Download or read book Clinical Applications of Mifepristone RU486 and Other Antiprogestins written by Institute of Medicine and published by National Academies Press. This book was released on 1993-02-01 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market. This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research.
Download or read book The Antiprogestin Steroid RU 486 and Human Fertility Control written by Etienne-Emile Baulieu and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in basic biological research have proceeded rapidly in recent years. The fields of molecular genetics and immunology have experienced dramatic breakthroughs, capturing the imagination of both the scientific community and the general public. With less public notice, receptor biology has brought a cascade of new discoveries and insights. The entire science of pharmacology has been virtually rewritten in terms of receptor phenomenology. In particular, the discovery of specific receptors for steroid and protein hormones has been of seminal importance. With this new information, we have advanced our understanding of the mechanism and specifity of hormone action. We can now explain how hormones interact selectively with specific target cells and how hormones alter biochemical events within the target cells. These facts have already impacted on applied problems of clinical medicine, particularly in diagnosis and treatment of cancer and some metabolic diseases. Now, a new and important application of basic receptor biology and chemistry looms ahead. Within a few short years since the discovery of the progesterone receptor, chemists have synthesized molecules with a greater affinity for the receptor than progesterone itself and which, while occupying the receptor, fail to trigger the events which transform a target cell from the unstimulated to the stimulated state. This is the basis of the competitive inhibitory action of the anti-progestational agent, synthesized by the chemists at Roussel Uc1af, Paris, and designated RU 486.
Download or read book Contraceptive Research and Development written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-04 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "contraceptive revolution" of the 1960s and 1970s introduced totally new contraceptive options and launched an era of research and product development. Yet by the late 1980s, conditions had changed and improvements in contraceptive products, while very important in relation to improved oral contraceptives, IUDs, implants, and injectables, had become primarily incremental. Is it time for a second contraceptive revolution and how might it happen? Contraceptive Research and Development explores the frontiers of science where the contraceptives of the future are likely to be found and lays out criteria for deciding where to make the next R&D investments. The book comprehensively examines today's contraceptive needs, identifies "niches" in those needs that seem most readily translatable into market terms, and scrutinizes issues that shape the market: method side effects and contraceptive failure, the challenge of HIV/AIDS and other sexually transmitted diseases, and the implications of the "women's agenda." Contraceptive Research and Development analyzes the response of the pharmaceutical industry to current dynamics in regulation, liability, public opinion, and the economics of the health sector and offers an integrated set of recommendations for public- and private-sector action to meet a whole new generation of demand.
Download or read book Progesterone and Progestins written by C. Wayne Bardin and published by Raven Press (ID). This book was released on 1983 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Primate Endometrium written by Carlo Bulletti and published by . This book was released on 1991 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sex and Gender Differences in Pharmacology written by Vera Regitz-Zagrosek and published by Springer Science & Business Media. This book was released on 2012-10-02 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.
Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Download or read book The Handbook of Contraception written by Donna Shoupe and published by Springer Nature. This book was released on 2020-09-22 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an up-to-date and comprehensive review of female contraception, offering an extensive overview of contraception types, including oral, injectable, emergency, and various cervical barrier contraceptives. It also discusses behavioral and sterilization methods of contraception as well as the clinical effectiveness, advantages, disadvantages, side effects, and mechanisms of action of each method. Now in its fully revised and expanded third edition, this text includes seven new chapters that address specific clinical issues that healthcare providers face daily. These issues include patients with medical problems, perimenopausal women, the adolescent population, post-pregnancy patients, patients with bleeding problems, fibroids or hyperplasia, obese patients and patients with acne or hirutism. There is also a new chapter dedicated to contraceptive methods that are currently in development. Each chapter reviews the correct use of the individual method, the most appropriate candidates, timing of initiation, red flag contraindications, risks and benefits, method of action, handling side effects, non-contraceptive benefits, switching methods and the CDC Medical Eligibility for the method. Importantly however, there is a new emphasis placed on standardized evidence-based practice recommendations incorporating the most recent US Selected Practice Recommendations and rationale as published by the US CDC. Written by experts in the field, The Handbook of Contraception, Third Edition, is a valuable resource for obstetricians, gynecologists, reproductive medicine specialists and primary care physicians.
Download or read book Handbook of Brain Tumor Chemotherapy written by Herbert B. Newton and published by Elsevier. This book was released on 2005-12-19 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including "targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy. - Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors - Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors - Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors
Download or read book Endometriosis written by Sics Editore and published by SICS Editore. This book was released on 2014-10-01 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is an oestrogen-dependent disease and is usually not encountered after menopause. Endometriosis-associated pain is treated with drugs that suppress oestrogen secretion in the ovaries. Hormonal products used to reduce pain also prevent pregnancy and are not recommended for infertility patients.Surgery relieves pain and may improve infertility.
Download or read book The Ovary written by Peter C.K. Leung and published by Academic Press. This book was released on 2018-09-10 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ovary, Third Edition, includes more than 60% new material that highlights the clinical aspects of human ovarian functions. It covers advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This updated edition synthesizes new information at the molecular, cellular and organismal levels, while also presenting modern ovarian physiology in a more understandable and comparative context. The book looks at ovarian function from a detailed molecular and cellular level that examines all phases of the ovarian lifecycle that places special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis. Represents an unparalleled compilation of chapters that are relevant to contemporary ovarian physiology Provides basic and clinical research on ovarian function, abnormalities, assisted reproductive technology, and cancer Highlights contemporary strategies and treatment paradigms in female factor infertility
Download or read book Mosby s Guide to Women s Health written by Tolu Oyelowo and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential clinical companion provides quick access to a wealth of information on effectively managing common womens health issues. It offers just the right level of coverage for health professionals, with concise, user-friendly protocols for diagnosing and treating a wide range of conditions. This book also explores alternative natural treatment options such as physical therapy, nutrition, herbs, chiropractic, and naturopathic therapies.
Download or read book Dewhurst s Textbook of Obstetrics and Gynaecology written by Keith Edmonds and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: This time honoured classic has been re-built completely: after sixeditions the editor has decided that a radical revision isnecessary. The new edition has been developed as a result ofintensive consultation with trainees in OB/GYN as to what theywant, what they need and how they learn. The book is organised into two halves covering obstetrics andgynaecology. Within each, the chapters are structured into sectionscontaining pedagogic features such as boxes, highlights and keypoints for the first time. It contains everything the clinicianneeds to practice the art of obstetrics and gynaecology andsufficient information to help sub-specialists develop theirspecific interests. This text is recommended reading for the RoyalCollege of Obstetrics and Gynaecology membership examination. This seventh edition contains 21 new chapters: Anatomy of the Pelvis and Reproductive Tract Placenta and Fetal Membranes Antenatal Care Anaesthesia and Analgesia Recurrent Miscarriage Ectopic Pregnancy Trophoblastic Disease Genetics and Prenatal Diagnosis Drugs and Pregnancy Obstetric Emergencies Prolonged Pregnancy Renal Disease Termination of Pregnancy Imaging in Gynaecology PMS Assisted Reproduction Hysteroscopy and Laparoscopy Sexual Dysfunction Psychological Aspects of Pregnancy Domestic Violence and Sexual Assault - now on MRCOG curriculum Ethical Dilemmas This seventh edition has been significantly updated with a widerange of internationally renowned contributors who are all expertsin their field, bringing this book to the cutting edge of knowledgein obstetrics and gynaecology. "It was my favourite textbook when I was working for myexaminations and I am still using it. I can recommend this editionto current trainees wholeheartedly. It is certainly worth buying."Journal of Obstetrics and Gynaecology
Download or read book General Gynecology written by Andrew I. Sokol and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Requisites in Obstetrics and Gynecology is a series of volumes that offers a concise overview of the field of obstetrics and gynecology in the following areas: High Risk Obstetrics, General Gynecology, Gynecologic Oncology, and Reproductive Endocrinology and Infertility. Each volume contains the core material that is fundamental to each area and includes a presentation that allows the user to absorb the information quickly and thoroughly. This volume is devoted to General Gynecology, which covers care of the female patient outside of pregnancy or during the initial weeks of pregnancy. Topics include gynecologic imaging, family planning, congenital and developmental abnormalities, abnormal uterine bleeding, and pelvic floor disorders.
Download or read book Safe Abortion written by World Health Organization and published by World Health Organization. This book was released on 2003-05-13 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: At a UN General Assembly Special Session in 1999, governments recognised unsafe abortion as a major public health concern, and pledged their commitment to reduce the need for abortion through expanded and improved family planning services, as well as ensure abortion services should be safe and accessible. This technical and policy guidance provides a comprehensive overview of the many actions that can be taken in health systems to ensure that women have access to good quality abortion services as allowed by law.
Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
Download or read book Abortion in the Developing World written by Axel I. Mundigo and published by . This book was released on 1999 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twenty million unsafe abortions are performed each year, 90% of which occur in the developing world. Even in countries such as China, where abortion is fully accessible in practice as well as in theory, our understanding of the phenomenon is very partial. The result of a global research project commissioned by the World Health Organization, this book provides new information on abortion, why it happens and what happens when it does. There are sections detailing women' s perspectives and also chronicling the providers views and the effect they have on medical provision. Several essays focus on the relationship between contraception and abortion, while a section on adolescents addresses a newly emerging concern for program managers around the world. Including much previously unavailable material, this book is the most comprehensive and up-to-date picture of abortion globally.
