Download or read book Pharmacokinetics Metabolism and Pharmaceutics of Drugs of Abuse written by and published by . This book was released on 1997 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetics and Pharmacodynamics of Abused Drugs written by MD, FFFLM, Steven B. Karch and published by CRC Press. This book was released on 2007-10-09 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Pharmacokinetics and Pharmacodynamics of Abused Drugs is a concise and focused volume devoted to the metabolism and measurable effects of drugs on the human body. Beginning with basic concepts and models
Download or read book Pharmacokinetics Metabolism and Pharmaceutics of Drugs of Abuse written by and published by . This book was released on 1997 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetics and Metabolism in Drug Design written by Dennis A. Smith and published by John Wiley & Sons. This book was released on 2012-05-14 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.
Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-02-23 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Download or read book Pharmacokinetics and Metabolism in Drug Design written by Dennis A. Smith and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
Download or read book Handbook of Essential Pharmacokinetics Pharmacodynamics and Drug Metabolism for Industrial Scientists written by Younggil Kwon and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.
Download or read book Introduction to Drug Disposition and Pharmacokinetics written by Stephen H. Curry and published by John Wiley & Sons. This book was released on 2017-01-30 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of knowledge of drug disposition, and skills in pharmacokinetics, are crucial to the development of new drugs and to a better understanding of how to achieve maximum benefit from existing ones. The book takes the reader from basic concepts to a point where those who wish to will be able to perform pharmacokinetic calculations and be ready to read more advanced texts and research papers. The book will be of benefit to students of medicine, pharmacy, pharmacology, biomedical sciences and veterinary science, including those who have elected to study the topic in more detail, such as via electives and special study modules. It will be of benefit to those involved in drug discovery and development, pharmaceutical and medicinal chemists, as well as budding toxicologists and forensic scientists who require the appropriate knowledge to interpret their findings and as an introductory text for clinical pharmacologists. Early chapters describe the basic principles of the topic while the later ones illustrate the application of those principles to modern approaches to drug development and clinical use. Full colour illustrations facilitate the learning experience and supporting material for course leaders and students can be found on the Companion Web Site "Another book on PK? Yes and there should be and it should be DD & PK. It is good, unique, and does fill a currently unmet need for those working in the xenobiotic arena. DD & PK is just like the perfect mystery novel—the one “you just can’t put down.” However, unlike a mystery novel which requires only one reading to find the answer, the reader of DD & PK will learn more than an answer to a single question. The reader will find many solutions to a wide variety of mysterious problems associated with the time course and actions of xenobiotics." —International Journal of Toxicology, John A. Budny, PhD, President, PharmaCal, Ltd, 2018 "This book has many innovations that make a welcome addition to the bookshelves of a wide range of pharmaceutical scientists. The effective use of figures and tables to summarize and clarify a wide range of issues is to be commended, as are the learning objectives at the start of the chapter coupled with the summary at the end providing a succinct way in understanding the objectives of the chapter and together with links to a website provides accessibility for all from the neophyte pharmacokineticist to the consultant physician. A book all in the Pharma industry should be aware of." —Int. J. of Pharmacokinetics, Howard M. Hill, ResolvPharma, 2018 "Overall, Introduction to Drug Disposition and Pharmacokinetics offers its readership an in-depth view of classic pharmacokinetic concepts. This book would be an excellent choice for a pharmacokinetics elective or as an adjunctive text for an introductory course. This book reviews a wide array of clinically relevant topics and encourages the reader to apply the knowledge gained to all medi-cations. A robust and varied amount of online material is provided to enhance understanding and encourage discussion. It is likely that all readers, novice or experienced pharmacists, would find value in this textbook." — Currents in Pharmacy Teaching and Learning, Milena McLaughlin, Midwestern University Chicago College of Pharmacy, 2018 "In summary, this is an excellent textbook for students new to the field of pharmaceutics and medical, pharmacy, and veterinary students, particularly those who envision a career in drug development research in either academia or industry." —Veterinary Pathology Review, John K. Amory, University of Washington, 2018
Download or read book Pharmacology and Pharmacokinetics written by T. Teorell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of papers by leading pharmacokineticists and pharmacolo gists is the proceedings of a conference held at the John E. · Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R.
Download or read book Pharmacology written by Carol T. Walsh and published by CRC Press. This book was released on 2004-12-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, this is the seventh edition of Levine's classic pharmacology textbook. Known for it's thorough coverage and intelligent organization, the book covers the basic principles of pharmacological interactions on the human body in a way that is useful for both undergraduate and graduate students. Beginning with historical perspectives, nomenclature and definitions, the topics broaden to include sites and mechanisms of drug actions and travel to sites of action, as well as termination and elimination. The book also includes drug response and time-response relationships, response variability, drug toxicity, drug abuse, drug dependence, and more.
Download or read book Pharmacokinetics and Drug Metabolism in Canada The Current Landscape written by Neal M. Davies and published by MDPI. This book was released on 2018-03-23 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape" that was published in Pharmaceutics
Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh and published by Springer. This book was released on 2011-09-07 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Download or read book Pharmacokinetics and Metabolism in Drug Design Volume 13 written by Dennis A. Smith and published by Wiley-VCH. This book was released on 2001 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. This book explains in readily comprehensible terms the problems that may arise, and how these may be taken into account at an early stage in drug development.
Download or read book Pharmacokinetics written by A. Pecile and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacologists can be considered pioneers of the study of kinetics of materials introduced into biological systems. The study of drug kinetics is particularly suited to a formulation of relatively simple models which make possible an interpretation of the time-dependent nature of various important phenomena (e. g. distribution by means of diffu sion through membranesl. The objective of the NATO ASI Course on Pharmacokinetics was that of presenting and dis cussing the mathematical and statistical approaches current ly available or being developed for the description, inter pretation and prediction of the fate of drugs and tracer substances administered to living beings. Different physi cal methods for measuring drugs and tracer substances were considered, but the emphasis was on the interpretation of the results of the measurements in terms of mathematical and statistical models. The present book contains all invit ed lectures given in this Course by outstanding internation al authorities and specialists from different fields. A great effort was made to keep a balance among the mathemati cal, physical, biological and clinical aspects of the prob lems; exchange of ideas and experiences between scientists with a physico-mathematical background and scientists with a biomedical background was encouraged and all participants were deeply involved in fruitful discussions. This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.
Download or read book Handbook of Drug Interactions written by Ashraf Mozayani and published by Springer Science & Business Media. This book was released on 2011-09-18 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adverse drug reactions and interactions are still a major headache for healthcare professionals around the world. The US Food and Drug Administration's database recorded almost 300,000 serious adverse events in 2009 alone, of which 45,000 instances proved fatal. This updated new edition of the indispensable guide to drug interactions incorporates fresh research completed since the book's original publication by Humana Press in 2004. Additions include a new section on pharmacogenomics, a rapidly growing field that explores the genetic basis for the variability of responses to drugs. This new material reviews important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation, using case studies involving opiates as exemplars. Existing chapters from the first edition have in most cases been updated and reworked to reflect new data or incorporate better tables and diagrams, as well as to include recent drugs and formulations. Recent references have been inserted too. The handbook features extra material on illicit drug use, with a new chapter tackling the subject that covers cocaine, amphetamines and cannabis, among others. The section on the central nervous system also deals with a number of drugs that are abused illicitly, such as benzodiazepines, opiates flunitrazepam and GHB, while so-called 'social' drugs such as alcohol and nicotine are still discussed in the book's section on environmental and social pharmacology. Focusing as before on detailed explanation and incorporating both pharmacokinetic and pharmacodynamic drug interactions, this book will continue to be a lodestar for health and forensic professionals as well as students.
Download or read book Drugs of Abuse written by Sherrel Howard and published by John Wiley & Sons. This book was released on 2014-02-27 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse
Download or read book Pharmacology written by R.R. Levine and published by CRC Press. This book was released on 2000-04-15 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.
