Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Download or read book GENERATION ECCH written by Jason Cohen and published by Touchstone. This book was released on 1994-08-24 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haunted by the spectre of the Beats and the Boomers, the Hippies and the Punks, today's twentysomethings are desperate for anything that gives them a generational self-image. This waggishly ironic book takes a riotous jab at the Generation X/twentysomething phenomenon and examines various aspects of their pop culture, including music, literature, and politics.
Download or read book Perspectives on Design and Digital Communication written by Nuno Martins and published by Springer Nature. This book was released on 2020-07-09 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shares new research findings and practical lessons learned that will foster advances in digital design, communication design, web, multimedia and motion design, graphic design and branding, and other related areas. It gathers the best papers presented at the 3rd International Conference on Digital Design and Communication, DIGICOM 2019, held on November 15–16, 2019, in Barcelos, Portugal. The respective contributions highlight new theoretical perspectives and practical research directions in design and communication, aimed at promoting their use in a global, digital world. The book offers a timely guide and a source of inspiration for designers of all kinds (Graphic, Digital, Web, UI & UX Design and Social Media), for researchers, advertisers, artists, entrepreneurs, and brand or corporate communication managers, and for teachers and advanced students.
Download or read book Service Design Capabilities written by Nicola Morelli and published by Springer Nature. This book was released on 2020-08-27 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book discusses service design capabilities in innovation processes, and provides a framework that guides design students, practitioners and researchers towards a better understanding of operational aspects of service design processes. More specifically, it revisits service designers’ capabilities in light of the new roles that have opened up in innovation processes on different scales. After years of being inadequately defined, the professional profile of service designers is now taking shape. Today private and public institutions recognize service designers as essential contributors to their innovation and development processes. What are the capabilities that characterize a service designer? These essential capabilities are what service designers should acquire in their education and can sell when looking for a job.
Download or read book AWI 1 written by United States. Department of Agriculture and published by . This book was released on with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inspire a Dream written by Steve Riach and published by . This book was released on 2000 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Football is built upon the dreams of players like Kurt Warner, who was told he didn't have what it takes to play at the professional level. It's about people like Mike Singletary, whowas told he was too small to ever make it big. It's about Steve Largent, who was told he was too slow to accel.These are men who have been inspired by a dream and, in turn, inspired other to dream with them and follow. They prove that true champions are not swayed by circumstances, labels, or past exzperiences, but rather are driven by a force within that pushes them to become something greater than they could have become by themselves.They are men who inspire us to push beyond our own limitations to reach our destiny.The dream is about what we are not yet, but can become.Highlighted by comments from some of the game's greatest players, a stunning collection of phototgraphs from Tom Henry, and the classic writing of author Steve Riach, this one-of-a-kind book reflect contemporary images and makes memories for tomorrow.
Download or read book Perspectives on Design and Digital Communication II written by Nuno Martins and published by Springer Nature. This book was released on 2021-05-29 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers new empirical findings fostering advances in the areas of digital and communication design, web, multimedia and motion design, graphic design, branding, and related ones. It includes original contributions by authoritative authors based on the best papers presented at the 4th International Conference on Digital Design and Communication, Digicom 2020, together with some invited chapters written by leading international researchers. They report on innovative design strategies supporting communication in a global, digital world, and addressing, at the same time, key individual and societal needs. This book is intended to offer a timely snapshot of technologies, trends and challenges in the area of design, communication and branding, and a bridge connecting researchers and professionals of different disciplines, such as graphic design, digital communication, corporate, UI Design and UX design. Chapter “Definition of a Digital Tool to Create Physical Artifacts: The Case of the Gamers4Nature Project” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Mind and Places written by Anna Anzani and published by Springer Nature. This book was released on 2020-05-12 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the contributions of psychological, neuroscientific and philosophical perspectives to the design of contemporary cities. Pursuing an innovative and multidisciplinary approach, it addresses the need to re-launch knowledge and creativity as major cultural and institutional bases of human communities. Dwelling is a form of knowledge and re-invention of reality that involves both the tangible dimension of physical places and their mental representation. Findings in the neuroscientific field are increasingly opening stimulating perspectives on the design of spaces, and highlight how our ability to understand other people is strongly related to our corporeity. The first part of the book focuses on the contributions of various disciplines that deal with the spatial dimension, and explores the dovetailing roles that science and art can play from a multidisciplinary perspective. In turn, the second part formulates proposals on how to promote greater integration between the aesthetic and cultural dimension in spatial design. Given its scope, the book will benefit all scholars, academics and practitioners who are involved in the process of planning, designing and building places, and will foster an international exchange of research, case studies, and theoretical reflections to confront the challenges of designing conscious places and enable the development of communities.
Download or read book Dentists written by Mary Meinking and published by Raintree. This book was released on 2021-08-05 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: Open wide! Dentists care for people's teeth. Give readers the inside scoop on what it's like to be a dentist. Readers will learn what dentists do, the tools they use, and how people get this exciting job.
Download or read book Formaldehyde and Other Aldehydes written by National Research Council and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and detailed guide to the science of formaldehyde and other aldehydes. This book covers the physical and chemical properties of aldehydes, their behavior in the environment, and their potential effects on human health. It also includes a thorough review of the regulatory landscape surrounding these compounds. This book is essential reading for scientists and policymakers alike. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book Design for Ergonomics written by Francesca Tosi and published by Springer Nature. This book was released on 2019-11-21 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the global quality of the design of systems that people interact with during their work activities and daily lives; a quality that involves the globality of people’s experience – physical, sensory, cognitive and emotional. It presents a concise and structured overview of the ergonomic approach to planning, and of methodological and operational tools from ergonomic research that can more directly and concretely contribute to the design process. The book also explores physical ergonomics and cognitive ergonomics, which are essential components of design culture. The final section addresses the main design problems and intervention criteria regarding the design of environments, products and equipment, as well as the design of communication, training and learning interface systems based on digital technologies. The book is chiefly intended for designers and anyone interested in the methods, tools and opportunities for in-depth analysis and development that ergonomics can offer regarding the conception, production and testing of products, environments and services, whether physical or virtual. It also offers a learning resource for professionals and students in Industrial Design and Planning.
Download or read book Visualizing the Data City written by Paolo Ciuccarelli and published by Springer Science & Business Media. This book was released on 2014-02-17 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates novel methods and technologies for the collection, analysis and representation of real-time user-generated data at the urban scale in order to explore potential scenarios for more participatory design, planning and management processes. For this purpose, the authors present a set of experiments conducted in collaboration with urban stakeholders at various levels (including citizens, city administrators, urban planners, local industries and NGOs) in Milan and New York in 2012. It is examined whether geo-tagged and user-generated content can be of value in the creation of meaningful, real-time indicators of urban quality, as it is perceived and communicated by the citizens. The meanings that people attach to places are also explored to discover what such an urban semantic layer looks like and how it unfolds over time. As a conclusion, recommendations are proposed for the exploitation of user-generated content in order to answer hitherto unsolved urban questions. Readers will find in this book a fascinating exploration of techniques for mining the social web that can be applied to procure user-generated content as a means of investigating urban dynamics.
Download or read book Healing by Laying on of Hands written by James Mack and published by . This book was released on 1879 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Chemical Muse written by D. C.A. Hillman, Ph.D. and published by Macmillan. This book was released on 2014-09-30 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The last wild frontier of classical studies." ---The Times (UK) The Chemical Muse uncovers decades of misdirection and obfuscation to reveal the history of widespread drug use in Ancient Rome and Greece. In the city-states that gave birth to Western civilization, drugs were an everyday element of a free society. Often they were not just available, but vitally necessary for use in medicine, religious ceremonies, and war campaigns. Their proponents and users existed in all classes, from the common soldier to the emperor himself. Citing examples in myths, medicine, and literature, D. C. A. Hillman shows how drugs have influenced and inspired the artists, philosophers, and even politicians whose ideas have formed the basis for civilization as we know it. Many of these ancient texts may seem well-known, but Hillman shows how timid, prudish translations have left scholars and readers in the dark about the reality of drug use in the Classical world. Hillman's argument is not simply "pro-drug." Instead, he appeals for an intellectual honesty that acknowledges the use of drugs in ancient societies despite today's conflicting social mores. In the modern world, where academia and university life are often politically charged, The Chemical Muse offers a unique and long overdue perspective on the contentious topic of drug use and the freedom of thought.
Download or read book Gender and Media written by Tonny Krijnen and published by Routledge. This book was released on 2021-10-27 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised second edition provides a critical overview of the contemporary debates and discussions surrounding gender and mediated communication. The book is divided into three parts: representing, producing, and consuming, with each section made up of three chapters. The first chapter of each section attempts to answer the most basic questions: ‘Who is represented?’, ‘Who produces what?’, and ‘Who consumes what?’. The second chapter of each section draws attention to the complexity of the relationship between gender and media, concentrating on the 'why'. The third and final chapter of each section addresses the latest debates in the fields of media and gender, adding a vital layer of understanding of the topic at hand. Throughout, text boxes provide additional information on the most important concepts and topics, and exercises help bridge the gap between theory and everyday life media practices. The second edition has been updated in light of current developments with regard to gender, media technologies, and globalisation, including recent theoretical insights and examples. This is an ideal textbook for students studying gender and media, and for general courses on gender studies, sociology, cultural studies, and women’s studies.
Download or read book Computational Methods for the Analysis of Genomic Data and Biological Processes written by Francisco A. Gómez Vela and published by MDPI. This book was released on 2021-02-05 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, new technologies have made remarkable progress in helping to understand biological systems. Rapid advances in genomic profiling techniques such as microarrays or high-performance sequencing have brought new opportunities and challenges in the fields of computational biology and bioinformatics. Such genetic sequencing techniques allow large amounts of data to be produced, whose analysis and cross-integration could provide a complete view of organisms. As a result, it is necessary to develop new techniques and algorithms that carry out an analysis of these data with reliability and efficiency. This Special Issue collected the latest advances in the field of computational methods for the analysis of gene expression data, and, in particular, the modeling of biological processes. Here we present eleven works selected to be published in this Special Issue due to their interest, quality, and originality.
