Download or read book Prognostic Factors in Cancer written by Paul Hermanek and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. K. Gospodarowicz, P. Hermanek, and D. E. Henson Attention to innovations in cancer treatment has tended to eclipse the importance of prognostic assessment. However, the recognition that prognostic factors often have a greater impact on outcome than available therapies and the proliferation of biochemical, molecular, and genetic markers have resulted in renewed interest in this field. The outcome in patients with cancer is determined by a combination of numerous factors. Presently, the most widely recognized are the extent of disease, histologic type of tumor, and treatment. It has been known for some time that additional factors also influence outcome. These include histologic grade, lymphatic or vascular invasion, mitotic index, performance status, symptoms, and most recently genetic and biochemical markers. It is the aim of this volume to compile those prognostic factors that have emerged as important determinants of outcome for tumors at various sites. This compilation represents the first phase of a more extensive process to integrate all prognostic factors in cancer to further enhance the prediction of outcome following treatment. Certain issues surround ing the assessment and reporting of prognostic factors are also considered. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5].

Download or read book Prognosis in Advanced Cancer written by Paul Glare and published by Oxford University Press. This book was released on 2008-03-20 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to make decisions and offer quality health care, it is essential to be able to predict survival and other outcomes. This practical, evidence-based book brings together prognosis information for patients with advanced cancer.

Download or read book Prognosis Research in Healthcare written by Richard D. Riley and published by Oxford University Press. This book was released on 2019-01-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: "What is going to happen to me?" Most patients ask this question during a clinical encounter with a health professional. As well as learning what problem they have (diagnosis) and what needs to be done about it (treatment), patients want to know about their future health and wellbeing (prognosis). Prognosis research can provide answers to this question and satisfy the need for individuals to understand the possible outcomes of their condition, with and without treatment. Central to modern medical practise, the topic of prognosis is the basis of decision making in healthcare and policy development. It translates basic and clinical science into practical care for patients and populations. Prognosis Research in Healthcare: Concepts, Methods and Impact provides a comprehensive overview of the field of prognosis and prognosis research and gives a global perspective on how prognosis research and prognostic information can improve the outcomes of healthcare. It details how to design, carry out, analyse and report prognosis studies, and how prognostic information can be the basis for tailored, personalised healthcare. In particular, the book discusses how information about the characteristics of people, their health, and environment can be used to predict an individual's future health. Prognosis Research in Healthcare: Concepts, Methods and Impact, addresses all types of prognosis research and provides a practical step-by-step guide to undertaking and interpreting prognosis research studies, ideal for medical students, health researchers, healthcare professionals and methodologists, as well as for guideline and policy makers in healthcare wishing to learn more about the field of prognosis.

Download or read book Prognostic Factors in Cancer written by Mary K. Gospodarowicz and published by Wiley-Liss. This book was released on 2001-04-16 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prognostic Factors in Cancer, Second Edition updates the first authoritative monograph on prognostic factors and their use in planning treatment for cancer patients. The text is an extension of the work of the International Union Against Cancer (UICC) on the TNM Classification of Malignant Tumours and their current focus on prognostic factors in cancer. The TNM classification is the most widely used system for staging the progression of cancer. The anatomic extent of disease represented by the TNM system is the single most important predictor for outcomes of most tumors. Prognostic Factors in Cancer, Second Edition is divided into two parts. The first section examines prognosis in general and more specifically prognosis in cancer patients, including issues surrounding accuracy of measurement of prognosis, the methodology of studying and classifying prognostic factors, and the application of prognostic factors in clinical decision-making in the treatment of cancer. The second section provides chapters on site-specific or tumor-specific neoplasms and the prognostic factors associated with them. These chapters contain an overview of the relevant literature and include summaries that classify prognostic factors according to subject and relevance. Prognostic Factors in Cancer, Second Edition illustrates the scope of the field as it stands today, and will provide perspective on likely outcomes of neoplastic disease for all physicians and others responsible for the care of patients with cancer.

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Download or read book Tietz s Applied Laboratory Medicine written by Mitchell G. Scott and published by John Wiley & Sons. This book was released on 2007-02-26 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a problem-based approach, Tietz's Applied Laboratory Medicine, Second Edition presents interesting cases to illustrate the current use and interpretation of the most commonly available clinical laboratory tests. The cases present detailed descriptions of the symptoms, diagnosis, and treatment of disease. The book begins with an up-to-date general discussion of selection and use of laboratory diagnostic and prognostic tests. Cases are then grouped by category, including cardiovascular, pulmonary, renal, liver, gastrointestinal, endocrine, gynaecologic & obstetrical, haematological, CNS, lipid, congenital, toxicological, infectious, and autoimmune diseases. Tietz's Applied Laboratory Medicine, Second Edition: Presents over 100 cases organised by disease group Reflects latest treatment and risk factor guidelines, testing algorithms and recommendations Newly covers coagulopathies, infectious diseases, and autoimmune diseases Provides excellent coverage of relevant pathophysiology and biochemistry, and includes cases in molecular diagnostics Discusses legal implications This book is an invaluable resource for all clinical chemists, clinical lab technologists, pathologists, and allied health professionals. It is also of interest for general practitioners, residents, medical students, and educators.

Download or read book Urological Pathology written by Mahul B. Amin and published by Lippincott Williams & Wilkins. This book was released on 2013-11-14 with total page 2443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge in the field of urologic pathology is growing at an explosive pace. Today’s pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology!

Download or read book Pointers to Cancer Prognosis written by B.A. Stoll and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 30 years have seen little improvement in the age-adjusted mortality rates for most common types of cancer, and until we develop more effective and less damaging treatment modalities for these tumours, selection of each patient's treatment must depend on prognostic pointers. These lead to a calculated trade off between our estimate of likely benefit to the patient, as against cost in terms of quality of life. But changes have occurred recently in our understanding of the traditional prognostic pointers used for selecting such individualised treatment. First, it is increasingly recognised that the stage at which a tumour presents is more related to the chromo logical age of the tumour (how far it has progressed before diagnosis) than to its biological characteristics. While advanced chronological age of the tumour may predict a greater likelihood of early death, only biological criteria can predict the tumour growth rate, the likelihood of prolonged survival, the likely course of the disease after the first recurrence or the likehood of response to systemic therapy. Second, there is increasing use of failure analysis in relating the clinical and biological characteristics of tumours to their response to standard treatments. In the past, the relationship was interpreted mainly in terms of survival rate, but the site and timing of first recurrence and the pattern and timing of subsequent spread provide a better assessment of the control possible from local or systemic therapy.

Download or read book The Frailty Model written by Luc Duchateau and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Readers will find in the pages of this book a treatment of the statistical analysis of clustered survival data. Such data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public health and demography. A typical example is the time to death in cancer patients, with patients clustered in hospitals. Frailty models provide a powerful tool to analyze clustered survival data. In this book different methods based on the frailty model are described and it is demonstrated how they can be used to analyze clustered survival data. All programs used for these examples are available on the Springer website.

Download or read book Prognostic and Predictive Factors in Breast Cancer written by Rosemary A Walker and published by CRC Press. This book was released on 2019-08-30 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER-2. Given the wealth of information in the medical literature on breast cancer, this volume is useful in that it focuses strictly on these factors. That focus makes this text extremely useful for oncologists and researchers who want to learn more about best practices in prognoses.

Download or read book CNS Cancer written by Erwin G. Van Meir and published by Springer Science & Business Media. This book was released on 2009-08-15 with total page 1294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

Download or read book Malignant Mesothelioma written by Harvey I. Pass and published by Springer Science & Business Media. This book was released on 2006-08-01 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malignant Mesothelioma brings together the most current diagnostic criteria and treatment plans from the world’s leading experts on this rare but devastating cancer. The first edition was a critical and commercial success and this revision builds on that reputation. The editors have brought together the world’s leading experts to fully explore the latest scientific breakthroughs in carcinogenesis, immunotherapy, potential vaccination strategies, and gene therapy. The clinical aspects of the book are equally strong, with thorough discussion of epidemiology, etiology, different clinical presentations, imaging (including interventional pulmonology), treatment of benign disease, strategies for multimodality treatment of malignant disease. Editors: Harvey I. Pass, M.D, Chief, Thoracic Surgery, New York University, New York, NY; Nicholas Vogelzang, M.D, Director, Nevada Cancer Institute, Las Vegas, NV; University of Chicago, Michele Carbone, M.D., Ph.D, Researcher and Director, Thoracic Oncology Program, Cancer Research Center of Hawaii, Honolulu, HI; and Anne S. Tsao, M.D, Department of Thoracic/Head & Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.

Download or read book Cancer Therapy written by Maurice J. Staquet and published by . This book was released on with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Therapy written by Maurice J. Staquet and published by Lippincott Williams & Wilkins. This book was released on 1975 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Kuerer s Breast Surgical Oncology written by Henry Kuerer and published by McGraw Hill Professional. This book was released on 2010-07-01 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete multidisciplinary guide to breast surgical oncology Includes DVD with surgical video clips and breast ultrasound atlas A Doody's Core Title for 2011! A British Medical Association Book Awards Runner-up, Oncology category! "Kuerer's new textbook of Breast Surgical Oncology is a comprehensive volume that contains exceptionally detailed and thorough information about the diverse aspects of breast cancer care, and would serve as a valuable resource for any breast cancer clinician, regardless of their specialty. ... (the book) is easy to read and navigate, where clinicians can quickly obtain reliable, up-to-date information on a broad range of topics relevant to breast cancer. --Annals of Surgery, August 2010 4 STAR DOODY'S REVIEW! "...a comprehensive and authoritative synthesis of current information is sorely needed, and this book fulfills that need admirably....The figures (many in color) and tables reproduce beautifully. The chapters on ultrasound, clinical trials, and plastic surgery, are particularly valuable. This is a terrific and incredibly useful book on breast surgical oncology, and will be an important reference in the field."--Doody's Review Service Written by an internationally recognized multidisciplinary team of authors, Kuerer's Breast Surgical Oncology is the first text specifically dedicated to breast surgical oncology. Turn to any page, and you’ll find cutting-edge, evidence-based information and insights—supplemented by a full-color presentation and a companion DVD—all designed to help provide a solid foundation for current and future best practices. Kuerer's examines all clinically relevant knowledge in the field, from the pathology of the breast and clinical management, to follow-up and complications following diagnosis and therapy. The book also focuses on the next wave of molecular studies that represent the future of the discipline. Features Complete integration of the relevant disease pathology with clinical management Major sections on both oncoplastic and advanced operative management procedures An entire section on landmark breast cancer clinical trials that highlights essential knowledge and evidence in the field Full-color design with 750 illustrations that depict anatomy, breast cancer pathology, and trial results A DVD with surgical video clips that details some of the important surgical techniques and procedures featured in the text An entire section on breast imaging and an atlas on breast ultrasound and biopsy techniques that facilitate accurate diagnosis and treatment Timely, special chapter on the influence of the media and the internet on breast cancer care and the funding of breast cancer research A detailed overview of currently open and accruing clinical trials, along with the future critical questions that must be answered to move the field forward Coverage of molecular findings that provides an enhanced perspsective on the full spectrum of malignancies with which they work

Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Download or read book Current Research in Head and Neck Cancer written by Henning Bier and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research.