Download or read book Studies Towards the Total Synthesis of Sch 49 210 and Everninomicin Antibiotic 13 384 1 written by Scott Robert Conley and published by . This book was released on 1997 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Download or read book Plant Growth Promoting Rhizobacteria PGPR Prospects for Sustainable Agriculture written by R. Z. Sayyed and published by Springer. This book was released on 2019-06-27 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sustainable increase in agricultural production while keeping the environmental quality, agro-ecosystem function and biodiversity is a real challenge in current agricultural practices. Application of PGPR can help in meeting the expected demand for increasing agricultural productivity to feed the world’s booming population. Global concern over the demerits of chemicals in agriculture has diverted the attention of researchers towards sustainable agriculture by utilizing the potential of Plant Growth Promoting Rhizobacteria (PGPR). Use of PGPR as biofertilizers, biopesticides, soil, and plant health managers has gained considerable agricultural and commercial significance. The book Plant Growth Promoting Rhizobacteria (PGPR): Prospects for Sustainable Agriculture has contributions in the form of book chapter from 25 eminent global researchers, that discusses about the PGPRs and their role in growth promotion of various crop plants, suppression of wide range of phytopathogens, their formulation, effect of various factors on growth and performance of PGPR, assessment of diversity of PGPR through microsatellites and role of PGPR in mitigating biotic and abiotic stress.This book will be helpful for students, teachers, researchers, and entrepreneurs involved in PGPR and allied fields. The book will be highly useful to researchers, teachers, students, entrepreneurs, and policymakers.
Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Download or read book Classics in Total Synthesis III written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 2011-03-14 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.
Download or read book Plant Growth Promoting Actinobacteria written by Gopalakrishnan Subramaniam and published by Springer. This book was released on 2016-06-02 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global yields of legumes have been relatively stagnant for the last five decades, despite the adoption of conventional and molecular breeding approaches. The use of plant growth-promoting (PGP) bacteria for improving agricultural production, soil and plant health has become one of the most attractive strategies for developing sustainable agriculture. Actinomycetes are bacteria that play an important role in PGP and plant protection, produce secondary metabolites of commercial interest, and their use is well documented in wheat, rice, beans, chickpeas and peas. In order to promote legumes, the general assembly of the UN recently declared 2016 the “International Year of Pulses.” In view of this development, this book illustrates how PGP actinomycetes can improve grain yield and soil fertility, improve control of insect pests and phytopathogens, and enhance host-plant resistance. It also addresses special topics of current interest, e.g. the role of PGP actinomycetes in the biofortification of legume seeds and bioremediation of heavy metals.
Download or read book Bioprospecting of Indigenous Bioresources of North East India written by Jubilee Purkayastha and published by Springer. This book was released on 2016-08-16 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is a comprehensive information on the indigenous bioresources of North Eastern India with the scope of bioprospecting for discovery and commercialization of new sources and products and long-term ecological balance. The exploration, conservation and sustainable utilization of bioresources of world’s Megabiodiversity Hotspots are undeniable. North Eastern India is a recognised biodiversity hot spot where the evolutionary forces are at its optimum, making this region as centre of origin for many species. Although little bit exploratory studies have been conducted in this part of the globe but a scientific exploitation of the bioresources is almost lacking. Unscientific exploitation and overexploitation without proper knowledge of the bioresources may lead to imbalanced ecosystem of this mega diversity region. At the same time, very less exploration and exploitation will hamper biodiversity based development. Today, unscientific dramatic changes are underway in this region. Human activities are changing, degrading and destroying the bioresources in an unplanned manner. Scientific bioprospecting of the bioresources will boost the economy while ensuring conservation. This book offers comprehensive information about various levels of bioprospecting of the gene pool of this Indo-Burma Mega Biodiversity Hot Spot, the North East India, which is endowed with huge biodiversity potential for exploration and exploitation for the benefit of humankind. Also, this book highlights the less and merely explored part of the indigenous biodiversity of North East India with explanation towards their better sustainable exploitation for benefit of the people, economy and environment. The novelty of the book lies in expert coverage of the bioresources of this mega-diverse region including plants, microbes, insects etc. with provisions for their sustainable scientific utilization. This book portrays North East India as a melting pot of bioresources which are little explored and also those resources which are still to be explored. The book mainly highlights the bioprospecting approaches for North East Indian bioresources, and thus, it make itself a unique one in filling the knowledge gap that is there regarding the bioprospecting of the biodiversity of this special region on the earth. The book concludes by the ecotourism potential of this region. The target audiences for this book include biodiversity economists who are working on technology and bioresource management issues, and especially on biotechnology and biodiversity, development economists addressing the issues of bioresources in developing countries. These people may be in academia, in government, in non-governmental organizations and in private companies. The other target audiences group is policy scholars in government/public sectors who are interested in issues of biotechnology, IPRs, and biodiversity. In addition, scholars/experts in both development studies and resource management studies form another group of target audiences. Also, the book will be useful for the interaction between developed and developing nations regarding the issues of biodiversity and bioprospecting, as North Eastern India is the hub of Biodiversity.
Download or read book Molecular Basis of Resilience written by Patrick L. Iversen and published by Springer. This book was released on 2019-01-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.
Download or read book Flavin based Catalysis written by Radek Cibulka and published by Wiley-VCH. This book was released on 2021-09-07 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a unique overview of this rapidly developing research field, presenting structures and properties of flavin derivatives as well as their proven application as bioinspired catalysts in various organocatalytic, biocatalytic, and photocatalytic reactions.
Download or read book C X Bond Formation written by Arkadi Vigalok and published by Springer. This book was released on 2010-06-30 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.
Download or read book Antimicrobials written by Flavia Marinelli and published by Springer Science & Business Media. This book was released on 2013-10-04 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
Download or read book Name Reactions of Functional Group Transformations written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2007-07-09 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature Contributors are well-known and respected for their work on the specific name reactions.
Download or read book Name Reactions in Heterocyclic Chemistry written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2004-12-27 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student. Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whom have discovered the very reactions they describe - Name Reactions in Heterocyclic Chemistry represents a state-of-the-art resource for students and researchers alike.
Download or read book Van Nostrand s Encyclopedia of Chemistry written by Glenn D. Considine and published by Wiley-Interscience. This book was released on 2005-02-03 with total page 1856 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists, engineers, and technologists in many fields need a knowledge of chemistry because of the importance of chemistry in diverse technologies. In addition, to "classical" topics of chemistry, the new Encyclopedia covers nanotechnology, fuel cell technology, green chemistry, forensic chemistry, supramolecular chemistry, combinatorial chemistry, materials chemistry, and proteomics. This fifth print edition has been revised and updated, and includes over 200 new articles, as well as 1,300 updated articles.
Download or read book Mechanism of Action of Antieukaryotic and Antiviral Compounds written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.
Download or read book Pathology of Domestic Animals written by K. V. F. Jubb and published by Elsevier. This book was released on 2013-10-02 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of Domestic Animals, Volume 1 elaborates on the bone structure and diseases, as well as the genital, circulatory, and respiratory systems, of domestic animals. The manuscript first offers information on bones, joints, and synovial structures and diseases of joints, including adaptational deformities of the skeleton, metabolic diseases of bones, necrosis and inflammation of bones, and discontinuities of bone and the healing of fractures. The text then ponders on the circulatory and respiratory systems. Discussions focus on congenital anomalies of the heart and large vessels, myocardium, hypertrophy and dilation of the heart, pharynx and guttural pouches, larynx and trachea, lungs, and pleura and mediastinum. The publication examines the haemopoietic system and endocrine glands. Topics include blood and bone marrow, general reactions of erythrocytes to injury, lymphoreticular tissues, adrenal glands and paraganglia, and polycythaemia. The book then reviews the male and female genital systems. The manuscript is a valuable source of data for readers interested in the pathology of domestic animals.
