Download or read book Design Construction and Operating Experience of Demonstration LMFBRs written by International Atomic Energy Agency and published by . This book was released on 1978 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Modeling in Drug Design written by Rebecca Wade and published by MDPI. This book was released on 2019-03-26 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first attempts at structure-based drug design about four decades ago, molecular modelling techniques for drug design have developed enormously, along with the increasing computational power and structural and biological information of active compounds and potential target molecules. Nowadays, molecular modeling can be considered to be an integral component of the modern drug discovery and development toolbox. Nevertheless, there are still many methodological challenges to be overcome in the application of molecular modeling approaches to drug discovery. The eight original research and five review articles collected in this book provide a snapshot of the state-of-the-art of molecular modeling in drug design, illustrating recent advances and critically discussing important challenges. The topics covered include virtual screening and pharmacophore modelling, chemoinformatic applications of artificial intelligence and machine learning, molecular dynamics simulation and enhanced sampling to investigate contributions of molecular flexibility to drug–receptor interactions, the modeling of drug–receptor solvation, hydrogen bonding and polarization, and drug design against protein–protein interfaces and membrane protein receptors.
Download or read book Combinatorial Library Design and Evaluation written by Arup Ghose and published by CRC Press. This book was released on 2001-06-26 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text traces developments in rational drug discovery and combinatorial library design with contributions from 50 leading scientists in academia and industry who offer coverage of basic principles, design strategies, methodologies, software tools and algorithms, and applications. It outlines the fundamentals of pharmacophore modelling and 3D Quantitative Structure-Activity Relationships (QSAR), classical QSAR, and target protein structure-based design methods.
Download or read book Understanding Protein Dynamics Binding and Allostery for Drug Design written by Guang Hu and published by Frontiers Media SA. This book was released on 2021-06-08 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Canadian Journal of Civil Engineering written by and published by . This book was released on 1974 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Design written by Kenneth M. Merz, Jr and published by Cambridge University Press. This book was released on 2010-05-31 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies. A variety of authors from academic and commercial institutions all over the world have contributed to this book, which is illustrated with more than 200 images. This is the only book to cover the subject of structure and ligand-based drug design, and it provides the most up-to-date information on a wide range of topics for the practising computational chemist, medicinal chemist, or structural biologist. Professor Kenneth Merz has been selected as the recipient of the 2010 ACS Award for Computers in Chemical & Pharmaceutical Research that recognizes the advances he has made in the use of quantum mechanics to solve biological and drug discovery problems.
Download or read book Review of Progress in Quantitative Nondestructive Evaluation written by Donald O. Thompson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this study was to increase the understanding of damage in composite materials with through-the-thickness reinforcements. As a first step it was necessary to develop new ultrasonic imaging technology to better assess internal damage of the composite. A useful ultrasonic imaging technique has been successfully developed to assess the internal damage of composite panels. The ultrasonic technique accurately determines the size of the internal damage. It was found that the ultrasonic imaging technique was better able to assess the damage in a composite panel with through-the-thickness reinforcements than by destructively sectioning the specimen and visual inspection under a microscope. Microscopic determination of crack location and lengths in a composite panel with through-the-thickness reinforcements was almost impossible. Five composite compression-after-impact panels were tested. The compression-after-impact strength of the panels with the through-the thickness reinforcements was almost twice that of the comparable panel without through-the-thickness reinforcement. REFERENCES 1. B.T. Smith, J.S. Heyman, A.M. Buoncristiani, Earl D. Blodgett, J.G. Miller, and S.M. Freeman, Correlation of the Deply TechniQue with the Ultrasonic Imaging of Impact Damage in Graphite/Epoxy Composites, Materials Evaluation, vol. 47, NO. 12, December 1989, pp 1408-1416. 2. NASA Tech Briefs, June 1987, p. 28. 3. P.M. Gammel, Improved Ultrasonic Detection using Analytic Signal Magnitude. Ultrasonics, Vol. 19, March 1981, pp 73-76. 4. R.C. Heyser, Determination of Loudspeaker Signal Arrival Times Part ~ Journal of the Audio Engineering Society, Vol. 19, Dec. 1971, pp 902-905.
Download or read book Applied Geotechnics for Construction Projects Volume 3 written by Ammar Dhouib and published by John Wiley & Sons. This book was released on 2023-01-19 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geotechnical engineering is now a fundamental component of construction projects. The third volume of this book is its backbone, dedicated to foundations for civil and industrial construction projects. Applied Geotechnics for Construction Projects 3 first presents the basic theoretical principles and rules governing the designing and validation of foundations; shallow, semi-deep and deep, then presents real foundation projects with a detailed comparison of the approaches and methods of calculating foundations in relation to the reference systems and rules in force, closely compared to and validated by the Eurocodes. The third chapter presents examples of foundation projects, covering high-side building rafts, strip footings, piles and embankments, enriched by an unprecedented level of experience in the field of foundations for civil and industrial construction projects. It ends with examples of damage to foundations and practical appendices. Each chapter of this third volume is illustrated with photographs and measurements of construction sites and is built on both theory and experience in the field of foundations as a whole. The result is a combination of geotechnical expertise and lessons learned from experience, both of which are highly valuable in the field of applied geotechnics for construction projects.
Download or read book Drug Design written by Kenneth M. Merz and published by Cambridge University Press. This book was released on 2010-05-31 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete snapshot of various experimental approaches to structure-based and ligand-based drug design and is illustrated with more than 200 images.
Download or read book Chemoinformatics Approaches to Structure and Ligand Based Drug Design Volume II written by Adriano D. Andricopulo and published by Frontiers Media SA. This book was released on 2022-07-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Data for Science and Technology written by K.H. Bockhoff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1049 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Conference, Antwerp, Belgium, September 6-10, 1982
Download or read book Bioinspired Structures and Design written by Wole Soboyejo and published by Cambridge University Press. This book was released on 2020-09-17 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master simple to advanced biomaterials and structures with this essential text. Featuring topics ranging from bionanoengineered materials to bio-inspired structures for spacecraft and bio-inspired robots, and covering issues such as motility, sensing, control and morphology, this highly illustrated text walks the reader through key scientific and practical engineering principles, discussing properties, applications and design. Presenting case studies for the design of materials and structures at the nano, micro, meso and macro-scales, and written by some of the leading experts on the subject, this is the ideal introduction to this emerging field for students in engineering and science as well as researchers.
Download or read book The Journal of Applied Rabbit Research written by and published by . This book was released on 1991 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Conformational Dynamics written by Ke-li Han and published by Springer Science & Business Media. This book was released on 2014-01-20 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
Download or read book Daylighting in Architecture written by Nick V. Baker and published by Routledge. This book was released on 2015-12-08 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Typically one third of the energy used in many buildings may be consumed by electric lighting. Good daylighting design can reduce electricity consumption for lighting and improve standards of visual comfort, health and amenity for the occupants.As the only comprehensive text on the subject written in the last decade, the book will be welcomed by all architects and building services engineers interested in good daylighting design. The book is based on the work of 25 experts from all parts of Europe who have collected, evaluated and developed the material under the auspices of the European Commission's Solar Energy and Energy Conservation R&D Programmes.
Download or read book Fast Reactor Physics 1979 written by and published by . This book was released on 1980 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nutrition Diagnosis written by American Dietetic Association and published by . This book was released on 2006 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
