Download or read book Excitation Contraction Coupling and Cardiac Contractile Force written by Donald Bers and published by Springer Science & Business Media. This book was released on 2001-08-31 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Simulation and Imaging of the Cardiac System written by S. Sideman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultrasound velocity tomography allows measurement of cardiac geometries for various phases in the cardiac cycle. The present tomograph makes reconstruc tions at intervals of 20 ms. Because of a lack of clear (intramural) landmarks (except the roots of the papillairy muscle), it is difficult to pinpoint spatial trajectories of particular points in the heart. Therefore, a second method was developed of injecting radiopaque markers in the heart and following their motion patterns during the cardiac cycle with help of a biplane X-ray equipment. The data obtained with both methods can be implemented in our finite element model of the heart to compute intramural stresses and strains. The results obtained sofar with the extended Darcy equation to account for the interaction of blood rheology and tissue mechanics look promising. Further testing with more sophisticated subjects than mentioned in Figure 9 is required before it will be implemented in our finite element model of the heart. We conclude that analysis of regional cardiac function, including regional myocardial blood flow, requires still a major research effort but the results obtained sofar justify, to our opinion, a continuation in this direction. Acknowledgement The authors acknowledge Dr. C. Borst and coworkers for doing the animal experiments and prof. Van Campen and dr. Grootenboer for their participation is some aspects of this work.

Download or read book Physiology And Pharmacology of Cardio Respiratory Control written by Albert Dahan and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: On 15 November 1997, the first international symposium "Neural and Chemical Control of Breathing: Pharmacological and Clinical Aspects" was held at Leiden University Medical Center on the occasion of the retirement of one of the members of the Control of Breathing Research Group of the Departments of Physiology and Anesthesiology, Dr. Aad Berkenbosch. Among others, Dr. Berkenbosch, played an important role in this research group, which made a large and significant contribution to scientific research on the regulation of breathing. This book presents the proceedings of that meeting together with papers of several authors who have strong bonds with the Leiden Departments of Physiology and Anesthesiology. All studies represent state of the art work on the subject of respiratory control and cardiovascular medicine, with emphasis on the physiological, pharmacological and anesthesiological aspects of both fields. The book is divided in several sections: Oxygen Physiology. Prof. John Severinghaus presents among other things his ideas on oxygen sensing and high altitude related diseases. Prof. Honda gives results from studies in a unique set of subjects without carotid bodies. The findings of Honda's group support the idea that an intact hypoxic drive from the carotid bodies is necessary for the generation of central hypoxic depression. Dr. Hans van Beek discusses the effects of hypoxia and hypercapnia on cardiac contractility in animal models. Prof. Oeseburg demonstrates the feasibility of Near Infra Red Oximetry for monitoring tissue oxygenation in patients. Central Chemoreception.

Download or read book Basic Physiology for Anaesthetists written by David Chambers and published by Cambridge University Press. This book was released on 2019-07-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.

Download or read book Cardiovascular Regulation written by David Jordan and published by Ashgate Publishing. This book was released on 1995 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Studies in Physiology series provides a concise introduction to developments in complex areas of physiology for a wide audience. Published on behalf of the Physiology Society, Cardiovascular Regulation provides an up-to-date account of our current understanding of the control of the cardiovascular system that is not covered by existing textbooks. Both students and lecturers of cardiovascular and exercise physiology, medicine, dentistry and biomedical sciences will find this book informative and easy to read. Each chapter has numerous summary boxes. 'Essential reading' suggestions provide additional reading for undergraduates and the suggestions for 'Further reading' cover the subject to postgraduate level.

Download or read book Calcium Signalling and Disease written by Ernesto Carafoli and published by Springer Science & Business Media. This book was released on 2007-09-29 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

Download or read book Heart of the Matter written by Cesare Terracciano and published by Springer Nature. This book was released on 2019-11-01 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed. All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College’s BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine.

Download or read book Essential Clinical Anesthesia Review written by Linda S. Aglio and published by Cambridge University Press. This book was released on 2015-01-08 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, evidence-based board review book, organized according to the ABA keyword list, covers all the fundamental concepts needed to pass written and re-certification board examinations. Each chapter begins with a case scenario or clinical problem from everyday practice, followed by concise discussion and clinical review questions and answers. Discussion progresses logically from preoperative assessment and intraoperative management to postoperative pain management, enhancing the reader's knowledge and honing diagnostic and clinical management skills. New guidelines and recently developed standards of care are also covered. Serving as a companion to the popular textbook Essential Clinical Anesthesia, this resourceful work reflects the clinical experiences of anesthesia experts at Harvard Medical School as well as individually known national experts in the field of anesthesiology. This practical review is an invaluable resource for anesthesiologists in training and practice, whether studying for board exams or as part of continuing education and ABA recertification.

Download or read book Core Topics in Cardiac Anesthesia written by Jonathan H. Mackay and published by Cambridge University Press. This book was released on 2012-03-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition of Core Topics in Cardiac Anaesthesia, the clinical landscape has undergone significant change. Recent developments include the increased use of electrophysiology, the resurgence of primary percutaneous intervention in acute coronary syndromes, the use of percutaneous devices in patients previously considered inoperable, and the withdrawal of aprotinin. Against this landscape, this invaluable resource has been fully updated. New chapters are dedicated to right heart valves, pulmonary vascular disease, cardiac tumours and cardiac trauma. All other chapters have been updated according to the latest international guidelines. Written and edited by an international author team with a wealth of expertise in all aspects of the perioperative care of cardiac patients, topics are presented in an easy to digest and a readily accessible manner. Core Topics in Cardiac Anaesthesia, Second Edition is essential reading for residents and fellows in anaesthesia and cardiac surgery and clinical perfusionists.

Download or read book Perioperative Hemodynamic Monitoring and Goal Directed Therapy written by Maxime Cannesson and published by Cambridge University Press. This book was released on 2014-09-04 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides clinicians and administrators with a comprehensive understanding of perioperative hemodynamic monitoring and goal directed therapy, emphasizing practical guidance for implementation at the bedside. Successful hemodynamic monitoring and goal directed therapy require a wide range of skills. This book will enable readers to: • Detail the rationale for using perioperative hemodynamic monitoring systems and for applying goal directed therapy protocols at the bedside • Understand the physiological concepts underlying perioperative goal directed therapy for hemodynamic management • Evaluate hemodynamic monitoring systems in clinical practice • Learn about new techniques for achieving goal directed therapy • Apply goal directed therapy protocols in the perioperative environment (including emergency departments, operating rooms and intensive care units) • Demonstrate clinical utility of GDT and hemodynamic optimization using case presentations. Illustrated with diagrams and case examples, this is an important resource for anesthesiologists, emergency physicians, intensivists and pneumonologists as well as nurses and administrative officers.

Download or read book Cardiovascular Physiology Concepts written by Richard E. Klabunde and published by Lippincott Williams & Wilkins. This book was released on 2020-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.

Download or read book Pathophysiology of Shock Sepsis and Organ Failure written by Günther Schlag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Download or read book Reflex Control of the Circulation written by Irving H. Zucker and published by CRC Press. This book was released on 2020-02-03 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflex Control of the Circulation presents an interdisciplinary discussion of concepts in the reflex control of circulation. This volume describes aspects of autonomic receptor physiology, central pathways of reflex control, the electrophysiology of cardiovascular afferents, the interaction between reflexes, the autonomic control of regional blood flows, the autonomic control of fluid and electrolyte balance, and neurohumoral control of the circulation through normal and pathological states (e.g., hypertension, congestive heart failure). In addition, the regulation of regional blood flow during exercise and developmental aspects of reflex control are examined. Any researcher interested in the autonomic system and its role in circulation will find this book fascinating reading.

Download or read book Mayo Clinic Cardiology written by Mayo Clinic and published by Oxford University Press. This book was released on 2012-12-06 with total page 1112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to present a comprehensive overview of the field of cardiology in an accessible, reader-friendly format that can be covered in about 12 months, this new edition contains roughly 50% new material, the cardiac pharmacology section has been completely reworked, cardiovascular trials have been included, and the entire book has been updated to reflect current practice guidelines and recent developments. The book is peppered throughout with numerous tables and clinical pearls that aid the student, as well as the teacher, to remain focused.

Download or read book Medical Pharmacology and Therapeutics E Book written by Derek G. Waller and published by Elsevier Health Sciences. This book was released on 2013-08-07 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice