Download or read book Small Animal SPECT Imaging written by Matthew A. Kupinski and published by Springer Science & Business Media. This book was released on 2007-05-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small-Animal SPECT Imaging is an edited work derived from the first workshop on Small-Animal SPECT Imaging held January 14-16, 2004 at the University of Arizona, Tucson, AZ, USA. The overall goal of the meeting and therefore this volume is to promote information exchange and collaboration between the research groups developing systems for small-animal applications. Topics include the biomedical significance of small-animal imaging, an overview of detector technologies including scintillation cameras and semi-conductor arrays, imager design and data acquisition systems, animal handling and anesthesia issues, objective assessment of image quality, and system modeling and reconstruction algorithms.
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Download or read book Handbook of Small Animal Imaging written by George C. Kagadis and published by CRC Press. This book was released on 2018-09-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer Science & Business Media. This book was released on 2010-11-29 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small animal imaging has been recognized as an important tool in preclinical research. Nevertheless, the results of non-invasive imaging are often disappointing owing to choice of a suboptimal imaging modality and/or shortcomings in study design, experimental setup, and data evaluation. This textbook is a practical guide to the use of non-invasive imaging in preclinical research. Each of the available imaging modalities is discussed in detail, with the assistance of numerous informative illustrations. In addition, many useful hints are provided on the installation of a small animal unit, study planning, animal handling, and the cost-effective performance of small animal imaging. Cross-calibration methods, data postprocessing, and special imaging applications are also considered in depth. This is the first book to cover all the practical basics in small animal imaging, and it will prove an invaluable aid for researchers, students, and technicians.
Download or read book Ultra high resolution Small animal SPECT Imaging written by Frans van der Have and published by . This book was released on 2007 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Emission Tomography written by Miles N. Wernick and published by Elsevier. This book was released on 2004-12-07 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging. *Contains thorough tutorial treatments, coupled with coverage of advanced topics *Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors *Include color artwork
Download or read book Physics of PET and SPECT Imaging written by Magnus Dahlbom and published by CRC Press. This book was released on 2017-02-17 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.
Download or read book Molecular Imaging of Small Animals written by Habib Zaidi and published by Springer. This book was released on 2014-05-27 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Download or read book Computational Framework for Small Animal SPECT Imaging written by Sang Hyeb Lee and published by . This book was released on 2015 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small animal Single Photon Emission Computed Tomography (SPECT) has been an invaluable asset in biomedical science since this non-invasive imaging technique allows the longitudinal studies of animal models of human diseases. However, the image degradation caused by non-stationary collimator-detector response and single photon emitting nature of SPECT makes it difficult to provide a quantitative measure of 3D radio-pharmaceutical distribution inside the patient. Moreover, this problem exacerbates when an intra-peritoneal X-ray contrast agent is injected into a mouse for low-energy radiotracers. In this dissertation, we design and develop a complete computational framework for the entire SPECT scan procedure from the radio-pharmaceutical injection, image acquisition, attenuation and scatter correction, and to the image reconstruction. Using this framework, we solve several challenging problems in small animal SPECT imaging. In particular, we perform an in-depth analysis of photon attenuation and scatter in small SPECT imaging and evaluate the performance of correction methods under various imaging circumstances in terms of image quality and computational complexity. Furthermore, we propose various techniques to accelerate correction methods using computational accelerators. This research also implements and validates a solution for solving the cross-talk contamination problem in I-123 and I-125 by using the ratio of detected low and high energy I-123 activity to separate the mixed low energy I-123 and I-125 activities using our simulation framework. Iterative reconstruction methods produce an accurate image using an accurate system matrix model of the image acquisition process at the expense of computational time. This research examines and proposes various techniques for accelerating the analytic system matrix generation for 3D SPECT.
Download or read book Development of a Combined MicroSPECT CT System for Small Animal Imaging written by Mingshan Sun and published by . This book was released on 2006 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Restraint free Small Animal SPECT Imaging System with Motion Tracking written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.
Download or read book Ultra high resolution small animal SPECT imaging written by Have and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Imaging written by Shankar Vallabhajosula and published by Springer Science & Business Media. This book was released on 2009-07-13 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.
Download or read book Quantitative Imaging in Small Animals Using SPECT CT written by Andrew Bing Hwang and published by . This book was released on 2006 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Particle Detection and Imaging written by Claus Grupen and published by Springer Science & Business Media. This book was released on 2012-01-08 with total page 1251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The handbook centers on detection techniques in the field of particle physics, medical imaging and related subjects. It is structured into three parts. The first one is dealing with basic ideas of particle detectors, followed by applications of these devices in high energy physics and other fields. In the last part the large field of medical imaging using similar detection techniques is described. The different chapters of the book are written by world experts in their field. Clear instructions on the detection techniques and principles in terms of relevant operation parameters for scientists and graduate students are given.Detailed tables and diagrams will make this a very useful handbook for the application of these techniques in many different fields like physics, medicine, biology and other areas of natural science.
Download or read book Design for a High resolution Small animal Spect System Usingpixellated Si Li Detectors for in Vivo Iodine 125 Imaging written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We propose a design for a high-resolution single-photon emission computed tomography (SPECT) system for in vivo 125I imaging in small animal using pixellated lithium-drifted silicon (Si(Li)) detectors. The proposed detectors are expected to have high interaction probability (>90%), good energy resolution (
Download or read book Small Animal Imaging written by John S. Mattoon and published by CRC Press. This book was released on 2018-01-29 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presented in an easy-to-ready format, Small Animal Imaging: Self-Assessment Color Review offers a case-based approach to reviewing and interpreting images and developing a differential diagnosis when necessary. Each case begins with the patient’s age, gender, breed, and species. The reason the patient was brought to the clinic is discussed along with preliminary examination and diagnostic test findings. The book Covers nearly 200 cases with supporting high-quality images for each case Provides detailed answers for each case, including radiographic findings and diagnosis Is written by well-respected experts in the field. A separate section presents detailed answers for each case including information on the radiographic findings. Also included are the radiographic diagnosis, comments, and notes on whether further imaging or evaluation is needed. This guide helps practitioners to develop a systematic approach to reviewing images. The easily-navigable text reminds practitioners of the basics in radiography and ultrasound interpretation and diagnosis, making it a quick and convenient reference.
