Download or read book Regulation of Soluble Immune Mediators by Non Coding RNAs written by Flavia Bazzoni and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Non coding RNA in immunotherapies and immune regulation written by Bertrand Kaeffer and published by Frontiers Media SA. This book was released on 2023-01-02 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Women in Cytokines and Soluble Mediators in Immunity written by Diana Boraschi and published by Frontiers Media SA. This book was released on 2024-02-13 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are delighted to present the inaugural Frontiers in Immunology “Women in Cytokines and Soluble Mediators in Immunity” series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and Science, Technology, Engineering and Mathematics (STEM) research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book STATs and IRFs in Innate Immunity From Transcriptional Regulators to Therapeutic Targets written by Chien-Kuo Lee and published by Frontiers Media SA. This book was released on 2019-10-21 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Exosomes Stem Cells and MicroRNA written by Karl L. Mettinger and published by Springer. This book was released on 2018-05-12 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Download or read book lncRNAs in Cancer Metastasis and Therapy Resistance written by Aamir Ahmad and published by Frontiers Media SA. This book was released on 2023-10-30 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: lncRNAs (long non-coding RNAs) are the relatively longer (more than 200 nucleotides long) subtypes of ncRNAs (non-coding RNAs) i.e the RNAs that do not code for any proteins. However, even without themselves being translated, lncRNAs impact the cellular gene expressions and functions in ways that are just beginning to be explored. The metastasis of human cancers as well as acquired resistance against the administered therapeutics are two major factors responsible for the cancer-associated mortality.
Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Download or read book Roles Of Non coding RNAs In Tumor Growth And Development written by Giovanni Blandino and published by Frontiers Media SA. This book was released on 2023-01-05 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Dendritic Cell Mediated Immune Tolerance and Autoimmunity written by Fang Zhou and published by Frontiers Media SA. This book was released on 2022-01-27 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Dr. Zhou is Employed by Cas Lamvac Biotech Co. Ltd. The Other Topic Editors Declare No Conflict of Interest With Regard to the Research Topic Theme.
Download or read book The Epstein Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Download or read book The Role of ncRNAs in Solid Tumors Prognosis From Laboratory To Clinical Utility written by Jian-Guo Zhou and published by Frontiers Media SA. This book was released on 2021-03-23 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gapmers written by Toshifumi Yokota and published by Humana. This book was released on 2021-09-15 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a comprehensive collection of detailed state-of-the-art protocols for gapmer-mediated RNA knockdown from leaders in the field. Chapters detail a historical and contemporary perspective of RNase H-inducing antisense oligonucleotides called gapmers and gapmer-mediated RNA knockdown for basic research and therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Gapmers: Methods and Protocols aims to provide diverse applications of gapmers along with protocols that will assist readers in moving the frontier.
Download or read book Prominin 1 CD133 New Insights on Stem Cancer Stem Cell Biology written by Denis Corbeil and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.
Download or read book S adenosylmethionine dependent Methyltransferases Structures And Functions written by Robert M Blumenthal and published by World Scientific. This book was released on 1999-07-23 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.
Download or read book Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development Progression and Treatment written by Katherine Chiappinelli and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
