Download or read book Retinal Pigment Epithelium in Health and Disease written by Alexa Karina Klettner and published by Springer Nature. This book was released on 2020-01-01 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
Download or read book Retinal Pigment Epithelium in Health and Disease written by Alexa Karina Klettner and published by . This book was released on 2020 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a contemporary resource on one of the major players in retinal diseases - the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Retina in Health and Disease written by Maurice Ptito and published by Mdpi AG. This book was released on 2021-12-27 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy.
Download or read book Retinal Degenerative Diseases written by Matthew M. LaVail and published by Springer Science & Business Media. This book was released on 2011-12-21 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
Download or read book The Pigment Epithelium Its Relationship to the Retina in Health and Disease written by National Eye Institute and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinal Pigment Epithelium and Macular Diseases written by Gabriel Coscas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Documenta Ophthalmologica Proceedings Series collects the scientific papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and the 4th Meeting of the European Macula Group held in Genoa, May 29-June 1, 1996. The Symposium on Retinal Pigment Epithelium was promoted by the University Eye Clinic of Genoa as the natural continuation of the first Symposium held with great success in Genoa in 1988. The previous Meetings of the European Macula Group were held in Coimbra (1988), Crete (1989) and Athens (1994). I was greatly pleased and honoured to host the fourth congress of this distinguished Society and I am grateful to Gabriel Coscas, Jose Cunha-Vaz and George Theodossiadis, found ers of the Society, for selecting Genoa on this occasion. The two meetings integrated well in an unicuum and brought together an exceptional number of outstanding retinal specialists coming from all over the world. All the aspects of the current research concerning retinal pigment epithelial and macular diseases were covered. Several interesting presentations regarded new techniques of retinal and choroidal imaging. A full session was dedicated to the latest advances in culture and transplantation of retinal pigment epithelial cells. Age-related macular degeneration was a major subject for discussion, including new approaches to treatment. This topic was high lighted by a mini-symposium on drusen, including a series of superb lectures on classification, clinicopathological studies, indocyanine green imaging, and laser treatment for prevention of choroidal neovascularization.
Download or read book THE PIGMENT EPITHELIUM ITS RELATIONSHIP TO THE RETINA IN HEALTH AND DISEASE PAPERS PRESENTED AT A SYMPOSIUM NATIONAL EYE INSTITUTE 2 PARTS written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organelle Trafficking in Health and Disease of the Retinal Pigment Epithelium written by Li Xuan Tan and published by . This book was released on 2018 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The retinal pigment epithelium (RPE) is a key site of damage in macular degeneration, which causes irreversible blindness in 30-50 million people globally. Our work aims to elucidate disease mechanisms and identify promising therapeutic targets. Using live-cell imaging, biochemical approaches and a mouse model of disease, this thesis examined the role of organelle trafficking in autophagy and complement regulation, two pathways implicated in macular degeneration. Autophagy is a major cellular clearance pathway essential for maintaining homeostasis in post-mitotic tissues such as the RPE. However, little is known regarding how autophagy is regulated in the RPE. Here, we showed that pathological accumulation of vitamin A metabolites in macular degeneration traps cholesterol in the RPE and inhibits both autophagosome biogenesis and autophagic clearance. Mechanistically, we determined that cholesterol activates acid sphingomyelinase (ASMase), causing increased generation of ceramide. This in turn promotes aberrant stabilization of microtubules and constraints autophagosome trafficking, preventing effective clearance of autophagic substrates. The work in this thesis also establishes a central role for organelle trafficking in regulating protective mechanisms against the abnormal activation of the complement system, which has been implicated in macular degeneration. These novel protective mechanisms in the RPE include accelerated recycling of the complement regulatory protein CD59 to the cell surface, and lysosome exocytosis-mediated membrane repair. Both protective mechanisms are impaired in diseased RPE due to alteration in organelle trafficking, leading to mitochondrial damage and oxidative stress upon exposure to complement. A key RPE function indispensable for vision is the phagocytosis and degradation of photoreceptor outer segments. The thesis characterized sequential interactions of outer segment phagosomes with autophagic machinery as the phagosomes traffic from the cell surface into the RPE. Moreover, outer segment phagocytosis activates transcription factor EB (TFEB), which regulates a vast arsenal of autophagy and lysosomal genes. Thus, the RPE may employ autophagy machineries for efficient clearance of phagocytosed outer segments. Altogether, these studies highlight the importance of organelle trafficking in RPE health and function. Importantly, this research revealed that removing excess cholesterol or inhibiting ASMase using FDA-approved drugs corrects organelle trafficking, thereby restoring autophagy and complement regulation in models of macular degeneration.
Download or read book Das Retinale Pigmentepithel Physiologie und Pathologie written by Alexa Karina Klettner and published by Springer-Verlag. This book was released on 2024-03-11 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Buch bietet eine aktuelle Quelle zu einem der Hauptakteure bei Netzhauterkrankungen - dem Retinalen Pigmentepithel (RPE). Im gesamten Buch werden die physiologische und die pathologische Funktion des RPE gleichberechtigt behandelt, um dem Leser zu helfen, das RPE als Ganzes zu verstehen. Darüber hinaus werden die Entwicklung des RPE in Diagnostik und Therapie sowie einige praktische Erkenntnisse über experimentelle RPE-Modelle behandelt. Retinal Pigment Epithelium in Health and Disease hebt neue Erkenntnisse der RPE-Forschung hervor und enthält den aktuellen Wissensstand zu jedem vorgestellten RPE-Thema. Dieses wichtige Merkmal hebt dieses Buch von anderen Publikationen ab, da die Kapitel nach einem Schema aufgebaut sind, das vom Allgemeinen zum Speziellen führt, um eine präzise Sammlung der bekannten Fakten zu bieten. Die Kapitel sind von namhaften Experten verfasst, die derzeit als Berater, Grundlagenwissenschaftler und Gruppenleiter auf dem Gebiet tätig sind undso eine fachkundige Anleitung zu den aktuellen Aspekten und Zukunftsaussichten dieses Themas bieten.
Download or read book Symposium on the Pigment Epithelium its Relationship to the Retina in Health and Disease written by and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Symposium on the Pigment Epithelium written by and published by . This book was released on 1976 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Embryonic Stem Cells written by Jon Odorico and published by Garland Science. This book was released on 2004-02-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first successful isolation and cultivation of human embryonic stem cells at the University of Wisconsin, Madison in 1998, there has been high levels of both interest and controversy in this area of research. This book provides a concise overview of an exciting field, covering the characteristics of both human embryonic stem cells and pluripotent stem cells from other human cell lineages. The following chapters describe state-of-the-art differentiation and characterization of specific ectoderm, mesoderm and endoderm-derived lineages from human embryonic stem cells, emphasizing how these can be used to study human developmental mechanisms. A further chapter discusses genetic manipulation of human ES cells. The concluding section covers therapeutic applications of human ES cells, as well as addressing the ethical and legal issues that this research have raised.
Download or read book Tissue Barriers in Disease Injury and Regeneration written by Nikolai V. Gorbunov and published by Elsevier. This book was released on 2021-06-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. - Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status - Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium
Download or read book Cell Based Therapy for Degenerative Retinal Disease written by Marco A. Zarbin and published by Springer. This book was released on 2019-03-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.
Download or read book The Retinal Pigment Epithelium written by Michael F. Marmor and published by Oxford University Press, USA. This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The retinal pigment epithelium is a critical tissue within the eye. It lies directly behind the retina, where it provides metabolic support to the photoreceptors and controls their local environment. As a result, the RPE is vital to retinal function, but also a site of aging and disease that cause dysfunction and visual loss. This book brings together comprehensive reviews of basic and clinical science concerning the RPE. It is organized to juxtapose chapters on RPE disease with chapters on the underlying pathophysiology. These include up-to-date accounts of growth factors, laser effects, proliferative vitreoretinopathy, Bruch's membrane pathology, as well as new diagnostic tools such as ocular coherence tomography, in vivo imaging of lipofuscin and non-photic electrical responses. Other chapters cover pharmacology and toxicology, mechanisms of retinal adhesion and detachment, RPE pigments and transport, congenital and dystrophic diseases, animal models of RPE disease, and different aspects of age-related macular degeneration. The history and evolutionary aspects of the RPE are also presented. The contributing authors are experienced clinicians and eminent basic scientists who work on this critical part of the eye. The book will be a valuable resource for anyone interested in the eye, and a necessity for specialists in the fields of retinal physiology and retinal disease.
Download or read book Genetic Diseases of the Eye written by Elias I. Traboulsi and published by OUP USA. This book was released on 2012-01-12 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book takes a clinical approach to the patient with a genetic disease that affects the eye. The chapters on particular types of diseases follow the same organizational format, covering history, pathogenesis and etiology, epidemiology, classification, clinical manifestations and diagnosis, and treatment. The recent progress achieved in the molecular genetics of eye disease is fully reflected throughout the book. It is written by leading experts in the field and provides clinical, molecular genetic and management information on common and rare diseases. The chapters are heavily illustrated and provide a good Atlas for the practicing ophthalmologist or geneticist.
