Download or read book Phospholipase A2 in Clinical InflammationMolecular Approaches to Pathophysiology written by Keith B. Glaser and published by CRC Press. This book was released on 1995-08-03 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipase A2 in Clinical Inflammation presents an up-to-date topical review of the biochemistry, molecular biology, and biology of mammalian phospholipase A2 (PLA2). The emphasis of this monograph is on the current aspects of PLA2 research using molecular approaches to investigate PLA2 structure and function, inhibitor design, and the regulation of sPLA2 and cPLA2 in cellular systems. The second section examines the major disease states where PLA2 has been implicated: rheumatoid diseases; acute pancreatitis; and psoriasis. These chapters, contributed by experts in the field, give the reader an overall sense of the clinical relevance of the molecular approaches to study PLA2 in relation to the disease entities that may be associated with altered PLA2 levels and activity. This comprehensive text not only provides the necessary historical review for beginning researchers but also addresses the more current molecular approaches as well as the major disease states for the seasoned researcher.
Download or read book Intestinal Lipid Metabolism written by Charles M. Mansbach II and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was stimulated by the enthusiasm shown by attendees at the meetings in Saxon River, VT, sponsored by the Federation ofAmerican Societies for Experimental Biology (FASEB), on the subject of the intestinal processing of lipids. When these meetings were first started in 1990, the original organizers, two of whom are editors ofthis volume (CMM and PT), had two major goals. The first was to bring together a diverse group ofinvestiga tors who had the common goal of gaining a better understanding of how the intestine ab sorbs lipids. The second was to stimulate the interest of younger individuals whom we wished to recruit into what we believed was an exciting and fruitful area ofresearch. Since that time, the field has opened up considerably with new questions being asked and new an swers obtained, suggesting that our original goals for the meetings were being met. In the same spirit, it occurred to us that there has not been a recentbook that draws to gethermuch ofthe informationavailableconcerninghow the intestineprocesses lipids. This book is intended to reach investigators with an interest in this area and their pre- and post doctoral students. The chapters are written by individuals who have a long-term interest in the areas about which they write, and many have been speakers at the subsequent FASEB conferences that have followed on the first.
Download or read book Manual of Immunological Methods written by Canadian Networking and published by CRC Press. This book was released on 1998-07-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to enhance the successful application of this science. It emphasizes the need for continuously improving the quality of experiments performed and maintaining consistency in the results obtained. The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work in the spirit of the Good Laboratory Practices. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduate students and practicing researchers in the areas of immunology and immunotoxicology will appreciate the Manual of Immunological Methods as a guide to standard operating procedures in the laboratory.
Download or read book Airway Wall Remodelling in Asthma written by A. G. Stewart and published by CRC Press. This book was released on 2020-10-28 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.
Download or read book Therapeutic Modulation of Cytokines written by M. W. Bodmer and published by CRC Press. This book was released on 1996-01-23 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.
Download or read book Muscarinic Receptor Subtypes in Smooth Muscle written by Richard M. Eglen and published by CRC Press. This book was released on 2020-10-07 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.
Download or read book Pharmacology in Exercise and Sports written by Satu M. Somani and published by CRC Press. This book was released on 1995-12-18 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to describe the pharmacological interaction of drugs and exercise with organ systems at molecular and cellular levels. It explains the effect of exercise on pharmacokinetics and pharmacodynamics of drugs, and the activation or induction of antioxidant enzymes which may take place via the adenosine receptor or may occur due to gene expression.
Download or read book Placental Pharmacology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1996-05-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placenta plays a very significant role in the development of secretory and regulatory functions for the maintenance of pregnancy and in the nutrition of the embryo. It shares many functions of the heart, lung, liver, endocrines, and other organs. In Placental Pharmacology, fourteen expert authors discuss how placenta and its component parts can be used effectively in drug development research and in the study of transfer mechanisms across membranes. This reference begins by describing the use of modern biophysical methods to study placental function and prospects for their application in pharmacological research. The next three chapters deal with placental hemodynamics, use of placental tissues and cells in pharmacological assays, and placental transfer of drugs used in pregnancy. Three more chapters contain up-to-date information on molecular biological aspects of placenta currently receiving lots of attention - phospholipase A2 isozymes, imprinted genes and embryogenesis, and placental growth factors. The final chapter describes the clinically relevant topics of placental metabolism and toxicity of homocysteine in placenta. Easy to understand, thorough, and complete, Placental Pharmacology is the perfect resource for scientists interested in placenta and its uses in drug development and testing.
Download or read book Chemoattractant Ligands and Their Receptors written by Richard Horuk and published by CRC Press. This book was released on 2020-01-31 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it contains detailed molecular and structural information on each of the major chemoattractants and their receptors. Its unique multidisciplinary approach encompasses biology, immunology, protein chemistry, and molecular biology. A time-saving reference for both researchers and students.
Download or read book Pharmacological Effects of Ethanol on the Nervous System written by Richard A. Deitrich and published by CRC Press. This book was released on 1995-12-21 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.
Download or read book ImmunoPharmaceuticals written by Edward S. Kimball and published by CRC Press. This book was released on 1995-11-27 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a leading researcher in immunology, ImmunoPharmaceuticals specifically focuses on immunologically active drugs recently tested for clinical activity or recently approved for medical use. Each chapter focuses on a single drug or class of drugs and discusses data from basic and preclinical research concerning mechanisms of action. Preclinical models are compared with clinical findings to allow the reader to evaluate the predictive value of those models. Featured drugs are being studied for therapy of cancer, arthritic disease, autoimmune disease, immunodeficiency disease, transplantation, and determination of sepsis. Overviews of the retinoids in cancer therapy and preclinical studies on flavonoids are featured.
Download or read book Receptor Dynamics in Neural Development written by Christopher Ari Shaw and published by CRC Press. This book was released on 1996-02-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of what receptors do in the nervous system, how they do it, the mechanisms by which receptor function is regulated, and the consequences of normal and abnormal receptor function. It contains a series of interrelated chapters describing key neurotransmitter receptors, protein kinases, and protein phosphatases, and details their expression and composition in the development of the central nervous system (CNS).
Download or read book CNS Injuries written by Martin Berry and published by CRC Press. This book was released on 2019-09-17 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an examination of developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including inflammatory and immune reactions scarring neuron death demyelination and remyelination axonal regeneration re-establishment of neuronal connectivity Providing a record of recent advances that will help point the way to future developments, this enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including: neurology, pharmacology, pathology, toxicology, immunology, and many others.
Download or read book Brain Mechanisms and Psychotropic Drugs written by Andrius Baskys and published by CRC Press. This book was released on 1996-03-14 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts in their fields, Brain Mechanisms and Psychotropic Drugs integrates clinical psychopharmacology with basic neuroscience and offers the latest in treatment approaches for major psychiatric disorders. The text is divided into three major sections. The first two sections focus on basic neuroscience, covering fundamental concepts such as ion channels, synapses, second messenger mechanisms, and the aging brain. The second section contains chapters on serotonin, dopamine, acetylcholine, GABA, glutamate, and peptides. The final section is clinically oriented and discusses major psychotropic drug classes: antidepressants, neuroleptics, mood stabilizers, benzodiazepines, and cognition-enhancing drugs. This is a must-have volume for all those involved in the clinical use of psychotropic medications, from medical students to practitioners and researchers.
Download or read book Drugs of Abuse and Addiction written by Raymond Niesink and published by CRC Press. This book was released on 1998-12-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs of Abuse and Addiction: Neurobehavioral Toxicology examines drugs of abuse and addiction and how they affect behavior. This book considers the entire range of addiction research in humans and animals, using a multidisciplinary approach to discuss all areas of the neuro- and behavioral sciences involved. Emphasis is on acute and chronic effect
Download or read book Taxol written by Matthew Suffness and published by CRC Press. This book was released on 2021-12-17 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.
Download or read book The Basis of Toxicity Testing written by Donald J. Ecobichon and published by CRC Press. This book was released on 1997-08-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This substantially updated edition presents fundamental principles and concepts behind the various types of toxicological studies, and explains how to design and conduct studies and interpret results. The text explains the increasing need to monitor, assess, and reevaluate the toxicity database of many agents and evaluates the place of individual studies in the overall toxicological assessment of a chemical. Concise descriptions of the formats of in vivo and in vitro studies and methods used in assessing endpoints of toxicity make this an essential introduction and guide for anyone who needs to understand or conduct toxicological studies. Reflecting increasing interest in the "Three Rs" (Reducing, Refining, and Replacement of existing animal tests) in recent years, the Second Edition includes much more information on a variety of new alternative testing protocols. Particular attention is given to the new in vitro alternative testing procedures being incorporated into EEC regulations. The text also covers studies required by regulatory agencies around the world.
