Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Download or read book GENERATION ECCH written by Jason Cohen and published by Touchstone. This book was released on 1994-08-24 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haunted by the spectre of the Beats and the Boomers, the Hippies and the Punks, today's twentysomethings are desperate for anything that gives them a generational self-image. This waggishly ironic book takes a riotous jab at the Generation X/twentysomething phenomenon and examines various aspects of their pop culture, including music, literature, and politics.
Download or read book Perspectives on Design and Digital Communication written by Nuno Martins and published by Springer Nature. This book was released on 2020-07-09 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shares new research findings and practical lessons learned that will foster advances in digital design, communication design, web, multimedia and motion design, graphic design and branding, and other related areas. It gathers the best papers presented at the 3rd International Conference on Digital Design and Communication, DIGICOM 2019, held on November 15–16, 2019, in Barcelos, Portugal. The respective contributions highlight new theoretical perspectives and practical research directions in design and communication, aimed at promoting their use in a global, digital world. The book offers a timely guide and a source of inspiration for designers of all kinds (Graphic, Digital, Web, UI & UX Design and Social Media), for researchers, advertisers, artists, entrepreneurs, and brand or corporate communication managers, and for teachers and advanced students.
Download or read book Service Design Capabilities written by Nicola Morelli and published by Springer Nature. This book was released on 2020-08-27 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book discusses service design capabilities in innovation processes, and provides a framework that guides design students, practitioners and researchers towards a better understanding of operational aspects of service design processes. More specifically, it revisits service designers’ capabilities in light of the new roles that have opened up in innovation processes on different scales. After years of being inadequately defined, the professional profile of service designers is now taking shape. Today private and public institutions recognize service designers as essential contributors to their innovation and development processes. What are the capabilities that characterize a service designer? These essential capabilities are what service designers should acquire in their education and can sell when looking for a job.
Download or read book Airbreathing Propulsion written by Tarit Bose and published by Springer Science & Business Media. This book was released on 2012-06-08 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Airbreathing Propulsion covers the physics of combustion, fluid and thermo-dynamics, and structural mechanics of airbreathing engines, including piston, turboprop, turbojet, turbofan, and ramjet engines. End-of-chapter exercises allow the reader to practice the fundamental concepts behind airbreathing propulsion, and the included PAGIC computer code will help the reader to examine the relationships between the performance parameters of different engines. Large amounts of data have on many different piston, turbojet, and turboprop engines have been compiled for this book and are included as an appendix. This textbook is ideal for senior undergraduate and graduate students studying aeronautical engineering, aerospace engineering, and mechanical engineering.
Download or read book AWI 1 written by United States. Department of Agriculture and published by . This book was released on with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Series of Plays in which it is Attempted to Delineate the Stronger Passions of the Mind Each Passion Being the Subject of a Tragedy and a Comedy written by Joanna Baillie and published by . This book was released on 1806 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Perspectives on Design and Digital Communication II written by Nuno Martins and published by Springer Nature. This book was released on 2021-05-29 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers new empirical findings fostering advances in the areas of digital and communication design, web, multimedia and motion design, graphic design, branding, and related ones. It includes original contributions by authoritative authors based on the best papers presented at the 4th International Conference on Digital Design and Communication, Digicom 2020, together with some invited chapters written by leading international researchers. They report on innovative design strategies supporting communication in a global, digital world, and addressing, at the same time, key individual and societal needs. This book is intended to offer a timely snapshot of technologies, trends and challenges in the area of design, communication and branding, and a bridge connecting researchers and professionals of different disciplines, such as graphic design, digital communication, corporate, UI Design and UX design. Chapter “Definition of a Digital Tool to Create Physical Artifacts: The Case of the Gamers4Nature Project” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Mind and Places written by Anna Anzani and published by Springer Nature. This book was released on 2020-05-12 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the contributions of psychological, neuroscientific and philosophical perspectives to the design of contemporary cities. Pursuing an innovative and multidisciplinary approach, it addresses the need to re-launch knowledge and creativity as major cultural and institutional bases of human communities. Dwelling is a form of knowledge and re-invention of reality that involves both the tangible dimension of physical places and their mental representation. Findings in the neuroscientific field are increasingly opening stimulating perspectives on the design of spaces, and highlight how our ability to understand other people is strongly related to our corporeity. The first part of the book focuses on the contributions of various disciplines that deal with the spatial dimension, and explores the dovetailing roles that science and art can play from a multidisciplinary perspective. In turn, the second part formulates proposals on how to promote greater integration between the aesthetic and cultural dimension in spatial design. Given its scope, the book will benefit all scholars, academics and practitioners who are involved in the process of planning, designing and building places, and will foster an international exchange of research, case studies, and theoretical reflections to confront the challenges of designing conscious places and enable the development of communities.
Download or read book Design for Ergonomics written by Francesca Tosi and published by Springer Nature. This book was released on 2019-11-21 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the global quality of the design of systems that people interact with during their work activities and daily lives; a quality that involves the globality of people’s experience – physical, sensory, cognitive and emotional. It presents a concise and structured overview of the ergonomic approach to planning, and of methodological and operational tools from ergonomic research that can more directly and concretely contribute to the design process. The book also explores physical ergonomics and cognitive ergonomics, which are essential components of design culture. The final section addresses the main design problems and intervention criteria regarding the design of environments, products and equipment, as well as the design of communication, training and learning interface systems based on digital technologies. The book is chiefly intended for designers and anyone interested in the methods, tools and opportunities for in-depth analysis and development that ergonomics can offer regarding the conception, production and testing of products, environments and services, whether physical or virtual. It also offers a learning resource for professionals and students in Industrial Design and Planning.
Download or read book Flexible Spacecraft Dynamics Control and Guidance written by Leonardo Mazzini and published by Springer. This book was released on 2015-10-27 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an up-to-date compendium on spacecraft attitude and orbit control (AOC) that offers a systematic and complete treatment of the subject with the aim of imparting the theoretical and practical knowledge that is required by designers, engineers, and researchers. After an introduction on the kinematics of the flexible and agile space vehicles, the modern architecture and functions of an AOC system are described and the main AOC modes reviewed with possible design solutions and examples. The dynamics of the flexible body in space are then considered using an original Lagrangian approach suitable for the control applications of large space flexible structures. Subsequent chapters address optimal control theory, attitude control methods, and orbit control applications, including the optimal orbital transfer with finite and infinite thrust. The theory is integrated with a description of current propulsion systems, with the focus especially on the new electric propulsion systems and state of the art sensors and actuators.
Download or read book In Spite of Myself written by Christopher Plummer and published by Vintage Canada. This book was released on 2009-10-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canada’s most celebrated and acclaimed actor lets loose in a magnificent memoir that will delight and enchant readers across the country. A rollicking, rich self-portrait written by one of today’s greatest living actors. The story of a “young wastrel, incurably romantic, spoiled rotten” – his privileged Montreal background, rich in Victorian gentility, included steam yachts, rare orchid farms, music lessons in Paris and Berlin – “who tore himself away from the ski slopes to break into the big, bad world of theater not from the streets up but from an Edwardian living room down.” Plummer writes of his early acting days – on radio and stage with William Shatner and other fellow Canadians; of the early days of the Stratford Festival in southern Ontario; of his Broadway debut at twenty-four in The Starcross Story, starring Eva Le Gallienne (“It opened and closed in one night, but what a night!”); of joining Peter Hall’s Royal Shakespeare Company (its other members included Judi Dench, Vanessa Redgrave and Peter O’Toole); of his first picture, Stage Struck, directed by Sidney Lumet; and of The Sound of Music, which he affectionately dubbed “S&M.” He writes about his legendary colleagues: Dame Judith Anderson (“the Tasmanian devil from Down Under”); Sir Tyrone Guthrie; Sir Laurence Olivier; Elia Kazan (“this chameleon of chameleons might change into you, wear your skin, steal your soul”); and “that reprobate” Jason Robards, among many others. A revelation of the wild and exuberant ride that is the actor’s – at least this actor’s – life.
Download or read book Visualizing the Data City written by Paolo Ciuccarelli and published by Springer Science & Business Media. This book was released on 2014-02-17 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates novel methods and technologies for the collection, analysis and representation of real-time user-generated data at the urban scale in order to explore potential scenarios for more participatory design, planning and management processes. For this purpose, the authors present a set of experiments conducted in collaboration with urban stakeholders at various levels (including citizens, city administrators, urban planners, local industries and NGOs) in Milan and New York in 2012. It is examined whether geo-tagged and user-generated content can be of value in the creation of meaningful, real-time indicators of urban quality, as it is perceived and communicated by the citizens. The meanings that people attach to places are also explored to discover what such an urban semantic layer looks like and how it unfolds over time. As a conclusion, recommendations are proposed for the exploitation of user-generated content in order to answer hitherto unsolved urban questions. Readers will find in this book a fascinating exploration of techniques for mining the social web that can be applied to procure user-generated content as a means of investigating urban dynamics.
Download or read book Inspire a Dream written by Steve Riach and published by . This book was released on 2000 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Football is built upon the dreams of players like Kurt Warner, who was told he didn't have what it takes to play at the professional level. It's about people like Mike Singletary, whowas told he was too small to ever make it big. It's about Steve Largent, who was told he was too slow to accel.These are men who have been inspired by a dream and, in turn, inspired other to dream with them and follow. They prove that true champions are not swayed by circumstances, labels, or past exzperiences, but rather are driven by a force within that pushes them to become something greater than they could have become by themselves.They are men who inspire us to push beyond our own limitations to reach our destiny.The dream is about what we are not yet, but can become.Highlighted by comments from some of the game's greatest players, a stunning collection of phototgraphs from Tom Henry, and the classic writing of author Steve Riach, this one-of-a-kind book reflect contemporary images and makes memories for tomorrow.
Download or read book Stability and Control of Conventional and Unconventional Aerospace Vehicle Configurations written by Bernd Chudoba and published by Springer. This book was released on 2019-07-23 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces a stability and control methodology named AeroMech, capable of sizing the primary control effectors of fixed wing subsonic to hypersonic designs of conventional and unconventional configuration layout. Control power demands are harmonized with static-, dynamic-, and maneuver stability requirements, while taking the six-degree-of-freedom trim state into account. The stability and control analysis solves the static- and dynamic equations of motion combined with non-linear vortex lattice aerodynamics for analysis. The true complexity of addressing subsonic to hypersonic vehicle stability and control during the conceptual design phase is hidden in the objective to develop a generic (vehicle configuration independent) methodology concept. The inclusion of geometrically asymmetric aircraft layouts, in addition to the reasonably well-known symmetric aircraft types, contributes significantly to the overall technical complexity and level of abstraction. The first three chapters describe the preparatory work invested along with the research strategy devised, thereby placing strong emphasis on systematic and thorough knowledge utilization. The engineering-scientific method itself is derived throughout the second half of the book. This book offers a unique aerospace vehicle configuration independent (generic) methodology and mathematical algorithm. The approach satisfies the initial technical quest: How to develop a ‘configuration stability & control’ methodology module for an advanced multi-disciplinary aerospace vehicle design synthesis environment that permits consistent aerospace vehicle design evaluations?
Download or read book The Chemical Muse written by D. C.A. Hillman, Ph.D. and published by Macmillan. This book was released on 2014-09-30 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The last wild frontier of classical studies." ---The Times (UK) The Chemical Muse uncovers decades of misdirection and obfuscation to reveal the history of widespread drug use in Ancient Rome and Greece. In the city-states that gave birth to Western civilization, drugs were an everyday element of a free society. Often they were not just available, but vitally necessary for use in medicine, religious ceremonies, and war campaigns. Their proponents and users existed in all classes, from the common soldier to the emperor himself. Citing examples in myths, medicine, and literature, D. C. A. Hillman shows how drugs have influenced and inspired the artists, philosophers, and even politicians whose ideas have formed the basis for civilization as we know it. Many of these ancient texts may seem well-known, but Hillman shows how timid, prudish translations have left scholars and readers in the dark about the reality of drug use in the Classical world. Hillman's argument is not simply "pro-drug." Instead, he appeals for an intellectual honesty that acknowledges the use of drugs in ancient societies despite today's conflicting social mores. In the modern world, where academia and university life are often politically charged, The Chemical Muse offers a unique and long overdue perspective on the contentious topic of drug use and the freedom of thought.
