Download or read book The Prostaglandins written by Sultan M.M. Karim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The voluminous literature on prostaglandins includes some excellent reviews. For some time however, there has been a need for the collection in one volume of information from individual experts actively engaged in different aspects of prostaglandin research. This book is an attempt to fulfil that need. In view of the expanding interest and ever-growing accumulation of data of the various effects of prostaglandins it is hoped to revise the book and bring it up-to-date periodically. The largest section is that on reproduction, in which field progress in research and clinical applications thereof have been, and are, of great significance particularly in the area of popula tion control. This is not to decry the skill and efforts of investi gators in other aspects of prostaglandin activity nor the potential biological or therapeutic importance of their findings. In this context, what may appear to be omissions are individual sections on prostaglandin activity in the central nervous system, in the eye and as mediators of the inflammatory response. These are considered in the chapter on General Pharmacology of the Prostaglandins not because they might be considered to be of lesser impact and significance but in order to achieve a rapid publication of the book. S. M. M. KARIM Kampala, Uganda. January 1972. Acknowledgements Tables and Figures previously published are, in general, acknowledged by the reference in the legends and I am grateful to the authors, editors and publishers for their per mission.
Download or read book Prostaglandines Et Physiologie de la Reproduction written by Institut national de la santé et de la recherche médicale (France) and published by . This book was released on 1980 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostaglandins written by David F. Horrobin and published by . This book was released on 1978 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostaglandins Leukotrienes and the Immune Response written by John L. Ninnemann and published by Cambridge University Press. This book was released on 1988-09-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.
Download or read book The Prostaglandins written by Peter Ramwell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is much evidence to suggest that prostaglandins may have a physiological role to play in the control of thyroid gland metabolism, although the precise nature of this role remains to be defined. Prostaglandins have been found in normal thyroid tissue, and there is evidence of increased levels in some, but not all, cases of medullary carcinoma of the thyroid. which may account for the associated diarrhea. Exogenous prostaglandins, like TSH, bind to thyroid plasma mem branes, stimulate the adenylate cyclase-cyclic AMP system, thyroid hormone secretion, iodide organification, colloid droplet formation, glucose oxidation, and 32p incorporation into phospholipids. Prosta glandins of the E series are the most potent, although their maximal effects are generally less than the maximal effects of TSH. The interrelationships existing between TSH and prostaglandins have been the subject of intensive investigation, but as yet no one uni fying concept has emerged. TSH and prostaglandins have been shown to occupy different receptors on the thyroid plasma membrane. Al though TSH can increase intracellular prostaglandin levels, probably as a result of increased synthesis, prostaglandins do not appear to be essential intermediates in TSH action on adenylate cyclase. The pos sibility that prostaglandins are part of a negative feedback system con trolling TSH action is, as yet, a tentative hypothesis, and further work will be required to unravel the interrelationships between these sub stances that now appear to be far more complex than has been envisaged thus far.
Download or read book Prostaglandins and Related Substances written by and published by Elsevier. This book was released on 1983-01-01 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins and Related Substances
Download or read book The Prostaglandin System written by F. Berti and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandin research is one of the most explosive fields in the biological science, and there have been a number of international symposia on this subject. In planning the second Advanced Course in Erice (Sicily) at the "Ettore Majorana" center it was realized that large congresses might not represent the best way to facilitate communication within specialized areas of biologic and medical research. In fact small meetings where in depth discussion is confined to a limited number of scientists, are now generally considered successful vehicles of scientific information. With this in mind, we made an effort in collecting a number of experts in both experimental and clinical use of these important arachidonate metabolites. We have been very fortunate in bringing together a faculty of international authorities who contributed to the course with brilliant presentations and lively discussion. Thus, this book represents an up-to-date overview of the physiology and pharmacology of different products derived from arachidonic acid metabolism, associated with outstanding suggestions of their clinical potential. It is our hope that from this Advanced Course, and its resulting publication, new ideas concerning the physio pathological role of these compounds will arise together with new directions for future research. We are deeply indebted to NATO for its interest and generous support which made this Second Course a reality.
Download or read book Practical Applications of Prostaglandins and their Synthesis Inhibitors written by Sultan M.M. Karim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the fourth in a series of books on Advances in Prostaglandin Research published by MTP Press. From laboratory and animal studies a large number of practical applications of prostaglandins have been identified. In some areas clinical trials have also been carried out. There is usually a long time interval between identifying practical applications of new drugs and clinical trials. Most of the information on practical applications of prostaglandins is scattered in different journals. Although a number of books dealing with prostaglandin research have been published (including some on practical applications in specific areas, e.g. reproduction) there is no single volume dealing with all areas of practical applications of these substances. This book aims at filling this gap and should be of interest to clinicians as well as to medical and basic scientists in academic institutions and in the pharmaceutical industry. In some areas, exciting potential applications of prostaglandins have been identified from basic research but clinical trials have so far not been carried out. Such areas of practical applications are covered in a separate intro ductory chapter. All contributors to the volume are scientists and clinicians actively engaged in prostaglandin research and most are recognized authorities in specific areas. The need for rapid publication in a fast-expanding field is obvious.
Download or read book The Prostaglandins written by Peter Ramwell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostaglandins written by Eric W. Horton and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was written at the invitation of Dr. H. GOTZE of Springer-Verlag for the series "Monographs in Endocrinology". It is not a comprehensive account of the prostaglandins but has been writ ten with a deliberate emphasis upon those aspects of the field in which I am particularly interested and to which, in some cases, I have made a contribution. I am grateful to Miss E. PFISTERER and her colleagues of Springer Verlag for their excellent work. I should also like to thank my wife without whose patience, encouragement and help this book would never have been completed. Finally this is an appropriate time to express my sincere gratitude to those scientists who over the years have given me samples of prostaglandins-namely Professors S.BERGSTROM and B.SAMUELSSON of the Karolinska Institute, Stockholm, Professor D. A. VAN DORP of the Unilever Research Laboratories, Vlaardingen and Dr. J. E. PIlm of the Upjohn Company, Kalamazoo. Without their help work in this field would have been extremely difficult.
Download or read book Recent Advances in Prostaglandin Thromboxane and Leukotriene Research written by Helmut Sinzinger and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Symposium on Prostaglandins and Related Compounds, first held in Vienna 1972, revisited the city after 24 years for the 10TH Symposium. For the many re searchers working in this multi-disciplinary field it was an opportunity to exchange their ex periences and share new data with colleagues from all around the world. This scientific exchange was largely encouraged by the unseasonably cold and rainy weather. For the first time, there was quite a large attendance from the former Communist countries. Eugene Garfield prepared a key note address delivered during the meeting (The Sci entist 1996, 12) reviewing the contribution of the Nobel Laureates U.S. von Euler, l.R. Vane, S.K. Bergstrom, and B.I. Samuelsson, discussing the relevance of the more than 40,000 pa pers in this area published since 1991. Overall, there is still a rapidly growing interest, and in particular a great variety of clinical applications of this family of compounds which were dis cussed in detail during the meeting. Beside the lectures there were 19 workshops covering nearly all the topics of key in terest. All the speakers were invited to prepare a manuscript which has resulted in the volume now in your hands. Special thanks to Dr. Patrick Wong and the new publisher of this series who helped to publish the proceedings in the usual quality and reasonable period of time. Looking forward to seeing all of you again in Florence in 1999, hopefully with much more sun.
Download or read book Prostaglandins and Immunity written by James S. Goodwin and published by Springer Science & Business Media. This book was released on 1985-04-30 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Download or read book The Prostaglandins written by M. F. Cuthbert and published by Elsevier. This book was released on 2016-01-26 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Prostaglandins: Pharmacological and Therapeutic Advances provides a concise account of the more important theoretical developments and areas in which the prostaglandins are being introduced into clinical practice or have potential clinical application. Chapters I to IV of this book deal with the chemistry and classification, distribution and metabolism, general pharmacology, and mechanism of action. The rest of the chapters discuss the relationship of the prostaglandins to the reproductive, cardiovascular, respiratory, and gastro-intestinal systems with an emphasis on the human pharmacology and potential therapeutic applications. This text also includes the speculations and suggestions of contributors regarding the possible and further use of the prostaglandins. This publication is a good reference for biochemists and medical students concerned with the potential of prostaglandins.
Download or read book Prostaglandins in Cancer Research written by Enrico Garaci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol ume is based on papers presented at the 1986 International Confer ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos sible use of some of these compounds as antineoplastic agents.
Download or read book Prostaglandins written by James B. Lee and published by Elsevier Publishing Company. This book was released on 1982 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostaglandins written by P. B. Curtis-Prior and published by North-Holland. This book was released on 1976 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Prostaglandin Leukotriene and other Bioactive Lipid Research written by Zeliha Yazici and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the Proceedings of the 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research: Basic Science and Clinical Applications, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid research with special attention to cancer, cardiovascular diseases, gastrointestinal diseases and respiratory diseases. Specific topics covered include the role of leukotrienes and lipoxins in inflammation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
