Download or read book Recent Trends in Computational Omics Concepts and Methodology written by Pramod Katara and published by . This book was released on 2020 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade has witnessed various technological advances in life sciences, especially high throughput technologies. These technologies provide a way to perform parallel scientific studies in a very short period of time with low cost. High throughput techniques, mainly, next generation sequencing, microarray and mass spectrometry, have strengthened the omics vision in the last decades (study of complete system) and now resulted in well-developed branches of omics i.e., genomics, transcriptomics, proteomics and metabolomics, which deal with almost every level of central dogma of life. Practice of high throughput techniques throughout the world with different aims and objectives resulted in a voluminous data, which required computational applications, i.e., database, algorithm and software to store, process and get biological interpretation from primary raw data. Researchers from different fields are looking to analyze these raw data for different purposes, but lacking of proper information and knowledge in proper documented form creates different kinds of hurdles and raises the challenges. This book contains thirteen chapters that deal with different computational biology/bioinformatics resources and concepts which are already in practice by the scientific community or can be utilized to handle various aspects of different classes of omics data. It includes different computational concepts, algorithm, resources and recent trends belonging to the four major branches of omics (i.e., genomics, transcriptomics, proteomics and metabolomics), including integrative omics. It will help all scholars who are working in any branch of computational omics and bioinformatics field as well as those who would like to perform research at a systemic biology through computational approaches.
Download or read book Integrative Omics written by Manish Kumar Gupta and published by Elsevier. This book was released on 2024-05-03 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to 'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways
Download or read book Bioinformatics written by Dev Bukhsh Singh and published by Academic Press. This book was released on 2021-10-21 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics: Methods and Applications provides a thorough and detailed description of principles, methods, and applications of bioinformatics in different areas of life sciences. It presents a compendium of many important topics of current advanced research and basic principles/approaches easily applicable to diverse research settings. The content encompasses topics such as biological databases, sequence analysis, genome assembly, RNA sequence data analysis, drug design, and structural and functional analysis of proteins. In addition, it discusses computational approaches for vaccine design, systems biology and big data analysis, and machine learning in bioinformatics.It is a valuable source for bioinformaticians, computer biologists, and members of biomedical field who needs to learn bioinformatics approaches to apply to their research and lab activities. - Covers basic and more advanced developments of bioinformatics with a diverse and interdisciplinary approach to fulfill the needs of readers from different backgrounds - Explains in a practical way how to decode complex biological problems using computational approaches and resources - Brings case studies, real-world examples and several protocols to guide the readers with a problem-solving approach
Download or read book Microbial Omics in Environment and Health written by Minu Kesheri and published by Springer Nature. This book was released on with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genomics of Plant Pathogen Interaction and the Stress Response written by Ashutosh Mani and published by CRC Press. This book was released on 2023-09-25 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are an indispensable part of human and animal lives for nutrition and health. But pests, diseases and abiotic stress adversely affect crop yield, which ultimately places significant pressure on society to provide food to an increasing population. Moreover, it also encourages increased chemical/pesticide usage on crops, which we see in the biomagnification of toxic and hazardous compounds polluting water bodies, soil and the environment. This condition will continue to worsen in the future due to the resistance-acquiring ability of pathogens against plant defense and chemical treatments. In addition, environmental disturbances and consumer health issues are being reported more promptly than before due to intensive use of pesticides in food production. Plant diseases affect our daily lives, as the use of insecticides and pesticides has become part of our food chain. As a result, precise disease diagnosis and management is crucial in order to avoid huge losses in plant production and related commodities. Accurate detection, precise diagnosis and proper management can play a significant role in keeping plants free from pathogens. In this book, scientists, researchers and scholars share their research knowledge, offering a valuable resource for understanding plant diseases, pathogen interaction and responses to stress through an omics perspective, contributing to further advancements in the field Diseases in plants may be caused by various factors, such as viruses, bacteria, fungi and abiotic stress. Disease causes low crop yield, production of poor-quality fruits and grains, and deficiency of nutrients, which have a direct impact on human and animal health. A genomics-based approach can be applied to disease diagnosis; disease outbreak; evolution of plant and pathogen genome for disease outbreak in relation to climate change; and development of long-term strategies for plant health and defense. This book presents an overview of omics technologies and approaches used to understand: 1) the relation between plants and their environment in terms of diseases 2) responses to abiotic stress 3) the genomics of plant–pathogen interaction 4) herbicide-resistance mechanisms 5) the epigenetics of plant–pathogen interaction 6) gene regulation during abiotic stress response 7) the oxidative stress response
Download or read book Computational Systems Biology written by Andres Kriete and published by Academic Press. This book was released on 2013-11-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Emerging Innovative Trends in the Application of Biological Processes for Industrial Wastewater Treatment written by Maulin P. Shah and published by Elsevier. This book was released on 2024-05-22 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Innovative Trends in the Application of Biological Processes for Industrial Wastewater Treatment discusses new and emerging innovative trends in the application of biological processes in industrial wastewater treatment. It also includes the fate of chemicals produced after the treatment process both at the laboratory scale and at the industrial scale. This book explores the unique biological aspects of the wastewater treatment process and highlights the advantages they provide for engineering applications in the industries. Each chapter covers a different biological-based approach and examines the basic principles, practical applications, recent breakthroughs, and associated limitations. Emerging Innovative Trends in the Application of Biological Processes for Industrial Wastewater Treatment also provides in-depth knowledge on the biological process for application in wastewater research which presents an array of cutting-edge wastewater treatment research and thereafter its applications in treatment, remediation, sensing, and pollution prevention processes which has a significant impact on maintaining the long-term quality, availability, and viability of water. - Serves as an easy-to-use guider manual for all the enlisted smart techniques - Describes and discusses the emerging futuristic technologies in industrial pollutants removal from wastewater - Covers advancements in biological treatments, advanced oxidation techniques, and membrane technology to remove water pollutants
Download or read book Protein Interaction Networks written by Rossen Donev and published by Academic Press. This book was released on 2022-07-21 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Interaction Networks, Volume 131 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Protein Chemistry and Structural Biology series - Includes the latest information on protein design and structure
Download or read book Concepts and Techniques in OMICS and System Biology written by Asmat Farooq and published by Elsevier. This book was released on 2024-08-23 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts and Techniques in OMICS and Systems Biology provides a concise and lucid account on the technical aspects of omics, system biology and their application in fields of different life science. With a strong focus on the fundamental principles understanding of metabolomics, ionomics and system biology, the book also gives an updated account on technical aspects of omics and system biology. Since both omics and systems biology fields are fast advancing filed of biological sciences, its significance and applications need to be understood from the baseline. In 10 chapters Concepts and Techniques in OMICS and Systems Biology introduces the reader to both Proteomics, Metabolomics and Ionomics, and System Biology, the technical applications, describes both the software in for proteomics as metabolomic enumeration and preludes Omics technologies and their applications. The chapters are designed in a well-defined chronology such that readers will understand the concepts and techniques involved in omics and system biology. This compilation will be ideal reading material for students, researchers and people working in the industries related to biological sciences. Provides an in-depth explanation of fundamental principles regarding the understanding of metabolomics, ionomics and system biology. Gives updated account on technical aspects of omics and system biology. Includes unique content in its theoretical background, technical approaches and advancements made in omics and systems biology
Download or read book Micronutrients and Metabolic Diseases written by Peng An and published by Frontiers Media SA. This book was released on 2024-03-25 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computer Applications in Pharmaceutical Research and Development written by Sean Ekins and published by John Wiley & Sons. This book was released on 2006-07-11 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.
Download or read book Environmental Microbiology written by Maulin Shah and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-09-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the importance of various emerging technologies that are used to clean up the environment from pollution caused by human activities. It assesses several existing applied and environmental microbiological techniques and introduces new technologies through applied aspects. Select topics covered include municipal wastewater treatment, environmental microorganisms, metal pollutants in the environment, and biogeochemical cycling.
Download or read book Concepts in Cell Biology History and Evolution written by Vaidurya Pratap Sahi and published by Springer. This book was released on 2018-03-01 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses central concepts and theories in cell biology from the ancient past to the 21st century, based on the premise that understanding the works of scientists like Hooke, Hofmeister, Caspary, Strasburger, Sachs, Schleiden, Schwann, Mendel, Nemec, McClintock, etc. in the context of the latest advances in plant cell biology will help provide valuable new insights. Plants have been an object of study since the roots of the Greek, Chinese and Indian cultures. Since the term “cell” was first coined by Robert Hooke, 350 years ago in Micrographia, the study of plant cell biology has moved ahead at a tremendous pace. The field of cell biology owes its genesis to physics, which through microscopy has been a vital source for piquing scientists’ interest in the biology of the cell. Today, with the technical advances we have made in the field of optics, it is even possible to observe life on a nanoscale. From Hooke’s observations of cells and his inadvertent discovery of the cell wall, we have since moved forward to engineering plants with modified cell walls. Studies on the chloroplast have also gone from Julius von Sachs’ experiments with chloroplast, to using chloroplast engineering to deliver higher crop yields. Similarly, advances in fluorescent microscopy have made it far easier to observe organelles like chloroplast (once studied by Sachs) or actin (observed by Bohumil Nemec). If physics in the form of cell biology has been responsible for one half of this historical development, biochemistry has surely been the other.
Download or read book Computational Methods for Multi Omics Data Analysis in Cancer Precision Medicine written by Ehsan Nazemalhosseini-Mojarad and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex and heterogeneous disease often caused by different alterations. The development of human cancer is due to the accumulation of genetic and epigenetic modifications that could affect the structure and function of the genome. High-throughput methods (e.g., microarray and next-generation sequencing) can investigate a tumor at multiple levels: i) DNA with genome-wide association studies (GWAS), ii) epigenetic modifications such as DNA methylation, histone changes and microRNAs (miRNAs) iii) mRNA. The availability of public datasets from different multi-omics data has been growing rapidly and could facilitate better knowledge of the biological processes of cancer. Computational approaches are essential for the analysis of big data and the identification of potential biomarkers for early and differential diagnosis, and prognosis.
Download or read book Systems and Computational Biology written by Ning-Sun Yang and published by BoD – Books on Demand. This book was released on 2011-09-12 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas some "microarray" or "bioinformatics" scientists among us may have been criticized as doing "cataloging research", the majority of us believe that we are sincerely exploring new scientific and technological systems to benefit human health, human food and animal feed production, and environmental protections. Indeed, we are humbled by the complexity, extent and beauty of cross-talks in various biological systems; on the other hand, we are becoming more educated and are able to start addressing honestly and skillfully the various important issues concerning translational medicine, global agriculture, and the environment. The two volumes of this book present a series of high-quality research or review articles in a timely fashion to this emerging research field of our scientific community.
Download or read book Recent Advances in Precision Vaccine Discovery Development written by Ofer Levy and published by Frontiers Media SA. This book was released on 2021-11-23 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Jay Evans is the co-founder, President and CEO of Inimmune Corporation. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
