Download or read book Superbugs written by William Hall (Author of Superbugs) and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Superbugs describes this growing global threat, the systematic failures that have led to it, and solutions that governments, industries, and public health specialists can adopt.--

Download or read book The Perfect Predator written by Steffanie Strathdee and published by Hachette Books. This book was released on 2019-02-26 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.

Download or read book Pseudomonas aeruginosa the Superbug written by Silpi Basak and published by Cambridge Scholars Publishing. This book was released on 2022-07-12 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas aeruginosa is one of the most commonly isolated bacterial species in clinical microbiology laboratories and it causes infections in hospitalized patients with strains resistant to many antimicrobials. In addition, it can form a biofilm especially in cystic fibrosis patients and patients with medical devices. Extracellular polymeric substances (EPS) or extracellular matrixes in biofilm prevent access of antimicrobial agents, disinfectants, and host-produced immune responses. Antimicrobial resistance in Pseudomonas aeruginosa is multifactorial and can be due to mutation, transfer of genes by plasmids, or transposons, among other causes. Production of β-lactamases causes resistance to β-lactam drugs including Carbapenems. Against this background of emergence of antibiotic resistance, this book studies different types of β-lactamases routinely produced by Pseudomonas aeruginosa strains in clinical microbiology laboratories. It shows that, although molecular methods like Polymerase Chain Reaction (PCR) are the gold standard for detection of different types of β-lactamases, they are very costly and require expertise.

Download or read book Superbug written by Maryn McKenna and published by Simon and Schuster. This book was released on 2010-03-23 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: LURKING in our homes, hospitals, schools, and farms is a terrifying pathogen that is evolving faster than the medical community can track it or drug developers can create antibiotics to quell it. That pathogen is MRSA—methicillin-resistant Staphyloccocus aureus—and Superbug is the first book to tell the story of its shocking spread and the alarming danger it poses to us all. Doctors long thought that MRSA was confined to hospitals and clinics, infecting almost exclusively those who were either already ill or old. But through remarkable reporting, including hundreds of interviews with the leading researchers and doctors tracking the deadly bacterium, acclaimed science journalist Maryn McKenna reveals the hidden history of MRSA’s relentless advance—how it has overwhelmed hospitals, assaulted families, and infiltrated agriculture and livestock, moving inexorably into the food chain. Taking readers into the medical centers where frustrated physicians must discard drug after drug as they struggle to keep patients alive, she discloses an explosion of cases that demonstrate how MRSA is growing more virulent, while evolving resistance to antibiotics with astonishing speed. It may infect us at any time, no matter how healthy we are; it is carried by a stunning number of our household pets; and it has been detected in food animals from cows to chickens to pigs. With the sensitivity of a novelist, McKenna portrays the emotional and financial devastation endured by MRSA’s victims, vividly describing the many stealthy ways in which the pathogen overtakes the body and the shock and grief of parents whose healthy children were felled by infection in just hours. Through dogged detective work, she discloses the unheard warnings that predicted the current crisis and lays bare the flaws that have allowed MRSA to rage out of control: misplaced government spending, inadequate public health surveillance, misguided agricultural practices, and vast overuse of the few precious drugs we have left. Empowering readers with the knowledge they need for self-defense, Superbug sounds an alarm: MRSA has evolved into a global emergency that touches almost every aspect of modern life. It is, as one deeply concerned researcher tells McKenna, "the biggest thing since AIDS."

Download or read book Your Medical Mind written by Jerome Groopman and published by Penguin Books. This book was released on 2012-08-28 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Groopman and Hartzband reveal a clear path for making the right medical choices. Such factors as authority figures, statistics, other patients' stories, technology, and natural healing are key factors that shape choices.

Download or read book Textbook of Diagnostic Microbiology written by Connie R. Mahon and published by Saunders. This book was released on 2011 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a solid introduction to the essentials of diagnostic microbiology, this accessible, full-color text helps you develop the problem-solving skills necessary for success in the clinical setting. A reader-friendly, "building block" approach to microbiology moves progressively from basic concepts to advanced understanding, guiding you through the systematic identification of etiologic agents of infectious diseases. Building block approach encourages recall of previously learned information, enhancing your critical and problem solving skills. Case in Point feature introduces case studies at the beginning of each chapter. Issues to Consider encourages you to analyze and comprehend the case in point. Key Terms provide a list of the most important and relevant terms in each chapter. Objectives give a measurable outcome to achieve by completing the material. Points to Remember summarize and help clearly identify key concepts covered in each chapter. Learning assessment questions evaluate how well you have mastered the material. New content addresses bone and joint infections, genital tract infections, and nosocomial infections. Significantly updated chapter includes current information on molecular biology and highlights content on multidrug resistant bacteria. Reorganized chapters accent the most relevant information about viruses and parasites that are also transmissible to humans. Case studies on the Evolve site let you apply the information that you learn to realistic scenarios encountered in the laboratory.

Download or read book Antibiofilm Agents written by Kendra P. Rumbaugh and published by Springer Science & Business Media. This book was released on 2014-05-08 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

Download or read book The Pangenome written by Hervé Tettelin and published by Springer Nature. This book was released on 2020-04-30 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Download or read book Superbugs written by Matt McCarthy and published by Scribe Publications. This book was released on 2019-06-04 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-resistant bacteria — known as superbugs — are one of the biggest medical threats of our time. Here, a doctor, researcher, and ethics professor tells the exhilarating story of his race to beat them and save countless lives. When doctor Matt McCarthy first meets Jackson, a mechanic from Queens, it is in the ER, where he has come for treatment for an infected gunshot wound. Usually, antibiotics would be prescribed, but Jackson’s infection is one of a growing number of superbugs, bacteria that have built up resistance to known drugs. He only has one option, and if that doesn’t work he may lose his leg or even his life. On the same day, McCarthy and his mentor Tom Walsh begin work on a groundbreaking clinical trial for a new antibiotic they believe will eradicate certain kinds of superbugs and demonstrate to Big Pharma that investment in these drugs can save millions of lives and prove financially viable. But there are countless hoops to jump through before they can begin administering the drug to patients, and for people like Jackson time is in short supply. Superbugs is a compelling tale of medical ingenuity. From the muddy trenches of the First World War, where Alexander Fleming searched for a cure for soldiers with infected wounds, to breakthroughs in antibiotics and antifungals today that could revolutionise how infections are treated, McCarthy takes the reader on a roller-coaster ride through the history — and future — of medicine. Along the way, we meet patients like Remy, a teenage girl with a dangerous and rare infection; Donny, a retired firefighter with a compromised immune system; and Bill, the author’s own father-in-law, who contracts a deadly staph infection. And we learn about the ethics of medical research: why potentially life-saving treatments are often delayed for years to protect patients from exploitation. Can McCarthy get his trial approved and underway in time to save the lives of his countless patients infected with deadly bacteria, who have otherwise lost all hope?

Download or read book The Bad Bug Book written by FDA and published by Imp. This book was released on 2004 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bad Bug was created from the materials assembled at the FDA website of the same name. This handbook provides basic facts regarding foodborne pathogenic microorganisms and natural toxins. It brings together in one place information from the Food & Drug Administration, the Centers for Disease Control & Prevention, the USDA Food Safety Inspection Service, and the National Institutes of Health.

Download or read book Understanding the Creeping Crisis written by Arjen Boin and published by Palgrave Macmillan. This book was released on 2021-05-21 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book explores a special species of trouble afflicting modern societies: creeping crises. These crises evolve over time, reveal themselves in different ways, and resist comprehensive responses despite periodic public attention. As a result, these crises continue to creep in front of our eyes. This book begins by defining the concept of a creeping crisis, showing how existing literature fails to properly define and explore this phenomenon and outlining the challenges such crises pose to practitioners. Drawing on ongoing research, this book presents a diverse set of case studies on: antimicrobial resistance, climate change-induced migration, energy extraction, big data, Covid-19, migration, foreign fighters, and cyberattacks. Each chapter explores how creeping crises come into existence, why they can develop unimpeded, and the consequences they bring in terms of damage and legitimacy loss. The book provides a proof-of-concept to help launch the systematic study of creeping crises. Our analysis helps academics understand a new species of threat and practitioners recognize and prepare for creeping crises.

Download or read book OECD Health Policy Studies Stemming the Superbug Tide written by OECD. and published by Org. for Economic Cooperation & Development. This book was released on 2019-01-21 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial resistance (AMR) is a large and growing problem with the potential for enormous health and economic consequences, globally. As such, AMR has become a central issue at the top of the public health agenda of OECD countries and beyond. In this

Download or read book Antimicrobial Resistance in Developing Countries written by Aníbal de J. Sosa and published by Springer Science & Business Media. This book was released on 2009-10-08 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Download or read book Strategies to Overcome Superbug Invasions Emerging Research and Opportunities written by Chopra, Dimple Sethi and published by IGI Global. This book was released on 2021-06-25 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, there has been an upsurge in microbial infections. Extensive and inappropriate usage of antimicrobial drugs in treating infections has led to the evolution of a resistant strain of microorganisms and irreversible immunosuppression in humans. Medical institutions and hospitals require solutions to combat these contagions in order to avoid future epidemics. Strategies to Overcome Superbug Invasions: Emerging Research and Opportunities highlights current research and potential strategies to prevent the emergence and re-emergence of drug-resistant pathogenic microbial strains. The content within this publication examines biosensing, global initiatives, nanomaterials, and alternative therapies. It is designed for microbiologists, biotechnologists, pharmacists, pharmacologists, virologists, formulation scientists, infectious disease specialists, government officials, policymakers, healthcare practitioners, doctors, nurses, hospital directors, researchers, surgeons, and academicians who are seeking research on innovative solutions for multi-drug-resistant infections.

Download or read book Mechanisms of antibiotic resistance written by Jun Lin and published by Frontiers Media SA. This book was released on 2015-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Download or read book Resistance of Pseudomonas Aeruginosa written by Michael Robert Withington Brown and published by John Wiley & Sons. This book was released on 1975 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Microbial Biofilms written by Hilary M. Lappin-Scott and published by Cambridge University Press. This book was released on 2003-09-18 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry and ecology of biofilms from industrial, medical and other viewpoints.