Download or read book Plant Aquaporins written by François Chaumont and published by Springer. This book was released on 2017-02-07 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaporins are channel proteins that facilitate the diffusion of water and small uncharged solutes across cellular membranes. Plant aquaporins form a large family of highly divergent proteins that are involved in many different physiological processes. This book will summarize the recent advances regarding plant aquaporins, their phylogeny, structure, substrate specificity, mechanisms of regulation and roles in various important physiological processes related to the control of water flow and small solute distribution at the cell, tissue and plant level in an ever-changing environment.

Download or read book Aquaporin Regulation written by Gerald Litwack and published by Academic Press. This book was released on 2020-02-13 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Download or read book Nephrology and Fluid Electrolyte Physiology written by William Oh and published by Elsevier Health Sciences. This book was released on 2018-06-25 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. - Stay fully up to date in this fast-changing field with Nephrology and Fluid/Electrolyte Physiology, 3rd Edition. - New chapters on Inherited Disorders of Calcium, Phosphate and Magnesium; Fluid and Electrolyte Management of High Risk Infants; Renal Development and Molecular Pathogenesis of Renal Dysplasia; and Prenatal Programming, which describes how prenatal insults can result in hypertension, kidney and cardiovascular disease. - The most current clinical information, including new content on the molecular basis for hereditary tubulopathies and inherited disorders of calcium, phosphate, and magnesium homeostasis. - New information on genetics and pharmacology, neonatal hypertension, diuretic use in the newborn, prenatal programming of adult diseases, lung fluid balance, and much more. - Consistent chapter organization to help you find information quickly and easily. - The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set!Gastroenterology and NutritionHematology, Immunology and GeneticsHemodynamics and CardiologyInfectious Disease and Pharmacology New Volume!Nephrology and Fluid/Electrolyte PhysiologyNeurologyThe Newborn Lung

Download or read book Aquaporins written by Baoxue Yang and published by Springer. This book was released on 2017-03-03 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 – AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 20 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions.

Download or read book Aquaporins in Health and Disease written by Graca Soveral and published by CRC Press. This book was released on 2020-01-14 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book's epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics. Stimulating future research on this important protein family, this book facilitates a paradigm shift in the understanding and roles of aquaporin membrane proteins in all biological settings. It encourages scientists to develop novel approaches for the treatment of human diseases based on aquaporin function or dysfunction.

Download or read book Fluid Electrolyte and Acid base Physiology written by Mitchell L. Halperin and published by Saunders. This book was released on 1999 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: This popular reference offers well-balanced coverage of fluid, electrolyte, and acid-base disorders. Thorough without going into extraneous detail, it synthesizes key theoretical and clinical information in a way that is easy to understand and apply. The 3rd Edition presents the most recent discoveries about molecular biology...acute and chronic hyponatremia...endogenous acid production...and much more.

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Download or read book Molecular and Cellular Insights to Ion Channel Biology written by Robert A. Maue and published by Gulf Professional Publishing. This book was released on 2004 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Contains fresh perspectives and up-to-date view points from international experts Illustrates the diverse array of techniques applied to ion channel research Represents a valuable resource to both the beginner and expert researcher, with over 2500 references and more than 100 figures and tables.

Download or read book Piezo Channels written by and published by Academic Press. This book was released on 2017-07-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piezo Channels, Volume 79, the latest volume in the Current Topics in Membranes series provides the necessary membrane research to assist readers in discovering the current state of a particular field and future directions. New chapters in the updated volume include A Tour de Force: The Discovery, Properties, and Function of Piezo Channels, Piezo1 Channels in Vascular Development and the Sensing of Shear Stress, the Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels, Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction, and The Structural Basis for Sensing by the Piezo1 Protein. Users of this series will find an up-to-date presentation of the current knowledge in the field of Piezo Channels. - Written by leading experts in the field - Contains original material, both textual and illustrative, that make it a very relevant reference - Presented in a very comprehensive manner - Ideal reference for both researchers in the field and general readers who will find this book to be relevant and up-to-date

Download or read book Vascular Transport in Plants written by N. Michelle Holbrook and published by Elsevier. This book was released on 2011-09-06 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Transport in Plants provides an up-to-date synthesis of new research on the biology of long distance transport processes in plants. It is a valuable resource and reference for researchers and graduate level students in physiology, molecular biology, physiology, ecology, ecological physiology, development, and all applied disciplines related to agriculture, horticulture, forestry and biotechnology. The book considers long-distance transport from the perspective of molecular level processes to whole plant function, allowing readers to integrate information relating to vascular transport across multiple scales. The book is unique in presenting xylem and phloem transport processes in plants together in a comparative style that emphasizes the important interactions between these two parallel transport systems. - Includes 105 exceptional figures - Discusses xylem and phloem transport in a single volume, highlighting their interactions - Syntheses of structure, function and biology of vascular transport by leading authorities - Poses unsolved questions and stimulates future research - Provides a new conceptual framework for vascular function in plants

Download or read book Water Movement Through Lipid Bilayers Pores and Plasma Membranes written by Alan Finkelstein and published by Wiley-Interscience. This book was released on 1987-03-12 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory. Osmotic equilibrium. Osmotic transport (Osmosis) induced by an impermeant solute. Tracer diffusion of water and the relationship between Pf and Pdw. Single-file transport. Osmotic transport (Osmosis) induced by a permeant (Leaky) solute. Lipid bilayer membranes. The unmodified membrane. Nystatin and Amphotericin B. Gramicidin A. Plasma membranes. General considerations. The red cell membrane. Epithelia: antidiuretic hormone (ADH) - induced water permeability.

Download or read book Mineral Nutrition of Higher Plants written by Horst Marschner and published by Gulf Professional Publishing. This book was released on 1995 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the principles of mineral nutrition in the light of current advances. For this second edition more emphasis has been placed on root water relations and functions of micronutrients as well as external and internal factors on root growth and the root-soil interface.

Download or read book TRP Channels as Therapeutic Targets written by Arpad Szallasi and published by Academic Press. This book was released on 2015-04-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. - Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials - Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more - Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2012-07-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.

Download or read book Aquaporins written by Eric Beitz and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.