Download or read book Stroke Recovery with Cellular Therapies written by Sean I. Savitz and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is the leading cause of serious, long term disability. This book proposes different cellular therapies under investigation to promote neural regeneration after stroke. Authored by an international panel of scientists and clinicians, this volume is a vital, one-of-a-kind resource for all scientists interested in regenerative medicine.
Download or read book Cell Based Therapies in Stroke written by Jukka Jolkkonen and published by Springer Science & Business Media. This book was released on 2013-01-30 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke remains one of the main causes of death and disability worldwide. While effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.
Download or read book Cellular Therapy for Stroke and CNS Injuries written by Li-Ru Zhao and published by Springer. This book was released on 2014-12-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addition, it will provide information on cell isolation and culture skills, transplantation methods, and neurological functional evaluations. This is the first book to focus on cellular therapy for stroke and other CNS injuries.
Download or read book Regenerative Therapies in Ischemic Stroke Recovery written by Syed Shadab Raza and published by Springer. This book was released on 2023-07-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.
Download or read book Cellular and Molecular Approaches to Regeneration and Repair written by Paul A. Lapchak and published by Springer. This book was released on 2017-11-04 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.
Download or read book Cell based Therapies for Stroke Promising Solution or Dead End written by Paulo Henrique Rosado-de-Castro and published by Frontiers Media SA. This book was released on 2020-05-22 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bone marrow stem cell therapy for stroke written by Kunlin Jin and published by Springer. This book was released on 2016-12-13 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.
Download or read book Healing the Broken Brain written by Dr. Mike Dow and published by Hay House, Inc. This book was released on 2017-05-02 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you’re holding this book, it likely means you or someone you love has had a stroke. Dealing with the onslaught of information about stroke can be confusing and overwhelming. And if you happen to be a stroke survivor with newly impaired language skills, it can be especially hard to comprehend everything your doctors, nurses, and specialists are telling you.This book consists of the top 100 questions that survivors and their families ask, with answers from the top physicians and therapists in the country. The questions start out basic but then get more specific to address different areas of recovery. And, for stroke survivors still struggling with reading comprehension, or for family members who are simply too tired to read long passages, there are Takeaway Pointsat the end of each chapter to help simplify everything.Includes answers to frequently asked questions such as:• What is a stroke, and who is at risk for one?• What is the best diet for a stroke survivor?• How does group therapy compare to individual therapy?• What should a stroke survivor look for in a therapist?• How long will it take to recover, and how can stroke survivors maximize their recovery?• What can someone do to prevent having another stroke?In this book, you’ll gain a wealth of information, inspiration, advice, and support as you navigate your journey through stroke recovery.
Download or read book Broken Movement written by John W. Krakauer and published by MIT Press. This book was released on 2022-06-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical physiology and molecular biology. The authors cast a critical eye at current frameworks and practices, offer new recommendations for promoting recovery, and propose new research directions for the study of brain repair. Krakauer and Carmichael discuss such subjects as the behavioral phenotype of hand and arm paresis in human and non-human primates; the physiology and anatomy of the motor system after stroke; mechanisms of spontaneous recovery; the time course of early recovery; the challenges of chronic stroke; and pharmacological and stem cell therapies. They argue for a new approach in which patients are subjected to higher doses and intensities of rehabilitation in a more dynamic and enriching environment early after stroke. Finally they review the potential of four areas to improve motor recovery: video gaming and virtual reality, invasive brain stimulation, re-opening the sensitive period after stroke, and the application of precision medicine.
Download or read book Cell Therapy Against Cerebral Stroke written by Kiyohiro Houkin and published by Springer. This book was released on 2018-07-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.
Download or read book Cell Therapy for Brain Injury written by David C. Hess and published by Springer. This book was released on 2015-05-15 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.
Download or read book Preclinical Development of a Neural Stem Cell Therapy for Stroke and Traumatic Brain Injury written by Emily Wyatt Baker and published by . This book was released on 2017 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke and traumatic brain injury (TBI) are leading causes of death and long-term disability worldwide. Despite the socioeconomic burden of these neural injuries, there are no restorative therapies. Induced pluripotent stem cell-derived neural stem cells (iNSCs) may be the critically needed therapy to restore neurological function after brain injury. Preclinical studies demonstrate that iNSCs are a multimodal therapeutic that improves recovery after neural injury. However, the enthusiasm of these results has been stifled by the hundreds of therapeutics shown to be effective in preclinical neural injury models but have failed in clinical trials, thus suggesting a lack of translatability of preclinical animal models to human patients. Compared to the rodent, the sole preclinical model iNSC therapy has been tested in, the pig possesses striking similarities in brain anatomy and physiology compared to the human and may be an ideal animal model to bridge the gap between preclinical rodent models and human patients. However, injury models and outcome measures are not well characterized in the pig, and more studies in the pig are needed to determine if large animals truly carry greater predictive power of clinical efficacy. The objectives of these studies were to 1) develop a translational pig model to study TBI pathophysiology and recovery mechanisms, and 2) assess whether iNSC therapy improves recovery in a pig stroke model. These studies strengthen current preclinical therapeutic development strategies for neural injury by improving the translational capacity of animal models and provide further insight into the potential of iNSC therapy for human patients.
Download or read book The Functional Role of Enhancing the Survival and Activity of Progenitor Cells During Stroke Recovery written by Sebastien Denize and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Following a stroke, there is a significant increase in the number of precursor cells (PCs) that migrate to the site of injury. Their functional significance, based on studies that ablate PCs, remains controversial. This thesis aims to determine if enhancing the survival of PCs, and/or optogenetically stimulating PCs, is sufficient to improve stroke recovery. After photothrombosis-induced stroke, tamoxifen was used to recombine the nestin-expressing PCs and their progeny in iBax-ChR2 mice: inducible Nestin CreERT2 mice that have a floxed Bax, pro-apoptotic gene, and a floxed channelrhodopsin (ChR2-YFP) which allows for the modulation of neural activity. Removal of the Bax gene results in a significantly increased number of PCs with a neuronal phenotype surrounding the infarct, in the absence of altering behavioral recovery. To test if enhancing the activation of PCs around the stroke site could alter recovery, iBax-ChR2 mice received daily optogenetic stimulation for 5 weeks. Interestingly, stimulation of PCs around the stroke site resulted in an increased rate of neuronal differentiation in WT-ChR2 mice but no behavioural improvements after stroke. These findings suggest that substantially increasing the neurogenic response following a stroke has no impact on behavioural recovery. Moreover, contrary to an increasing number of studies stimulating the cortex post-stroke, specifically activating PCs in the ipsilesional cortex does not alter recovery. The implications of these data are becoming increasingly relevant as stroke researchers are beginning to experiment with non-invasive stimulation and stem cell therapies for stroke survivors.
Download or read book Efficacy of Stem Cell Derived Therapy for Ischemic Stroke written by Shannon Helsper and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a leading causing of death and disability world-wide, and yet, few options for therapeutic treatment exist. Cell therapies, particularly human bone-marrow derived mesenchymal stem cells (hMSC), have elicited particular interest recently. Of the approximately 29 clinical trial studies worldwide, none however has yet established a robust hMSC approach to treat stroke, largely due to variance with in vivo stem cell response and varying preconditioning metrics. This work describes the development of unique magnetic resonance imaging and spectroscopy (MRI/S) methods to assess early markers of tissue recovery in response to hMSC-derived therapies in ischemic stroke. Combining 23Na MRI and 1H MRS provides a highly sensitive, multinuclear approach enabling real time monitoring of the in vivo efficacy of hMSC therapies by probing ionic and energetic homeostasis, starting at therapeutic administration through the evolution of disease progression and recovery. Utilizing a preclinical cerebral ischemia model, this work demonstrates that these highly sensitive MR metrics can discern therapeutic efficacy and assess the differential impacts of 2D and 3D hypoxic preconditioning on hMSC when applied in vivo. The early assessment provided by MR evaluation correlate positively with extended neurological recovery assessed by neuromotor analysis and immunohistochemistry as well as with in vitro assays and ischemic challenges over extended cell culture. With the aid of a novel method to label hMSC-derived extracellular vesicles for investigating biodistribution and therapeutic efficacy of the hMSC secretome, enhanced MR sensitivity further provides insight into the mechanism of action by these stem cells. Overall, results demonstrate the superior benefits of intra-arterially injected hMSC that are pre-conditioned using 3D aggregation with respect to the recovery of ionic and metabolic homeostasis both at the lesion and systemically. However, hypoxically conditioned 2D hMSC and extracellular vesicles also displayed improvement in ionic and metabolic recovery over untreated ischemia. These approaches (e.g., 3D versus 2D culture or direct cell implantation versus extracellular vesicles) have significant ramifications for the feasible translation of hMSC into clinical use. With the ability to monitor treatment efficacy with MR techniques, these preconditioning steps can be developed further to aid in refinement of cell and extracellular vesicle preparation at clinically relevant scales as they are moved towards therapeutic implementation for ischemic stroke.
Download or read book Stroke Recovery and Rehabilitation written by Richard L. Harvey, MD and published by Demos Medical Publishing. This book was released on 2008-11-20 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Doody's Core Title 2012 Stroke Recovery and Rehabilitation is the new gold standard comprehensive guide to the management of stroke patients. Beginning with detailed information on risk factors, epidemiology, prevention, and neurophysiology, the book details the acute and long-term treatment of all stroke-related impairments and complications. Additional sections discuss psychological issues, outcomes, community reintegration, and new research. Written by dozens of acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, Stroke Recovery and Rehabilitation features: The first full-length discussion of the most commonly-encountered component of neurorehabilitation Multi-specialty coverage of issues in rehabilitation, neurology, PT, OT, speech therapy, and nursing Focus on therapeutic management of stroke related impairments and complications An international perspective from dozens of foremost authorities on stroke Cutting edge, practical information on new developments and research trends Stroke Recovery and Rehabilitation is a valuable reference for clinicians and academics in rehabilitation and neurology, and professionals in all disciplines who serve the needs of stroke survivors.
Download or read book Regenerative Rehabilitation written by Sarah M. Greising and published by Springer Nature. This book was released on 2022-06-01 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.
Download or read book Stroke written by Jens Minnerup and published by Morgan & Claypool. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies. Table of Contents: Introduction / Pathophysiology of Acute Injury / Recovery and Regeneration / Future Therapeutic Strategies / References
