Download or read book Handbook of Process Chromatography written by Gunter Jagschies and published by Elsevier. This book was released on 2007-12-08 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design
Download or read book Protein Chromatography written by Giorgio Carta and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.
Download or read book Process Chromatography written by Gail K. Sofer and published by Academic Press. This book was released on 2015-09-02 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research and development into biological products for therapeutic use has increased dramatically over the last 10 years. With this, strict regulatory requirements have been imposed by authorities such as the U.S. Food & Drug Administration, so that today validation has become a key issue in the biopharmaceutical industry.This concise book addresses validation issues in the chromatography of biotherapeutics. It covers process design, qualification and validation, including an overview of analytical techniques commonly used in the validation of processes. A concluding section comments on product changeover and presents four case studies.
Download or read book Protein Chromatography written by Giorgio Carta and published by John Wiley & Sons. This book was released on 2010-06-08 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its focus on process development and large-scale bioseparation tasks, this is tailor-made reading for the professional bioengineer in both the biotech and pharmaceutical industries. Following a tried-and-tested concept, this guide has been developed over several years in training courses for biotech and chemical engineers in Europe and the U.S. The first part deals with the theory, introducing chromatography and its dynamics, as well as discussing mass transfer and dispersion effects. The second part then goes on to cover equipment and protocols, determining the retention factor and HETP from isocratic and elution experiments, as well as the mass transfer and intraparticle diffusivity from batch and shallow-bed adsorption experiments.
Download or read book Handbook of Process Chromatography written by Gail K. Sofer and published by Academic Press. This book was released on 1997-06-24 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: With examples from companies with establised processes and approved biotherapeutics, this pack considers the entire scope of process chromatography, including scale-up, regulatory issues, equipment, evaluation studies, scheduling and cost effectiveness.
Download or read book Protein Chromatography written by Giorgio Carta and published by John Wiley & Sons. This book was released on 2020-02-21 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.
Download or read book Process Scale Liquid Chromatography written by Ganapathy Subramanian and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the industrial chromatographer and production scientist with a comprehensive account of process scale liquid chromatography. The basic theory is presented, guiding the reader through system design, simulation and modelling techniques, giving due consideration to economic aspects, as well as safety and regulatory factors. A thorough, up-to-date survey of current techniques and media does stress their advantages and limitations in such a way as to faciliate their application to real-life problems. In view of rapid rate of development in industrial chromatography one chapter provides an assessment of future developments. The chapters are written by acknowledged experts from Europe and the United States.
Download or read book Process Chromatography written by G. K. Sofer and published by . This book was released on 1989 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatography has today become an integral part of the biotechnology industry, playing a vital role in the purification of biologicals from natural sources as those produced by recombinant DNA and hybridoma techniques. This book is intended as a practical guide and reference source for all those involved in the development of economic chromatographic purification processes. Its purpose extends beyond the description of individual methods to teach the integration of steps, both up and downstream, that lead to a complete process for the successful purification of a desired protein. Researchers, advanced students, senior technicians, and process plant managers working in the biotechnology, biochemical, and pharmaceutical industries will find this text indispensible.
Download or read book Process Gas Chromatographs written by Tony Waters and published by John Wiley & Sons. This book was released on 2020-04-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the fundamentals of applied gas chromatography and the process gas chromatograph, with practical procedures for design and troubleshooting This comprehensive resource provides the theory that underpins a full understanding of the fundamental techniques of gas chromatography and the process analyzer. Without relying on complex mathematics, the book addresses hands-on applications of gas chromatographs within process industries. The author – a noted expert on the topic – details both the scientific information needed to grasp the material presented and the practical applications for professionals working in the field. Process Gas Chromatographs: Fundamentals, Design and Implementation comprises 15 chapters, a glossary of terms and a series of self-assessment questions and quizzes. This important resource: Describes practical procedures for design and troubleshooting Contains concise chapters that provide a structured course for advanced students in process engineering Reviews the fundamentals of applied gas chromatography Details the operation and maintenance of process gas chromatographs Offers a summary, and self-assessment questions, for every chapter Is written by an international expert in the field with extensive industry knowledge and teaching experience in courses on process sampling systems and gas chromatography Written for process analyzer engineers and technicians, application engineers, and industrial environmental engineers, Process Gas Chromatographs: Fundamentals, Design and Implementation offers an essential guide to the basics of gas chromatography and reviews the applications of process gas chromatographs in industry today.
Download or read book Fundamentals of Preparative and Nonlinear Chromatography written by Georges Guiochon and published by Academic Press. This book was released on 2006-03-21 with total page 991 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Preparative and Nonlinear Chromatography is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography. This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration. The book describes the fundamentals of thermodynamics, mass transfer kinetics, and flow through porous media that are relevant to chromatography. It presents the models used in chromatography and their solutions, discusses the applications made, describes the different processes used, their numerous applications, and the methods of optimization of the experimental conditions of this process.
Download or read book Preparative Chromatography written by H. Schmidt-Traub and published by John Wiley & Sons. This book was released on 2012-09-27 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes. Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.
Download or read book Chromatographic and Membrane Processes in Biotechnology written by Carlos A. Costa and published by Springer Science & Business Media. This book was released on 1991 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Chromatographic Processes.- Modelling Equilibrium and Kinetics in Chromatographic Processes.- Theory of Linear and Nonlinear Chromatography.- Hydrodynamics of Chromatographic Columns.- Cyclic Fixed Bed Sorption Processes for Bioseparations - Design Aspects.- Separations by Continuous Annular Chromatography.- Gradient Elution Chromatography.- Rate Processes in Supercritical Fluid Desorption and Extraction.- 2. Membrane Processes.- Fundamentals of Membrane Separation Processes.- Pressure-Driven Membrane Processes.- Ellectrically-Driven Membrane Processes.- Novel Membranes - Formation and Process Applications.- Cell Harvesting Using Cross-Flow Microfiltration.- Recovery of Intracellular Products.- Pervaporation in Biotechnology.- 3. Affinity Processes.- Affinity Chromatography: Principles and Applications.- Theory of Affinity Chromatography.- Affinity Partitioning.- Prediction of Partition Coefficients for Peptides in Aqueous Two-Phase Systems.- Membrane Affinity Filtration.- 4. Design of Separation Media.- Affinity Chromatography: Design of Biospecific Chromatographic Materials.- Membranes for Bioprocessing: Design Considerations.- 5. Scale-Up, Optimization and Process Integration.- Operating Modes, Scale-up and Optimization of Chromatographic Processes.- Scale-up and Optimization of Membrane Processes.- Simultaneous Reaction and Chromatography.- Membrane bioreactors.- Recombinant Human Tissue-Plasminogen Activator: Biochemistry, Pharmacology, and Process Development.- List of Contributors and Participants.
Download or read book Chromatographic Processes written by Roger-Marc Nicoud and published by Cambridge University Press. This book was released on 2015-04-20 with total page 675 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing all aspects of the design, modeling and simulation of chromatographic processes, this result-oriented primer provides a practical guide to all the necessary approaches, methodologies and tools. Beginning with key definitions and concepts, it builds up from the most simple to the most complex situations, including multicomponent systems, non-uniform velocity profiles, bed instability, particle size distributions, and the influence of complex environments on chromatographic process design. In addition to covering classical approaches, it introduces efficient tools for investigating chromatographic processes, such as the 'Russian-Lego' approach for linear systems, phenomenological models, and specific shortcuts for deriving the key properties of industrial processes. With an emphasis on real-world problems and applications, step-by step modeling design guidelines, and detailed exercises for self-assessment, this is a must-have guide for practitioners and researchers working in chemical, biochemical, food and pharmaceutical engineering.
Download or read book Handbook of Process Chromatography written by Gail Sofer and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Preparative and Production Scale Chromatography written by G. Ganetsos and published by CRC Press. This book was released on 1992-09-16 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the latest developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process. The book covers every important process design and reveals actual, immediately applicable techniques and is designed to appeal to design, chemical/biochemical, and research and development engineers, process development managers, bioprocess technologists, analytical and clinical chemists and biochemists, pharmacists, and upper-level undergraduate, graduate, and continuing-education students in these disciplines.
Download or read book Preparative Chromatography for Separation of Proteins written by Arne Staby and published by John Wiley & Sons. This book was released on 2017-02-02 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides. • Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives • Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling • Features a variety of chromatographic case studies not readily accessible to the general public • Represents an essential reference resource for academic, industrial, and pharmaceutical researchers
Download or read book Process Gas Chromatography written by Raymond Annino and published by . This book was released on 1992 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook on the principles and practices pertinent to the design, operation, and application of on-line gas chromatographs in an industrial environment, for instrument specification engineers, instrument maintenance personnel, internal support personnel, (such as laboratory chemists), technical sa
