 4 BFEDA SYNTHESIS AND CHARACTERIZATION written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: N, N2-bis(ferrocenylmethylene)ethylenediamine was prepared from the reaction of ferrocenecarboxaldehyde and ethylenediamine and characterized by IR, Raman, 1H and 13C-NMR spectroscopy. The electrochemical behaviour of this ligand was also studied for the first time by cyclic voltammetry. Diferrocenyl diimine ligand was used in the thermal substitution of 1,5-cyclooctadiene in Cr(CO)4(2:2-1,5-cyclooctadiene) at 38°C in toluene for two hours to form the tetracarbonyl[N, N2-bis(ferrocenylmethylene)ethylenediamine]chromium(0), [Cr(CO)4(BFEDA)]. This complex was succesfully isolated and crystallized from its 1:1 toluene/dichloromethane solution and characterized by elemental analysis, MS, IR, 1H, 13C-NMR spectroscopy. Electrochemical behaviour of the complex was also studied by cyclic voltammetry and the mechanism of electrode reaction was investigated by in-situ UV-VIS and IR spectroscopy measurements. This new complex has the iron atom of ferrocene unit in conjugation with the chromium metal center and, therefore, shows an electronic communication between two metal atoms.
Download or read book Synthesis and Characterization of Tungsten Carbonyl Complexes Containing an Alkyne and a Trialkylphosphine Ligands written by Demircani Oktay and published by . This book was released on 2002 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Frontiers and Advances in Molecular Spectroscopy written by Jaan Laane and published by Elsevier. This book was released on 2017-11-13 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers and Advances in Molecular Spectroscopy once again brings together the most eminent scientists from around the world to describe their work at the cutting-edge of molecular spectroscopy. Much of what we know about atoms, molecules and the nature of matter has been obtained using spectroscopy over the last one hundred years or so. Going far beyond the topics discussed in Jaan Laane’s earlier book on the subject, these chapters describe new methodologies and applications, instrumental developments and theory, which are taking spectroscopy into still new frontiers. The robust range of topics once again demonstrates the wide utility of spectroscopic techniques. New topics include ultrafast spectroscopy of the transition state, SERS/far-uv spectroscopy, femtosecond coherent anti-Stokes Raman spectroscopy, high-resolution laser induced fluorescence spectroscopy, Raman spectroscopy and biosensors, vibrational optical activity, ultrafast two-dimensional spectroscopy, biology with x-ray lasers, isomerization dynamics and hydrogen bonding, single molecule imaging, spectra of intermediates, matrix isolation spectroscopy and more. Covers spectroscopic investigations on the cutting edge of science Written and edited by leading experts in their respective fields Allows researchers to access a broad range of essential modern spectroscopy content from a single source rather than wading through hundreds of scattered journal articles
Download or read book Molecular Interfacial Phenomena of Polymers and Biopolymers written by P Chen and published by Taylor & Francis US. This book was released on 2005-07-22 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines three fundamental areas of interest to the science and engineering community, these being material science, nanotechnology and molecular engineering. Although there have been various results published in this field, there has yet to be a fully comprehensive review. This book covers key research on molecular mechanisms and thermodynamic behaviour of (bio)polymer surfaces and interfaces, from theoretical and experimental perspectives.
Download or read book Advances in Cross Coupling Reactions written by José Pérez Sestelo and published by MDPI. This book was released on 2020-12-03 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.
Download or read book Modern Flow Analysis written by Pawel Koscielniak and published by . This book was released on 2020 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow analysis is an automatic, precise and fast way to perform analytical tests. Flow instruments are used for clinical and pharmaceutical analyses, quality control of industrial products, monitoring of environmental pollution and many other fields. The book presents the latest methodological, technical and instrumental achievements in flow analysis. It shows new possibilities for the miniaturization and full mechanization of flow systems, together with examples of their interesting application. The proposed solutions contribute to reducing the amount of used reagents and waste, as well as increasing the safety of working with hazardous reagents, resulting in modern devices operating in accordance with the principles of green chemistry. A number of innovative methods of processing and measuring analytical samples have also been described. The book very well reflects the current state of flow analysis and development directions.
Download or read book Pharmaceutical Residues in the Environment written by Jolanta Kumirska and published by MDPI. This book was released on 2020-11-18 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceuticals, due to their pseudo-persistence and biological activity as well as their extensive use in human and veterinary medicine, are a class of environmental contaminants that is of emerging concern. In contrast to some conventional pollutants, they are continuously delivered at low levels, which might give rise to toxicity even without high persistence rates. These chemicals are designed to have a specific physiological mode of action and to resist frequently inactivation before exerting their intended therapeutic effect. These features, among others, result in the bioaccumulation of pharmaceuticals which are responsible for toxic effects in aquatic and terrestrial ecosystems. It is extremely important to know how to remove them from the environment and/or how to implement procedures or treatments resulting in their biological inactivation. Although great advances have been made in their detection in aquatic matrices, there remains limited analytical methodologies available for the trace analysis of target and non-target pharmaceuticals in matrices such as soils, sediments, or biota. There are still many gaps in the data on their fate and behavior in the environment as well as on their threats to ecological and human health. This book has included nine current research and three review articles in this field.
Download or read book Nitro Compounds and Their Derivatives in Organic Synthesis written by Nagatoshi Nishiwaki and published by . This book was released on 2020 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Radiolabelled Molecules for Brain Imaging with PET and SPECT written by Peter Brust and published by . This book was released on 2020 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body's functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood-brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors.
Download or read book Terpenes and Terpene Derivatives written by Pavel B Drasar and published by Mdpi AG. This book was released on 2021-10-18 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprises selected communications on terpenes and terpene derivatives. It clearly demonstrates the sustained interest and importance in this field of natural products; the field connected to secondary metabolites; and renewable resources of plant and animal compounds for medicinal, material, supramolecular, and general chemistry research. It includes 17 papers, 5 review articles, and 12 research communications with a vast range of topics with different perspectives. It commemorates the great work and legacy of prof. Kenji Mori, and provides important material not only to many chemists but also to specialists in several other fields.
Download or read book Anticancer Agents written by Qiao-Hong Chen and published by MDPI. This book was released on 2021-03-02 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Download or read book Radiolabeled Compounds for Diagnosis and Treatment of Cancer written by Krishan Kumar and published by Mdpi AG. This book was released on 2021-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals.
