Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Download or read book Relevance of Steroid Biosynthesis Metabolism and Transport in Pathophysiology and Drug Discovery written by Tea Lanišnik Rižner and published by Frontiers Media SA. This book was released on 2019-07-10 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid hormones have important roles in human physiology, but they are also implicated in the development of hormone-dependent cancers and various non-maligant diseases. Furthermore, changes in the concentrations of steroid hormones have important effects on the homeostasis of pre- and post-menopausal women, as well as of men in andropause. The associations of steroid hormones with pathophysiological processes and the altered mechanisms of their actions in disease are still not completely understood. It has been known for more than thirty years that in addition to their endocrine activity, steroid hormones act in an intracrine manner. In target organs, active androgens and estrogens can be formed from inactive, or less active, precursor steroid hormones, mainly dehydroepiandrosterone-sulfate (DHEA-S), and estrone-sulfate (E1-S) after their translocation into cells through the transporter proteins of the organic anion-transporting polypeptide (OATP) and organic anion-transporter (OAT) families. The combination of altered uptake of precursors, changed activation and action of estrogens and androgens, in concert with the changes in the metabolism and excretion may thus have major roles in the development of hormone-dependent malignant and non-malignant diseases. To date, the salient roles of the individual players in disease pathophysiology have not been precisely defined. The aim of this Research Topic is thus to highlight the progress made in the field of steroid transport and intracrine actions and metabolism, with special emphasis on the involvement of these processes in the pathophysiology of hormone-dependent disorders and on the identification of novel drug targets.

Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Obesity and Cancer written by Tobias Pischon and published by Springer. This book was released on 2016-12-01 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk. Individual chapters discuss potential pathways for the observed associations and explore possible mechanisms from both an epidemiological and an experimental perspective. It concludes with a population perspective on the cancer risk that is attributable to obesity and is thus potentially avoidable. This book is of particular value to researchers and epidemiologists and is also of interest to public health workers and clinicians.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1990 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oncologic Therapies written by Everett E. Vokes and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition has been updated in a user-friendly layout that makes its comprehensive information extremely accessible. The handbook, written for all physicians who treat cancer patients, provides a survey of current therapeutic concepts of solid tumors and hematologic malignancies in internal oncology. Each individual chapter of this shortened new edition is structured in the same way and features a brief outline or tabular summary of the main aspects of epidemiology, pathology, staging, and diagnosis. The main focus is on the therapeutic strategy, i.e., an interdisciplinary approach to systemic drug therapy. Surgical and radiological concepts of treatment are also covered, as are supportive care, pain relief methods and ethical problems. This title is a must for clinicians and practitioners as well as interns, residents and postgraduate students.

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Integrative Medicine E Book written by David Rakel and published by Elsevier Health Sciences. This book was released on 2012-04-12 with total page 1297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative Medicine, by Dr. David Rakel, provides the practical, evidence-based guidance you need to safely and effectively integrate complementary and alternative medical treatments into your practice. This medical reference book lays the framework for making the best use of these therapeutic modalities and understanding the mechanisms by which these interventions work, keeping you at the forefront of the trend toward integrative health care. Incorporate therapeutic integrative medicine modalities into clinical practice through the "Tools for Your Practice" section that offers how-to application for recommending mediation, prescribing probiotics, and how to do an elimination diet. Apply integrative treatments for a full range of diseases and conditions including autism, stroke, chronic fatigue syndrome, and various forms of cancer...see how to advise patients on health maintenance and wellness...and get valuable advice on topics such as meditation, diet, and exercises for back pain. Avoid potential complications with recommended dosages and precautions. Enhance patient care with therapy-based guidance and printable patient education guides. Implement proven integrative treatments for various diseases thanks to an evidence-based therapeutic approach. Weigh the likely effectiveness of various treatments vs. their potential harm with helpful icons based on the SORT (Strength of Recommendation Taxonomy) method. Validate potential interventions through the latest research in genomics and advanced imaging technologies, such as MRI.

Download or read book Re Balancing the Balance Another Story of Cardio Oncology written by Cezar Angi Iliescu and published by Frontiers Media SA. This book was released on 2022-06-06 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Anticancer Research written by and published by . This book was released on 1998 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Subject Index of Current Extramural Research Administered by the National Cancer Institute written by National Cancer Institute (U.S.) and published by . This book was released on 1977 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides information concerning research grants and contracts supported by the National Cancer Institute.

Download or read book Interferon and Antiviral Substances Bibliography from MEDLARS written by and published by . This book was released on 1977 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Research written by and published by . This book was released on 2007-12 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Integrative Medicine written by David Rakel and published by Elsevier Health Sciences. This book was released on 2012 with total page 1298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Counterstrain -- Acupuncture for headache -- Acupuncture for nausea and vomiting -- Saline nasal irrigation -- Bioenergetics -- Integrating spiritual assessment and care -- Therapeutic homeopathy -- Human energetic therapies -- Other therapeutic considerations -- Creating a greener clinic: the impact of global warming on health -- Creating ceremony and ritual in the medical encounter -- Appendix: laboratory testing resources in integrative medicine.