Download or read book Steroids and the Nervous System written by GianCarlo Panzica and published by . This book was released on 2003 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.
Download or read book Steroids and the Nervous System written by Cristin Roth and published by American Medical Publishers. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biologically active organic compound with four rings arranged in a specific molecular configuration is termed as a steroid. Steroid hormones are essential for cell life and they affect the neuroendocrine and behavioral functions in humans. Steroids perform two main biological functions. The first function is that they form an essential part of cell membranes which alters the membrane fluidity. The second function is signal transduction or cell signaling that facilitates cellular response. During early development, steroids regulate the activity and plasticity of neurons and the glial cells. They continue to exert trophic and protective effects on the adult nervous system. Steroids are synthesized by the gonads and adrenal glands, and are transmitted to the brain, spinal cord and the peripheral nerves through the bloodstream. Neurosteroids such as pregnenolone, progesterone, dehydroepiandrosterone and sulfate esters are produced within the nervous system. This book unravels the recent studies related to the importance of steroids in the nervous system. The topics covered herein are of utmost significance and bound to provide incredible insights to the readers. Through this book, we attempt to further enlighten the readers about the new concepts in this field of study.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Steroids and the Nervous System written by GianCarlo Panzica and published by . This book was released on 2011 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurosteroids and the Nervous System written by Steven R. King and published by Springer Science & Business Media. This book was released on 2012-11-09 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
Download or read book Steroids in Diseases of the Central Nervous System written by Rudy Capildeo and published by . This book was released on 1989-10-12 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Outstanding contributions present an overview of steroids, starting with their molecular biology, pharmacology, and immunology. Steroids in Diseases of the Central Nervous System deals with the current applications of steroids in a variety of clinical conditions; treatments are described for brain tumors, malignant glioma, head and spinal damage, Guillain-Barré syndrome, polymyositis, and other neurological diseases.
Download or read book CNS Neurotransmitters and Neuromodulators written by Trevor W. Stone and published by CRC Press. This book was released on 1996-03-27 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference. Well-known international authors have contributed up-to-date reviews covering a wide-range of interdisciplinary aspects of neuroactive steroid function. Specifically, this volume includes chapters dealing with the expression and properties of steroid receptors in the central nervous system (CNS); steroid interactions with amino acids, amines, and growth factors; electrophysiology; hypothalamic and feeding control; and the extremely topical issue of steroid influences on sexual differentiation of the brain. Neuroactive Steroids is an indispensable reference work for any researcher involved with steroids in the CNS, particularly in the areas of physiology, anatomy, neuropharmacology, neurochemistry, psychiatry, and molecular biology. In addition, it provides the perfect one-stop introduction for students.
Download or read book Steroids and Neuronal Activity written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.
Download or read book Neurosteroid Effects in the Central Nervous System written by Sheryl S. Smith and published by CRC Press. This book was released on 2003-10-27 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility,
Download or read book Neuroactive Steroids in Brain Function Behavior and Neuropsychiatric Disorders written by Abraham Weizman and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.
Download or read book Meningitis and Encephalitis written by Rodrigo Hasbun and published by Springer. This book was released on 2018-07-19 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meningitis and Encephalitis are associated with high rates of mortality and neurological sequelae. The differential diagnosis includes a wide spectrum of infectious and non-infectious etiologies, some requiring urgent therapy for survival. The current management challenges in patients with meningitis and encephalitis include a low sensitivity of meningeal signs, overutilization of unnecessary screening cranial imaging, delays in diagnosis of urgent treatable causes, a large proportion of unknown etiologies, low sensitivity of current microbiological techniques especially in the setting of previous antibiotic therapy, underutilization of available molecular diagnostic tests, and empiric antibiotic therapy and hospitalization for viral meningitis cases. Even though there are published guidelines, compliance with them is not optimal and physicians do not follow standardized algorithms in their empirical approach. As meningitis and encephalitis is associated with high rates of adverse clinical outcomes, prevention, when feasible is of upmost importance. Adherence to protocols to prevent health-care associated meningitis and ventriculitis are effective but compliance with them is not uniformly performed. This book seeks to improve outcomes for meningitis and encephalitis cases handled by physicians who may or may not be thoroughly trained for these challenges. The text introduces the current guidelines but also discusses the gaps that leave clinicians struggling to implement the most appropriate approaches for these particular neurological infections. Each chapter delivers the tools necessary to identify and adhere to the most appropriate diagnostic technique, management protocols, and prevention approach for each situation. All chapters conclude with discourse on future directions in research and quality improvement. Written by experts in infectious diseases, the book covers topics that are the most devastating, including healthcare-acquired infections, autoimmune encephalitis, and infections as they present in HIV patients. Meningitis and Encephalitis is a well-rounded resource for all medical professionals encountering these neurological syndromes, including infectious disease specialists, neurologists, primary care physicians, and immunologists.
Download or read book Neurosteroids written by Etienne-Emile Baulieu and published by Humana Press. This book was released on 2010-11-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.
Download or read book Non genomic Effects of Steroids in the Central Nervous System written by Mark J. Roberts and published by . This book was released on 1999 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Download or read book Sites of Steroid Action in the Central Nervous System of Mammals written by Yvonne Schaelchlin Palka and published by . This book was released on 1965 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Aging Nervous System written by Gabe J. Maletta and published by Greenwood. This book was released on 1980 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Perspectives in Neurosteroids action a Special Player Allopregnanolone written by Valerio Magnaghi and published by Frontiers Media SA. This book was released on 2015-07-01 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early in the 80’s date the first observations on the existence of hormonal steroids that may be synthesized and act in the nervous system. In order to refer to these endogenous steroids, proved important to control both central and peripheral nervous system, it was proposed the term “neurosteroids” (NSs). Over the years, their importance in regulating the physiological functions of neuronal and glial cells increased progressively. These steroids can be involved in several pathophysiological conditions such as depression, anxiety, premenstrual syndrome (PMS), schizophrenia and Alzheimer disease. Among the different classes of NSs, the progestagens revealed particularly important. The progesterone metabolite 5a-pregnan-3a-ol-20-one, also named tetrahydroprogesterone or allopregnanolone (ALLO) was one of the first most important steroid that was originally shown to act as neurosteroid. ALLO is synthesized through the action of the 5aR-3a-HSD, which converts P into DHP and subsequently, via a bidirectional reaction, into ALLO. NSs exert complex effects in the nervous system through ‘classic’, genomic, and ‘non-classic’, non-genomic actions. ALLO displays a rapid ‘non-genomic’ effect, which mainly involves the potent modulation of the GABA type A (GABA-A) receptor function. Recently a membrane receptor has been identified as target for ALLO effects, i.e. the membrane progesterone receptors (mPRs) that are able to activate a signalling cascade through G protein dependent mechanisms. By these ways, ALLO is able to modulate several cell functions, acting as neurogenic molecule on neural progenitor cells, as well as by activating proliferation and differentiation of glial cells in the central and peripheral nervous system. In this topic, we review the most recent acquisitions in the field of neurosteroids, focusing our attention on ALLO because its effects on the physiology of neurons and glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues and for the treatment of neuropsychiatric disorders.
