Download or read book Trends in Signal Transduction Research written by Jennifer N. Meyers and published by Nova Publishers. This book was released on 2007 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Download or read book Signal Transduction Research Trends written by Nickolas O. Grachevsky and published by Nova Publishers. This book was released on 2007 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Download or read book Signal Transduction Pathways Mechanisms and Diseases written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Download or read book Signal Transduction written by ljsbrand M. Kramer and published by Academic Press. This book was released on 2015-10-23 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition. In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventions Essential signaling events embedded in rich physiological and pathological contexts Extensive conceptual colour artwork to assist with comprehension of key topics Special emphasis on how molecular structure determines protein function and subcellular localization Employment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web
Download or read book Signal Transduction and Human Disease written by Toren Finkel and published by John Wiley & Sons. This book was released on 2003-07-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Download or read book Trends in Cellular Signaling written by Dave E. Caplin and published by Nova Publishers. This book was released on 2006 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell signalling is the communication inside a cell or with its environment. It plays an important role in cellular growth, survival and apoptosis. For instance, the growth of a cell requires production of certain proteins. The genes that encode these proteins are located in DNA inside the nucleus while the initial signal for cellular growth may come from outside the cell. To induce the expression of these genes, the external signal must pass through specific pathways to reach these genes in DNA. The signalling pathway involves several proteins. If any one of them becomes abnormal or non-functional, the cellular process would be altered, which may cause disease. Therefore, knowing the detailed pathway is very important in understanding the pathogenesis of diseases.
Download or read book Recent Trends in Cancer Biology Spotlight on Signaling Cascades and microRNAs written by Sundas Fayyaz and published by Springer. This book was released on 2018-03-07 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.
Download or read book Cell Signalling written by Barry L. Brown and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signal Transduction Protocols written by Louis M. Luttrell and published by Humana Press. This book was released on 2011-08-31 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly clear that signal transduction is a highly organized and integrated process. Divided into two convenient sections, Signal Transduction Protocols, Third Edition focuses on experimental approaches to better understand the complexity of signal transduction. Introductory chapters provide perspective on several of the challenges involved in signal transduction research and offer guidance on selecting the best approaches to various types of questions. The individual chapters provide detailed experimental protocols covering various topics, from the effects of ligand binding on receptor conformation and effector coupling, to moving inside the cell in order to capture the spatial and temporal characteristics of signaling events. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Signal Transduction Protocols serves as an ideal guide to scientists of all backgrounds and is a valuable resource for future progress in the field of signal transduction research.
Download or read book Signal Transduction written by B. D. Gomperts and published by Academic Press. This book was released on 2009 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal Transduction, 2e Bastien D. Gomperts University College, London, United Kingdom Ijsbrand M. Kramer University of Bordeaux, Talence, France Peter E.R. Tatham University College, London, United Kingdom Miranda Gomperts KEY FEATURES: * Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and intracellular calcium * Extensive conceptual colour artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signalling mechanisms DESCRIPTION: Signal Transduction is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. RELATED TITLES: Latchman: EUKARYOTIC TRANSCRIPTION FACTORS, 3E (1998; ISBN: 0-12-437176-0; $62.95) · In-depth insight into a subject central to cell biology and fundamental to biomedicine, including drug development · Extensive conceptual colour artwork to assist with comprehension of key topics · Special emphasis on the integration of how molecular (domain) structure determines protein function · Comprehensive referencing of both core and historical literature · Guided access and inclusion of Protein Data Bank and Swiss-Prot accession codes and URLs
Download or read book Calmodulin and Signal Transduction written by Linda J. Van Eldik and published by Academic Press. This book was released on 2012-12-02 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calmodulin and Signal Transduction focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with other regulatory pathways. Molecular mechanisms of calcium signal transduction through calmodulin-regulated enzymes Selected case studies and precedents related to molecular mechanisms Protein-protein recognition between calmodulin and the enzymes it regulates Cross-talk and interdigitation with other signal transduction pathways
Download or read book Cellular Signal Transduction in Toxicology and Pharmacology written by Jonathan W. Boyd and published by John Wiley & Sons. This book was released on 2019-04-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Download or read book Integrins and Ion Channels written by Andrea Becchetti and published by Springer Science & Business Media. This book was released on 2010-12-28 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.
Download or read book Signalling Pathways in Embryonic Development written by Juan J. Sanz-Ezquerro and published by Frontiers Media SA. This book was released on 2017-11-30 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.
Download or read book Protein Kinase mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Biochemistry of Signal Transduction and Regulation written by Gerhard Krauss and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes. Directed to advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis. "Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level" (Angewandte Chemie) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research)
