Download or read book Robust Design Framework for Automating Multi component DNA Origami Structures with Experimental and MD Coarse grained Model Validation written by Chao-Min Huang and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Major advances in DNA nanofabrication by the self-assembly process have occurred over the last decade to construct nano-devices for many applications of science and technology. However, advances in design methodology as well as advanced computational design tools have lagged behind, including computer-aided design (CAD) and coarse-grained models. Currently, for the majority of research in DNA nanotechnology, the design process is carried out using a bottom-up manual approach, which requires expertise and limits complexity. Recently developed top-down automated approaches that are limited to select types of static geometries, sacrificing the design flexibility for various applications. In addition, the integration between CAD and coarse-grained models require extra steps and limits the realization of virtual iterative design for engineering DNA assemblies in a robust manner. Here, we establish a versatile CAD tool that integrates top-down design automation with bottom-up control of component geometry and connectivity to build DNA nanomachines with various geometries (solid, shell, wireframe, or combinations), selected mobility (static, 1D, 2D, or 3D motion), large size via multi-structure assemblies. Based on this custom CAD tool, MagicDNA, we proposed a closed-loop integrated framework with MagicDNA and coarse-grained models, which enables the product design pipeline similar to macroscopic engineering (CAD and CAE) into nanoscale DNA assemblies for evaluating design parameters, rapid prototyping and eventually a robust design for experimental characterization and applications. Several structures were further fabricated to validate not only the target geometry but also the motion pathway, which in all cases generally agreed with simulation results. For these nanomachines, thermal fluctuation plays an important role to affect the component geometry and was quantified with hybrid coarse-grained models and kinematic variance analysis to predict the performance of the DNA assemblies. This framework provides an intuitive platform for novices and experts to broaden the design space of structural DNA nanotechnology and is a critical step to enable dynamic structures and design of functional properties beyond shape.
Download or read book Structural DNA Nanotechnology written by Nadrian C. Seeman and published by Cambridge University Press. This book was released on 2015 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.
Download or read book 3D DNA Nanostructure written by Yonggang Ke and published by Humana. This book was released on 2016-11-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume presents a comprehensive technical overview of DNA nanotechnology with an emphasis on 3D DNA nanostructure design and applications. Coverage spans from basic design principles for DNA and RNA nanostructures to their cutting-edge applications in a variety of fields, with the book divided into basic DNA and RNA nanostructure design strategies as well as applications utilizing DNA nanostructures, including but not limited to nanomedicine, bioimaging, biosensing, nanoplasmonics, nanoelectronics, nanofabrication, crystallography, biophysics, and analytical chemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, 3D DNA Nanostructure: Methods and Protocols provides the most up-to-date tutorial style overviews and technical style protocols to benefit researchers in a wide variety of areas.
Download or read book Nanophotonics and Plasmonics written by Dr. Ching Eng (Jason) Png and published by CRC Press. This book was released on 2017-08-21 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a first integrated view of nanophotonics and plasmonics, covering the use of dielectric, semiconductor, and metal nanostructures to manipulate light at the nanometer scale. The presentation highlights similarities and advantages, and shows the common underlying physics, targets, and methodologies used for different materials (optically transparent materials for nanophotonics, vs opaque materials for plasmonics). Ultimately, the goal is to provide a basis for developing a unified platform for both fields. In addition to the fundamentals and detailed theoretical background, the book showcases the main device applications. Ching Eng (Jason) Png is Director of the Electronics and Photonics Department at the Institute of High Performance Computing, Agency for Science Technology and Research, Singapore. Yuriy A. Akimov is a scientist in the Electronics and Photonics Department at the Institute of High Performance Computing, Agency for Science Technology and Research, Singapore.
Download or read book Modeling and Simulating Cardiac Electrical Activity written by David J. Christini and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.
Download or read book Liquid Crystal Elastomers written by Mark Warner and published by Oxford University Press. This book was released on 2007-04-05 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a primer for liquid crystals, polymers, rubber and elasticity. It is directed at physicists, chemists, material scientists, engineers and applied mathematicians at the graduate student level and beyond.
Download or read book Quantitative Bioimaging written by Raimund J. Ober and published by CRC Press. This book was released on 2020-12-15 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative bioimaging is a broad interdisciplinary field that exploits tools from biology, chemistry, optics, and statistical data analysis for the design and implementation of investigations of biological processes. Instead of adopting the traditional approach of focusing on just one of the component disciplines, this textbook provides a unique introduction to quantitative bioimaging that presents all of the disciplines in an integrated manner. The wide range of topics covered include basic concepts in molecular and cellular biology, relevant aspects of antibody technology, instrumentation and experimental design in fluorescence microscopy, introductory geometrical optics and diffraction theory, and parameter estimation and information theory for the analysis of stochastic data. Key Features: Comprises four parts, the first of which provides an overview of the topics that are developed from fundamental principles to more advanced levels in the other parts. Presents in the second part an in-depth introduction to the relevant background in molecular and cellular biology and in physical chemistry, which should be particularly useful for students without a formal background in these subjects. Provides in the third part a detailed treatment of microscopy techniques and optics, again starting from basic principles. Introduces in the fourth part modern statistical approaches to the determination of parameters of interest from microscopy data, in particular data generated by single molecule microscopy experiments. Uses two topics related to protein trafficking (transferrin trafficking and FcRn-mediated antibody trafficking) throughout the text to motivate and illustrate microscopy techniques. An online appendix providing the background and derivations for various mathematical results presented or used in the text is available at http://www.routledge.com/9781138598980.
Download or read book Campanian Foraminifera from the Stanford University Campus California written by Joseph John Graham and published by . This book was released on 1963 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mapping Cyberspace written by Martin Dodge and published by Routledge. This book was released on 2003-09-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mapping Cyberspace is a ground-breaking geographic exploration and critical reading of cyberspace, and information and communication technologies. The book: * provides an understanding of what cyberspace looks like and the social interactions that occur there * explores the impacts of cyberspace, and information and communication technologies, on cultural, political and economic relations * charts the spatial forms of virutal spaces * details empirical research and examines a wide variety of maps and spatialisations of cyberspace and the information society * has a related website at http://www.MappingCyberspace.com. This book will be a valuable addition to the growing body of literature on cyberspace and what it means for the future.
Download or read book Handbook of Lipid Bilayers Second Edition written by Derek Marsh and published by CRC Press. This book was released on 2013-02-15 with total page 1176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, the Handbook of Lipid Bilayers is a groundbreaking work that remains the field’s definitive text and only comprehensive source for primary physicochemical data relating to phospholipid bilayers. Along with basic thermodynamic data, coverage includes both dynamic and structural properties of phospholipid bilayers. It is an indispensable reference for users of bilayer model membranes and liposome delivery systems and for those interested in the biophysics of membrane structure. Each chapter in the second edition contains considerable amounts of explanation and elaboration, including, in many cases, extensive analysis of structural connections between the data. New in the Second Edition: Chapters on crystal structures of phospholipids include new structures and more comprehensive data on bond lengths, bond angles, and torsion angles—and all coordinates are Cartesian Wide-angle data is indexed whenever possible to characterize chain-packing modes in gel and crystalline lamellar phases Low-angle data are analyzed in terms of the lipid and water thicknesses Headgroup separations in electron density profiles for phospholipids are included, and a separate section is devoted to the in-depth analysis of electron density profiles that provides the most detailed structural information on fluid lamellar phases Phase diagrams of phospholipid mixtures are vastly expanded and have been redrawn in standardized format to aid intercomparison. Cholesterol, including ternary systems, is now featured. New sections on titration calorimetry, and much extended data on the temperature dependence of transfer rates The greatly expanded chapter on bilayer–bilayer interactions features new and detailed information on the components of interbilayer pressures
Download or read book Reality Is Broken written by Jane McGonigal and published by Penguin. This book was released on 2011-01-20 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: “McGonigal is a clear, methodical writer, and her ideas are well argued. Assertions are backed by countless psychological studies.” —The Boston Globe “Powerful and provocative . . . McGonigal makes a persuasive case that games have a lot to teach us about how to make our lives, and the world, better.” —San Jose Mercury News “Jane McGonigal's insights have the elegant, compact, deadly simplicity of plutonium, and the same explosive force.” —Cory Doctorow, author of Little Brother A visionary game designer reveals how we can harness the power of games to boost global happiness. With 174 million gamers in the United States alone, we now live in a world where every generation will be a gamer generation. But why, Jane McGonigal asks, should games be used for escapist entertainment alone? In this groundbreaking book, she shows how we can leverage the power of games to fix what is wrong with the real world-from social problems like depression and obesity to global issues like poverty and climate change-and introduces us to cutting-edge games that are already changing the business, education, and nonprofit worlds. Written for gamers and non-gamers alike, Reality Is Broken shows that the future will belong to those who can understand, design, and play games. Jane McGonigal is also the author of SuperBetter: A Revolutionary Approach to Getting Stronger, Happier, Braver and More Resilient.
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Download or read book Developing Minds in the Digital Age written by Oecd and published by Org. for Economic Cooperation & Development. This book was released on 2019-05-27 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Consilience written by E. O. Wilson and published by Vintage. This book was released on 2014-11-26 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER • "A dazzling journey across the sciences and humanities in search of deep laws to unite them." —The Wall Street Journal One of our greatest scientists—and the winner of two Pulitzer Prizes for On Human Nature and The Ants—gives us a work of visionary importance that may be the crowning achievement of his career. In Consilience (a word that originally meant "jumping together"), Edward O. Wilson renews the Enlightenment's search for a unified theory of knowledge in disciplines that range from physics to biology, the social sciences and the humanities. Using the natural sciences as his model, Wilson forges dramatic links between fields. He explores the chemistry of the mind and the genetic bases of culture. He postulates the biological principles underlying works of art from cave-drawings to Lolita. Presenting the latest findings in prose of wonderful clarity and oratorical eloquence, and synthesizing it into a dazzling whole, Consilience is science in the path-clearing traditions of Newton, Einstein, and Richard Feynman.
Download or read book Nanoengineering Materials for Biomedical Uses written by Emilio I. Alarcon and published by Springer Nature. This book was released on 2019-11-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills the gap between fundamental and applied research in the use of nanomaterials in biomedical applications, covering the most relevant areas, such as the fundamental concepts of the preparation of nanostructures and regulatory requirements for their safe use in biomedical devices. It also critically discusses what has been achieved in the field, and what needs to be urgently addressed and reviews the state-of-the-art medical uses of nanomaterials for treating damaged organs and tissues. Combining the expertise of clinical researchers working in the field of tissue engineering and novel materials, the book explores the main topics regarding the characterization of materials, specific organ-oriented biomaterials and their applications, as well as regulations and safety. Further, it also examines recent advances, difficulties, and clinical requirements in terms of human bone, cornea, heart, skin and the nervous system, allowing readers to gain a clear and comprehensive understanding of current nanomaterial use in biomedical applications and devices, together with the challenges and future trends. This book is a valuable tool for multidisciplinary scientists and experts interested in fundamental concepts and synthetic routes for preparing nanomaterials. It is also of interest to students and researchers involved in cross-disciplinary research in nanomaterials for clinical applications and offers practical insights for clinicians as well as engineers and materials scientists working in nanoengineering.
Download or read book NanoFormulation written by Gordon Tiddy and published by Royal Society of Chemistry. This book was released on 2012 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: NanoFormulation covers advances in research, development and applications of innovative formulation technologies where nanomaterials play an essential role.
Download or read book Modeling and Simulation in Polymers written by Purushottam D. Gujrati and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap in the literature and all set to become the standard in this field, this monograph begins with a look at computational viscoelastic fluid mechanics and studies of turbulent flows of dilute polymer solutions. It then goes on discuss simulations of nanocomposites, polymerization kinetics, computational approaches for polymers and modeling polyelectrolytes. Further sections deal with tire optimization, irreversible phenomena in polymers, the hydrodynamics of artificial and bacterial flagella as well as modeling and simulation in liquid crystals. The result is invaluable reading for polymer and theoretical chemists, chemists in industry, materials scientists and plastics technologists.
