Download or read book Statistical Methodology for Computed Tomography Scans of the Lung written by Sarah Marie Ryan and published by . This book was released on 2018 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: As computed tomography (CT) scans of the lung become more widely used for clinical research, methods that can meaningfully identify population-level features across lung images are needed. Approaches to characterize lung CT scans have traditionally relied on visual assessments, making it challenging to objectively identify quantitative patterns across scans. This dissertation advances quantitative image analysis for lung CT scans three-fold. First, we create the first publicly available standard lung template to enable spatial registrations between lung scans. Next, we develop a population-level spatial modeling approach for the analysis of lung CT scans, called spatial voxel-based morphometry, which identifies spatial regions with significant associations between the radiodensity from the scans and a set of covariates of interest. Lastly, we extend an unsupervised machine learning framework by both clustering medical imaging data and visualizing cluster-specific activation maps, providing a data-driven approach to uncover novel subtypes of lung disease based purely on CT scan presentation. We apply these methodologies to a population of patients with pulmonary sarcoidosis from the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis study, resulting in improved clinical understanding of this disease. Together, these methodologies advance the field of lung imaging by providing publicly available software and state-of-the-art methodologies to perform population-level inference and clustering for lung CT scans, and lay the groundwork for further methodological and clinical advancements for other lung diseases.

Download or read book Statistical Analysis of Computed Tomography Lung Images written by Heather Pettitt and published by . This book was released on 2015 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Computed Tomography of the Lung written by Johny A. Verschakelen and published by Springer Science & Business Media. This book was released on 2007-12-20 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the main appearance and distribution patterns of lung disease with the help of many color drawings and high-quality illustrations. This approach enables the reader to recognize these patterns and to interpret them in order to reach a diagnosis. In addition, the book includes many typical cases so that the reader can see how the information is applied.

Download or read book Lung Imaging and Computer Aided Diagnosis written by Ayman El-Baz and published by CRC Press. This book was released on 2016-04-19 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient's chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because

Download or read book Lung Imaging and CADx written by Ayman El-Baz and published by CRC Press. This book was released on 2019-04-24 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing an effective computer-aided diagnosis (CAD) system for lung cancer is of great clinical importance and can significantly increase the patient's chance for survival. For this reason, CAD systems for lung cancer have been investigated in a large number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This book overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. Overviews the latest state-of-the-art diagnostic CAD systems for lung cancer imaging and diagnosis Offers detailed coverage of 3D and 4D image segmentation Illustrates unique fully automated detection systems coupled with 4D Computed Tomography (CT) Written by authors who are world-class researchers in the biomedical imaging sciences Includes extensive references at the end of each chapter to enhance further study Ayman El-Baz is a professor, university scholar, and chair of the Bioengineering Department at the University of Louisville, Louisville, Kentucky. He earned his bachelor’s and master’s degrees in electrical engineering in 1997 and 2001, respectively. He earned his doctoral degree in electrical engineering from the University of Louisville in 2006. In 2009, he was named a Coulter Fellow for his contributions to the field of biomedical translational research. He has 17 years of hands-on experience in the fields of bio-imaging modeling and noninvasive computer-assisted diagnosis systems. He has authored or coauthored more than 500 technical articles (132 journals, 23 books, 57 book chapters, 211 refereed-conference papers, 137 abstracts, and 27 U.S. patents and disclosures). Jasjit S. Suri is an innovator, scientist, a visionary, an industrialist, and an internationally known world leader in biomedical engineering. He has spent over 25 years in the field of biomedical engineering/devices and its management. He received his doctorate from the University of Washington, Seattle, and his business management sciences degree from Weatherhead School of Management, Case Western Reserve University, Cleveland, Ohio. He was awarded the President’s Gold Medal in 1980 and named a Fellow of the American Institute of Medical and Biological Engineering for his outstanding contributions in 2004. In 2018, he was awarded the Marquis Life Time Achievement Award for his outstanding contributions and dedication to medical imaging and its management.

Download or read book Imaging of Head and Neck Cancer written by A. T. Ahuja and published by Cambridge University Press. This book was released on 2003-01-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise integrated handbook looks at all available imaging methods for head and neck cancer, highlighting the strengths and weaknesses of each method. The information is provided in a clinical context and will guide radiologists as to the information the clinician actually needs when managing a patient with head and neck cancer. It will also provide the clinician with the advantages and limitations of imaging. The text therefore deals with Ultrasound, CT and MRI. The initial chapters aim to give the reader a core knowledge, which can be used in imaging by the various methods described. The subsequent chapters are directed towards clinical problems and deal with the common cancers in a logical order.

Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

Download or read book Lung Ultrasound in the Critically Ill written by Daniel A. Lichtenstein and published by Springer. This book was released on 2015-09-29 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a pioneer in critical care ultrasound, this book discusses the basic technique and “signatures” of lung ultrasound and explains its main clinical applications. The tools and clinical uses of the BLUE protocol, which allows diagnosis of most cases of acute respiratory failure, are first described in detail. Careful attention is then devoted to protocols derived from the BLUE protocol – the FALLS protocol for diagnosis and management of acute circulatory failure, the Pink protocol for use in ARDS, and the SESAME protocol for use in cardiac arrest – and to the LUCI-FLR program, a means of answering clinical questions while reducing radiation exposure. Finally, the book discusses all the possible settings in which lung ultrasound can be used, discipline by discipline and condition by condition. Lung Ultrasound in the Critically Ill comprehensively explains how ultrasound can become the stethoscope of modern medicine. It is a superb complement to the author’s previous book, Whole Body Ultrasonography in the Critically Ill.

Download or read book MRI of the Lung written by Hans-Ulrich Kauczor and published by Springer Science & Business Media. This book was released on 2008-11-12 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.

Download or read book Registration Methods for Pulmonary Image Analysis written by Alexander Schmidt-Richberg and published by Springer Science & Business Media. This book was released on 2014-01-28 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various applications in the field of pulmonary image analysis require a registration of CT images of the lung. For example, a registration-based estimation of the breathing motion is employed to increase the accuracy of dose distribution in radiotherapy. Alexander Schmidt-Richberg develops methods to explicitly model morphological and physiological knowledge about respiration in algorithms for the registration of thoracic CT images. The author focusses on two lung-specific issues: on the one hand, the alignment of the interlobular fissures and on the other hand, the estimation of sliding motion at the lung boundaries. He shows that by explicitly considering these aspects based on a segmentation of the respective structure, registration accuracy can be significantly improved.

Download or read book Diseases of the Chest Breast Heart and Vessels 2019 2022 written by Juerg Hodler and published by Springer. This book was released on 2019-02-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.

Download or read book Infant Respiratory Function Testing written by Janet Stocks and published by John Wiley & Sons. This book was released on 1996-02-14 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a step-by-step guide to procedures and analysis of infant lung function testing. Each test description is preceded by a brief resume of the theoretical background. A troubleshooting section compiles the problems most frequently encountered during measurement and analysis. This book will provide those training in pediatric pulmonary with a sound grasp of the fundamental principles and practical issues involved in measuring infant lung function.

Download or read book Statistical Shape Analysis to Quantify Lung Structure Function Relationships Over the Adult Lifespan written by Mahyar Osanlouy and published by . This book was released on 2018 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effect of aging on specific organ systems varies widely from one person to another. Simple observations will attest to the fact that we do not all age at the same rate. Organ systems also age independent of one another. Both aging and disease processes alter the body’s organ systems in both structure and function; they are independent, but tend to overlap in producing similar signs and symptoms. Age serves as a significant modifying factor in respiratory disease, where it increases severity, disability, resistance to treatment, and mortality. The significant increase in life expectancy over the last century has become an important issue in the physiology of aging. This research targets the clinically significant condition of functional decline of the lung with age, which occurs irrespective of disease or exposure. Statistical shape analysis is able to define standard distributions of normality and pathology. By combining imaging-derived finite-element models of the lungs with state-of-the-art statistical methods, this thesis has established a normative model of the adult lungs to encode and describe such distributions. First, a standardized statistical shape model of the lungs from subjects aged 20¡90 years old was built to describe the lung shape and its main components of variation. Secondly, parameters of shape variation were analyzed against parameters of lung function to investigate the lungs structure-function relationship. Thirdly, the model was used to derive a priori knowledge to robustly estimate the locations of pulmonary fissures on Computed Tomography (CT) imaging, aiding the current lobar segmentation algorithms. Lastly, a novel technique was developed to predict the lung shape of a new healthy human subject with no prior image information, by using only their age and pulmonary function test measurements. Results show that the model is able to capture and quantify major modes of shape variation which are known correlates of aging. Also the model allows linking lung anatomy and physiology, with results indicating a significant reduction of lung function due to age-associated changes of shape. In addition, the model presents a unique application to identifying pulmonary fissures on CT, and further, to predicting a new lung shape in the absence of CT. The model provides a wealth of knowledge which can be further extended via addition of abnormal pulmonary conditions and using larger samples.

Download or read book A Computationally Efficient Spatial Point Process Framework for Characterizing Lung Computed Tomography Scans written by Brian Edward Vestal and published by . This book was released on 2017 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary emphysema is a destructive disease of the lungs that is currently diagnosed via visual of lung Computed Tomography (CT) scans by a trained radiologist. Visual assessment can have poor inter- rater reliability, is time consuming, and requires access to trained assessors. Quantitative methods that reliably summarize the biologically relevant characteristics of an image are needed to improve the way lung diseases are characterized. The goal of this work is show how spatial point process models can be used to create a set of quantitative radiologically derived lung biomarkers of emphysema. We formalize a general framework for applying spatial point processes to lung CT scans, and develop a Shot Noise Cox Process to quantify how radiologically based emphysematous tissue clusters into larger structures. Two Bayesian estimation methods are derived, one using Birth-Death MCMC and another using a novel hybrid 2-stage approach to first find clusters, and subsequently quantify their characteristics. The hybrid method sacrifices some of the theoretical properties of the BD-MCMC, but takes about 1/90th the time to generate estimates, opening up the possibility of applying this computationally expensive model to larger applications. Finally, we validate the spatial measures created with the clustering model by showing strong associations with clinically and functionally important measures.

Download or read book Multidetector Row CT of the Thorax written by U. Joseph Schoepf and published by Springer Science & Business Media. This book was released on 2003-11-18 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of multidetector-row technology, excitement has returned to computed tomography. Not only can we now image faster and with better resolution than ever before. More importantly, the development of sophisticated image acquisition techniques has enabled us to venture into areas previously considered to be beyond the scope of CT imaging. The knowledge, experience, and vision of a host of renowned international experts in cutting-edge thoracic applications of multidetector-row CT are condensed within this book. The result is a critical, comprehensive review of the novel opportunities, but also the new challenges, brought about by the development of ever-faster CT acquisition techniques. Presents the latest developments in CT imaging of the thorax Comprehensively reviews the literature Offers useful practical guidelines Addresses both opportunities and challenges Written by leading international experts

Download or read book Spectral Photon Counting Computed Tomography written by Katsuyuki Taguchi and published by CRC Press. This book was released on 2020-07-14 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectral, Photon Counting Computed Tomography is a comprehensive cover of the latest developments in the most prevalent imaging modality (x-ray computed tomography (CT)) in its latest incarnation: Spectral, Dual-Energy, and Photon Counting CT. Disadvantages of the conventional single-energy technique used by CT technology are that different materials cannot be distinguished and that the noise is larger. To address these problems, a novel spectral CT concept has been proposed. Spectral Dual-Energy CT (DE-CT) acquires two sets of spectral data, and Spectral Photon Counting CT (PC-CT) detects energy of x-ray photons to reveal additional material information of objects by using novel energy-sensitive, photon-counting detectors. The K-edge imaging may be a gateway for functional or molecular CT. The book covers detectors and electronics, image reconstruction methods, image quality assessments, a simulation tool, nanoparticle contrast agents, and clinical applications for spectral CT.

Download or read book Computed Tomography of the Lung written by Sergio Galluzzi and published by Piccin-Nuova Libraria. This book was released on 1988-01 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: