Download or read book Stem Cells in Neurotoxicology written by and published by Elsevier. This book was released on 2024-09-16 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells in Neurotoxicology, Volume Twelve in the Advances in Neurotoxicology series, presents interesting chapters written by an international board of authors. Chapters in this new release include Brain organoids as a translational model of human developmental neurotoxicity, Self-organizing human neuronal cultures in the modeling of environmental impacts on learning and intelligence, Utilization of human stem cell/neural progenitor tests to examine neurotoxic impacts on differentiation, Characterization of neuronal and other cellular sub-types in human stem cell cortical neuron differentiations, Utility of human stem cell models to study persistent neurotoxicity, and Utility of human stem cell models to study chronic neurotoxicity.
Download or read book Human Stem Cell Toxicology written by James L Sherley and published by Royal Society of Chemistry. This book was released on 2016-08-09 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Download or read book Alternative Methods in Neurotoxicology written by and published by Elsevier. This book was released on 2023-06-08 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative Methods in Neurotoxicology, Volume Nine, the latest release in this series, provides an overview of important in vitro and non-vertebrate animal models available to study the neurotoxicity of a range of toxicants of occupational and environmental relevance. Chapters in this new release include Evaluation of mitochondrial function in neurotoxicology using alternative models, Planarians as a model to study neurotoxic agents, Role of Drosophila melanogaster in neurotoxicology studies: Responses to different harmful substances, Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans, Neurotoxicology of environmental toxicants using Caenorhabditis elegans as a model, Nauphoeta cinerea as an emerging model in neurotoxicology, and more. Other chapters cover Human Neural Stem Cells in Developmental Neurotoxicology: Current Scenario and Future Prospects, Use of Drosophila melanogaster for advances in developmental neurotoxicology studies, 3D neurospheres and neurotoxicity of organophosphorus and TCE, Genetic factors in methylmercury-induced neurotoxicity: what we have learned from Caenorhabditis elegans models, and more. Give an up-to-date about the utilization of popular invertebrates (Drosophila melanogaster and Caenorhabditis elegans) in neurotoxicology Brings concise information on emerging invertebrate models in neurotoxicology (from basic to environmental approaches) Presents updates on the in vitro exploitation of human stem cell in developmental neurotoxicology
Download or read book Handbook of Developmental Neurotoxicology written by William Slikker Jr. and published by Academic Press. This book was released on 2018-01-04 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts
Download or read book Stem Cell Derived Models in Toxicology written by Mike Clements and published by Methods in Pharmacology and To. This book was released on 2018-12-10 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stem Cells in Birth Defects Research and Developmental Toxicology written by Theodore P. Rasmussen and published by John Wiley & Sons. This book was released on 2018-03-27 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives
Download or read book Stem Cells in Toxicology and Medicine written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2016-10-13 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
Download or read book Neurotoxicity Screening Using Human Pluripotent Stem Cell Derived Neurons and Astrocytes for Adverse Outcome Pathway Mapping written by Xian Wu and published by . This book was released on 2016 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is overwhelming evidence that environmental factors play a role in the development and progression of a host of central nervous system disorders. Of over 80,000 chemicals are commercially available now, only about 200 have undergone developmental neurotoxicity (DNT) testing according the established guidelines. Human embryonic stem cells based DNT assays mimic neuron development in vitro and have become an alternative to expensive and time consuming animal DNT models. The main focus on this study was to establish in vitro human models for adverse outcome pathway mapping. For this main purpose, first study involved mimicking events associated with early human neurogenesis beginning with proliferating human neuron progenitor cells (hNP), progressing through differentiation and maturation of post mitotic neurite extending neurons at 14 days in vitro. The neuron in vitro differentiation model demonstrated neurotoxicant exposure during a maturation continuum affected human neurogenesis including neuron maturation and neurite outgrowth at substantially lower levels than previously known. The 14 day in vitro neuron was further differentiated to a pure neuron population for high throughput neurite outgrowth toxicity screening. A training set of chemicals including pesticides and endocrine disruptors were tested and their neurotoxicity were validated in the screening, showing the promise of this human model at cellular level for adverse outcome pathway mapping. Finally, these pure neurons were co-cultured with hNP derived astrocytes to study the role of cytochrome P450 in astrocyte neuroprotection. The hNP derived neuron and astroyte co-culture model identify critical role of cytochrome P450 in chlorpyrifos metabolism and indicated cell type specific neurotoxicitity for chlorpyrifos in brain. The hNP derived in vitro cell models in this study showed broad application of hNP derived neurons and astrocytes for DNT study and in the future the cells should be used to replace animal models in order to decrease the uncertainty associated with extrapolating toxicity across species.
Download or read book Environmental Neurotoxicology written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Download or read book Advances in Neurotoxicology written by L. Manzo and published by Pergamon. This book was released on 1980 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization and Application of Human Pluripotent Stem Cell derived Neurons to Evaluate the Risk of Developmental Neurotoxicity with Antiepileptic Drugs in Vitro written by William Sam Cao and published by . This book was released on 2015 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Examination of the Effects of BDNF and Other Placental Stem Cell Secreted Soluble Factors as Potential Treatments for Neurotoxicity written by Yasmine Mourad and published by . This book was released on 2013 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Embryonic Stem Cell derived Test Systems for Developmental Neurotoxicity written by Anne-Kathrin Krug and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Download or read book Human Neural Stem Cells written by Leonora Buzanska and published by Springer. This book was released on 2018-09-12 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Download or read book Concepts and Applications of Stem Cell Biology written by Gabriela Rodrigues and published by Springer Nature. This book was released on 2020-06-30 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal, and several types of muscular cells, in biomedical research and clinical applications. This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
Download or read book Alterations in Stress Response Patterns During in Vitro Differentiation of Pluripotent Stem Cell derived Neural Stem Cells written by Vesselina Semkova and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
