Download or read book Radiosensitizers and Radiochemotherapy in the Treatment of Cancer written by Shirley Lehnert and published by CRC Press. This book was released on 2014-12-08 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must

Download or read book Radioprotectors and Radiosensitizers written by Nidha Gaba and published by LAP Lambert Academic Publishing. This book was released on 2011-01 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiotherapy is the most common modality for treating human cancers.Eighty percent of cancer patients need radiotherapy, either for curative or palliative purpose. Chemical modification is the concept in cancer therapy in which the state of tumor cells or normal tissues is modified such that the therapeutic gain can be achieved using conventional modalities. Radiosensitizers are the drugs that make cancer cells more sensitive to the effects of radiation therapy. Radioprotectors (also called radioprotectants) are drugs that protect normal (non cancerous) cells from the damage caused by radiation therapy. Therefore, chemical modifier field is developing novel approaches to the cancer treatment and increasing the understanding of the basics of cancer biology.

Download or read book Molecular Targeted Radiosensitizers written by Henning Willers and published by Springer Nature. This book was released on 2020-08-10 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Download or read book Modification of Radiosensitivity in Cancer Treatment written by Tsutomu Sugahara and published by . This book was released on 1984 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Radiochemotherapy in Multimodal Cancer Therapy written by Benjamin Frey and published by Frontiers Media SA. This book was released on 2022-03-02 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Radiation Therapy written by M. Guckenberger and published by Karger Medical and Scientific Publishers. This book was released on 2018-04-12 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.

Download or read book Practical Radiotherapy Chemotherapy Planning written by Mirza Qaiser Baig and published by JP Medical Ltd. This book was released on 2017-03-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to radiotherapy and chemotherapy providing clinicians with the most up to date thinking and latest advances in the field. Divided into five sections, the book begins with an overview of radiotherapy, its planning and techniques, followed by chapters on radiobiology explaining how radiotherapy works in the treatment of cancer. The next section explains the concepts of chemotherapy and common drugs, followed by detailed discussion on the planning and application of both radiotherapy and chemotherapy in the treatment of many different types of cancer. The final part of the book explains general management in oncology, covering the role of steroids and antacids, bleeding and anaemia, and treatment of pain. Key Points Comprehensive guide to radiotherapy and chemotherapy Discusses planning and application of both treatment methods Covers numerous different types of cancer Includes more than 300 images, diagrams and tables

Download or read book Radiation Sensitizers written by N. G. Huilgol and published by CRC Press. This book was released on 2001 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of years of clinical research and trials of a variety of new and promising therapies, cancer remains as a major cause of morbidity and mortality. Use of ionizing radiation in treatment of cancer quickly followed the discovery of X-rays and radioactivity at the dawn of the last century. The limited success of radiotherapy has been attributed to several factors if which the intrinsic radioresistance of tumor cells, their fast reproduction, and tumor hypoxia are the major causes. Radiation Sensitizers: A Contemporary Audit presents data on newer hypoxic cell sensitizers like senazole and deal with old molecules such as chlorpromazine in a new role of sensitization. Bringing together information scattered throughout published and unpublished literature, the book contains contributions from an international panel that examines new therapies and new uses of old therapies. It contains tables and diagrams that illustrate the concepts and make the information easy to find.

Download or read book Particle Radiotherapy written by Arabinda Kumar Rath and published by Springer. This book was released on 2016-03-10 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: The results of decades of research and development are providing compelling evidence about the efficacy of radiation therapy with proton and carbon ion beams to achieve superior complication free tumor control leading to a world-wide rapid growth in their clinical use. This book contains comprehensive reviews of the state of the art of the technology and physics of heavy charge particle therapy by the experts from the leading cancer centers of world that will be valuable as a practical guide for radiation therapy professionals interested in these modalities.

Download or read book Radioimmunotherapy of Cancer written by Paul G. Abrams and published by CRC Press. This book was released on 2000-07-11 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of

Download or read book In Vitro Studies of a New Radiosensitizer for Radiotherapy of Breast Cancer written by Yurui Wu and published by . This book was released on 2015 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most commonly diagnosed cancer among women and is the leading cause of cancer death in both developing and developed areas. Triple-negative breast cancer, one of the subtypes of breast cancer, is generally more aggressive and has fewer treatment options compared with other subtypes, due to the absence of drug-targetable receptors. Radiotherapy delivers ionizing radiation to cancerous areas, leading to DNA damage and cell death. There has been controversy about the molecular mechanism of DNA damage induced by ionizing radiation. According to conventional notions, biological damage by ionizing radiation is primarily induced by the hydroxyl radical, but Lu et al., using femtosecond time-resolved laser spectroscopy, have discovered that the dissociative electron transfer (DET) reaction of the weakly-bound prehydrated electron plays an important role in causing chemical bond and DNA strand breaks. Building on the better understanding of DET reaction mechanisms of prehydrated electron, the mechanism behind the radiosensitizing effect of cisplatin and halopyrimidines has been discovered by our group. However, cisplatin has severe toxicity, and the DET reaction efficiency of halopyrimidines is low. A newly discovered non-platinum-based compound, FMD-Br-DAB, identified through the femtomedicine approach, was tested in this research as a potential radiosensitizer. Our in vitro results have confirmed that FMD-Br-DAB can exert radiosensitizing effects on treated triple-negative breast cancer (MDA-MB-231) cells when combined with radiation. Our results also indicate that FMD-Br-DAB can enhance DNA damage in a dose-dependent manner when combined with radiation.

Download or read book Combining Targeted Biological Agents with Radiotherapy written by William Small, Jr., MD and published by Demos Medical Publishing. This book was released on 2008-06-03 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiotherapy plays an integral role in cancer treatment. Approximately 60% of cancer patients will receive radiotherapy at some point in their treatment. A major improvement in patient outcomes occurs with the use of combined chemotherapy and radiotherapy. The combination of targeted biological agents with radiotherapy is the latest cutting-edge extension in cancer therapy for radiation oncologists. Combining Targeted Biological Agents with Radiotherapy: Current Status and Future Directions is an overview of the current state of clinical and pre-clinical research in combining radiotherapy with targeted biological agents to fight cancer. The text provides a general overview of targeted agents, reviews the current clinical trials, and includes a look at the future of this state-of-the-art practice. This book begins with a general overview of the topic, including an introduction to the subject; the basic science rationale behind the two most important current targeted agents: epidermal growth factor (EGFR) receptors and vascular epithelial growth factor (VEGF) receptors; the dermatologic manifestations of targeted agents; and an introduction to radioimmunotherapy a treatment that has the ability to combine targeted agents directly with radiotherapy. The second half of the book focuses on specific disease sites, including malignant gliomas, head and neck, lung, pancreatic, cervical, and endometrial cancers. Biologically targeted agents promise to be the next significant breakthrough in cancer therapy. Written by leading experts in the field, Combining Targeted Biological Agents with Radiotherapy is a comprehensive evaluation of the entire field.

Download or read book Carbon Ion Radiotherapy written by Hirohiko Tsujii and published by Springer Science & Business Media. This book was released on 2013-12-25 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Download or read book Advanced Topics on Radiosensitizers of Hypoxic Cells written by A. Breccia and published by Springer. This book was released on 1982-05 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clinical Application." Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give the conference the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved a proposal which also came from the Faculty of Pharmacy, to offer an advanced course on the topic "Radiosensitizers of Hypoxic Cells This course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the conference and the course are closely inter-related, it was logical to plan the conference as part of the overall course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy, and the development of drugs for use in cancer in general.

Download or read book Advanced Techniques for Radiotherapy written by Marco Castiglioni and published by Springer. This book was released on 1992 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: For physicians, particularly oncologists, and for specialists involved with the equipment or procedures of nuclear medicine, describes the use of large nuclear installations to treat cancer. Reviews the results obtained with neutrons produced by accelerators of different energies; details the use of nuclear reactors for Boron Neutron Capture Therapy, emphasizing the collaboration between disciplines; surveys the experience of medium- and high- energy accelerators in various laboratories; and the assesses the advantages of Synchrotron light emitted from large electron storage rings in both diagnosis and therapy. No index. Annotation copyright by Book News, Inc., Portland, OR

Download or read book Combined Effects of Chemotherapy and Radiotherapy on Normal Tissue Tolerance written by Jerome M. Vaeth and published by . This book was released on 1979 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimization of Gold Nanoparticle Radiosensitizers for Cancer Therapy written by Lei Cui and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation therapy (RT) plays a pivotal role in cancer treatment, and radiosensitizing agents are widely used to improve the outcome of RT. There is keen interest in the development of new tumor-specific radiosensitizing strategies given that most of the commonly used radiosensitizers are inherently toxic. In recent years, the radosensitizing effects of gold nanoparticles (AuNPs) have been explored extensively. To further optimize radiosensitization by AuNPs, this thesis aims to (1) synthesize and characterize AuNPs with varied physicochemical properties including size, surface coating, and targeting moieties (2) investigate the cellular response (i.e., cell uptake and toxicity) to AuNPs (3) assess the in vitro radiosensitizing effects of AuNPs and identify the key parameters which determine the extent of radiosensitization by AuNPs and (4) evaluate and compare the individual and combined radiation enhancement effects of AuNPs and cisplatin both in vitro and in vivo. Overall, the current work demonstrated that the cell response to AuNPs is highly dependent on a number of factors including the physicochemical properties and concentration of the AuNPs, incubation time with AuNPs, as well as the cell line employed. Importantly, cellular localization of AuNPs and oxygen conditions were shown to be crucial in determining the radiosensitizing effect of AuNPs. The highest level of radiosensitization was observed when AuNPs are internalized, and in cells that are under oxia. In comparison to cisplatin at three doses of IC25, AuNPs administered intratumorally demonstrated an equivalent radiation enhancement effect without showing intrinsic toxicity or increasing the toxicity of IR, as such AuNPs can be considered as a true radiosensitizer. The combination of AuNPs and cisplatin resulted in an additive and significant radiation enhancement effect with fractionated RT, and is thus a promising strategy to be further considered. Future research is warranted on the design of formulations that resulted in improved tumor bioavailability of AuNPs and co-delivery of AuNPs and cisplatin to tumor sites, for the achievement of tumor-specific radiosensitzation, minimal toxicity, and therefore a greater therapeutic window for AuNP aided RT.