Download or read book Role of the IL 23 IL 17 Pathway in Chronic Immune Mediated Inflammatory Diseases Mechanisms and Targeted Therapies written by Elisabetta Bianchi and published by Frontiers Media SA. This book was released on 2021-11-10 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Targeting the IL 17 Pathway in Inflammatory Disorders written by Cong-Qiu Chu and published by Springer. This book was released on 2016-11-26 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals.
Download or read book Moderate to Severe Psoriasis Fourth Edition written by John Y. M. Koo and published by CRC Press. This book was released on 2014-03-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis patient that are perfect for the dermatologist in daily practice. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics.
Download or read book Th 17 Cells Role in Inflammation and Autoimmune Disease written by Valérie Quesniaux and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.
Download or read book Treatment of Non infectious Uveitis written by Phoebe Lin and published by Springer Nature. This book was released on 2019-09-12 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique, comprehensive book provides a much-needed reference on the treatment and management of non-infectious uveitis. Carefully designed, Treatment of Non-infectious Uveitis is the first book of its kind to provide an in-depth, clinically-relevant, expert-driven resource for ophthalmologists focusing on modalities of uveitis treatment, their mechanism of action, dosing, and side effects. Each chapter provides an introduction, mechanism of action, indication, dosage, side effects, and efficacy summaries from clinical trials and other published literature. Topics range from topical treatment, to locally administered therapy including drug-releasing implants, to systemic immunosuppressive treatments both tried and new, as well as surgical management, with each chapter highlighting important practice pearls as well as easy-reference dosing tables, side effects, and lab monitoring pertinent to the agents discussed. The book concludes with a discussion of novel approaches to the treatment of non-infectious uveitis, and special considerations when treating uveitis in the pediatric patient. The majority of patients with non-infectious uveitis are treated by comprehensive ophthalmologists, many of whom are less familiar with established treatment guidelines outlining the role of corticosteroids and immunomodulatory therapy. While the non-specialist, resident, or fellow is sure to benefit from this one-stop guide to uveitis treatment, retina and uveitis specialists alike will also appreciate the practice tips and thorough coverage of this expertly-written reference. Treatment of Non-infectious Uveitis is the ideal reference for all ophthalmologists who seek to improve their understanding of the causes of uveitis and learn how to best treat this condition.
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Download or read book IL 17 IL 22 and Their Producing Cells Role in Inflammation and Autoimmunity written by Valérie Quesniaux and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
Download or read book Th 17 Cells Role in Inflammation and Autoimmune Disease written by Valérie Quesniaux and published by Birkhäuser. This book was released on 2009-08-29 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.
Download or read book Act1 Mediated RNA Metabolism in IL 17 Driven Inflammatory Diseases written by Lingzi Hong and published by . This book was released on 2021 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 17 (IL-17, also known as IL-17A) is a key signature cytokine of Th17 cells and is also produced by innate immune cells. While IL-17 is required for host defense against extracellular microorganisms, IL-17 plays a critical role in the pathogenesis of autoimmune and inflammatory diseases, including psoriasis, rheumatoid arthritis, multiple sclerosis, and asthma. IL-17 signals through adaptor protein Act1, resulting in transcription of pro-inflammatory and neutrophil-mobilizing cytokines and chemokines, including CXCL1, TNF, IL-6 and GM-CSF. Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. We discovered that Act1 also acts as an RNA binding protein to stabilize mRNAs encoding key inflammatory proteins through a stem-loop structure element, named as SBE (SEFIR-binding element). mRNA-bound Act1 directs formation of three compartmentally distinct RNA-protein complexes (RNPs) that regulate three distinct events in inflammatory-mRNA metabolism: preventing mRNA decay in the nucleus, inhibiting mRNA decapping in P bodies and promoting translation. SBE RNA aptamers decreased IL-17-mediated mRNA stabilization in vitro as well as IL-17-induced skin inflammation and airway inflammation in a mouse asthma model, thus providing a therapeutic strategy for autoimmune diseases. These results reveal a network in which Act1 assembles RNPs on the 3' UTRs of select mRNAs and consequently controls receptor-mediated mRNA stabilization and translation during inflammation. Asthma is a T cell-mediated heterogeneous disease clinically characterized by bronchial hyperresponsiveness, inflammation, and airflow obstruction. Glucocorticoids are the gold standard in asthma therapy as they can successfully control asthma in a large proportion. A substantial body of research has shown that interleukin (IL)-17A plays a critical role in the pathogenesis of severe, steroid resistant asthma. Clinical studies have also indicated that a subgroup of asthma patients responded to IL-17 signaling blockers, but the mechanism is not well understood. We showed CEBPB was the critical transcription factor that is synergistically induced by IL17-A and glucocorticoid (GC). In addition, LCN2 and SAA were also synergistically induced by IL17A and glucocorticoid (GC) through CEBPB in cultured airway cells. Mechanistically, IL17A and GC collaboratively regulated CEBPB at both transcriptional and posttranscriptional levels, which involved direct binding and stabilization of CEBPB mRNA by Act1. LCN2 and SAA may serve as LCN2 and SAA as potential circulating biomarkers for endotyping type-17 severe asthma. In one cohort study, severe asthma patients showed significantly higher plasma LCN2 and SAA as compared with healthy controls; a positive correlation was also revealed between blood IL-17A and LCN2 or SAA in patients. Taken together, our study elucidates the molecular mechanism of IL17A-Act1/CEBPB axis on steroid-resistant IL17-A targets, LCN2 and SAAs, which may serve as useful biomarkers to distinguish type-17 severe asthma endotype for anti-IL17A therapy.
Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Download or read book T Cell Clones written by Harald von Boehmer and published by Elsevier Publishing Company. This book was released on 1985 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Characterization of Novel Mechanisms for Interleukin 17 and Its Essential Signaling Mediator Act1 in Airway Epithelial Cells written by Sharlene Velichko and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the proinflammatory cytokine interleukin-17 (IL-17) in the airway has been under investigation for the last 12 years. Many studies have been published demonstrating its pleiotropic role in the production of chemokines, cytokines, mucins, and antimicrobial proteins. Many in vivo models have demonstrated the association of IL-17 in airway inflammation in response to allergens as well as environmental insults, as well as chronic inflammatory lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease and asthma. However, relatively little is known regarding the downstream signaling mechanisms by which IL-17 mediates its many effects. What is known is that the signaling is complex; IL-17 has been shown to involve multiple signaling pathways, including: the canonical NF-kappaB pathway, multiple mitogen-activated protein (MAP) kinase pathways, as well as C/EBP, PI-3 kinase and JAK. Both cell type and target gene appear to determine the signaling pathway involved downstream of IL-17. Little is known regarding the protein-protein interactions that mediate these signaling events. What is known is that the intracellular protein Act1 (also known as CIKS) is an important downstream mediator of IL-17 induced signaling. Cells derived from Act1-deficient mice are largely unresponsive to IL-17A stimulation. Act1 has been shown to contain both TRAF6 and IL-17 receptor binding sites, and therefore acts as an intermediate to connect the activated IL-17 receptor complex to pathways downstream of TRAF6. However, Act1 has additional functions as well. It can also bind to the IL-25, CD40 and BAFF-R receptors, and has recently been shown to act as a U-box type E3 ubiquitin ligase. Recently, a single nucleotide polymorphism (SNP) that encodes a loss-of-function mutation in the gene for Act1, TRAF3IP2, was associated with psoriasis, an autoimmune inflammatory skin disease, and psoriatic arthritis. As IL-17 is associated with the pathogenesis of psoriasis, this is counter-intuitive to the known functions of Act1, indicating that Act1 may have other functions as well. This dissertation details a novel nuclear function for Act1 as a transcriptional enhancer. Subsequent RNA-seq comparison of cells ectopically expressing Act1 and IL-17A stimulated cells identified a number of cornified envelope constituents whose expression is up-regulated by both Act1 and IL-17. The cornified envelope is a structure formed in the outermost layer of stratified squamous epithelia. Finally, we detail the use of a yeast two hybrid assay to identify novel Act1 interacting proteins, and further characterize the interaction of Act1 with one of these proteins, COMMD1 (copper metabolism (Murr1) domain containing 1), which might represent a new target of Act1's ubiquitin ligase activity.
Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Download or read book Cutaneous Fungal Infections written by B. Elewski and published by Wiley-Blackwell. This book was released on 1998-03-13 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: With greater occurance of fungal infections of the skin, especially in immuno compromised patients, the attention paid to this topic has increased in recent years. The second edition of Cutaneous Fungal Infections answers the need for more information on skin infections and the many new easy-to-use, effective drugs on the market today.
Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Download or read book Cytokines in Health and Disease written by Steven L. Kunkel and published by Marcel Dekker. This book was released on 1992 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive text providing much of the currently available knowledge in the field of cytokines. There are four areas covered, including general overviews of each of the major cytokines, listings of the important interactions these cytokines have with inflammatory cells, discussions of current an
Download or read book The Spondylarthritides written by Andrei Calin and published by Oxford University Press, USA. This book was released on 1998 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term Spondylarthitides refers to a group of common rheumatic disorders affecting the spine and peripheral joints. The distribution of this disease is world-wide, with both men and women affected (the average age of onset being below 30 years). These also serve as a model system for understanding the interaction between disease-inducing micro-organisms, and genetically-susceptible host, since both of these components are particularly well defined in the spondylarthopathies. They are therefore of great interest from the point of veiw of understanding the pathogenesis of inflammatory and autoimune diseases, such as arthritis, inflammatory bowel disease, and insulin dependent diabetes mellitus, all of which involve an interplay of microbial and genetic factors. The Spondylarthritides provides up to date, in depth reviews of the current state of knowledge of the genetic, epidemiologic, microbiologic, and immunologic aspects of these disorders. The book provides extensive clinical descriptions of the spondylarthritides, as well as reviews of the clinical features of these diseases. Written by an international team comprised of leading authorities in the field, the book will be of considerable interest to researchers and clinicians investigating these specific disorders, as well as related inflammatory disorders.
