Download or read book Regulatory RNAs in the Nervous System 2nd Edition written by Tommaso Pizzorusso and published by Frontiers Media SA. This book was released on 2018-11-13 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics and Epigenetics of Psychiatric Diseases 2nd Edition written by Cunyou Zhao and published by Frontiers Media SA. This book was released on 2020-10-09 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-coding regions, the disease-associated common variants might be enriched in regulatory domains, including enhancers and regions of active chromatin state. These lead us to focus on the possible role of non-sequence-based genomic variation in health and disease. Of particular interest are epigenetic modifications that regulate gene expression through modifications to DNA, RNA, histone proteins, and chromatin. The availability of high-throughput profiling methods for quantifiying epigenomic modifications in large numbers of samples has enabled us to perform epigenome-wide association studies (EWAS) aimed at screening methylomic variations associated with environmental exposure and disease. Thus systematic integration of genetic, epigenetic and epidemiological approaches will contribute to improving our understanding of the molecular mechanisms underlying disease phenotypes.
Download or read book From Molecules to Networks written by John H. Byrne and published by Elsevier. This book was released on 2003-11-10 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.* Highly referenced for readers to pursue topics of interest in greater detail* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks* Richly illustrated, four color presentation throughout* Includes CD-ROM of all of the illustrations
Download or read book microRNAs in Development written by and published by Academic Press. This book was released on 2012-11-15 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. - Concentrates on microRNAs in development - Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA - With an international team of authors, this volume is a must-have addition for researchers and students alike
Download or read book Epigenetic Regulation in the Nervous System written by Jeremy J. Day and published by Elsevier Inc. Chapters. This book was released on 2012-12-31 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book RNA Regulation in Development and Disease written by Maritza Jaramillo and published by Frontiers Media SA. This book was released on 2020-06-15 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Control Second Edition written by David Latchman and published by Garland Science. This book was released on 2015-02-20 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams.The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.
Download or read book Genomic Regulatory Systems written by Eric H. Davidson and published by Elsevier. This book was released on 2001-01-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.* Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Download or read book Development and Reproduction in Humans and Animal Model Species written by Werner A. Mueller and published by Springer. This book was released on 2015-01-03 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes human development including sexual reproduction and stem cell research with the development of model organisms that are accessible to genetic and experimental analysis in readily understandable texts and 315 multi-colored graphics. The introductory account of model organisms selected from the entire animal kingdom presents general principles, which are then outlined in subsequent chapters devoted to, for example, sexual development; genes controlling development and their contemporary molecular-analysis methods; production of clones and transgenic animals; development of the nervous and circulatory systems; regenerative medicine and ageing. Finally the evolution of developmental toolkits and novelties is discussed including the genetic basis of the enlargement of the human forebrain. Separate boxes are devoted to controversial questions such as the benefits and problems of prenatal diagnostics or the construction of ancient body plans.
Download or read book Neuromodulatory Control of Brainstem Function in Health and Disease written by Brian R. Noga and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MCAT Biology Review 2nd Edition written by The Princeton Review and published by Princeton Review. This book was released on 2016-01-05 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make sure you’re studying with the most up-to-date prep materials! Look for the newest edition of this title, The Princeton Review MCAT Biology Review, 3rd Edition (ISBN: 9780593516232, on-sale November 2022). Publisher's Note: Products purchased from third-party sellers are not guaranteed by the publisher for quality or authenticity, and may not include access to online tests or materials included with the original product.
Download or read book Molecular Mechanisms of Neuropathic Pain and Novel Therapeutic Targets written by Wuping Sun and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Program and Proceedings written by Nebraska Academy of Sciences. Annual Meeting and published by . This book was released on with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nature written by Sir Norman Lockyer and published by . This book was released on 2008 with total page 1432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Sclerosis and Related Disorders written by Robert J. Fox, MD and published by Springer Publishing Company. This book was released on 2018-08-28 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and updated second edition of Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, the only comprehensive but practical source of core information on multiple sclerosis and other demyelinating disorders. Intended as a ready reference for clinicians who provide ongoing care to MS patients, this book combines evidence-based science with experience-based guidance to present current standards and management protocols from leading MS centers. Beginning with the scientific underpinnings of MS for clinicians, the book proceeds through diagnosis, including initial symptoms, diagnostic criteria and classification, imaging, and differential diagnosis, and onto approved treatments for the various MS types and emerging therapies. Later parts of the book discuss symptom management and rehabilitation with chapters focusing on specific side effects, along with considerations for special populations, comorbidities, societal and family issues, and related autoimmune disorders that are often mistaken for MS. Throughout, chapters include lists of Key Points both for clinicians and for patients and families, and management pearls are boxed for quick reference and clinical utility. Illustrations, tables, algorithms, assessment scales, and up-to-date MRI imaging enrich the text, making this a wide-ranging clinical reference for all members of the MS care team. New to the Second Edition: Includes summary recommendations from new AAN practice guidelines for use of DMTs All chapters updated to reflect the latest literature and diagnostic criteria Five entirely new chapters added to expand coverage of treatment, rehabilitation and symptom management, and special issues related to MS Treatment section has been completely revised to better capture current approaches to disease modifying therapies, with separate chapters devoted to injection and oral therapies, infusion therapies, and treatments for progressive forms of MS Related autoimmune diseases section significantly expanded to include transverse myelitis, autoimmune encephalitis, and neurosarcoidosis
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1987 with total page 1228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
