Download or read book Parkinson s Disease Cell Vulnerability and Disease Progression written by Javier Blesa and published by Frontiers Media SA. This book was released on 2016-01-04 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease.

Download or read book International Ethical Guidelines for Health Related Research Involving Humans written by Council for International Organizations of Medical Sciences (CIOMS) and published by World Health Organization. This book was released on 2017-01-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In the new 2016 version of the ethical guidelines, CIOMS provides answers to a number of pressing issues in research ethics. The Council does so by stressing the need for research having scientific and social value, by providing special guidelines for health-related research in low-resource settings, by detailing the provisions for involving vulnerable groups in research and for describing under what conditions biological samples and health-related data can be used for research."--Page 4 de la couverture.

Download or read book Comparative Quantification of Health Risks Sexual and reproductive health written by Majid Ezzati and published by World Health Organization. This book was released on 2004 with total page 2282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive assessment of the scientific evidence on prevalence and the resulting health effects of a range of exposures that are know to be hazardous to human health, including childhood and maternal undernutrition, nutritional and physiological risk factors for adult health, addictive substances, sexual and reproductive health risks, and risks in the physical environments of households and communities, as well as among workers. This book is the culmination of over four years of scientific equiry and data collection, know as the comparative risk assessment (CRA) project.

Download or read book Mathematical Demography written by David P. Smith and published by Springer Science & Business Media. This book was released on 2013-07-23 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical demography is the centerpiece of quantitative social science. The founding works of this field from Roman times to the late Twentieth Century are collected here, in a new edition of a classic work by David R. Smith and Nathan Keyfitz. Commentaries by Smith and Keyfitz have been brought up to date and extended by Kenneth Wachter and Hervé Le Bras, giving a synoptic picture of the leading achievements in formal population studies. Like the original collection, this new edition constitutes an indispensable source for students and scientists alike, and illustrates the deep roots and continuing vitality of mathematical demography.

Download or read book The Belmont Report written by United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research and published by . This book was released on 1978 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Conservation Biology of Tortoises written by IUCN/SSC Tortoise and Freshwater Turtle Specialist Group and published by IUCN. This book was released on 1989 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Psychosocial Aspects of a Deadly Epidemic written by Judy Kuriansky and published by Bloomsbury Publishing USA. This book was released on 2016-03-21 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a clinical psychologist who has been on the ground helping to develop psychosocial support for Ebola survivors in one of the hardest-hit regions of West Africa, this book explains the devastating emotional aspects of the epidemic and its impact on survivors and the population in West Africa, families in the diaspora, and people in the United States and other countries. It also describes lessons learned from past epidemics like HIV/AIDS and SARS, and valuable approaches to healing from future epidemics. While the devastating Ebola epidemic has been contained, the effects of this outbreak—referred to by the World Health Organization as "the most severe acute public health emergency seen in modern times"—have wreaked a tremendous emotional toll on the populations of West Africa as well as on families and survivors worldwide. This groundbreaking book covers the psychosocial needs, programs, and policies related to the Ebola epidemic and examines broader lessons of the outbreak, such as changes in the ways in which healing from future epidemics can be handled. Edited by Judy Kuriansky, PhD, a noted clinical psychologist and United Nations NGO representative with extensive experience helping after disasters worldwide, and direct experience gained from being "on the ground" in West Africa in the midst of the epidemic, this book identifies and explains universal psychological factors at play in all such crises. It debunks myths regarding Ebola and describes the resulting psychological and social harm caused by the epidemic. The chapters cover overarching emotional issues and problems as well as the long-term impact on at-risk groups, such as children, women, and health workers; the impact of emotional issues on social and economic life; responses of government officials, media, and various aid organizations; and solutions being offered by groups worldwide, including service and humanitarian organizations, politicians, policymakers, and public health education groups.

Download or read book Reproducibility and Replicability in Science written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-10-20 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science.

Download or read book Impact of Science on Society written by and published by . This book was released on 1990 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Sports Medicine and Science written by Yves C. Vanlandewijck and published by John Wiley & Sons. This book was released on 2016-06-07 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the esteemed IOC Handbook of Sports Medicine and Science series, this new volume on Training and Coaching the Paralympic Athlete will be athlete-centred with each chapter written for the practical use of medical doctors and allied health personnel. The chapters also consider the role of medical science in the athlete’s sporting career and summarize current international scientific Paralympic literature. Provides a concise, authoritative overview of the science, medicine and psycho-social aspects of training and coaching disabled and Paralympic athletes Offers guidance on medical aspects unique to the training and coaching of Paralympic athletes Endorsed by both the International Olympic Committee (IOC) and the International Paralympic Committee (IPC) Written and edited by global thought leaders in sports medicine

Download or read book Yearbook of International Organizations written by and published by . This book was released on 1989 with total page 1478 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Geographical Research with Vulnerable Groups written by Nadia von Benzon and published by Routledge. This book was released on 2019-10-23 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on varied expertise from specialisms across the sub-disciplines of social and cultural geography, this book seeks to interrogate what it is to do research with people widely considered to be vulnerable. Written from an emancipatory standpoint, this book addresses the ethical and practical challenges that face researchers working with marginalised people. With chapters exploring the authors’ own experiences of working with a wide range of participants including homeless people, indigenous peoples, drug addicts, learning disabled children, and prisoners, the book draws on research undertaken by academics across the globe. Geographical Research with ‘Vulnerable Groups’ unpicks and interrogates each part of the research process, from obtaining ethics permission from review bodies, to recruitment and gatekeepers, through to dissemination of research findings. Throughout the discussion, authors foreground the relational identities of the actors in the research process, highlighting the ways in which institutional attempts to protect marginalised people from risk, perpetuate a perceived, and even material, vulnerability. This honest and empirically driven text will provide an illuminating insight for researchers embarking on research with marginalised people. The chapters in this book were originally published as a special issue of Social & Cultural Geography.

Download or read book Tobacco and Public Health written by Peter Boyle and published by . This book was released on 2004 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the science and policy issues relevant to one of the major public health disasters of modern times. It pulls together the aetiology and burden of the myriad of tobacco related diseases with the successes and failures of tobacco control policies. The book looks at lessons learnt to help set health policy for reducing the burden of tobacco related diseases. The book also deals with the international public health policy issues which bear on control of the problem of tobacco use and which vary between continents. The editors are an international group distinguished in the field of tobacco related diseases, epidemiology, and tobacco control. The contributors are world experts drawn from the various clinical fields. This major reference text gives a unique overview of one of the major public health problems in both the developed and developing world. The book is directed at an international public health and epidemiology audience includng health economists and those interested in tobacco control.

Download or read book Principles of Nutrigenetics and Nutrigenomics written by Raffaele De Caterina and published by Academic Press. This book was released on 2019-09-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. - Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics - Includes a valuable guide to ethics for genetic testing for nutritional advice - Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts - Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book

Download or read book World Report on Road Traffic Injury Prevention written by Marjorie Peden and published by DIANE Publishing. This book was released on 2008-09 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day thousands of people are killed and injured on our roads. Millions of people each year will spend long weeks in the hospital after severe crashes and many will never be able to live, work or play as they used to do. Current efforts to address road safety are minimal in comparison to this growing human suffering. This report presents a comprehensive overview of what is known about the magnitude, risk factors and impact of road traffic injuries, and about ways to prevent and lessen the impact of road crashes. Over 100 experts, from all continents and different sectors -- including transport, engineering, health, police, education and civil society -- have worked to produce the report. Charts and tables.

Download or read book Practical Tools for Designing and Weighting Survey Samples written by Richard Valliant and published by Springer Science & Business Media. This book was released on 2013-05-16 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Survey sampling is fundamentally an applied field. The goal in this book is to put an array of tools at the fingertips of practitioners by explaining approaches long used by survey statisticians, illustrating how existing software can be used to solve survey problems, and developing some specialized software where needed. This book serves at least three audiences: (1) Students seeking a more in-depth understanding of applied sampling either through a second semester-long course or by way of a supplementary reference; (2) Survey statisticians searching for practical guidance on how to apply concepts learned in theoretical or applied sampling courses; and (3) Social scientists and other survey practitioners who desire insight into the statistical thinking and steps taken to design, select, and weight random survey samples. Several survey data sets are used to illustrate how to design samples, to make estimates from complex surveys for use in optimizing the sample allocation, and to calculate weights. Realistic survey projects are used to demonstrate the challenges and provide a context for the solutions. The book covers several topics that either are not included or are dealt with in a limited way in other texts. These areas include: sample size computations for multistage designs; power calculations related to surveys; mathematical programming for sample allocation in a multi-criteria optimization setting; nuts and bolts of area probability sampling; multiphase designs; quality control of survey operations; and statistical software for survey sampling and estimation. An associated R package, PracTools, contains a number of specialized functions for sample size and other calculations. The data sets used in the book are also available in PracTools, so that the reader may replicate the examples or perform further analyses.

Download or read book Sociological Abstracts written by Leo P. Chall and published by . This book was released on 2003 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: CSA Sociological Abstracts abstracts and indexes the international literature in sociology and related disciplines in the social and behavioral sciences. The database provides abstracts of journal articles and citations to book reviews drawn from over 1,800+ serials publications, and also provides abstracts of books, book chapters, dissertations, and conference papers.