Download or read book Solving a 3D Structural Puzzle written by Casper Rønn Hoeck and published by Springer. This book was released on 2018-11-03 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores how nuclear magnetic resonance (NMR) spectroscopy may be used for spatial structural elucidation of novel compounds from fungal and synthetic sources. Readers will discover the exciting world of NOE (nuclear Overhauser effect), RDC (residual dipolar coupling) and J-coupling constants, both short- and long range. With emphasis on obtaining structural knowledge from these NMR observables, focus is moved from solving a static 3D structure to solving the structural space inhabited by small organic molecules. The book outlines the development and implementation of two Heteronuclear Multiple Bond Correlation-type NMR experiments, and the 3D structural elucidation of multiple known and novel compounds. In addition, a new method of back-calculating RDCs (allowing for more flexible structures to be investigated), and the synthesis and evaluation of novel chiral alignment media for ab initio determination of absolute stereochemistry of small molecules using RDCs are also included. Challenges that 3D structural generation of small compounds face are also covered in this work.

Download or read book Unstable Singularities and Randomness written by Joseph P. Zbilut and published by Elsevier. This book was released on 2004-06-18 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, randomness and determinism have been viewed as being diametrically opposed, based on the idea that causality and determinism is complicated by "noise. Although recent research has suggested that noise can have a productive role, it still views noise as a separate entity. This work suggests that this not need to be so. In an informal presentation, instead, the problem is traced to traditional assumptions regarding dynamical equations and their need for unique solutions. If this requirement is relaxed, the equations admit for instability and stochasticity evolving from the dynamics itself. This allows for a decoupling from the "burden of the past and provides insights into concepts such as predictability, irreversibility, adaptability, creativity and multi-choice behaviour. This reformulation is especially relevant for biological and social sciences whose need for flexibility a propos of environmental demands is important to understand: this suggests that many system models are based on randomness and nondeterminism complicated with a little bit of determinism to ultimately achieve concurrent flexibility and stability. As a result, the statistical perception of reality is seen as being a more productive tool than classical determinism. The book addresses scientists of all disciplines, with special emphasis at making the ideas more accessible to scientists and students not traditionally involved in the formal mathematics of the physical sciences. The implications may be of interest also to specialists in the philosophy of science.·Presents the ideas in an informal language.·Provides tools for exploring data for singularities.

Download or read book Thinking Skills and Problem solving written by Belle Wallace and published by Routledge. This book was released on 2004 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book tells teachers all they need to know about multiple intelligences and problem solving and provides a bank of problems that can be integrated into any lesson plan.

Download or read book Handbook of Chemical Biology of Nucleic Acids written by Naoki Sugimoto and published by Springer Nature. This book was released on 2023-07-29 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

Download or read book RNA 3D Structure Analysis and Prediction written by Neocles Leontis and published by Springer Science & Business Media. This book was released on 2012-06-05 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.

Download or read book Proceedings of the International Conference on Computing and Communication Systems written by Arnab Kumar Maji and published by Springer Nature. This book was released on 2021-04-11 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the latest research work presented at the International Conference on Computing and Communication Systems (I3CS 2020) held at North-Eastern Hill University (NEHU), Shillong, India. The book presents original research results, new ideas and practical development experiences which concentrate on both theory and practices. It includes papers from all areas of information technology, computer science, electronics and communication engineering written by researchers, scientists, engineers and scholar students and experts from India and abroad.

Download or read book Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes written by Adam Liwo and published by Springer. This book was released on 2018-12-19 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of modern computer-based techniques for analyzing the structure, properties and dynamics of biomolecules and biomolecular processes. It is organized in four main parts; the first one deals with methodology of molecular simulations; the second one with applications of molecular simulations; the third one introduces bioinformatics methods and the use of experimental information in molecular simulations; the last part reports on selected applications of molecular quantum mechanics. This second edition has been thoroughly revised and updated to include the latest progresses made in the respective field of research.

Download or read book DNA and Biotechnology written by Molly Fitzgerald-Hayes and published by Academic Press. This book was released on 2009-09-08 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Appropriate for a wide range of disciplines, from biology to non-biology, law and nursing majors, DNA and Biotechnology uses a straightforward and comprehensive writing style that gives the educated layperson a survey of DNA by presenting a brief history of genetics, a clear outline of techniques that are in use, and highlights of breakthroughs in hot topic scientific discoveries. Engaging and straightforward scientific writing style Comprehensive forensics chapter Parallel Pedagogic material designed to help both readers and teachers Highlights in the latest scientific discoveries Outstanding full-color illustration that walk reader through complex concepts

Download or read book The Structure of Game Design written by Wallace Wang and published by Springer Nature. This book was released on 2023-07-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Structure of Game Design is designed to help aspiring and existing game designers turn their ideas into working games. Creating a game involves understanding the core foundational elements of all types of games from paper-based games to the latest video games. By understanding how these core principles work in all types of games, you can apply these same principles to design your own game. Games are about goals, structure, play and fun. While everyone will always have their own idea of what might be “fun”, any game designer can maximize player enjoyment through meaningful choices that offer various risks and rewards. Such challenges, combined with rules and limitations, force players to overcome obstacles and problems using a variety of skills including dexterity, puzzle solving, intelligence, and strategy. Essentially games allow players to venture forth into new worlds and overcome problems in a safe but exciting environment that allows them to triumph in the end. Just as playing games have proven popular around the world to all ages, genders, and cultures, so has game designing proven equally popular. Games can challenge players to make the best move, solve puzzles, engage in combat, manage resources, and tell stories. By understanding how randomness, psychology, and balance can change the way games play, readers can decide what game elements are best for their own game creation. Whether your goal is to make money, learn something new, make a social statement, improve on an existing game idea, or challenge your artistic, programming, or design skills, game design can be just as much fun as game playing. By knowing the parts of a game, how they work, how they interact, and why they’re fun, you can use your knowledge to turn any idea into a game that others can play and enjoy.

Download or read book Mondo Nano written by Colin Milburn and published by Duke University Press. This book was released on 2015-04-24 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Mondo Nano Colin Milburn takes his readers on a playful expedition through the emerging landscape of nanotechnology, offering a light-hearted yet critical account of our high-tech world of fun and games. This expedition ventures into discussions of the first nanocars, the popular video games Second Life, Crysis, and BioShock, international nanosoccer tournaments, and utopian nano cities. Along the way, Milburn shows how the methods, dispositions, and goals of nanotechnology research converge with video game culture. With an emphasis on play, scientists and gamers alike are building a new world atom by atom, transforming scientific speculations and video game fantasies into reality. Milburn suggests that the closing of the gap between bits and atoms entices scientists, geeks, and gamers to dream of a completely programmable future. Welcome to the wild world of Mondo Nano.

Download or read book Theoretical Nuclear Physics in Italy written by G. Pisent and published by World Scientific. This book was released on 2001 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cortona Conference is a biennial meeting of all Italian groups from about 20 universities who are active in theoretical nuclear physics.This volume presents the main achievements and perspectives of Italian theoretical nuclear physics, with particular reference to the last two years.The first part contains the invited talks on: (1) Nuclear structure, (2) Light nuclei physics, (3) Hadronic degrees of freedom, (4) Nuclear physics with electroweak probes, (5) Nuclear dynamics and nuclear matter, and (6) First results about the AIACE experiment. Furthermore it includes two longer communications on: (7) Nuclear physics with exotic beams, and (8) Solution of the folding problem in protein models. The second part contains contributed papers.

Download or read book The Catalyst RNA and the Quest to Unlock Life s Deepest Secrets written by Thomas R. Cech and published by W. W. Norton & Company. This book was released on 2024-06-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of Literary Hub's Most Anticipated Books of 2024 Exploring the most transformative breakthroughs in biology since the discovery of the double helix, a Nobel Prize–winning scientist unveils the RNA age. For over half a century, DNA has dominated science and the popular imagination as the “secret of life.” But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA—long overlooked as the passive servant of DNA—sits at the center of biology’s greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century. A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA’s spectacular powers, to Cech’s own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA—once thought merely to transmit DNA’s genetic instructions to the cell’s protein-making machinery—may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies—from CRISPR, the revolutionary tool that uses RNA to rewrite the code of life, to the groundbreaking mRNA vaccines that have saved millions during the pandemic, and more—may enable us to improve and even extend life beyond nature’s current limits. Written by one of our foremost scientists, The Catalyst is a must-read guide to the present and future of biology and medicine.

Download or read book Fundamentals and Advances in Medical Biotechnology written by Mumtaz Anwar and published by Springer Nature. This book was released on 2022-07-15 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as an introduction to the concepts of medical biotechnology, with great details about fundamentals and early disciplines of study as well as emerging fields and the latest research. The book follows a chronological order from the earliest discoveries and breakthroughs of medical biotechnology to the latest areas of study. The book contains up-to-date citations for each chapter and section, which makes it easy for the reader to understand the concept and also to follow the latest developments in the particular area. It is an ideal book for undergraduate and graduate students who aspire to derive basic knowledge and are also keen on learning about the latest advancements in the field of medical biotechnology.

Download or read book Theoretical Nuclear Physics In Italy Procs Of The 8th Conf On Problems In Theoretical Nuclear Physics written by Sigfrido Boffi and published by World Scientific. This book was released on 2001-06-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cortona Conference is a biennial meeting of all Italian groups from about 20 universities who are active in theoretical nuclear physics.This volume presents the main achievements and perspectives of Italian theoretical nuclear physics, with particular reference to the last two years.The first part contains the invited talks on: (1) Nuclear structure, (2) Light nuclei physics, (3) Hadronic degrees of freedom, (4) Nuclear physics with electroweak probes, (5) Nuclear dynamics and nuclear matter, and (6) First results about the AIACE experiment. Furthermore it includes two longer communications on: (7) Nuclear physics with exotic beams, and (8) Solution of the folding problem in protein models. The second part contains contributed papers.

Download or read book Genomics in the AWS Cloud written by Catherine Vacher and published by John Wiley & Sons. This book was released on 2023-04-19 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perform genome analysis and sequencing of data with Amazon Web Services Genomics in the AWS Cloud: Analyzing Genetic Code Using Amazon Web Services enables a person who has moderate familiarity with AWS Cloud to perform full genome analysis and research. Using the information in this book, you'll be able to take a FASTQ file containing raw data from a lab or a BAM file from a service provider and perform genome analysis on it. You'll also be able to identify potentially pathogenic gene sequences. Get an introduction to Whole Genome Sequencing (WGS) Make sense of WGS on AWS Master AWS services for genome analysis Some key advantages of using AWS for genomic analysis is to help researchers utilize a wide choice of compute services that can process diverse datasets in analysis pipelines. Genomic sequencers that generate raw data files are located in labs on premises and AWS provides solutions to make it easy for customers to transfer these files to AWS reliably and securely. Storing Genomics and Medical (e.g., imaging) data at different stages requires enormous storage in a cost-effective manner. Amazon Simple Storage Service (Amazon S3), Amazon Glacier, and Amazon Elastics Block Store (Amazon EBS) provide the necessary solutions to securely store, manage, and scale genomic file storage. Moreover, the storage services can interface with various compute services from AWS to process these files. Whether you're just getting started or have already been analyzing genomics data using the AWS Cloud, this book provides you with the information you need in order to use AWS services and features in the ways that will make the most sense for your genomic research.

Download or read book Games with a Purpose GWAPS written by Mathieu Lafourcade and published by John Wiley & Sons. This book was released on 2015-06-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human brains can be seen as knowledge processors in a distributed system. Each of them can achieve, conscious or not, a small part of a treatment too important to be done by one. These are also "hunter / gatherers" of knowledge. Provided that the number of contributors is large enough, the results are usually better quality than if they were the result of the activity of a single person, even if it is a domain expert. This type of activity is done via online games.

Download or read book Instrumental Analysis of Intrinsically Disordered Proteins written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2011-01-31 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.