Download or read book Single Nucleotide Polymorphisms written by Anton A. Komar and published by Humana Press. This book was released on 2012-02-25 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. In Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.
Download or read book Scottish National Party SNP Leaders written by James Mitchell and published by Biteback Publishing. This book was released on 2016-09-15 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: By any measure, the story of the Scottish National Party is an extraordinary one. Forced to endure decades of electoral irrelevance since its creation in the 1930s, during which it often found itself grappling with internal debate on strategy, and rebellion from within its own ranks, the SNP virtually swept the board in the 2015 general election, winning all but three of Scotland's fifty-nine seats in Westminster. What's more, under the current leadership of Nicola Sturgeon, the SNP has never been a more important force in the landscape of British politics. The leaders who have stood at its helm during this tumultuous eighty-year history - from Sir Alexander MacEwen to Nicola Sturgeon and Alex Salmond - have steered the SNP vessel with varying degrees of success, but there is no doubt that all have contributed to the shape, purpose and ultimate goal of the party of government we see today. The latest addition to the acclaimed British Political Leaders series, Scottish National Party Leaders examines each of these senior figures for the first time, and is essential reading for anyone curious about how this former fringe party evolved into a political phenomenon, changing not only the face of Scottish politics, but British politics as well.
Download or read book Single Nucleotide Polymorphisms written by Pui-Yan Kwok and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive collection of readily reproducible techniques for the difficult process of single nucleotide polymorphisms (SNP) discovery and genotyping. These cutting-edge protocols for mutation/SNP detection utilize denaturing high-performance liquid chromatography (dHPLC), single-strand conformation polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE), chemical cleavage, and direct sequencing. Equally powerful and up-to-date methods are given for genotyping SNPs, including molecular beacons, the Taqman assay, single-base extension approaches, pyrosequencing, ligation, the Invader assay, and primer extension with mass spectrometry detection.
Download or read book Association Mapping in Plants written by Nnadozie C. Oraguzie and published by Springer Science & Business Media. This book was released on 2007-01-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides both basic and advanced understanding of association mapping and an awareness of population genomics tools to facilitate mapping and identification of the underlying causes of quantitative trait variation in plants. It acts as a useful review of the marker technology, the statistical methodology, and the progress to date. It also offers guides to the use of single nucleotide polymorphisms (SNPs) in association studies.
Download or read book Modern SNP written by Gerry Hassan and published by Edinburgh University Press. This book was released on 2009-10-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Scottish National Party has played a significant role in the politics of Scotland in the last forty years. In particular it has contributed to and shaped the impact and dynamics of devolution. This collection brings together academics, writers, commentators and analysts of Scottish politics to address the nature of the SNP: its position in Scotland, its influence on devolution, its role as a minority administration and its relationship with other institutions in Scotland, the UK and Europe.
Download or read book SNP written by Peter A. Lynch and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though the SNP has existed since 1934, no full-length history of the Scottish National Party was written until the first edition of this book in 2002. With the SNP having governed Scotland since 2007, and with an outright majority since 2011, the long-held SNP policy of an Independence Referendum is now a reality and scheduled to be held in 2014.
Download or read book Direct to Consumer Genetic Testing written by National Research Council and published by National Academies Press. This book was released on 2011-01-16 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, scores of companies, primarily in the United States and Europe, are offering whole genome scanning services directly to the public. The proliferation of these companies and the services they offer demonstrate a public appetite for this information and where the future of genetics may be headed; they also demonstrate the need for serious discussion about the regulatory environment, patient privacy, and other policy implications of direct-to-consumer (DTC) genetic testing. Rapid advances in genetic research already have begun to transform clinical practice and our understanding of disease progression. Existing research has revealed a genetic basis or component for numerous diseases, including Parkinson's disease, Alzheimer's disease, diabetes, heart disease, and several forms of cancer. The availability of the human genome sequence and the HapMap, plummeting costs of high-throughput screening, and increasingly sophisticated computational analyses have led to an explosion of discoveries of linkages between patterns of genetic variation and disease susceptibility. While this research is by no means a straight path toward better public health, improved knowledge of the genetic linkages has the potential to change fundamentally the way health professionals and public health practitioners approach the prevention and treatment of disease. Realizing this potential will require greater sophistication in the interpretation of genetic tests, new training for physicians and other diagnosticians, and new approaches to communicating findings to the public. As this rapidly growing field matures, all of these questions require attention from a variety of perspectives. To discuss some of the foregoing issues, several units of the National Academies held a workshop on August 31 and September 1, 2009, to bring together a still-developing community of professionals from a variety of relevant disciplines, to educate the public and policy-makers about this emerging field, and to identify issues for future study. The meeting featured several invited presentations and discussions on the many technical, legal, policy, and ethical questions that such DTC testing raises, including: (1) overview of the current state of knowledge and the future research trajectory; (2) shared genes and emerging issues in privacy; (3) the regulatory framework; and (4) education of the public and the medical community.
Download or read book On the Algorithmic Tractability of Single Nucleotide Polymorphism SNP Analysis and Related Problems written by Sebastian Wernicke and published by diplom.de. This book was released on 2014-04-02 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaltsangabe:Abstract: This work brings together two areas of science biology and informatics that have only recently been connected in the emerging (and vastly growing) research field of Bioinformatics. In order to achieve a common basis for Parts 2 and 3 of this work, Part 1 intends to introduce the computer scientist to the relevant biological background and terminology (Chapter 2), and to familiarize the biologist with the relevant topics from theoretical computer science (Chapter 3). Chapter 2 first introduces some terminology from the field of genetics, thereby defining SNPs. We then motivate the analysis of SNPs by two applications, i.e. the analysis of evolutionary development and the field of pharmacogenetics. Especially the field of pharmacogenetics is capable of having an enormous impact on medicine and the pharmaceutical industry in the near future by using SNP data to predict the efficacy of medication. Chapter 3 gives a brief introduction to the field of computational complexity. We will see and motivate how algorithms are analyzed in theoretical computer science. This will lead to the definition of complexity classes , introducing the class NP which includes computationally hard problems. Some of the hard problems in the class NP can be solved efficiently using the tool of fixed-parameter tractability, introduced at the end of this chapter. An important application of SNP data is in the analysis of the evolutionary history of species development (phylogenetic analysis part two chapters 4 and 5). As will be made plausible in Chapter 5 using SNP data is in many ways superior to previous approaches of phylogenetic analysis. In order to analyze the development of species using SNP data, an underlying model of evolution must be specified. A popular model is the so-called perfect phylogeny, but the construction of this phylogeny is a computationally hard problem when there are inconsistencies (such as read-errors or an imperfect .t to the model of perfect phylogeny) in the underlying data. Chapter 4 analyzes the problem of forbidden submatrix removal which is closely connected to constructing perfect phylogenies we will see in Chapter 5 that its computational complexity is directly related to that of constructing a perfect phylogeny from data which is partially erroneous. In this chapter, we analyze the algorithmic tractability of forbidden submatrix removal , characterizing cases where this problem is NP-complete (being [...]
Download or read book Takeover written by Robert Johns and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advanced Topics in Forensic DNA Typing Interpretation written by John M. Butler and published by Academic Press. This book was released on 2014-07-28 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence Worked mixture examples illustrate the impact of different statistical approaches for reporting results Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011
Download or read book Computational Methods for SNPs and Haplotype Inference written by Sorin Istrail and published by Springer. This book was released on 2004-02-13 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the post-proceedings of the DIMACS/RECOMB Satellite Workshop on Computational Methods for SNPs and Haplotype Inference held in Piscataway, NJ, USA, in November 2002. The book presents ten revised full papers as well as abstracts of the remaining workshop papers. All relevant current issues in computational methods for SNP and haplotype analysis and their applications to disease associations are addressed.
Download or read book The Scottish National Party written by James Mitchell and published by Oxford University Press (UK). This book was released on 2012 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on an unprecedented survey of the entire membership and over 80 elite interviews The Scottish National Party is the definitive account of the nature of the SNP following its election as a party of government for the first time in its eighty year history.
Download or read book Nicola Sturgeon written by David Torrance and published by Casemate Publishers. This book was released on 2015-03-23 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biography of the Scottish leader by an author with “an excellent eye for political detail” (Scotland on Sunday). Nicola Sturgeon became involved in politics as a teenager, and then began a law career in Glasgow. She would go on to become Scotland’s youngest parliamentary candidate in 1992, in her early twenties. Considered a rising star, she eventually reached the pinnacle of Scottish government as First Minister and leader of the Scottish National Party—the party she’d joined at the age of sixteen. This book explores her reputation for efficiency and shrewd political judgment, her family life, and her role in the country’s turbulent recent years with the campaign for Scottish independence from the United Kingdom and the Brexit vote. It is a portrait of a fascinating woman as well as an “illuminating appraisal” of her impressive career (Spectator).
Download or read book SNP and Microsatellite Genotyping written by Ali Hajeer and published by Eaton Publishing Company/Biotechniques Books. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Life Script written by Nicholas Wade and published by Simon and Schuster. This book was released on 2002-03-02 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the decoding of the human genome, researchers can now read the script in which evolution has written the program for the design and operation of the human body. A new generation of medical treatments is at hand. Researchers are developing therapies so powerful that there is now no evident obstacle to the ancient goal of conquering most major diseases. Nicholas Wade has covered the sequencing of the genome, as well as other health and science stories, for The New York Times, in the course of which he has interviewed many of the principal researchers in the field. In this book he describes what the genome means for the health of present and future generations. Someday soon physicians will have access to DNA chips that, from a drop of blood, will screen a person's genes for all the diseases to which he or she may be genetically vulnerable. From full knowledge of the instruction manual of the human body, provided by the genome, pharmaceutical companies hope to develop a new generation of sophisticated drugs; one of the first genome-derived drugs is already undergoing clinical trials. Another vital tool will be regenerative medicine, a new kind of therapy in which new organs and tissues will be grown from a patient's own cells to replace those that are old or diseased. With the help of DNA chips, medical researchers will soon be able to diagnose diseases such as cancer much more precisely and to tailor specific treatments for each patient. Individualized medicine will also become an important part of the pharmaceutical world. Many drugs will be prescribed based on information from DNA chips that identify which of a range of drugs is best for each patient, as well as which drugs are likely to cause side effects. The medicine of the post-genomic era will be customized for a patient's genetic make-up, providing treatments based on a precise understanding of the mechanism of disease. Life Script describes a future in which good health, even perfect health, may become the standard for everyone -- at every age.
Download or read book Human Genome News written by and published by . This book was released on 2000-11 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA from A to Z written by Daniel H. Farkas and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2004 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition of a work previously titled DNA Simplified: The Hitchhiker's Guide to DNA reflects the many changes in the field that have occurred in the last five years, including the completion of the sequencing of the Human Genome. Entries are written in plain language with a sense of whimsy, and are illustrated with color and b&w images and photos. The book will be useful for students, professionals, and general readers. Author information is not given. Annotation: 2004 Book News, Inc., Portland, OR (booknews.com).
