Download or read book Postnatal Maturation of the Rhesus Macaque Brain written by Julia Apelian Scott and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The primate brain undergoes significant maturational processes after birth, resulting in substantial growth. The expansion of the brain reflects underlying cellular changes that create a more complex and efficient neural network. Structural magnetic resonance imaging (MRI) can document growth in vivo, which relates to the cellular level processes. Normative imaging studies of postnatal brain development in non-human primates are scarce and were conducted with subjects that were raised in laboratory environments. To enrich our understanding of the postnatal brain maturation, a group of naturalistically-reared rhesus macaques (Macaca mullata) was imaged longitudinally over the first year of life. Subsequent analyses of the MRI demonstrated global and local maturational properties. Brain volume increased to near adult size by one year of age, which was described by a logarithmic growth curve. Male and female brains had similar growth trajectories though males had larger brains from birth. Weight gain significantly predicted variation in the growth curve; more rapid weight gain was associated with greater postnatal growth of the brain regardless of initial brain size. Maturation within the brain was asynchronous and generally progressed from posterior to anterior regions. Apparent myelination and lobar size reached an adult-like state earlier in the occipital, parietal and frontal motor areas than prefrontal and temporal areas. At one year of age, the amygdala and hippocampus were larger in males compared to females; sexual dimorphism in these structures was proportional to the whole brain size variation. Hemispheric asymmetry was also evaluated at one year. The cerebrum showed a slight leftward asymmetry, which was also observed in the hippocampus. On average, the amygdala appeared to be symmetric, but there was substantial individual variation in asymmetry values. This study showed some of the common features of normal rhesus macaque brain development from birth to juvenile stage of maturation. The patterns seen by MRI can be correlated with the extensive neuroanatomical work in this species in order to hypothesize what cellular level changes cause the macroscopic growth. This study stands as the first longitudinal MRI dataset of naturalistically-reared rhesus macaques, which serves as a model of early postnatal brain development in the primate.

Download or read book Quantitative Analysis of Postnatal Neurogenesis and Neuron Number in the Macaque Monkey Dentate Gyrus written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The dentate gyrus is one of only two regions of the mammalian brain where substantial neurogenesis occurs postnatally. However, detailed quantitative information about the postnatal structural maturation of the primate dentate gyrus is meager. We performed design-based, stereological studies of neuron number and size, and volume of the dentate gyrus layers in rhesus macaque monkeys (Macaca mulatta) of different postnatal ages. We found that about 40% of the total number of granule cells observed in mature 5- 0-year-old macaque monkeys are added to the granule cell layer postnatally; 25% of these neurons are added within the first three postnatal months. Accordingly, cell proliferation and neurogenesis within the dentate gyrus peak within the first 3 months after birth and remain at an intermediate level between 3 months and at least 1 year of age. Although granule cell bodies undergo their largest increase in size during the first year of life, cell size and the volume of the three layers of the dentate gyrus (i.e. the molecular, granule cell and polymorphic layers) continue to increase beyond 1 year of age. Moreover, the different layers of the dentate gyrus exhibit distinct volumetric changes during postnatal development. Finally, we observe significant levels of cell proliferation, neurogenesis and cell death in the context of an overall stable number of granule cells in mature 5- 0-year-old monkeys. These data identify an extended developmental period during which neurogenesis might be modulated to significantly impact the structure and function of the dentate gyrus in adulthood.

Download or read book Postnatal Development of the Striate Cortex in the Macaque Monkey written by John O'Kusky and published by . This book was released on 1981 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Postnatal Development of the Human Hippocampal Formation written by Ricardo Insausti and published by Springer Science & Business Media. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The postnatal development of the human hippocampal formation (HF) is subject of increasing interest due to its implication in important pathologies that hamper the normal development of children. In this work, the authors present a glimpse of the main events that constitute important milestones in the development and shaping of some of the most important psychological capabilities such as autobiographical memory. Although they examined some cases in the last trimester of gestation, their description starts at birth, around 40 gestational weeks. Serial sections with thionin for Nissl analysis revealed that all fields of the HF were present and identifiable at birth. However, the relative growth of the cortical mantle was much higher relative to the HF. The main structural changes took place during the first postnatal year, in particular in the dentate gyrus and in the entorhinal cortex. At subsequent ages, a growth in size was noted in all components of the HF. This growth was more evident at the body and tail of the hippocampus, as evidenced by measurements of the neuroanatomical series. In addition, the authors examined in some cases the MRI appearance of the HF at different postnatal ages obtained by post-mortem imaging. MRI neuroanatomical series provided anatomically identified landmarks useful for the MRI identification of different components of the HF during postnatal development.

Download or read book The Oxford Handbook of Developmental Psychology Vol 1 written by Philip David Zelazo and published by Oxford University Press. This book was released on 2013-03-21 with total page 1049 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Download or read book A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates written by Kadharbatcha S. Saleem and published by Academic Press. This book was released on 2012-04-23 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Second Edition maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET. The first rhesus monkey brain atlas with horizontal, coronal, and sagittal planes of sections, derived from the same animal Shows the first detailed delineations of the cortical and subcortical areas in horizontal, coronal, and sagittal plane of sections in the same animal using different staining methods Horizonal series illustrates the dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographic sections matched with 47 detailed diagrams (Chapter 3) Coronal series presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographic sections, with 76 corresponding drawings (Chapter 4) Sagittal series shows the complete mediolateral extent of the left hemisphere in 30 sagittal MRI sections, with 30 corresponding drawings (Chapter 5). The sagittal series also illustrates the location of different fiber tracts in the white matter Individual variability - provides selected cortical and subcortical areas in three-dimensional MRI (horizontal, coronal, and sagittal MRI planes). For comparison, it also provides similar areas in coronal MRI section in six other monkeys. (Chapter 6) Vasculature - indicates the corresponding location of all major blood vessels in horizontal, coronal, and sagittal series of sections Provides updated information on the cortical and subcortical areas, such as architectonic areas and nomenclature, with references, in chapter 2 Provides the sterotaxic grid derived from the in-vivo MR image

Download or read book Brain Maturation and Cognitive Development written by Anne Petersen and published by Routledge. This book was released on 2017-09-29 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume adopts a unique, multidisciplinary approach to the study of the development of the human brain and early behavior. It includes chapters by researchers from several disciplines whose work addresses specific aspects of brain-behavioral interactions in development. The chapters provide strong evidence that the development of both brain and behavior is a response to biological and environmental variations.Language is also discussed, and provides a useful example of biosocial development because linguistic and brain functions and development can be examined under controlled conditions of both genetic and environmental deprivation. Research in this area has produced particularly exciting results pointing to the universality of language capacity among humans and illuminating the processes by which language competence develops.Brain Maturation and Cognitive Development provides new views in the understanding of human nature and present new, biosocially oriented research directions that are unique in their focus.

Download or read book The Behavioral Ecology of the Tibetan Macaque written by Jin-Hua Li and published by Springer Nature. This book was released on 2019-11-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book summarizes the multi-disciplinary results of one of China’s main primatological research projects on the endemic Tibetan macaque (Macaca thibetana), which had continued for over 30 years, but which had never been reported on systematically. Dedicated to this exceptional Old World monkey, this book makes the work of Chinese primatologists on the social behavior, cooperation, culture, cognition, group dynamics, and emerging technologies in primate research accessible to the international scientific community. One of the most impressive Asian monkeys, and the largest member of its genus, the Tibetan macaque deserves to be better known. This volume goes a long way towards bringing this species into the spotlight with many excellent behavioral analyses from the field. - Frans de Waal, Professor of Psychology, Emory University, USA. Macaques matter. To understand primate patterns and trends, and to gain important insight into humanity, we need to augment and expand our engagement with the most successful and widespread primate genus aside from Homo. This volume focuses on the Tibetan macaque, a fascinating species with much to tell us about social behavior, physiology, complexity and the macaque knack for interfacing with humans. This book is doubly important for primatology in that beyond containing core information on this macaque species, it also reflects an effective integrated collaboration between Chinese scholars and a range of international colleagues—exactly the type of collaborative engagement primatology needs. This volume is a critical contribution to a global primatology. - Agustín Fuentes, Professor of Anthropology, University of Notre Dame, USA. I have many fond memories of my association with Mt. Huangshan research beginning in 1983, when together with Professor Qishan Wang we established this site. It is such a beautiful place and I miss it. It is gratifying to see how far research has progressed since we began work there, becoming more internationalized and very much a collaborative endeavor under the long-term direction of Professor Jin-Hua Li and colleagues. This book highlights the increased interest in this species, representing a variety of disciplines ranging from macro aspects of behavior, cognition and sociality, to micro aspects of microbes, parasites and disease, authored by a group of renowned Chinese and international primatologists. I applaud their efforts and expect more interesting work to come from this site in the years ahead. - Kazuo Wada, Professor Emeritus, Kyoto University, Japan.

Download or read book Brain maturation and cognitive development written by Kathleen R. Gibson and published by AldineTransaction. This book was released on with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Originally published in 1991 by Aldine De Gruyter."

Download or read book The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment written by Joerg Bluemel and published by Academic Press. This book was released on 2015-03-13 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Download or read book The Evolutionary Roots of Human Brain Diseases written by Nico J. Diederich and published by Oxford University Press. This book was released on 2024 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Traditionally, studies and textbooks in Neurology or Psychiatry, as well as allied disciplines, deal with proximate causes of diseases and therapies, but remain mute or minimally interested in their ultimate causes including the phylogeny and adaptive significance of disease manifestations. Yet, as clinicians or basic researchers, we are conscious of potential evolutionary roots of neurological and psychiatric symptoms, often offering a rudimentary explanation but never delving deeply into the current role of evolutionary science as it relates to health and disease. We may miss appreciation of the role of adaptive properties, evolutionarily based neuronal circuitries, unbalanced cellular energy demands, and the potential health consequences of residual syndromic behaviors that were possibly useful in early times of human development, but presently are obsolete and pathological. The problem is amplified, because there is often no interdisciplinary dialogue between anthropology and evolutionary biology on one side and clinical sciences on the other side. However, the evolutionary tracing back of disease pathways may disclose unexpected insights and trigger the design of innovative research as well as propel the development of new therapeutic interventions. There could also be a better apprehension of compensatory behaviors, both at the cellular level as well as the systemic the behavioural levels, that could be the expected fruits of such collaborations. So far scientists fall short in modeling the complexity of human (social) life, human language, or manual dexterity, and mental or emotional behaviors that typify human neurological or psychological function and dysfunction. Finally, there remain obstacles in the form of poor animal modeling for human brain diseases and for human longevity. The present book aims to fill these gaps by presenting an evolutionary view of neurological and psychiatric conditions that is meant to complement and enrich existing medical perspectives"--

Download or read book The Cambridge Handbook of Cognitive Development written by Olivier Houdé and published by Cambridge University Press. This book was released on 2022-03-03 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: How does cognition develop in infants, children and adolescents? This handbook presents a cutting-edge overview of the field of cognitive development, spanning basic methodology, key domain-based findings and applications. Part One covers the neurobiological constraints and laws of brain development, while Part Two covers the fundamentals of cognitive development from birth to adulthood: object, number, categorization, reasoning, decision-making and socioemotional cognition. The final Part Three covers educational and school-learning domains, including numeracy, literacy, scientific reasoning skills, working memory and executive skills, metacognition, curiosity-driven active learning and more. Featuring chapters written by the world's leading scholars in experimental and developmental psychology, as well as in basic neurobiology, cognitive neuroscience, computational modelling and developmental robotics, this collection is the most comprehensive reference work to date on cognitive development of the twenty-first century. It will be a vital resource for scholars and graduate students in developmental psychology, neuroeducation and the cognitive sciences.

Download or read book Handbook of Developmental Cognitive Neuroscience second edition written by Charles A. Nelson and published by MIT Press. This book was released on 2008-07-11 with total page 985 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of an essential resource to the evolving field of developmental cognitive neuroscience, completely revised, with expanded emphasis on social neuroscience, clinical disorders, and imaging genomics. The publication of the second edition of this handbook testifies to the rapid evolution of developmental cognitive neuroscience as a distinct field. Brain imaging and recording technologies, along with well-defined behavioral tasks—the essential methodological tools of cognitive neuroscience—are now being used to study development. Technological advances have yielded methods that can be safely used to study structure-function relations and their development in children's brains. These new techniques combined with more refined cognitive models account for the progress and heightened activity in developmental cognitive neuroscience research. The Handbook covers basic aspects of neural development, sensory and sensorimotor systems, language, cognition, emotion, and the implications of lifelong neural plasticity for brain and behavioral development. The second edition reflects the dramatic expansion of the field in the seven years since the publication of the first edition. This new Handbook has grown from forty-one chapters to fifty-four, all original to this edition. It places greater emphasis on affective and social neuroscience—an offshoot of cognitive neuroscience that is now influencing the developmental literature. The second edition also places a greater emphasis on clinical disorders, primarily because such research is inherently translational in nature. Finally, the book's new discussions of recent breakthroughs in imaging genomics include one entire chapter devoted to the subject. The intersection of brain, behavior, and genetics represents an exciting new area of inquiry, and the second edition of this essential reference work will be a valuable resource for researchers interested in the development of brain-behavior relations in the context of both typical and atypical development.

Download or read book Behavioural Brain Research in Naturalistic and Semi Naturalistic Settings written by E. Alleva and published by Springer. This book was released on 1995-07-31 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The September 1994 NATO ASI, held in Acquafredda di Maratea, Italy, had the goal of filling a gap in the behavioral neuroscience of mammals, namely the relations between ecology and behavior in the so- called laboratory species (today mostly mice and rats). To this end, a group of neuroscientists who have developed an approach of combining laboratory and field techniques for the study of brain, behavior, and ecology in singing and food-storing birds were brought together with students of mouse and rat behavior with a penchant towards evolutionary biology. The proceedings, including informal discussion groups, are organized in four parts: brain, behavior, ontogeny, and evolution; bird studies; hippocampus--a hot issue; and behavioral brain research, methodology, and telemetry. Annotation copyright by Book News, Inc., Portland, OR

Download or read book Evolutionary Neuroscience written by Jon H Kaas and published by Academic Press. This book was released on 2009-07-28 with total page 1039 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolutionary Neuroscience is a collection of articles in brain evolution selected from the recent comprehensive reference, Evolution of Nervous Systems (Elsevier, Academic Press, 2007). The selected chapters cover a broad range of topics from historical theory to the most recent deductions from comparative studies of brains. The articles are organized in sections focused on theories and brain scaling, the evolution of brains from early vertebrates to present-day fishes, amphibians, reptiles and birds, the evolution of mammalian brains, and the evolution of primate brains, including human brains. Each chapter is written by a leader or leaders in the field, and has been reviewed by other experts. Specific topics include brain character reconstruction, principles of brain scaling, basic features of vertebrate brains, the evolution of the major sensory systems, and other parts of brains, what we can learn from fossils, the origin of neocortex, and the evolution of specializations of human brains. The collection of articles will be interesting to anyone who is curious about how brains evolved from the simpler nervous systems of the first vertebrates into the many different complex forms now found in present-day vertebrates. This book would be of use to students at the graduate or undergraduate levels, as well as professional neuroscientists, cognitive scientists, and psychologists. Together, the chapters provide a comprehensive list of further reading and references for those who want to inquire further. The most comprehensive, authoritative and up-to-date single volume collection on brain evolution Full color throughout, with many illustrations Written by leading scholars and experts

Download or read book Neurophysiology and Neuropsychology of Motor Development written by Kevin J. Connolly and published by Cambridge University Press. This book was released on 1997-01-23 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique analysis of childhood motor development from the perspectives of both neuropsychology and neurophysiology.