Download or read book Reviews on Biomarker Studies in Aging and Anti Aging Research written by Paul C. Guest and published by Springer Nature. This book was released on 2019-09-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.
Download or read book Biomarker Studies in Brain Aging written by Maddy Evans and published by American Medical Publishers. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of aging refer to those biomarkers that can predict functional capacity at a later age more accurately than chronological age. Validated biomarkers of aging can enable interventions which can extend the lifespan, as any changes in the biomarkers can be observed during the life span of the organism. The levels of CD4 and CD8 memory T cells along with naive T cells are found to provide an estimate of lifespan. One of the significant biomarker of aging is the epigenetic clock, which has the capability to forecast human chronological age accurately. Some of the other prominent biomarkers of determining brain aging are proteomic clocks and neuroimaging age predictors. Furthermore, cell counts and blood chemistry can also be used for predicting chronological age accurately. This book is compiled in such a manner, that it will provide in-depth knowledge about the biomarker studies in brain aging. From theories to research to practical applications, case studies related to all contemporary topics of relevance to this area of study have been included herein. This book will provide comprehensive knowledge to the readers.
Download or read book Studies on Biomarkers and New Targets in Aging Research in Iran written by Paul C. Guest and published by Springer. This book was released on 2021-06-20 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today it is the center of many world issues due to its economic, religious and political importance. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications and the country of Iran has spearheaded this progress. Much of the research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human healthspan. This book provides a comprehensive overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. Hundreds of studies have now been published describing the health benefits of this spice. The importance of this research is exemplified by poor data regarding health and longevity as only 0.08% of the population in Iran consists of individuals over 90 years of age. This is approximately 10 times lower than the percentage of this same age group in the United Kingdom and the United States of America and almost 20 times lower than that in Japan. This book presents a series of reviews and meta-studies describing research which has resulted in identification potential new biomarkers and drug targets for age-related disorders. All of the studies have focussed on the testing of curcumin and related products, which have already shown some promising leads in age-related conditions such as heart-disease, diabetes, cognitive impairment and cancer. The authors in this series come from different centers and cities of Iran, including Mashhad, Tehran, Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters feature collaborations with other countries of the Middle East and throughout the world, including Brazil, Italy, Mexico, Oman, Poland, Switzerland, the United Kingdom and the United States of America. This underscores the emergence of the Middle East into this arena of research. The book will be of high interest to scientific and clinical researchers in the subject of aging and age-related disease, and to physicians and pharmaceutical company scientists since it gives insights into the latest strategies, biomarkers and targets involved in the mechanism of action of curcumin to promote healthy aging. It will also provide important information on disease mechanisms related to age-related disorders, as each chapter will be presented in the context of specific chronic diseases.
Download or read book Exceptional Longevity written by Bernard Jeune and published by . This book was released on 1995 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: States that the number of genuine long-livers is exploding and a substantial proportion of new-borns in developed countries may survive to celebrate their 100th birthday. This book examines the storied realms of exceptional longevity.
Download or read book Epigenetics of Aging and Longevity written by Alexey Moskalev and published by Academic Press. This book was released on 2017-11-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan
Download or read book Biomarkers of Human Aging written by Alexey Moskalev and published by . This book was released on 2019 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Download or read book Neuroprotective Effects of Phytochemicals in Brain Ageing written by Surajit Pathak and published by Springer Nature. This book was released on with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human diseases Research and textbook 1 written by Aliasghar Tabatabaei Mohammadi and published by Nobel TM. This book was released on 2022-11-12 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research and textbook about new advances in human diseases research.
Download or read book Age Related Macular Degeneration written by Weiye Li and published by Elsevier Health Sciences. This book was released on 2021-03-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: A consolidated view of a complex disorder, Age-Related Macular Degeneration, summarizes the latest evidence-based studies and translates these advancements into practical, actionable knowledge. This concise resource covers the fundamentals of age-related macular degeneration (AMD) diagnosis and treatment along with a modern definition of the disorder that acknowledges the range of presentations that ophthalmologists see in real practice. Offering practical, clinical guidance in addition to capturing new therapeutic approaches in the pipeline, this book is an essential reference for ophthalmologists, optometrists, and researchers. Takes a concise, yet comprehensive, approach to AMD, covering both basic science and clinical guidance. Features clinical guidelines on the diagnosis and treatment of AMD, including classification, signs/symptoms, imaging, and differential diagnosis in the pre-optical coherence tomography (OCT) and modern OCT eras. Presents up-to-date information on AMD therapies currently in the development pipeline and offers insights for the future of translational research. Explains molecular genetics and pathogenic events of AMD from both basic and clinical perspectives, which may help readers seek promising new therapeutic targets Contains more than 250 images, with multimodal imaging techniques that clearly demonstrate AMD pathophysiology and clinical pathology.
Download or read book Biomarkers written by William Evans and published by . This book was released on 1991 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on exciting new research at the USDA Human Nutrition Research Center on Aging at Tufts University, this medically-proven program can slow down the aging process and add renewed strength and vitality to readers' lives--no matter what their age. Line drawings and graphs throughout.
Download or read book How Not to Age written by Michael Greger, M.D., FACLM and published by Flatiron Books. This book was released on 2023-12-05 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: Instant New York Times Bestseller Uncover the evidence-based science to slowing the effects of aging, from the New York Times bestselling author of the How Not to Die series When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don’t need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life. Physicians have long treated aging as a malady, but getting older does not have to mean getting sicker. There are eleven pathways for aging in our bodies’ cells and we can disrupt each of them. Processes like autophagy, the upcycling of unusable junk, can be boosted with spermidine, a compound found in tempeh, mushrooms, and wheat germ. Senescent “zombie” cells that spew inflammation and are linked to many age-related diseases may be cleared in part with quercetin-rich foods like onions, apples, and kale. And we can combat effects of aging without breaking the bank. Why spend a small fortune on vitamin C and nicotinamide facial serums when you can make your own for up to 2,000 times cheaper? Inspired by the dietary and lifestyle patterns of centenarians and residents of “blue zone” regions where people live the longest, Dr. Greger presents simple, accessible, and evidence-based methods to preserve the body functions that keep you feeling youthful, both physically and mentally. Brimming with expertise and actionable takeaways, How Not to Age lays out practical strategies for achieving ultimate longevity.
Download or read book Handbook of Mental Health and Aging written by Nathan Hantke and published by Academic Press. This book was released on 2020-04-11 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Mental Health and Aging, Third Edition provides a foundational background for practitioners and researchers to understand mental health care in older adults as presented by leading experts in the field. Wherever possible, chapters integrate research into clinical practice. The book opens with conceptual factors, such as the epidemiology of mental health disorders in aging and cultural factors that impact mental health. The book transitions into neurobiological-based topics such as biomarkers, age-related structural changes in the brain, and current models of accelerated aging in mental health. Clinical topics include dementia, neuropsychology, psychotherapy, psychopharmacology, mood disorders, anxiety, schizophrenia, sleep disorders, and substance abuse. The book closes with current and future trends in geriatric mental health, including the brain functional connectome, repetitive transcranial magnetic stimulation (rTMS), technology-based interventions, and treatment innovations. Identifies factors influencing mental health in older adults Includes biological, sociological, and psychological factors Reviews epidemiology of different mental health disorders Supplies separate chapters on grief, schizophrenia, mood, anxiety, and sleep disorders Discusses biomarkers and genetics of mental health and aging Provides assessment and treatment approaches
Download or read book Clinical Evaluation Criteria for Aging and Aging related Multimorbidity written by Ilia Stambler and published by Frontiers Media SA. This book was released on 2021-10-29 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Genetics and Genomics of Aging written by Juan Carlos Gomez-Verjan and published by Springer. This book was released on 2021-04-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.
Download or read book More than One Health written by Irus Braverman and published by Taylor & Francis. This book was released on 2022-12-01 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume examines the complex entanglements of human, animal, and environmental health. It assembles leading scholars from the humanities, social sciences, natural sciences, and medicine to explore existing One Health approaches and to envision a mode of health that is both more-than-human and also more sensitive to, and explicit about, colonial and neocolonial legacies—urging the decolonization of One Health. While acknowledging the importance of One Health, the volume at the same time critically examines its roots, highlighting the structural biases and power dynamics still at play in this global health regime. The volume is distinctive in its geographic breadth. It travels from Inuit sled dogs in the Arctic to rock hyraxes in Jerusalem, from black-faced spoonbills in Taiwan to street dogs in India, from spittle-bugs on Mallorca’s almond trees to jellyfish management at sea, and from rabies in sub-Saharan Africa to massive culling practices in South Korea. Together, the contributors call for One Health to move toward a more transparent, plural, and just perception of health that takes seriously the role of more-than-humans and of nonscientific knowledges, pointing to ways in which One Health can—and should—be decolonized. This volume will appeal to researchers and practitioners in the medical humanities, posthumanities, environmental humanities, science and technology studies, animal studies, multispecies ethnography, anthrozoology, and critical public health. The Open Access version of chapter 1, available at http://www.taylorfrancis.com/books/e/9781003294085, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. Funded by the Wellcome Trust.
Download or read book Future Directions for the Demography of Aging written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-07-21 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost 25 years have passed since the Demography of Aging (1994) was published by the National Research Council. Future Directions for the Demography of Aging is, in many ways, the successor to that original volume. The Division of Behavioral and Social Research at the National Institute on Aging (NIA) asked the National Academies of Sciences, Engineering, and Medicine to produce an authoritative guide to new directions in demography of aging. The papers published in this report were originally presented and discussed at a public workshop held in Washington, D.C., August 17-18, 2017. The workshop discussion made evident that major new advances had been made in the last two decades, but also that new trends and research directions have emerged that call for innovative conceptual, design, and measurement approaches. The report reviews these recent trends and also discusses future directions for research on a range of topics that are central to current research in the demography of aging. Looking back over the past two decades of demography of aging research shows remarkable advances in our understanding of the health and well-being of the older population. Equally exciting is that this report sets the stage for the next two decades of innovative researchâ€"a period of rapid growth in the older American population.
