Download or read book Prescriptions for Working Statisticians written by Albert Madansky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first course in statistics, no matter how "good" or "long" it is, typically covers inferential procedures which are valid only if a number of preconditions are satisfied by the data. For example, students are taught about regression procedures valid only if the true residuals are independent, homoscedastic, and normally distributed. But they do not learn how to check for indepen dence, homoscedasticity, or normality, and certainly do not learn how to adjust their data and/or model so that these assumptions are met. To help this student out! I designed a second course, containing a collec tion of statistical diagnostics and prescriptions necessary for the applied statistician so that he can deal with the realities of inference from data, and not merely with the kind of classroom problems where all the data satisfy the assumptions associated with the technique to be taught. At the same time I realized that I was writing a book for a wider audience, namely all those away from the classroom whose formal statistics education ended with such a course and who apply statistical techniques to data.

Download or read book Statistical Thinking for Non Statisticians in Drug Regulation written by Richard Kay and published by John Wiley & Sons. This book was released on 2014-10-23 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.

Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.

Download or read book Probability for Statisticians written by Galen R. Shorack and published by Springer Science & Business Media. This book was released on 2006-05-02 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: The choice of examples used in this text clearly illustrate its use for a one-year graduate course. The material to be presented in the classroom constitutes a little more than half the text, while the rest of the text provides background, offers different routes that could be pursued in the classroom, as well as additional material that is appropriate for self-study. Of particular interest is a presentation of the major central limit theorems via Steins method either prior to or alternative to a characteristic function presentation. Additionally, there is considerable emphasis placed on the quantile function as well as the distribution function, with both the bootstrap and trimming presented. The section on martingales covers censored data martingales.

Download or read book Risk Assessment written by Edward A. McBean and published by John Wiley & Sons. This book was released on 2018-05-29 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the methodologies, typical mathematical notation, and assumptions used in risk assessment calculations Risk Assessment describes the methodologies, the math, and assumptions needed in risk assessment calculations and explores the various statistical analysis procedures that are used for estimating the parameters employed in risk assessment approaches. The author—a noted expert in the field—outlines a logical step-by-step approach to assessment: Identify a hazard; Analyze the risk associated with that hazard; and Determine if the elimination, or control of the risk is warranted. The text puts the focus on assessing environmental risk and describes the basics used in hypothesis testing to determine when there are differences in environmental quality at various locations. The author describes statistical techniques in approachable terms that are designed to be understandable to the non-statistician. The text downplays mathematical notation while offering clear explanations for the development of equations. It highlights applications with numerous examples of problems of censored data as they influence the use of alternative tests. In addition, the text focuses on both parametric and non-parametric procedures. This important resource: Describes in understandable terms the methodologies, typical mathematical notation, and assumptions used in risk assessment calculations Explores the fundamental calculation procedures and approaches for risk characterization Contains a wealth of example problems of interpretations of environmental monitoring results and shows how each procedure is used Includes problems at the end of each chapter that stress the fundamental concepts outlined Written for senior undergraduate and graduate students and as a course text in engineering, Risk Assessment offers a guide to the fundamental calculation procedures and methodologies for characterizing risk in clear and accessible terms.

Download or read book An Introduction to Probability and Stochastic Processes written by Marc A. Berger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: These notes were written as a result of my having taught a "nonmeasure theoretic" course in probability and stochastic processes a few times at the Weizmann Institute in Israel. I have tried to follow two principles. The first is to prove things "probabilistically" whenever possible without recourse to other branches of mathematics and in a notation that is as "probabilistic" as possible. Thus, for example, the asymptotics of pn for large n, where P is a stochastic matrix, is developed in Section V by using passage probabilities and hitting times rather than, say, pulling in Perron Frobenius theory or spectral analysis. Similarly in Section II the joint normal distribution is studied through conditional expectation rather than quadratic forms. The second principle I have tried to follow is to only prove results in their simple forms and to try to eliminate any minor technical com putations from proofs, so as to expose the most important steps. Steps in proofs or derivations that involve algebra or basic calculus are not shown; only steps involving, say, the use of independence or a dominated convergence argument or an assumptjon in a theorem are displayed. For example, in proving inversion formulas for characteristic functions I omit steps involving evaluation of basic trigonometric integrals and display details only where use is made of Fubini's Theorem or the Dominated Convergence Theorem.

Download or read book Introduction to Time Series and Forecasting written by Peter J. Brockwell and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some of the key mathematical results are stated without proof in order to make the underlying theory acccessible to a wider audience. The book assumes a knowledge only of basic calculus, matrix algebra, and elementary statistics. The emphasis is on methods and the analysis of data sets. The logic and tools of model-building for stationary and non-stationary time series are developed in detail and numerous exercises, many of which make use of the included computer package, provide the reader with ample opportunity to develop skills in this area. The core of the book covers stationary processes, ARMA and ARIMA processes, multivariate time series and state-space models, with an optional chapter on spectral analysis. Additional topics include harmonic regression, the Burg and Hannan-Rissanen algorithms, unit roots, regression with ARMA errors, structural models, the EM algorithm, generalized state-space models with applications to time series of count data, exponential smoothing, the Holt-Winters and ARAR forecasting algorithms, transfer function models and intervention analysis. Brief introducitons are also given to cointegration and to non-linear, continuous-time and long-memory models. The time series package included in the back of the book is a slightly modified version of the package ITSM, published separately as ITSM for Windows, by Springer-Verlag, 1994. It does not handle such large data sets as ITSM for Windows, but like the latter, runs on IBM-PC compatible computers under either DOS or Windows (version 3.1 or later). The programs are all menu-driven so that the reader can immediately apply the techniques in the book to time series data, with a minimal investment of time in the computational and algorithmic aspects of the analysis.

Download or read book Probability via Expectation written by Peter Whittle and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a complete revision of the earlier work Probability which ap peared in 1970. While revised so radically and incorporating so much new material as to amount to a new text, it preserves both the aim and the approach of the original. That aim was stated as the provision of a 'first text in probability, de manding a reasonable but not extensive knowledge of mathematics, and taking the reader to what one might describe as a good intermediate level'. In doing so it attempted to break away from stereotyped applications, and consider applications of a more novel and significant character. The particular novelty of the approach was that expectation was taken as the prime concept, and the concept of expectation axiomatized rather than that of a probability measure. In the preface to the original text of 1970 (reproduced below, together with that to the Russian edition of 1982) I listed what I saw as the advantages of the approach in as unlaboured a fashion as I could. I also took the view that the text rather than the author should persuade, and left the text to speak for itself. It has, indeed, stimulated a steady interest, to the point that Springer-Verlag has now commissioned this complete reworking.

Download or read book Introduction to Reliability Analysis written by Shelemyahu Zacks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliability analysis is concerned with the analysis of devices and systems whose individual components are prone to failure. This textbook presents an introduction to reliability analysis of repairable and non-repairable systems. It is based on courses given to both undergraduate and graduate students of engineering and statistics as well as in workshops for professional engineers and scientists. As aresult, the book concentrates on the methodology of the subject and on understanding theoretical results rather than on its theoretical development. An intrinsic aspect of reliability analysis is that the failure of components is best modelled using techniques drawn from probability and statistics. Professor Zacks covers all the basic concepts required from these subjects and covers the main modern reliability analysis techniques thoroughly. These include: the graphical analysis of life data, maximum likelihood estimation and bayesian likelihood estimation. Throughout the emphasis is on the practicalities of the subject with numerous examples drawn from industrial and engineering settings.

Download or read book Statistical Tables and Formulae written by Stephen Kokoska and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: All students and professionals in statistics should refer to this volume as it is a handy reference source for statistical formulas and information on basic probability distributions. It contains carefully designed and well laid out tables for standard statistical distributions (including Binomial, Poisson, Normal, and Chi-squared). In addition, there are several tables of Critical Values for various statistics tests.

Download or read book Recent Studies on Risk Analysis and Statistical Modeling written by Teresa A. Oliveira and published by Springer. This book was released on 2018-08-22 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the latest developments in the field of risk analysis (RA). Statistical methodologies have long-since been employed as crucial decision support tools in RA. Thus, in the context of this new century, characterized by a variety of daily risks - from security to health risks - the importance of exploring theoretical and applied issues connecting RA and statistical modeling (SM) is self-evident. In addition to discussing the latest methodological advances in these areas, the book explores applications in a broad range of settings, such as medicine, biology, insurance, pharmacology and agriculture, while also fostering applications in newly emerging areas. This book is intended for graduate students as well as quantitative researchers in the area of RA.

Download or read book Statistical Thinking for Non Statisticians in Drug Regulation written by Richard Kay and published by John Wiley & Sons. This book was released on 2022-11-29 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: STATISTICAL THINKING FOR NON-STATISTICIANS IN DRUG REGULATION Statistical methods in the pharmaceutical industry are accepted as a key element in the design and analysis of clinical studies. Increasingly, the medical and scientific community are aligning with the regulatory authorities and recognizing that correct statistical methodology is essential as the basis for valid conclusions. In order for those correct and robust methods to be successfully employed there needs to be effective communication across disciplines at all stages of the planning, conducting, analyzing and reporting of clinical studies associated with the development and evaluation of new drugs and devices. Statistical Thinking for Non-Statisticians in Drug Regulation provides a comprehensive in-depth guide to statistical methodology for pharmaceutical industry professionals, including physicians, investigators, medical science liaisons, clinical research scientists, medical writers, regulatory personnel, statistical programmers, senior data managers and those working in pharmacovigilance. The author’s years of experience and up-to-date familiarity with pharmaceutical regulations and statistical practice within the wider clinical community make this an essential guide for the those working in and with the industry. The third edition of Statistical Thinking for Non-Statisticians in Drug Regulation includes: A detailed new chapter on Estimands in line with the 2019 Addendum to ICH E9 Major new sections on topics including Combining Hierarchical Testing and Alpha Adjustment, Biosimilars, Restricted Mean Survival Time, Composite Endpoints and Cumulative Incidence Functions, Adjusting for Cross-Over in Oncology, Inverse Propensity Score Weighting, and Network Meta-Analysis Updated coverage of many existing topics to reflect new and revised guidance from regulatory authorities and author experience Statistical Thinking for Non-Statisticians in Drug Regulation is a valuable guide for pharmaceutical and medical device industry professionals, as well as statisticians joining the pharmaceutical industry and students and teachers of drug development.

Download or read book Probability and Statistical Inference written by J.G. Kalbfleisch and published by Springer Science & Business Media. This book was released on 1985 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: A carefully written text, suitable as an introductory course for second or third year students. The main scope of the text guides students towards a critical understanding and handling of data sets together with the ensuing testing of hypotheses. This approach distinguishes it from many other texts using statistical decision theory as their underlying philosophy. This volume covers concepts from probability theory, backed by numerous problems with selected answers.

Download or read book Pharmaceutical Statistics Using SAS written by Alex Dmitrienko, Ph.D. and published by SAS Institute. This book was released on 2007-02-07 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces a range of data analysis problems encountered in drug development and illustrates them using case studies from actual pre-clinical experiments and clinical studies. Includes a discussion of methodological issues, practical advice from subject matter experts, and review of relevant regulatory guidelines.

Download or read book Engineering Biostatistics written by Brani Vidakovic and published by John Wiley & Sons. This book was released on 2017-11-06 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a one-stop resource for engineers learning biostatistics using MATLAB® and WinBUGS Through its scope and depth of coverage, this book addresses the needs of the vibrant and rapidly growing bio-oriented engineering fields while implementing software packages that are familiar to engineers. The book is heavily oriented to computation and hands-on approaches so readers understand each step of the programming. Another dimension of this book is in parallel coverage of both Bayesian and frequentist approaches to statistical inference. It avoids taking sides on the classical vs. Bayesian paradigms, and many examples in this book are solved using both methods. The results are then compared and commented upon. Readers have the choice of MATLAB® for classical data analysis and WinBUGS/OpenBUGS for Bayesian data analysis. Every chapter starts with a box highlighting what is covered in that chapter and ends with exercises, a list of software scripts, datasets, and references. Engineering Biostatistics: An Introduction using MATLAB® and WinBUGS also includes: parallel coverage of classical and Bayesian approaches, where appropriate substantial coverage of Bayesian approaches to statistical inference material that has been classroom-tested in an introductory statistics course in bioengineering over several years exercises at the end of each chapter and an accompanying website with full solutions and hints to some exercises, as well as additional materials and examples Engineering Biostatistics: An Introduction using MATLAB® and WinBUGS can serve as a textbook for introductory-to-intermediate applied statistics courses, as well as a useful reference for engineers interested in biostatistical approaches.

Download or read book Regression Analysis written by Ashish Sen and published by Springer Science & Business Media. This book was released on 1997-04-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, rigorous, and lucid treatment of the theory, methods, and applications of regression analysis, and thus ideally suited for those interested in the theory as well as those whose interests lie primarily with applications. It is further enhanced through real-life examples drawn from many disciplines, showing the difficulties typically encountered in the practice of regression analysis. Consequently, this book provides a sound foundation in the theory of this important subject.

Download or read book Perspectives on Promotion and Database Marketing written by Robert C. Blattberg and published by World Scientific. This book was released on 2010 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative marketing as a discipline started around the mid 60's and has been dominated by only a handful of individuals. Robert Blattberg is one of them and has been a leader in setting a research agenda for this discipline. The collection of articles in this book along with commentary by some of his doctoral students is a magnificent testament to the genius of Robert Blattberg. The chapters in this book are organized into six parts. The first part, titled ?Early Bob?, traces research which he completed during the first decade after he joined University of Chicago. The second part is titled ?Statistical Bob?. This part comprises papers that Robert wrote in characterizing the response of consumers to dealing. The third part is titled ?Promotional Bob?, and covers roughly a ten-year stretch from 1987 to 1996. The fourth part titled ?Big Bob?, describes Robert's contribution to and impact on marketing practice. The fifth part is titled ?Direct Bob?, and focuses on what customer level data should be gathered, how they should be organized, linked and analyzed, and what metrics should be used to assess customer value. The sixth and final part titled ?Micro-Macro Bob?, is not genre or area specific as much as an illustration of Robert's overall research interests in marketing-mix modeling.