Download or read book Rescue of Host Innate Immunity in Pigs Infected with Nsp1 Mutant PRRSV written by Duan-Liang Shyu and published by . This book was released on 2015 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porcine reproductive and respiratory syndrome virus (PRRSV) is widespread globally, causing huge economic loss to pig farmers. In infected pigs, PRRSV dysregulates the host innate immunity by inhibition of type I Interferon (IFN-alpha) production and NK cell-cytotoxicity followed by down-regulating the adaptive immunity. Recently, PRRSV non-structural proteins (Nsps) are found to be playing important roles in suppressing the host innate immune response, especially through the viral Nsp1ß protein. In vitro studies have demonstrated rescue in the IFN-alpha production in cells infected with mutant Nsp1ß PRRSV. Therefore, our goal was to evaluate whether in mutant Nsp1ß PRRSV infected pigs there will be a rescue in innate immune response compared to wild-type virus. Our results showed that, in mutant Nsp1ß PRRSV infected pigs the NK cell-cytotoxicity and IFN-alpha production were significantly rescued, which partially increased the production of a vital adaptive immune response inducing anti-viral cytokine IFN-gamma. Furthermore, improvement in adaptive immune responses was supported by substantial increase in the frequency of cytotoxic T cell and memory T cell responses in pigs. In summary, our findings have provided better understanding of the function of PRRSV Nsp1ß protein in pigs, which could help in developing new PRRSV vaccine candidates.
Download or read book The Nidoviruses written by Stanley Perlman and published by Springer. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases. The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting. This represents the only comprehensive book to cover this field in the last five years.
Download or read book Viral Vectors in Veterinary Vaccine Development written by Thiru Vanniasinkam and published by Springer Nature. This book was released on 2020-11-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology.
Download or read book Animal Origin Viral Zoonoses written by Yashpal Singh Malik and published by Springer Nature. This book was released on 2020-09-23 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second volume in the series Livestock Diseases and Management, and reviews the importance and implications of animal origin viral zoonoses. It also highlights the specific etiology and epidemiology of these viral infections and discusses their various biological and mechanical transmission mechanisms. Further, the book reviews various measures for controlling viral zoonoses and examines novel therapeutic and prophylactic strategies. Discussing recent studies on the pathogenesis and host immune response to these infections, it underscores the importance of using vaccines against these viral diseases to reduce the risk of them being transmitted to humans.Lastly, it describes in detail the challenges posed by these viral infections and our readiness to face them.
Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2012-02-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
Download or read book Bee Products Chemical and Biological Properties written by José M Alvarez-Suarez and published by Springer. This book was released on 2017-09-05 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an updated discussion of the chemical composition and biological properties of the main bee products. Specific attention is focused on the beneficial biological activities of bee products in human health. Honey, royal jelly, propolis, bee pollen and bee venom are used as nutriment and in traditional medicine. Their composition is rather variable and depends on the floral source and external factors, such as seasonal, environmental conditions and processing. Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed.
Download or read book The World of Rhabdoviruses written by Z.F. Fu and published by Springer. This book was released on 2014-09-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the unique and common features of rhabdoviruses, which have a very wide host range and are associated with human diseases and also infect domestic livestock and agricultural plants, causing enormous economic loss.
Download or read book The Science of Animal Growth and Meat Technology written by Steven M. Lonergan and published by Academic Press. This book was released on 2018-10-27 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science of Animal Growth and Meat Technology, Second Edition, combines fundamental science- based and applied, practical concepts relating to the prenatal and postnatal growth of cattle, sheep and pigs. It provides the necessary components to understand the production and growth of livestock for safe and quality meat products and presents an understanding of the principles of meat science and technology that is needed to understand the meat industry. Information on the slaughter process of animals, muscle structure and meat tenderness, meat quality, meat safety, and microbiology makes this a valuable self-study reference for students and professionals entering the field. - Describes principles in muscle metabolism, meat quality and meat safety using case studies - Discusses the microbial safety of meat products, primary pathogens of concern, and pathogen detection - Offers solutions on how to control bacterial growth to improve the safety and quality of meat - Presents a new chapter on packaging for meat and meat products that focuses on flexible film technology, packaging materials and equipment technology - Includes new information on inspection systems prior to slaughter, during slaughter, and the inspection of meat processing systems
Download or read book Apoptosis and the Immune System written by Christopher D. Gregory and published by Wiley-Liss. This book was released on 1995-03-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.
Download or read book Clostridia written by Nigel P. Minton and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: To the uninitiated, the genus Clostridium is likely more to be associated with disease than biotechnology. In this volume, we have sought to remedy this misconception by compiling aseries of chapters which, together, provide a practically-oriented handbook of the biotechnologie potential of the genus. Clostridium is a broad grouping of organisms that together undertake a myriad of biocatalytic reactions. In the first two chapters, the reader is introduced to this diversity, both taxonomically and physiologically. In the following chapter, the current state of genetic analysis of members of the genus is reviewed. The remaining chapters concentrate on specific, exploit able aspects of individual Clostridium species-highlighting their range of unique capabilities (of potential or recognized industrial value), particu larly in the areas of biotransformation, enzymology, and the production of chemical fuels. Fittingly, the final chapter demonstrates that even the most toxic of the clostridia can be of therapeutic value. The contributors to this volume reflect the trans national interest in Clostridium, and we are indebted to each of them for making this volume possible. We particularly wish to acknowledge the contributions, both to this volume and to microbiology in general, of Dr. Elizabeth Cato, who, sadly, died shortly be fore publication ofthis volume. Finally, we would like to join the authors in recommending closer and wider consideration of the attributes and capabilities of this genus.
Download or read book Pig Health written by John Carr and published by CRC Press. This book was released on 2018-04-17 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining the health of pigs is vital in pig farming and production. This new book written by experts from around the world focuses on the health of pigs, first with coverage of the disorders of pigs organised by clinical sign and body system. The book explores environmental medicine and then health maintenance. Treatment options are discussed, emphasizing a reduction in antimicrobial use and an increased awareness of a holistic approach to treatment. The book includes over 1,500 high-quality illustrations to enhance the clinical description, as well as a wealth of high-quality videos to test the reader in making differential diagnoses with treatment options. Quizzes at the end of each section also encourage reflective learning. International experts from the UK, USA, Australia, Spain and Taiwan cover clinical examination of the individual pig and groups along with environmental medicine, making this the ideal reference for veterinary practitioners and students. Those interested in population medicine (poultry, aquaculture, cattle and small ruminant and apiaries) will particularly enjoy the holistic approach to veterinary medicine. All those who appreciate the many talents of pigs will enjoy the practical approach to managing the health of their animals. This book moves veterinary science forward, promoting health rather than treating disease. It will be your number one reference for keeping your pigs healthy.
Download or read book Current Therapy in Large Animal Theriogenology E Book written by Robert S. Youngquist and published by Elsevier Health Sciences. This book was released on 2006-11-23 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for both students and practitioners, this comprehensive text provides practical, up-to-date information about normal reproduction and reproductive disorders in horses, cattle, small ruminants, swine, llamas, and other livestock. Featuring contributions from experts in the field, each section is devoted to a different large animal species and begins with a review of the clinically relevant aspects of the reproductive anatomy and physiology of both males and females. Key topics include the evaluation of breeding soundness, pregnancy diagnosis, diagnosis and treatment of infertility, abortion, obstetrics, surgery of the reproductive tract, care of neonates, and the latest reproductive technology. Includes coverage of all large animal species. All sections provide a review of clinically pertinent reproductive physiology and anatomy of males and females of each species. Complete coverage of the most current reproductive technology, including embryo transfer, estrous synchronization, and artificial insemination. A new section on alternative farming that addresses reproduction in bison, elk, and deer. New to the equine section: stallion management, infertility, and breeding soundness evaluation. New to the bovine section: estrous cycle synchronization, reproductive biotechnology, ultrasonographic determination of fetal gender, heifer development, and diagnosis of abortion. New to the porcine section: artificial insemination, boar/stud management, diseases of postpartum period, and infectious disease control. New to the llama section: infectious disease and nutrition.
Download or read book Farm Animal Surgery E Book written by Susan L. Fubini and published by Elsevier Health Sciences. This book was released on 2016-03-01 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Veterinary Medicine** Master the surgical techniques needed to treat large animals! A comprehensive resource, Farm Animal Surgery, 2nd Edition provides clear, step-by-step guidelines to performing common, field-tested surgical procedures. Coverage includes key information such as patient examination and preparation, diagnostic imaging, surgical procedures by body system, anesthesia concerns, fluid therapy, and postoperative management. Written by large animal specialists Susan Fubini and Norm Ducharme, along with a team of expert contributors, this resource is also an invaluable tool in preparing for ACVS or ECVS board exams. - Consistent, logical organization makes it easy to find important information, with each section devoted to a single animal and chapters organized by body system. - Step-by-step guidelines cover bovine, sheep and goat, and swine surgeries by body system. - 775 full-color photographs and anatomic drawings illustrate common disorders, techniques, and equipment for large animal surgery. - Up-to-date information on key surgical techniques keeps you aware of advances in the field and practical knowledge of animal care. - 35 expert contributors provide a diverse, authoritative perspective on the many aspects of large animal surgery. - References are provided for very specialized procedures. - NEW surgical procedures are included for each species — many with illustrated, step-by-step instructions. - NEW coverage of the physical examination includes cow, swine, goats, and sheep, to facilitate more accurate diagnoses of medical or surgical conditions.
Download or read book Emerging Swine Viruses written by Zhenhai Chen and published by Frontiers Media SA. This book was released on 2020-05-13 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tryptophan Serotonin and Melatonin written by Gerald Huether and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), held at the University of Hamburg, Germany, from October 10 to 14, 1998. At this meeting the recent developments in the field of tryptophan research were presented by leading researchers from all over the world in 81 oral and 48 poster contri butions. Research on tryptophan and its derivatives provides an inexhaustible subject. At the conference we tried to compose a multifacetted picture of the recent investiga tions through contributions from the major disciplines involved. Thus, we tried to strike a balance between basic research topics and clinical, nutritional or industrial applica tions. We offered workshops on tryptophan (in sleep and mood), melatonjn, IDO-acti vation and the eosinophilia-myalgia syndrome (EMS) as a platform for intensive discussion for the participants. In these proceedings many contributions are multidisciplinary and have practical or theoretical implications for different research fields. Hence, we have organized this volume in nine main chapters according to basic disciplines and subjects. We are aware that this classification is artificial, but we hope that it is the best compromise for contributors and readers.
Download or read book Avian Influenza Virus written by Erica Spackman and published by Springer Science & Business Media. This book was released on 2008-02-28 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the growing global fear of a major pandemic, avian influenza (AI) virus research has greatly increased in importance. In Avian Influenza Virus, an expert team of researchers and diagnosticians examine the fundamental, yet essential, virological methods for AI virus research and diagnostics as well as some of the newest molecular procedures currently used for basic and applied research. They present exciting, cutting-edge new methods that focus both on studying the virus itself and on work with avian hosts, an area greatly lacking in research.
