Download or read book Structure Function Studies of Ribonucleotide Reductase from Escherichia Coli written by Åke Larsson and published by . This book was released on 1990 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nucleotide Metabolism written by J. Frank Henderson and published by Academic Press. This book was released on 2014-06-28 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Novel Cofactors written by Judith P. Klinman and published by Gulf Professional Publishing. This book was released on 2001-10-05 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cofactor is a component part of many enzymes and functions by uniting with another molecule in order to become active. The use of cofactors to supplement the native amino acids of a protein is essential to maintain the chemical capabilities necessary for organisms to survive. This volume focuses on the significant advances of the past decade in identifying and describing new cofactors--either small molecules or those derived posttranslationally.
Download or read book Mitochondria and Anaerobic Energy Metabolism in Eukaryotes written by William F. Martin and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-12-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.
Download or read book Prokaryotic Metabolism and Physiology written by Byung Hong Kim and published by Cambridge University Press. This book was released on 2019-05-16 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.
Download or read book Biochemical Basis of Medicine written by Eric D. Wills and published by Butterworth-Heinemann. This book was released on 2014-04-24 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Basis of Medicine discusses academic biochemistry and the applications of biochemistry in medicine. This book deals with the biochemistry of the subcellular organelles, the biochemistry of the body , and of the specialized metabolism occurring in many body tissues. This text also discusses the various applications of biochemistry as regards environmental hazards, as well as in the diagnosis of illnesses and their treatment. This text explains the structure of the mammalian cell, the cell's metabolism, the nutritional requirements of the whole body, and the body's metabolism. This book explains the specialized metabolisms involved in tissues such as those occurring in blood clotting, in the liver during carbohydrate metabolism, or in the kidneys during water absorption. The text explains toxicology or biochemical damage caused by excess presence of copper, mercury, or lead in the body. Chelation therapy can remove these toxic metals. This book describes the effects of alcohol on plasma liquids, the multistage concept of carcinogenesis, and the biochemical basis of diagnosis. Diagnosis and treatment include the determination of typical enzymes found in the plasma, tests for genetic defects in blood proteins, and the use of chemotherapeutic drugs. This book is suitable for chemists, students and professors in organic chemistry, and laboratory technicians whose work is related to pharmacology.
Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Download or read book Radical SAM Enzymes written by and published by Academic Press. This book was released on 2018-08-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.
Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book 2 Oxoglutarate Dependent Oxygenases written by Christopher J Schofield and published by Royal Society of Chemistry. This book was released on 2015-05-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
Download or read book Essentials of Biochemistry written by Herbert J. Fromm and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook, Essentials of Biochemistry is aimed at chemistry and biochemistry undergraduate students and first year biochemistry graduate students. It incorporates the lectures of the authors given to students with a strong chemistry background. An emphasis is placed on metabolism and reaction mechanisms and how they are studied. As the title of the book implies, the text lays the basis for an understanding of the fundamentals of biochemistry.
Download or read book Hydroxamic Acids written by Satya P. Gupta and published by Springer Science & Business Media. This book was released on 2013-09-30 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Satya P. Gupta's Hydroxamics Acids is the first book to compile invited articles written by international experts on the class of compounds hydroxamic acids. Found to possess a wide spectrum of biological activities, the hydroxamic acids are of interest to theoretical and experimental chemists who can study and make use of them in drug design and development. Chapters in this book provide a diverse and comprehensive coverage of this compound class and consequently this publication is a valuable resource for researchers in chemical, pharmaceutical and biological sciences.
Download or read book Medical Biochemistry written by John W Baynes and published by Elsevier Health Sciences. This book was released on 2018-01-03 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now fully revised, this acclaimed textbook efficiently links basic biochemistry with the day-to-day practice of medicine. You will learn basic science concepts and see them illustrated by clinical cases that describe patients you will likely encounter in your clinical training. You will also learn about the use of laboratory tests to diagnose and monitor the most important conditions. Brought to you in a thorough yet accessible manner, this new edition of Medical Biochemistry highlights the latest developments in regulatory and molecular biology, signal transduction, biochemistry and biomarkers of chronic disease, and bioinformatics and the ‘–omics’. It highlights the most important global medical issues: diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and addresses the role of nutrition and exercise in medicine. Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today’s integrated courses. Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today's integrated courses. Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer
Download or read book Chemistry and Biochemistry of B12 written by Ruma Banerjee and published by John Wiley & Sons. This book was released on 1999-11-03 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Definitive New Reference for the Latest Advances in B_12 Chemistry and Biochemistry Over the past decade, the field of B_12 research has been revolutionized by such major breakthroughs as the unraveling of the entire biosynthetic pathway for this important vitamin. This comprehensive compendium surveys the wealth of information that has accumulated, covering in one volume virtually all aspects of the field-from physical and inorganic chemistry to enzymology, microbiology, medicine, and diagnostic and therapeutic applications. Edited by Dr. Ruma Banerjee, a highly respected and active member of the B_12 community, this work provides B_12 researchers with a dependable and up-to-date reference on the subject. Leading authorities from five continents explore such new areas as the structural biology of B_12-dependent enzymes, free-radical-mediated reaction mechanisms, biosynthesis, and much more. The role of B_12 in nutrition and disease, and B_12 transport, are also thoroughly examined. Complete with color illustrations and extensive references, Chemistry and Biochemistry of B_12 is a one-of-a-kind resource for biochemists, biophysicists, spectroscopists, microbiologists, molecular biologists, and anyone with an interest in "nature's most beautiful cofactor."
Download or read book Molecular Life Sciences written by Robert D. Wells and published by Springer. This book was released on 2018-01-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. The work will include articles on genes and genomes, protein structure and function, systems biology using genomics and proteomics as the focus, molecular aspects of cell structure and function, unifying concepts and theories from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences (including teaching perspectives and assessment tools), and basic aspects of the various experimental approaches that are used in the Molecular Life Sciences.
Download or read book The Human Mitochondrial Genome written by Giuseppe Gasparre and published by Academic Press. This book was released on 2020-07-23 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. - Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies - Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically - Outlines and discusses essential research protocols and perspectives for young scientists to pick up - Features an international team of authoritative contributors from basic biologists to clinician-scientists
