Download or read book Polypeptide Chain Initiation and the Characterization of Ribosomal Binding Sites in E Coli written by and published by . This book was released on 1966 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Polypeptide Chain Elongation Factor Tu from Escherichia Coli written by Guido Willem Maria Swart and published by . This book was released on 1987 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Characterization of the Binding of Escherichia Coli Initiation Factor 3 to Polynucleotides written by Brian Frederick Schmidt and published by . This book was released on 1983 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Characterization of an Escherichia Coli Ribosomal ATPase written by Michael Christopher Kiel and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein synthesis is a unifying process of all living cells. The macromolecules involved in translation, ribosomes, RNAs and protein factors, as well as the mechanisms of protein synthesis, are all largely conserved across the spectrum of cell types. In this thesis, a ribosome-associated ATPase, RbbA, is identified in 'Escherichia coli' extracts. RbbA can bind both 70S ribosomes and 30S ribosomal subunits. The ATPase activity of RbbA increases two-fold in the presence of purified 70S ribosomes. RbbA cross-reacts with antibody raised against the fungal-specific translation factor EF-3, and like EF-3, RbbA stimulates the synthesis of polyphenylalanine from a poly(U) template 'in vitro'. Cross-linking data show that RbbA lies near 30S ribosomal subunit protein S1 and binds to a poly(G)-rich region of the 30S subunit rRNA, 16S rRNA. This region of the ribosome is known as the decoding region of the ribosome and is important for the binding of aminoacyl-tRNAs to the ribosomal A-site. Upon binding of RbbA, 16S rRNA undergoes a specific conformational change that has been demonstrated previously to affect translational fidelity. EF-Tu, which escorts aminoacyl-tRNAs to the A-site of the ribosome, is also capable of binding with RbbA. Hygromycin, an antibiotic that interferes with protein synthesis by binding to the decoding center of the ribosome, is able specifically to inhibit the ribosomal ATPase activity by displacing RbbA from the ribosome. Together, the data suggest that RbbA, the first ATPase demonstrated to be involved in prokaryotic protein synthesis, plays a major role in protein chain elongation.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1985 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Biology A Comprehensive Treatise V4 written by David M. Prescott and published by Elsevier. This book was released on 2012-12-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Biology, A Comprehensive Treatise, Volume 4: Gene Expression: Translation and the Behavior of Proteins discusses the translation of genetic information into proteins. It also explains the activities and behaviors of proteins, which is the final stage of gene expression. This book opens with a discussion of the components and mechanism of the translational machinery – their structures, biogenesis, and cellular levels. It then explains the protein synthesis, wherein each chapter focuses on one aspect of the detailed process. Other topics covered in this book are the structure and function of cytoplasmic ribonucleoprotein complexes and the proteolytic cleavage in the posttranslational processing of proteins. This text also covers the regulation of enzyme activity and the movement of material between nucleus and cytoplasm. The last three chapters are more in-depth discussions on protein synthesis, intracellular transport, regulation, and secretion. As with the other volumes of this book series, readers will definitely benefit from the vast information provided in this book regarding protein, its activities, behaviors, and synthesis.
Download or read book RNA and Protein Synthesis written by Kivie Moldave and published by Elsevier. This book was released on 2012-12-02 with total page 831 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA and Protein Synthesis is a compendium of articles dealing with the assay, characterization, isolation, or purification of various organelles, enzymes, nucleic acids, translational factors, and other components or reactions involved in protein synthesis. One paper describes the preparatory scale methods for the reversed-phase chromatography systems for transfer ribonucleic acids. Another paper discusses the determination of adenosine- and aminoacyl adenosine-terminated sRNA chains by ion-exclusion chromatography. One paper notes that the problems involved in preparing acetylaminoacyl-tRNA are similar to those found in peptidyl-tRNA synthesis, in particular, to the lability of the ester bond between the amino acid and the tRNA. Another paper explains a new method that will attach fluorescent dyes to cytidine residues in tRNA; it also notes the possible use of N-hydroxysuccinimide esters of dansylglycine and N-methylanthranilic acid in the described method. One paper explains the use of membrane filtration in the determination of apparent association constants for ribosomal protein-RNS complex formation. This collection is valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and investigators working with enzymes.
Download or read book Cold Spring Harbor Symposia on Quantitative Biology written by Cold Spring Harbor Laboratory of Quantitative Biology and published by . This book was released on 1971 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Single stranded RNA phages written by Paul Pumpens and published by CRC Press. This book was released on 2020-02-03 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
Download or read book The Eukaryotic Ribosome written by Heinz Bielka and published by Walter de Gruyter GmbH & Co KG. This book was released on 1982-12-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "The Eukaryotic Ribosome".
Download or read book Biological Regulation and Development written by Robert Goldberger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The motivation for us to produce a treatise on regulation was mainly our convic tion that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We had ourselves written reviews for various volumes over the years, most of them bringing together all possible facts relevant to a particular operon, virus, or biosynthetic system. And we were not convinced of the value of such reviews for anyone but the expert in the field reviewed. We thought it might be more interesting and more instructive-for both author and reader-to avoid reviewing topics that anyone scientist might work on, but instead to review the various parts of what many different scientists work on. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who possess sufficient breadth of knowledge and who are willing to write about areas outside those pursued in their own laboratories. For example, no one scientist works on suppression per se. He may study the structure of suppressor tRNAs in Escherichia coli, he may study phenotypic suppression of various characters in drosophila, he may study polarity in gene expression, and so on.
Download or read book Recoding Expansion of Decoding Rules Enriches Gene Expression written by John F. Atkins and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.
Download or read book Lung Cancer written by Harvey I. Pass and published by . This book was released on 2000 with total page 1256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The all-new Second Edition of this groundbreaking volume reviews the results of today's most current breast cancer clinical trials worldwide and highlights the clinical implications of recent breakthroughs in translational and molecular research. The book helps practitioners make sense of the latest trial results and develop sound, evidence-based diagnostic and therapeutic strategies. Coverage includes clinical trial data published up to 2002 on all treatment modalities--including surgery, radiation, chemotherapy, and hormones--and comprehensive drug information to help clinicians choose the most appropriate chemotherapeutic regimen. Levels of evidence are indicated to help practitioners assess the weight of evidence on efficacy and toxicity for each treatment.
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book mRNA Translational Control as a Mechanism of Post transcriptional Gene Regulation written by Daniel L. Kiss and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress in Molecular and Subcellular Biology 3 written by Robert E. Rhoads and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
