Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Download or read book Endocrine Disruptors Brain and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017-04-10 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...

Download or read book Endocrine Disrupting Chemicals written by Andrea C. Gore and published by Springer Science & Business Media. This book was released on 2007-06-08 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.

Download or read book Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies written by Muhammad Sajid Hamid Akash and published by Springer. This book was released on 2021-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Ecohydraulics written by Ian Maddock and published by John Wiley & Sons. This book was released on 2013-07-01 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecohydraulics: An Integrated Approachprovides a research level text which highlights recent developments of this emerging and expanding field. With a focus on interdisciplinary research the text examines:- the evolution and scope of ecohydraulics interactions between hydraulics, hydrology, fluvial geomorphology and aquatic ecology the application of habitat modelling in ecohydraulic studies state of the art methodological developments and approaches detailed case studies including fish passage design and the management of environmental flow regimes research needs and the future of ecohydraulics research The contributions offer broad geographic coverage to encapsulate the wide range of approaches, case studies and methods used to conduct ecohydraulics research. The book considers a range of spatial and temporal scales of relevance and aquatic organisms ranging from algae and macrophytes to macroinvertebrates and fish. River management and restoration are also considered in detail, making this volume of direct relevance to those concerned with cutting edge research and its application for water resource management. Aimed at academics and postgraduate researchers in departments of physical geography, earth sciences, environmental science, environmental management, civil engineering, biology, zoology, botany and ecology; Ecohydraulics: An Integrated Approach will be of direct relevance to academics, researchers and professionals working in environmental research organisations, national agencies and consultancies.

Download or read book Designing Sustainable Technologies Products and Policies written by Enrico Benetto and published by Springer. This book was released on 2018-07-03 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides insight into the implementation of Life Cycle approaches along the entire business value chain, supporting environmental, social and economic sustainability related to the development of industrial technologies, products, services and policies; and the development and management of smart agricultural systems, smart mobility systems, urban infrastructures and energy for the built environment. The book is based on papers presented at the 8th International Life Cycle Management Conference that took place from September 3-6, 2017 in Luxembourg, and which was organized by the Luxembourg Institute of Science and Technology (LIST) and the University of Luxembourg in the framework of the LCM Conference Series.

Download or read book Application of Systematic Review Methods in an Overall Strategy for Evaluating Low Dose Toxicity from Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-14 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-10-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Download or read book Emerging Pollutants in the Environment written by Marcelo Larramendy and published by BoD – Books on Demand. This book was released on 2015-09-02 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, Emerging Pollutants in the Environment Current and Further Implications, includes overviews by significant researchers on the topic of emerging pollutants toxicology, which covers the hazardous effects of common emerging xenobiotics employed in our every day anthropogenic activities. We hope that this book will meet the expectations and needs of all those who are interested in the negative implications of several emerging pollutants on living species.

Download or read book Developmental Origins of Health and Disease written by Peter Gluckman and published by Cambridge University Press. This book was released on 2006-04-20 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Download or read book Endocrine Disrupting Chemicals written by and published by Academic Press. This book was released on 2021-08-27 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Pharmacology series - Updated release includes the latest information on Endocrine-Disrupting Chemicals

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 456 H295R Steroidogenesis Assay written by OECD and published by OECD Publishing. This book was released on 2011-07-28 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...

Download or read book Toxic Timescapes written by Simone M. Müller and published by Ohio University Press. This book was released on 2023-01-17 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: An interdisciplinary environmental humanities volume that explores human-environment relationships on our permanently polluted planet. While toxicity and pollution are ever present in modern daily life, politicians, juridical systems, media outlets, scholars, and the public alike show great difficulty in detecting, defining, monitoring, or generally coming to terms with them. This volume’s contributors argue that the source of this difficulty lies in the struggle to make sense of the intersecting temporal and spatial scales working on the human and more-than-human body, while continuing to acknowledge race, class, and gender in terms of global environmental justice and social inequality. The term toxic timescapes refers to this intricate intersectionality of time, space, and bodies in relation to toxic exposure. As a tool of analysis, it unpacks linear understandings of time and explores how harmful substances permeate temporal and physical space as both event and process. It equips scholars with new ways of creating data and conceptualizing the past, present, and future presence and possible effects of harmful substances and provides a theoretical framework for new environmental narratives. To think in terms of toxic timescapes is to radically shift our understanding of toxicants in the complex web of life. Toxicity, pollution, and modes of exposure are never static; therefore, dose, timing, velocity, mixture, frequency, and chronology matter as much as the geographic location and societal position of those exposed. Together, these factors create a specific toxic timescape that lies at the heart of each contributor’s narrative. Contributors from the disciplines of history, human geography, science and technology studies, philosophy, and political ecology come together to demonstrate the complex reality of a toxic existence. Their case studies span the globe as they observe the intersection of multiple times and spaces at such diverse locations as former battlefields in Vietnam, aging nuclear-weapon storage facilities in Greenland, waste deposits in southern Italy, chemical facilities along the Gulf of Mexico, and coral-breeding laboratories across the world.

Download or read book Endocrine Disrupting Chemicals written by Paromita Chakraborty and published by Elsevier. This book was released on 2023-11-24 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disrupting Chemicals: Fate, Detection and Remediation provides both the practical and theoretical aspects of the origin and removal of EDCs. The book integrates in one system all relevant research in monitoring, detection and control, and provides a multi-barrier approach to managing EDCs that helps relevant stakeholders take preventive measures for the risks associated with EDCs in the environment (e.g., water, wastewater, soil and other natural ecosystems). The book not only provides a technological solution for managing these emerging pollutants but also comprehensively treats the origin, fate, and mechanisms of EDCs.This makes the book an indispensable source of information for researchers to develop sustainable, affordable and commercially viable monitoring and remedial systems. - Crucial resource for the development of sustainable, affordable and commercially viable monitoring and remedial systems - Describes existing removal methodologies, along with the discussion on the future scope of improvement in terms of their efficiency and deployment - Elucidates both practical and theoretical aspects of EDCs origin, monitoring and removal