Download or read book Science of Synthesis Metal Catalyzed Cyclization Reactions written by Shengming Ma and published by Thieme. This book was released on 2016-12-14 with total page 1253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Download or read book Science of Synthesis Metal Catalyzed Cyclization Reactions written by Shuanhu Gao and published by Thieme. This book was released on 2016-12-14 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation.
Download or read book Science of Synthesis written by Shengming Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cyclization Reactions written by Shengming Ma and published by Thieme Chemistry. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: Metal-Catalyzed Cyclization Reactions presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Download or read book Metal Catalyzed Cyclization Reactions 2 written by S. Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cyclization Reactions written by J. M. Alderson and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal Catalyzed Cyclization Reactions 1 written by S. Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cyclization 2 written by U. Bora and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cross coupling Reactions written by François Diederich and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.
Download or read book Synthesis of Heterocycles via Metal Catalyzed Reactions that Generate One or More Carbon Heteroatom Bonds written by John P. Wolfe and published by Springer. This book was released on 2013-09-11 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Carboamination or Carboalkoxylation Reactions, by John P. Wolfe Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Diamination, Aminoalkoxylation, or Dialkoxylation Reactions, by Sherry R. Chemler Synthesis of Heterocycles via Metal-Catalyzed Wacker-Type Oxidative Cyclization Reactions of Alkoxy- or Amino-Alkenes, by Wanbin Zhang Synthesis of Saturated Heterocycles via Metal-Catalyzed Hydroamination or Hydroalkoxylation Reactions, by Lisa D. Julian Synthesis of Saturated Heterocycles via Metal-Catalyzed Allylic Alkylation Reactions, by Aaron Aponick Synthesis of Heterocycles via Metal-Catalyzed Cascade/Domino Reactions that Generate a C–N or C–O Bond, by Mark Lautens Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions that Generate a C–N or C–O Bond, by Jerome Waser
Download or read book Cyclization Reactions written by C. Thebtaranonth and published by CRC Press. This book was released on 1993-05-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclization Reactions provides a quick update of the latest advances in cyclization reactions. It covers the basic principles of cyclization chemistry, emphasizing practical applications. Chapters are organized according to the different cyclization intermediates-cationic, radical, anionic, and metal complex intermediates. The last chapter covers macrolactonization, vicinal tricarbonal, and Bergman (enediyne) reactions, which are of particular interest today. More than 2,600 structures illustrate key concepts throughout the book. Various cyclizations are organized into mechanistic groups to help researchers choose and change between methods when searching for maximum efficiency in synthesis. Critical coverage of the literature up to 1992 is provided. Cyclization Reactions is essential reading for anyone involved in the synthesis of ring compounds or who is seeking a rapid overview of the field. Newcomers as well as experienced researchers will benefit from this book. It also is excellent reference material for students at the advanced undergraduate and graduate levels.
Download or read book Metal Catalyzed Cascade Reactions written by Thomas J.J. Müller and published by Springer. This book was released on 2010-11-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. This is a comprehensive overview of an exciting and highly dynamic, and innovative methodological concept.
Download or read book Transition Metal Catalyzed Carbene Transformations written by Jianbo Wang and published by John Wiley & Sons. This book was released on 2022-05-16 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an up-to-date overview of the rapidly growing field of carbene transformations Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area. This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer. Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.
Download or read book Organic Synthesis Using Transition Metals written by Roderick Bates and published by John Wiley & Sons. This book was released on 2012-04-30 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last two decades the subject has mushroomed - established reactions are seeing both technical improvements and increasing numbers of applications, and new reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies, and its importance is underlined by the fact that three Nobel prizes have been awarded for discoveries in this field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Edition considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis, both for pharmaceutical compounds and for natural products. It concentrates on the bond-forming reactions that set transition metal chemistry apart from "classical" organic chemistry. Each chapter is extensively referenced and provides a convenient point of entry to the research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes h3- or p-allyl -allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revised and expanded to reflect the significant improvements and advances in the field since the first edition, as well as the large number of new transition metal-catalysed processes that have come to prominence in the last 10 years – for example the extraordinary progress in coupling reactions using “designer” ligands, catalysis using gold complexes, new opportunities arising from metathesis chemistry, and C-H activation – without neglecting the well established chemistry of metals such as palladium. Organic Synthesis Using Transition Metals, 2nd Edition will find a place on the bookshelves of advanced undergraduates and postgraduates working in organic synthesis, catalysis, medicinal chemistry and drug discovery. It is also useful for practising researchers who want to refresh and enhance their knowledge of the field.
Download or read book Transition Metal Catalyzed Cyclization and Synthesis of Triptolide Analogs written by Jiehui Pan and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Transition Metal Catalyzed Cyclization and Synthesis of Triptolide Analogs" by Jiehui, Pan, 潘杰輝, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled TRANSITION METAL CATALYZED CYCLIZATION AND SYNTHESIS OF TRIPTOLIDE ANALOGS Submitted by Pan Jiehui for the Degree of Doctor of Philosophy at The University of Hong Kong in March 2006 (-)-Triptonide, (-)-triptolide, and 16-hydroxytriptolide are bioactive natural product, isolated from the Chinese medicinal plant Tripterygium wilfordii Hook. F. (Lei Gong Teng). They show potent immunosuppressive, antileukemic, and antifertile activities. However, their mechanisms of actions still remain elusive, and only limited structure-activity relationship studies of triptolide and its analogs have been carried out. I have successfully synthesized bioactive alkyne-derived triptolide probe and azide functionalized fluorophore tags, which were designed for identifying the receptors of triptolide by using the click chemistry method. A model reaction simulating the cycloaddition between the bioactive triptolide probe and rhodamine tag has been successfully accomplished, which could be applied in the search for the receptors of triptolide. Synthetic studies of triptolide analogs could provide new methods to prepare analogs containing moieties different from the original triptolide molecule, and possibly enable its curative effects to be distinguished from its toxic effects. Two efficient cross-coupling methods including the Heck reaction and the Sonogashira coupling have been utilized for the introduction of the C-13 side chain of triptolide analogs. These protocols provide new ways to modify the triptolide molecule at the C-13 position in addition to the Claisen rearrangement. Several novel dimeric triptolide analogs with different functionalities at the C-13 position have been prepared. The exploration of transition metal-catalyzed cyclization reactions has been at the frontier of organic synthesis. I have prepared several sterically bulky N, N'-disubstituted cyclic thiourea-gold(I) complexes. The crystal structures of the complexes reveal the different coordination nature of sulphur in these complexes in the solid state. In solution, a ligand scrambling reaction has been observed with the N, N'-dialkyl cyclic thiourea ligands. Useful information about the equilibrium of ligand scrambling reaction has been obtained from the H NMR experiments. I have used bulky N, N'-disubstituted cyclic thioureas as effective ligands for the Au(I)-catalyzed carbocyclization of 1,3-dicarbonyl compounds with alkynes. The reactions can be readily conducted with a low catalyst loading, short reaction time in an "open flask" system and in high yields. In addition, I have demonstrated an application of the bulky N, N'-disubstituted cyclic thiourea-Au(I) complexes in the cycloisomerization of acetylenic 1,3-dicarbonyl compounds to form γ-lactones and γ-lactams. These reactions can be readily conducted with low catalytic loading in an "open flask" system and provide a new method to generate γ-lactones and γ-lactams. DOI: 10.5353/th_b3776596 Subjects: Ring formation (Chemistry) Bioactive compounds - Synthesis Transition metal catalysts
Download or read book Transition Metal Catalyzed Heterocycle Synthesis via C H Activation written by Xiao-Feng Wu and published by John Wiley & Sons. This book was released on 2016-03-07 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
Download or read book Science of Synthesis Metal catalyzed heck type reactions and C C cross coupling via C H activation written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Science of Synthesis: Cross Coupling and Heck-Type Reactions, expert authors present and discuss the best and most reliable methods currently available for the formation of new carbon-carbon and carbon-heteroatom bonds using these reactions, highlighted with representative experimental procedures. Together, the three volumes of Cross Coupling and Heck-Type Reactions provide an extensive overview of the current state of the art in this field of central importance in modern chemistry, and are an invaluable resource for the practicing synthetic organic chemist. This volume provides comprehensive coverage of the different classes of Heck-type reactions. It describes the state-of-the-art developments in each area whilst critically evaluating the strengths and weaknesses of the different methods. In accordance with the growing demand for synthetic efficiency and practicality in organic synthesis, many of these newly developed Heck-type methods feature operationally convenient conditions, high catalytic efficiency, and high levels of chemical, regiochemical, and stereochemical control. Metal-catalyzed C-H functionalization has also been developed into a powerful tool for organic synthesis, providing for original C-C disconnections in retrosynthetic analysis and improving the overall efficiency of the desired transformations. This volume also summarizes the most important concepts and methods in this hot research area. This volume is part of a 3-volume set: Cross Coupling and Heck-Type Reactions Workbench Edition General information about Science of Synthesis
