Download or read book R ponse immune cellulaire et th rapie de l infection par le VIH written by Yovana Pacheco Nieva and published by . This book was released on 2010 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pendant le traitement antirétroviral de l'infection par le VIH, différents cas d'échecs thérapeutiques peuvent survenir, dans ce travail nous nous sommes intéressés à deux aspects de cet échec: D'une part la grande variabilité du VIH permet au virus d'échapper aux médicaments antirétroviraux et peut être à l'origine d'un échec virologique. Il a été observé que plusieurs mutations de résistances sont localisées au sein des épitopes reconnus par les CTL, suggérant que la réponse immune peut avoir un effet sur les virus résistants. Afin d’étudier cette question, nous avons évalué, la réponse cytotoxique dirigée contre l’épitope RT181-189 chez 34 patients HLA-A2+ séropositif pour le VIH. Cet épitope comprend la mutation M184V, responsable de la résistance virale à la Lamivudine. Chez la majorité des patients en échec virologique sous Lamivudine la réponse contre cet épitope n'est pas présente alors qu'elle est fréquente chez les patients naïfs de traitement. Une étude détaillée sur les facteurs influençant le développement de la réponse à cet épitope a été effectuée. Par ailleurs, chez certains patients la reconstitution du compartiment CD4 n’est pas complète, il s'agit d'un échec immunologique. Dans ce cadre nous avons comparé les effets de trois cytokines (IL-2, IL-7, IL-15) et d'un agoniste de l'IL-15 RLI, sur les CD4+ et CD8+ des patients pour évaluer leur possible rôle thérapeutique dans la reconstitution de l'immunocompétence. Nos résultats montrent que la réponse proliférative des patients à l'IL-7 est préservée chez les patients VIH+ même chez ceux dont le taux de CD4 est faible. L'IL-15 et le RLI induisent une prolifération efficace de la population CD4 effecteur mémoire.
Download or read book Restriction des tapes pr coces de l infection par le VIH 1 et le VIH 2 dans les cellules my lo des et lympho des written by Lise Chauveau and published by . This book was released on 2016 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les Virus de l'Immunodéficience Humaine de type 1 et 2 (VIH-1 et VIH-2) sont des virus proches causant le Syndrome de l'ImmunoDéficience Acquise (SIDA). Cependant, chez les patients infectés par le VIH-2, la progression vers la maladie est plus lente et moins fréquente. Cette différence de pathogénicité est associée à des réponses immunitaires humorales et cytotoxiques plus efficace dans l'infection par le VIH-2.Les caractéristiques du virus influençant ces différences de réponse immunitaire sont peu comprises. Au niveau moléculaire, la protéine accessoire Vpx est présente dans le VIH-2 et pas dans le VIH-I . Vpx dégrade SAMHD1, un facteur cellulaire de défense antivirale actif dans les macrophages, monocytes, cellules dendritiques (DC) et lymphocytes T CD4 non activés. Les DC sont des cibles du virus et constituent une première ligne de défense signalant aux autres cellules immunitaires la présence du virus et induisant des réponses humorale et cytotoxique efficaces. Il est donc important de comprendre les interactions des VIH-1 et 2 avec les cellules dendritiques. Nous montrons ici que grâce à l'expression de Vpx qui dégrade le facteur de restriction SAMHD1, le VIH-2 infecte les lymphocytes T CD4 non activés mais que Vpx n'est pas suffisant pour permettre l'infection des DC Celles-ci sont peu susceptibles à l'infection par les VIH-1 et VIH-2 car elles expriment peu de CD4 à leur surface et la fusion du virus est donc peu efficace. Les DC sont impliquées dans l'initiation de la réponse immunitaire et l'absence d'infection dans ces cellules pourrait être une stratégie virale pour éviter la détection par le système immunitaire et l'induction d'une réponse efficace.
Download or read book Extracorporeal Photochemotherapy written by Francis P. Gasparro and published by R. G. Landes. This book was released on 1994 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Artificial Intelligence in Society written by OECD and published by OECD Publishing. This book was released on 2019-06-11 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The artificial intelligence (AI) landscape has evolved significantly from 1950 when Alan Turing first posed the question of whether machines can think. Today, AI is transforming societies and economies. It promises to generate productivity gains, improve well-being and help address global challenges, such as climate change, resource scarcity and health crises.
Download or read book Beyond AIDS written by George R. Melton and published by . This book was released on 1988 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gender Mainstreaming in HIV AIDS written by and published by Commonwealth Secretariat. This book was released on 2002 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women, especially young women, have increasing infection rates from HIV/AIDS and the death rate among women is now almost as high as men.
Download or read book Biology and Chemistry of Jerusalem Artichoke written by Stanley J. Kays and published by CRC Press. This book was released on 2007-08-13 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique plant on many levels, the distinctive properties of the Jerusalem artichoke, or Helianthus tuberosus L., present novel answers to some of today's most pressing problems. The potential of Jerusalem artichoke as a source for inulin, a fructose polymer that may provide dietary health benefits for obesity, diabetes, and several other health is
Download or read book Antiviral Chemotherapy written by D. J. Jeffries and published by . This book was released on 1995-07-11 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable advances have been made in the treatment of antiviral diseases over the last decade. Several new drugs have been introduced while new clinical information has been gathered on the efficacy of existing drugs. This study aims to provide an examination of the basic science (drug formulae, structure and biochemical activity) and clinical information (usage and efficacy) on chemotherapy, as well as describing future potentials.
Download or read book Comprehensive Cervical Cancer Control written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most women who die from cervical cancer, particularly in developing countries, are in the prime of their life. They may be raising children, caring for their family, and contributing to the social and economic life of their town or village. Their death is both a personal tragedy, and a sad and unnecessary loss to their family and their community. Unnecessary, because there is compelling evidence, as this Guide makes clear, that cervical cancer is one of the most preventable and treatable forms of cancer, as long as it is detected early and managed effectively. Unfortunately, the majority of women in developing countries still do not have access to cervical cancer prevention programmes. The consequence is that, often, cervical cancer is not detected until it is too late to be cured. An urgent effort is required if this situation is to be corrected. This Guide is intended to help those responsible for providing services aimed at reducing the burden posed by cervical cancer for women, communities and health systems. It focuses on the knowledge and skills needed by health care providers, at different levels of care.
Download or read book Pediatric AIDS written by Philip A. Pizzo and published by Lippincott Williams & Wilkins. This book was released on 1998 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recommended in the Brandon/Hill selected list of print books and journals for the small medical library - April 2001 & 2003 The Third Edition of this very popular book offers the most authoritative and comprehensive review of the impact of the HIV disease in infants, children, and adolescents.
Download or read book Cell Wall Deficient Forms written by Lida H. Mattman and published by CRC Press. This book was released on 2000-10-26 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous infectious diseases are described as idiopathic, meaning that "the cause is a complete mystery." For many idiopathic diseases, the causes become clear when certain techniques are applied to the patient's blood or other tissues. Cell Wall Deficient Forms: Stealth Pathogens, Third Edition describes these techniques. In the case of tuberculos
Download or read book Adverse Effects of Pertussis and Rubella Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 1991-01-01 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines: The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome. The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura. The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.
Download or read book Government at a Glance Southeast Asia 2019 written by OECD and published by OECD Publishing. This book was released on 2019-09-10 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Government at a Glance Southeast Asia 2019 is the first edition in the Government at a Glance series for the region. It provides the latest available data on public administrations in the 10 ASEAN member countries: Brunei Darussalam, Cambodia, Indonesia, Lao People’s Democratic Republic, Malaysia, Myanmar, the Philippines, Singapore, Thailand and Viet Nam.
Download or read book Critical Care Nursing written by Linda Diann Urden and published by Saunders. This book was released on 2010 with total page 1242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on critical care nursing, this full-color text provides an examination of the important aspects of critical care nursing. It is organized in ten units around alterations in body systems.
Download or read book Diseases of the Lung written by Nestor Luiz Müller and published by . This book was released on 2003 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively illustrated atlas for radiologists, pulmonologists and pathologists describes the anatomic and pathogenetic bases of various radiologic abnormalities seen in chest disease. Organized according to patterns seen on standard chest radiographs and CT scans (e.g., a solitary pulmonary nodule, multiple cavities, etc.), each pattern is defined and illustrated by a number of cases. Also featured is a succinct background of diseases, including clinical and pathological definition. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Download or read book Clinical Mycology written by William E. Dismukes and published by . This book was released on 2003 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the field of infectious diseases, medical mycology has experienced significant growth over the last decade. Invasive fungal infections have been increasing in many patient populations, including: those with AIDS; transplant recipients; and the elderly. As these populations grow, so does the diversity of fungal pathogens. Paralleling this development, there have been recent launches of several new antifungal drugs and therapies. Clinical Mycology offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.
Download or read book High resolution CT of the Lung written by Wayne Richard Webb and published by . This book was released on 2009 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly revised Fourth Edition of this widely acclaimed volume explains how to use the newest high-resolution CT technology to detect and diagnose lung abnormalities. Still the only complete text on the topic, this compact, affordable reference is written by the foremost experts and provides cutting-edge technical and clinical information. It includes state-of-the-art HRCT scans of interstitial lung diseases and differential diagnosis tables summarizing the most helpful diagnostic features of interstitial and airspace diseases. This edition includes full-color illustrations of histologic findings in lung disease, correlated with HRCT manifestations. Also included are updated HRCT images obtained on multidetector CT scanners with many coronal and sagittal reformations. Two new chapters on the idiopathic interstitial pneumonias detail the differential diagnosis, pathophysiology, histology, clinical manifestations, and HRCT features of these entities. A companion Website will offer the fully searchable text plus an image bank containing all illustrations from the text.
